Gene 22340 (Tetrahymena)

22340

Species: Tetrahymena
Alias: 3701.m00125, TTHERM_00219120, 22340, 18.m00366, PreTt22340, 511
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
22340.AA Protein None 656 None Fasta, JSON
22340.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
22340.NA RNA None 1971 None Fasta, JSON

Protein domain

Protein domains of 22340.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22340.AA Ciliate-E2-Unclassified 118-378 24 3.6e-91 309.21 In-house 1-352 (352) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-352/352
Sequence Identity: 24% (86 aa)

FKLLRCLGEGGYGRVFEARNRISKEKV-----AIKMIDSS-KIKNAKDTDMIYKELIALKN----------------LNHRNIVKVYNCYTLQKEQKVAL
.|.....|.||.| |......  | ..     ..|... . |... || ... ....  ..                ||| ....|. .|. |..|.. .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ILEYLDGGDLREYLNEK-----------------KILPEKEAQ-----KLFIQLYSAIQYCHREN-IIHRDLKLENIMFEDKA-KEKLKVVDFGIS-GRQ
..||..||||..|....                 ||..|..|.     ..| |. ....|.|..| |||||.|.|||.| ..  . ..|. |||||   |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

TLVYVDHTE----------------AGSARYL----SPEVITQHFPAHP---CIDVWAMGCILFWMLTGNSPFPQNTRDA----------------VQDS
. .. | |.                .|. .|.    .|||. .. . |.   ..|.|..|.||..||.|. ||..|...                 ... 
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

ILKGKWSFSPADK----KKLTRSVQDLIK----KMLIINHNQRITMNEIGEHRWI
|......|.....    |..  ...|.|.    |||  | |.|||...| .| |.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 22340.AA Ciliate-E2 118-378 23 7.4e-86 291.54 In-house 1-365 (365) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

FKLLRCLGEGGYGRVFEARNRISKEKVAIKMIDSSK------------------IKNAKDTDMIYKELIALK----------------NLNHRNIVKVYN
.|.....|.|..| |......  ....|||.||  |                  |.. ..  .| .|.  ..                .||| ||.| | 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CYTLQKEQKVALILEYLDGGDLREYLNEKKILP-----------EKEAQKLFIQLYS---------------AIQYCHREN-IIHRDLKLENIMFEDKAK
|.  ...... |..||..||||..|....|.             |||..... |. .               |..|.| .| |||||.|.|||.|     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

EKLKVVDFGISGRQTLVYVDHTE--------------------------------AGSARYLSPEVIT--------QHFPAHPCIDVWAMGCILFWMLTG
  .|..|||.| ...  . ..|.                                .|.. |..||..         .. .    .|.|..|.||..||.|
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

NSPFPQNTRDAVQDSILKGKWSFSPA--------------DKKKLTRSVQDLIKK----MLIINHNQRIT-MNEIGEHRWI
. ||        |. |...|..|...              ..||.. ...|||||    ||  . ..||| ...| .| |.
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22340.AA S_TKc 118-378 28 9.9e-84 285.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-231/231
Sequence Identity: 28% (80 aa)

FKLLRCLGEGGYGRVFEARNRISKEKVAIKMIDSSKIKNAKDTDMIYKELIALKNLNHRNIVKVYNCYTLQKEQKVALILEYLDG--GDLREYLNEKKI-
...|| .|.|..|.|. .|.. ....||||.|.          ..|..|.  ||. .| |||| | ..     ... ...||.||  |||..|. ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LPEKEAQKLFIQLYSAIQYCHRENIIHRDLKLENIMFEDKAKEKLKVVDFGISGRQTLVYVDHTEAGSARYLSPEVITQHFPAHP-CIDVWAMGC
     .|| .|.... |. .|..|||. .||||||| |||.. .     .|. |||.. .       .|  |.  |..|||.    .  .  .|.|. ||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

ILFWMLTGNSPFPQNTRDAVQDSILKGKWSFSPADKKKLTRSVQDLIKKMLIINHNQRITMNEIGE-------HRWI
||. ||.|  |||  . ... . |.              .... |.|.|.|  . ..|.|  |. .       | |.
ILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22340.AA CAMKL 118-378 30 1.2e-81 260.32 In-house 1-297 (297) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-297/297
Sequence Identity: 30% (91 aa)

FKLLRCLGEGGYGRVFEARN-RISKEKVAIKMIDSSKIKNAKDTDM------------IYKELIALKNLN---HRNIVKVYNCYTLQKE----QKVALIL
..... ||.|..| |  |.. |. .||||||.|| .||.|   ...            |..|   .| ||   | ||.| | ... ..     .|. |..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYLDGGD--LREYLNEK----KILPEKEAQKLFIQLYSAIQYCHRENIIHRDLKLENIMFEDKAKEKLKVVDFGISGRQT---LVYVD--HTEAGSARYL
|| .||.  | .|. ..    . .||.||...| |. ||..|||. .|.|||.|.|||.. .. ....|..||| |  ..     . .  .|  ||  | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEVITQ-HFPAH-PCIDVWAMGCILFWMLTGNSPFPQNTR------DAVQDSILKGKWSFSPADKKKLTRSVQDLIKKMLIINHNQRITMNEIGEHRWI
.||..   . | . | .|.|..| ||. |..|. || . |       .       . .  . |   ...  ...|||.|||  | ..|.|. .| .|.| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 22340.AA CAMK 123-378 21 4e-81 261.02 In-house 1-425 (425) Show / Hide 
Range on Protein: 123-378
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

CLGEGGYGRVFEARNRISK------------EKVAIKMIDSSKIKN-------------------------AKDTDMIYKELIALKN-------LNHRNI
 ||.|..| |...... ..            .|||||.|| .|.|.                         .|| .....|.  .|.       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKVYNCY-------------TLQK-----EQKVALIL---EYLDGG----DLREYLNEK---------------KILPEKEAQKLFIQLYSAIQYCHREN
.| |  |             | .|     .... ...   || .||    || .|. |.               . ..|.||...| |. ||..|||  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKLENIMFEDKAKE---------------KLKVVDFGISGRQTLVYVDHTE------------------------AGSARYLS-PEVITQ-----
|.|||||.|||.. |. ..               ..|..||| . . .    ....                         |.  | . |||. .     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------HFPAHPCIDVWAMGCILFWMLTGNSPFPQNTRDAVQD-------------SILKGKWSFSPADKKK--------------------LTRSVQ
        . .  | .|.|..|.||. ||.| .||   ...   .              |.|||..| |   ..                    .. ...
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLIKKMLIINHNQRITMNEIGEHRWI
|||.|||  . ..|.|  .. .| |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 22340.AA CAMKL-Unclassified 118-378 32 4.4e-76 258.33 In-house 1-290 (290) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-290/290
Sequence Identity: 32% (96 aa)

FKLLRCLGEGGYGRVFEARNRISKEKVAIKMIDSSKIKNAKDTDMIYKELIALKNLNHRNIVKVYNCYTLQKEQKVALILEYLDGGDLREYLNEKKILPE
. ... .||||.|.|  |  .. .||.|||..  . ...| | ||.. |  .|| |||.||||. |||||  . || .| |||.||.| ..   .  . |
YNIVQVIGEGGFGQVQLAEHKQTQEKFAIKFVKTMNHGCAMDIDMVFREAEILKSLNHKNIVKIKNCYTLS-DMKVVMIMEYLQGGELLDWCRKNGHFNE

KEAQ-------KLFIQLYSAIQYCHRENIIHRDLKLENIMFE-DKAKEKLKVVDFGISGRQTL-VYVDHTEAGSARYLSPEVITQHFPA-HPCIDVWAMG
 .|        . | |   |.|||| ..||||||||||.           |..|||| |     . |   ..|| ||  ||.  |      . ||.||||
NNARRQPWEIQQYFQQIVDAMQYCHKNCIIHRDLKLENVLLRQQDSSPVIKIFDFGIAGVANVNQNVFNINGGSLRYMAPEMKNQQVKQIQYSIDIWAMG

CILFWMLTGNSPFPQ---------------NTRDAVQDSILKGKWSFSPADKKKLTRSVQD-----LIKKMLIINHNQRITMNEIGEHRWI
 .|. .  .. ||                  .   .   | .| ..|    .|.|.  . |     || . .. |  .|.|  .|  | |.
VMLYMCIVQFFPFNGNGNNGKNNNSDGNENDNNNNIMFKITRGPYEFPEQINKPLPDECKDQRLISLIENIFQVNPKNRFTTHQIMQHPWM
Kinase 22340.AA Pkinase 118-378 26 1.6e-73 255.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

FKLLRCLGEGGYGRVFEARNRISKEKVAIKMIDSSKIKNAKD-----TDMIYKELIALKNLNHRNIVKVYNCYTLQKEQKVALILEYLDGG----DLREY
....|..|.|..|.|...... . ..||.| |. ...|  ||     .     |.  .|.||| |||. | ...   .... ...||..||    || .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

LN--EKKIL--PEKEAQKLFIQLYSAIQYCHRENIIHRDLKLENIMFE--DKAKEKLKVVDFGISGR--QTLVYVDHTEAGSARYLSPEVITQHFPAHPC
.   ... .  .|.|... . |. ....|||...|||||||.|||..   .  ....|. |||..           .| .|. .|..||||  . .  | 
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDVWAMGCILFWMLTGNSPFPQN------TRDAVQDSILKGKWSFSPADKKKLT-----------------RSVQDLIKKMLIINHNQRITMNEIGEHRW
.|.|..||||. ||.|. |||.       . ... . |......|.   .                     .. .|.||..|  . ..|.|  .| .| |
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

I
.
F
Kinase 22340.AA AGC 118-378 18 8.6e-72 184.0 In-house 1-395 (395) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-395/395
Sequence Identity: 18% (75 aa)

FKLLRCLGEGGYGRVFEARNR------ISKEKVAIKMIDSSK-IKNAK--DTDMIYKE------------LIALKNLN----------HRNIVK-VYNCY
|..|...|.|..|.|. .| .       ...  |.|... .. |.  |  . .... |               |...|          | .|||  .  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILH--Y

TLQKEQK--VALILEYLD---------GG-DLREYLN---EKKILPEKEAQKLFIQ-------LYSAIQYCHR-ENIIHRD-LKLENIMFEDKAKEKLKV
. | ...  . ...||.          || .|  .|     .....|..|.  . .       . .|..| |.  .||||| ||.|||.. ..    .| 
SFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED--GHIKL

VDFGISG----------------------------------------------------RQTLVYVDHTEAG--SARYLSPEVITQHFPAHPCIDVWA--
.||| .                                                     |       .|  |  .. |..||..       .  | |.  
TDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFG

MGCILFWMLTGNSPFPQNT----------RDAVQDSIL------KGKWSFSPA------DKKKLTRSVQDLIKKMLIINHNQRIT----------MNEIG
.||... |||| .||  ..          .. . ..|.      . |  | .       . ....   .|||||.|  . ..|..           .|| 
LGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIK

EHRWI
.| | 
NHPWF
Kinase 22340.AA ULK 118-378 27 2.9e-66 226.48 In-house 1-329 (329) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-329/329
Sequence Identity: 27% (89 aa)

FKLLRCLGEGGYGRVFEARNRISK----EKVAIKMIDSSK-IKNAKD------TDMIYKELIALKNLN--------HRNIVKVYNCYTLQKEQKVALILE
. | .|||.| .|.|...|| ..|    ||||.||||..| ... ..       ... .|   .| |.        | |||| | ..  ...  . .|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YLDGGDLREYLN----------EKKILPEKEAQKLFIQLYSAIQYCHRENIIHRDLKLENIMFEDKAKEK----------LKVVDFGISGR-QT---LVY
| .||||..|..          |||.|.|.||.. |.|. .. .. | .||||||.|..||.  ..   .          ||. ||| .   .       
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VDHTEA------GSARYLSPEVIT-Q--HFPAHPC-IDVWAMGCILFWMLTGNSPF---PQNTR-----DAVQD------SILKGKWSFSPA-DKKKLTR
. .|        |.  | .|...  |  . | .    |.| .|||...||.|  ||   .. .      . ...       | | .  | .. .....  
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

SVQDLIKKMLIINHNQRITMNEIGEHRWI
 ..|||..||... ..||.  |. .| |.
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 22340.AA ULK 118-378 27 6.1e-65 222.05 In-house 1-324 (324) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-324/324
Sequence Identity: 27% (88 aa)

FKLLRCLGEGGYG-RVFEARNRIS---KEKVAIKMIDSSKIKNAKDT-------DMIYKELIALKNLN---HRN--IVKVYNCYTLQKEQKVALILEYLD
. | .|||.| .|  |...|| ..   ...||.|||| .|... |         ... .|   .| |.   | |  ||| | ..  . .  . .|.|| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLREYLN---------EKKILPEKEAQKLFIQLYSAIQYCHRENIIHRDLKLENIMFEDKAKEK----------LKVVDFGISGR-Q---TLVYVDHT
||||..|..         |||.|.|.||.. |.|. .. .. | .||||||.|..||.  ..   .          ||. ||| .   .       . .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

EA------GSARYLSPEVIT-Q--HFPAHPC-IDVWAMGCILFWMLTGNSPFPQNTRDAVQ----DS----------ILKGKWSFSPA-DKKKLTRSVQD
        |.  | .|...  |  . | .    |.| .|||...||.|  ||  .     .    .           | . .  | .  . .|.   ..|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIKKMLIINHNQRITMNEIGEHRWI
||..||... ..||.  || .| |.
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 22340.AA CDPK 118-378 31 6.4e-62 188.78 In-house 1-271 (271) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-271/271
Sequence Identity: 31% (87 aa)

FKLLRCLGEGGYGRVFEARNR-ISKEKV-AIKMIDSSKIKNAKDTDMIYKELIALKNLNHRNIVKVYNCYTLQKEQKVALILE--YLDGGDLREYLNEKK
.|. . ||.|..| |. . .. .....  |.|.|  |..|.... ..  .|.  ||.| | ||.|.|  |  | |. . ...|  |. ||.| .|  ||.
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFY--QDEKNYYIVMETEYCTGGELFDYIIEKG

ILPEKEAQKLFIQLYSAIQYCHRENIIHRDLKLENIMFEDKAKE-----KLKVVDFGISGRQTLV-----YVDHTEAGSARYLSPEVITQHFPAHPCIDV
 ..||||.. . |. ||..|||  ||.||||| |||.|. | .       .||.|.|.| ..         .  . .|   |..|||. .      | |.
HFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKC-DI

WAMGCILFWMLTGNSPFPQNTRDAVQDSILKGKWSFSPADKKKLTRSVQDLIKKMLIINHNQRITMNEIGEHRWI
|  | ||. .| |  ||   ..  ..... ||| ||   . .. . . .|||.|||  . ..|.. ... .| |.
WSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 22340.AA MARK 118-265 35 1.7e-49 160.06 In-house 1-151 (262) Show / Hide 
Range on Protein: 118-265
Range on HMM: 1-151/262
Sequence Identity: 35% (54 aa)

FKLLRCLGEGGYGRVFEARNRISKEKVAIKMIDSSKIKNAKDTDMIYKELIALKNLNHRNIVKVYNCYTLQ--KEQK-VALILEYLDGGDLREYLNEK--
.|.|...|.|.|. |  |... ...|||||...  |.   .   ... |.  .| |.| ||.| .  .. .   ||. . ||.||  ||.|..|. ..  
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLF--HVIEQDTEQHQIYLIMEYASGGELYDYIKAHPN

KILPEKEAQKLFIQLYSAIQYCHRENIIHRDLKLENIMFEDKAKEKLKVVDFG
  |.|.|| ..| |. ||..|||. ||.|||.|.|||.  .. . . |  |||
GRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG
Kinase 22340.AA MARK 301-378 28 5.6e-17 52.2 In-house 187-262 (262) Show / Hide 
Range on Protein: 301-378
Range on HMM: 187-262/262
Sequence Identity: 28% (23 aa)

IDVWAMGCILFWMLTGNSPFPQNT--RDAVQDSILKGKWSFSPADKKKLTRSVQDLIKKMLIINHNQRITMNEIGEHRWI
.|.|..| .|. |..|. ||   |      .  ||.|| .. .     . .. ..||...| .| ..|.|. || .|.|.
VDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 22340.AA Pkinase_Tyr 118-244 28 6.8e-17 57.84 Pfam 1-137 (270) Show / Hide 
Range on Protein: 118-244
Range on HMM: 1-137/270
Sequence Identity: 28% (40 aa)

FKLLRCLGEGGYGRVFEARNR----ISKEKVAIKMIDSSKIKNAKD--TDMIYKELIALKNL-NHRNIVKVYNCYTLQKEQ-KVALILEYLDGGDLREYL
 .... |||| .|.|.... .      | .||.||.        ..   ..  .|.  .|.| .| |||. | . | |.|. .. ...||  .|||..||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

NE----KKILPEKEAQKLFIQLYSAIQYCHRENIIHRDL
 .    |. |. |.  .  .|  .. .| .. |.|||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 22340.AA TyrKc 118-378 22 9.9e-16 31.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 118-378
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FKLLRCLGEGGYGRVFEARNRISKEKVAIKMIDSSKIKNAKDTDMIYKELIALKNL--NHRNIVKVYNCYTLQKE-----QKVALILEYLDGGDLREYLN
 .|.. |||| .|.|.... .   ..||.||. ...        ....|.  ...|  .| |||. | . | |..     . . ...|| ..|||..|| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EKKI-LPEKEAQKLFIQLYSAIQYCHRENIIHRDLKLENIMFEDKAKEKLKVVDFGISGRQTLV--------YVD-----HTEA-GSARYLSPEVITQHF
...  |. |.  .  .|  .  .| |. |.|||||   |..  ..     |. ||| |   .          | .     .. .    | ..||.|  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

PAHPCIDVWAMGCILFWMLT-GNSPFPQ-----NTRDAVQDSILKGKWSFSPAD--KKK----LTRSVQDLIKKMLIINHNQRITMNEIGEHRWI
  .   |||. |  .. ..| | .| |       . . |   . .|.    |..          .  . ...|.    . ..| |..||  |. .
FTTKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF