Gene 24302 (Tetrahymena)

24302

Species: Tetrahymena
Alias: TTHERM_00134780, 3698.m00072, 550, 10.m00351, PreTt24302, 24302
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
24302.AA Protein None 825 None Fasta, JSON
24302.kin_dom Protein Kinase Domain None 350 None Fasta, JSON
24302.NA RNA None 2478 None Fasta, JSON

Protein domain

Protein domains of 24302.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 24302.AA Ank 142-175 11 29.975374 1.55 Pfam 1-33 (33) Show / Hide 
Range on Protein: 142-175
Range on HMM: 1-33/33
Sequence Identity: 11% (4 aa)

EGMNCMLMCCMVDNIDLLKKLVNDYNSNPSVINS
.|. .  . |. .... .| |.. .. .. . . 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 24302.AA Ank 182-204 30 0.018954 13.09 Pfam 6-28 (33) Show / Hide 
Range on Protein: 182-204
Range on HMM: 6-28/33
Sequence Identity: 30% (7 aa)

LHYACMHNNPEILTFLLSKNTSL
||.||.....|....||... ..
LHLACRCGHTEVVKMLLQHGADV
Ank 24302.AA Ank 211-243 24 1.7e-07 31.25 Pfam 1-33 (33) Show / Hide 
Range on Protein: 211-243
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

NECTPLYYAALNNSEKCVEILLNYDANIHLPNN
. .||| .|........|. ||.. |.... ..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Kinase 24302.AA AGC 408-757 22 1.7e-140 365.73 In-house 1-395 (395) Show / Hide 
Range on Protein: 408-757
Range on HMM: 1-395/395
Sequence Identity: 22% (109 aa)

FTFYRQIGEGSFGEVYLVKINENAVKQTSSKSSSSGSSESSVIEKIKNDLNNRAKQMENKENSNQQILSIADGRQTDIMIRDENKEEAEDNKIDQNAAHI
| |.. ||.||||.||||. ... .                                                                           
FEFLKVIGKGSFGKVYLVRKKDGCH---------------------------------------------------------------------------

KRLQFLLNKNNDELDDPSQKFYALKIIRKEA---LKKKKLAQYIEFE------------KSVMQEIK----------HPFVAK-LHLTFQNDTH--LFLL
               . ..|.||.|...|.    .|||.  ...  |            . ......          |||. | || .||...|  |...
--------------KKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFV

MDFYQ---------GG-DLGRILEK--DIE-VDEFQVKVWAAQ-------IVLALEELHK-NDIIYRD-LKPENVVLDAKGNLHLIDFGLAKKGVN----
|....         || .|  .| .  .    || ... .||.       |||||| ||. ..||.|| |||||..||..|...| ||||.|.|.|    
MEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEK

------------------------------------------------AITSSFCG--TPIYLPPEIVGRSGHNKMVDWYS--LGVIIYELLIGRPPYFS
                                                . |..|||  || |..|||.    ..| .||.|  ||...||.|.|.||...
GQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYG

S----------DCKQLFNDIQ------TQPLRLP----------KSLPEESKSILIQLLKKNYKTRLGYEKD------AEEVKQHPWF
           . ...|. |.      ......|          ... .| |... .||.|. . |||. ..      |||.|.||||
DNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 24302.AA SGK 526-757 40 3.8e-109 338.29 In-house 42-283 (283) Show / Hide 
Range on Protein: 526-757
Range on HMM: 42-283/283
Sequence Identity: 40% (98 aa)

QKFYALKIIRKEALK-------KKKLAQYIEFEK-SVMQEIKHPFVAKLHLTFQNDTHLFLLMDFYQGGDLGRILEKDIEVDEFQVKVWAAQIVLALEEL
.||||.|...|..         |||.. .|  |.  ... .||||  .||  ||... |.. ||. .||...  | .     | ...  ||.||.|||.|
DKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYL

HKNDIIYRDLKPENVVLDAKGNLHLIDFGLAKKGV--NAITSSFCGTPIYLPPEIVGRSGHNKMVDWYSLGVIIYELLIGRPPYFSSDCKQLFNDIQTQP
|. |||||||||||..||..|.. | ||||.| |.  |  |..||||| || ||.    .| . |||..|| . ||...| ||..| . .|..  |  ||
HSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQP

LRLPKSLPEESKSILIQLLKKNYKTRLGYEKDAEEVKQHPWF
|..|..   . .... .||.|. | |||  .|..|.|.||.|
LQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 24302.AA Akt 525-757 40 2.1e-105 337.91 In-house 23-264 (264) Show / Hide 
Range on Protein: 525-757
Range on HMM: 23-264/264
Sequence Identity: 40% (98 aa)

SQKFY-ALKIIRKEALKKKKLAQYIEFEKSVMQEIKHPFVAKLHLTFQNDTHLFLLMDFYQGGDLGRILEKDIEVDEFQVKVWAAQIVLALEELHKNDII
.||.| |.|...|. . .|.  ...  |. . | ..|||. .||  ||. ..|.. ||. .||.|   | ..   .| . .  .|.|.||.| ||...||
TQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNII

YRD-LKPENVVLDAKGNLHLIDFGLAKKG-VNA--ITSSFCGTPIYLPPEIVGRSGHNKMVDWYS-LGVIIYELLIGRPPYFSSDCKQLFNDIQTQPLRL
||| |||||...|..|.. | ||||.|.. .    .| .||||| ||.|||    || |.|||.. ||...||.. ||||... | .|.|  |..||.. 
YRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKF

P--KSLPEESKSILIQLLKKNYKTRLG-YEKDAEEVKQHPWF
|  . .  | |.....||.|..| |||  ..||.|.|.||||
PDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 24302.AA AktR 525-757 39 1e-100 340.91 In-house 24-268 (268) Show / Hide 
Range on Protein: 525-757
Range on HMM: 24-268/268
Sequence Identity: 39% (97 aa)

SQKFYALKIIRKEALKKKKLAQYIEFEKSVMQ-EIKHPFVAKLHLTFQNDTHLFLLMDFYQGGDLGRILEKDIEVDEFQVKVWAAQIVLALEELHKN-DI
.||.||.|.|.|. ..........  |. .|. ...|||  ||| .||....||..|....||.| ..| |.   .| |..  .|||.|||| ||.. .|
NQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNI

IYRDLKPENVVLDAKGNLHLIDFGLAK-KGV---NAITSSFCGTPIYLPPEIVGR-SGHNKMVDWYSLGVIIYELLIGRPPYFSSDCKQLFNDIQTQP-L
||||||||| .||  |.. ..||||.|  ..   . .. |||||| |..||.. .  ||||.|||...|. |||...| || .... .|.|  |.... .
IYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQN

RLPKS--LPEESKSILI-QLLKKNYKTRLG-YEKDAEEVKQHPWF
. |..  . .. |...  .||.|| . ||| | ...||.| ||||
KFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 24302.AA Ciliate-E2 408-757 19 1.6e-86 293.75 In-house 1-365 (365) Show / Hide 
Range on Protein: 408-757
Range on HMM: 1-365/365
Sequence Identity: 19% (90 aa)

FTFYRQIGEGSFG-----EVYLVKINENAVKQTSSKSSSSGSSESSVIEKIKNDLNNRAKQMENKENSNQQILSIADGRQTDIMIRDENKEEAEDNKIDQ
. | ..||.|.||     .|..|. ... ....  |. ....                   |.                                     
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQ-------------------MQ-------------------------------------

NAAHIKRLQFLLNKNNDELDDPSQKFYALKIIRKEALKKKKLAQYIE----------FEKSVMQEIKHPFVAKLHLTFQ--NDTHLFLLMDFYQGGDLGR
                   .   .|.||.||..|  .. .|  ..|            ||.......||.. |.. .||  .|....| |...|||||  
-------------------EKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFD

ILE-------------------KDIEVDEFQVK-------VWAAQIVLALEELHKND-IIYRDLKPENVVLDAKGNLHLIDFGLAK--------------
...                   . ... . ...        ..|.|.||||.||..  ||.||.||||...     . .|||||.|              
YIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQ

------KGVNAITSS-------------FCGTPIYLPPEIVGRSG---------HNKMVDWYSLGVIIYELLIGRPPYFSSDCKQLFNDIQTQPLRLP--
      |. . .|..             .|||| |..|||... .         .....|..|||||.||.| |.||.        .. |. .....|  
CKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCP

----------------KSLPEESKSILIQ----LLKKNYKTRLGYEKDAEEVKQHPWF
                |....| | .. .    .|.|. . |..   ..|....||||
EWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
Kinase 24302.AA Ciliate-E2-Unclassified 408-757 21 4.7e-85 288.89 In-house 1-352 (352) Show / Hide 
Range on Protein: 408-757
Range on HMM: 1-352/352
Sequence Identity: 21% (91 aa)

FTFYRQIGEGSFGEVYLVKINENAVKQTSSKSSSSGSSESSVIEKIKNDLNNRAKQMENKENSNQQILSIADGRQTDIMIRDENKEEAEDNKIDQNAAHI
... .|||.|.||.||... ...  ..     ... .  .  |.. . ...| .|.|.||.. ..|  .                               
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQR-K-------------------------------

KRLQFLLNKNNDELDDPSQKFYALKIIRKEALKKKKLAQYIEFEKSVMQE----IKHPFVAKLHLTFQNDTHLFLLMDFYQGGDLGRILEKDIE------
                                        .   .  ||.    ..|||. |.. .||.. .... |.. .||||  ...|         
----------------------------------------Y---NKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGN

-----------VDEFQVK-----VWAAQIVLALEELHKND-IIYRDLKPENVVLDAKG---NLHLIDFGLAK--------KGVN----------AITSSF
           ..|.|.|      ..|||...|| ||..  ||.||.||||...| .|   .. .||||..|        .  |           ....|
DLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTF

CGTPIYL----PPEIVGRSGHN----KMVDWYSLGVIIYELLIGRPPYFSSDCKQ----------------LFNDIQTQPLRLPK--------SLPEESK
||||.|.    .||. .. ...    ...|..|||||.||.| |..|... .|.|                |...|. ...  ||         ...| |
CGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAK

SILIQLLKKNYKTRLGYEKDAEEVKQHPWF
 .. .||.|. | ....  ..|....||||
DFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 24302.AA RSK-Unclassified 525-757 33 3.9e-84 264.1 In-house 23-283 (283) Show / Hide 
Range on Protein: 525-757
Range on HMM: 23-283/283
Sequence Identity: 33% (88 aa)

SQKFYALKIIRKEALKKKKLAQYIEFEKSVMQEIKHPFVAKLHLTFQNDTHLFLLMDFYQGGDLGRILE--KDIEVDEFQVKVWAAQIVLALEELHKNDI
.|. ||.|.  |. . .... .|.  |. .|   .|||. .|   ||    |.| |..  |||..| |   |.  . | .|...|. ...||| ||| |.
TQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCEDDVRFYASEVTAALEYLHKRDF

IYRDLKPENVVLDAKGNLHLIDFGLAKKG-------VN----------------AITSSFCGTPIYLPPEIVGRSGHNKMVDWYSLGVIIYELLIGRPPY
|||||||.|.||.  |   | ||.| ...       .                   | |||||  || ||.. | || | |||. ||...||.|.| |||
IYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPY

FSSDCKQLFNDIQTQPLRLP--KSLPEESKSILIQLLKKNYKTRLGYEKD-AEEVKQHPWF
       .|. | ......|  . .  . .. .  ||..|   |||  .  |...|.|| |
YGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 24302.AA RSK 525-757 34 1.7e-83 283.69 In-house 23-278 (278) Show / Hide 
Range on Protein: 525-757
Range on HMM: 23-278/278
Sequence Identity: 34% (89 aa)

SQKFYALKIIRKEALKKKKL-AQYIEFEKSVMQEIK-HPFVAKLHLTFQNDTHLFLLMDFYQGGDLGRILEKDIE---VDEFQVKVWAAQIVLALEELHK
... || |...|  .....  . .   | ....... |||. .|| .|| ...|.| |..  ||.|.. |.|       .|  ... .|.||||.| ||.
TGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQ

NDIIYRDLKPENVVLDA---KGNLHLIDFGLAKKGVNA---ITSSFCGTPIYLPPEIVG----RSGHNKMVDWYSLGVIIYELLIGRPPYFS---SDCKQ
 .||.|||||||...|     | . |.|||..|....     | .||.|  |..||..     ..||.| .||.||||..||.| |.||. .   .. |.
QGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKE

LFNDIQTQP--LRLP--KSLPEESKSILIQLLKKNYKTRLGY-EKDAEEVKQHPWF
... ||.    |..|  ..| .| |... ..|... . |||.  .||||.||||||
IMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 24302.AA S_TKc 408-757 22 1.2e-75 258.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 408-757
Range on HMM: 1-231/231
Sequence Identity: 22% (82 aa)

FTFYRQIGEGSFGEVYLVKINE----NAVKQTSSKSSSSGSSESSVIEKIKNDLNNRAKQMENKENSNQQILSIADGRQTDIMIRDENKEEAEDNKIDQN
... |.||.|.||.||... ..     |.|. .                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

AAHIKRLQFLLNKNNDELDDPSQKFYALKIIRKEALKKKKLAQYIEFEKSVMQEIKHPFVAKLHLTFQNDTHLFLLMDFYQG--GDLGRILEKDIE----
                                          . |. | ..... .||.. ||. .||. .||.. |..  |  ||| ....|       
------------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VDEFQVKVWAAQIVLALEELHKNDIIYRDLKPENVVLDAKGNLHLIDFGLAKKGVNAITSSFCGTPIYLPPEIVGRSGHNK-MVDWYSLGVIIYELLI
   .| ... ...||..||| .|.. ||.|||||||. ||   .. ..|||||..      ..||||| |..||..   |..|  .||.|.|.|.||.| 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRPPYFSSDCKQLFNDIQTQPLRLPKSLPEESKSILIQLLKKNYKTRLGYEKDAE---EVKQHPWF
|.||.   . ...|. |           ..| |... ..|.|. . |..  .  .   ..|.||||
GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24302.AA PKA 524-757 38 9.1e-72 244.74 In-house 22-263 (263) Show / Hide 
Range on Protein: 524-757
Range on HMM: 22-263/263
Sequence Identity: 38% (94 aa)

PSQKFYALKIIRKEALKKKKLAQYIEFEKSVMQEIKHPFVA-KLHLTFQNDTHLFLLMDFYQGGDLGRILEKDIEVDEFQVKVWAA-QIVLALEELHKND
.| ..||.|...|.  .. |  . .  ||...|.|||||.  |.  |||.|..|...|.. .||..   | |    .. . |  || ||||||| ||. .
HSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYLHSQN

IIYRDLKPENVVLDAKGNLHLIDFGLAKKGVNAITSSFCGTPIYLPPEIVGRS-GHNKMVDWYSLGVIIYELLIGRPPYFSS--DCKQLFNDIQTQPLRL
||||||||||  .| .|.. . ||| ||| ..  |.. |||| ||.|||. .. ||.| ||| .||..|||.| | || . .  |  |... |.   .. 
IIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKF

PKSLPEES---KSILIQLLKKNYKTRLGYEK-DAEEVKQHPWF
| ..       |. . .|| .. . |.|  | ... .| |.||
PRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 24302.AA RSK 525-757 36 2.4e-66 226.73 In-house 26-271 (271) Show / Hide 
Range on Protein: 525-757
Range on HMM: 26-271/271
Sequence Identity: 36% (89 aa)

SQKFYALKIIRKEALKKKKLAQYIEFEKSVMQEIKHPFVAKLHLTFQNDTHLFLLMDFYQGGDLGRILEKDIEVDEFQVKVWAAQIVLALEELHKNDIIY
... || |||.| ... |   .. | |  .. .. |||. |||  ||  ..... ||| .||||.  | |     |  ||  .| | ||.| ||. .|..
TNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVH

RDLKPENVVLDAK----GNLHLIDFGLAKK--GVNAITSSFCGTPIYLPPEIVGRSGHNKMVDWYSLGVIIYELLIGRPPYFSSDCKQLFNDIQTQPLRL
|||||||...|..    | . . |||.||.  . | .. .||.|  |. ||.. | || . .||.|.||. || | |..|. . . . ..| || ..| .
RDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGM

-------PKSLPEESKSILIQLLKKNYKTRLGY-EKDAEEVKQHPWF
       . .. .| |. | ..|. .   |||    ..|..||||||
FSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 24302.AA Pkinase 522-757 29 5.9e-64 223.59 Pfam 20-293 (293) Show / Hide 
Range on Protein: 522-757
Range on HMM: 20-293/293
Sequence Identity: 29% (84 aa)

DDPSQKFYALKIIRKEALKKKKLAQYIEF--EKSVMQEIKHPFVAKLHLTFQNDTHLFLLMDFYQGG----DLGRILE--KDIEV--DEFQVKVWAAQIV
.  ..| .|.|||.|.  .|..  |.     | ..|....||.. .|. .|....|. . |.. .||    || ....  ..  .  .| ..| .. ||.
HKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQIL

LALEELHKNDIIYRDLKPENVVLDAKGNL----HLIDFGLAK---KGVNAITSSFCGTPIYLPPEIVG-RSGHNKMVDWYSLGVIIYELLIGRPPYFSS-
 .|| .|.. ||.|||||||. .| .|..    ...||||||      |  ...||||| |..||..  .... . ||..|.|.|.||.| ||||. .. 
RGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC

-----DCKQLFNDIQTQPLRLPKSLP---------------------EESKSILIQLLKKNYKTRLGYEKDAEEVKQHPWF
     | .|... |   ||. . . .                     || |...  .|.|. | |..    ||...|||||
WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase 24302.AA TyrKc 408-751 15 7.5e-11 -47.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 408-751
Range on HMM: 1-280/280
Sequence Identity: 15% (59 aa)

FTFYRQIGEGSFGEVYLVKINENAVKQTSSKSSSSGSSESSVIEKIKNDLNNRAKQMENKENSNQQILSIADGRQTDIMIRDENKEEAEDNKIDQNAAHI
 |. ...||| |||||. . .                                                                               
ITLGKKLGEGAFGEVYKGTWK-------------------------------------------------------------------------------

KRLQFLLNKNNDELDDPSQKFYALKIIRKEALKKKKLAQYIEFEK--SVMQEI--KHPFVAKLHLTFQND-------THLFLLMDFYQGGDLGRILEKDI
                      | | ....|          .| .  ..| ..  .|| . .|.     .         |...| .  .|||   | |  
-------------------IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

E-VDEFQVKVWAAQIVLALEELHKNDIIYRDLKPENVVLDAKGNLHLIDFGLAKKGVNA---------ITSSF--CGT---PI-YLPPEIVGRSG-HNKM
. .   .   .. ||    | ||.. .| |||   |. .....     ||||.... .          ....   .|    ||  ..||   . |  .  
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTK

VDWYSLGVIIYELL-IGRPPYFS-----SDCKQLFNDIQTQ-PLRLPKS--------LPEESKSILIQLLKKNYKTRLGYEKDAEEV
 | .| || ..|..  | .||        . .........   .. |..         |.|  .|  |  . . . |   .   |. 
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 24302.AA SGK 408-426 63 4.4e-08 20.56 In-house 1-19 (283) Show / Hide 
Range on Protein: 408-426
Range on HMM: 1-19/283
Sequence Identity: 63% (12 aa)

FTFYRQIGEGSFGEVYLVK
| |   ||.||||.||.||
FDFLKVIGKGSFGKVYQVK
Kinase 24302.AA AktR 408-426 52 1e-06 21.97 In-house 1-19 (268) Show / Hide 
Range on Protein: 408-426
Range on HMM: 1-19/268
Sequence Identity: 52% (10 aa)

FTFYRQIGEGSFGEVYLVK
|..|. .|.| ||.||||.
FHVYKCLGKGAFGKVYLVQ
Kinase 24302.AA RSK-Unclassified 408-426 57 3e-06 15.05 In-house 1-19 (283) Show / Hide 
Range on Protein: 408-426
Range on HMM: 1-19/283
Sequence Identity: 57% (11 aa)

FTFYRQIGEGSFGEVYLVK
|   | || |.||.||||.
FIKHRLIGQGDFGKVYLVR
Kinase 24302.AA RSK 408-426 42 1.2e-05 16.42 In-house 1-19 (271) Show / Hide 
Range on Protein: 408-426
Range on HMM: 1-19/271
Sequence Identity: 42% (8 aa)

FTFYRQIGEGSFGEVYLVK
. . . ||.|||..||..|
YELHECIGQGSFSKVYVCK
Kinase 24302.AA Akt 408-426 57 6.7e-05 11.5 In-house 1-19 (264) Show / Hide 
Range on Protein: 408-426
Range on HMM: 1-19/264
Sequence Identity: 57% (11 aa)

FTFYRQIGEGSFGEVYLVK
|.| . .| |||| |.|||
FDFLKVLGKGSFGKVFLVK
Kinase 24302.AA Pkinase_Tyr 408-424 58 0.000417 14.53 Pfam 1-17 (270) Show / Hide 
Range on Protein: 408-424
Range on HMM: 1-17/270
Sequence Identity: 58% (10 aa)

FTFYRQIGEGSFGEVYL
 || ...|||.|||||.
ITFGKKLGEGAFGEVYK
Kinase 24302.AA Pkinase 408-426 47 0.000527 15.24 Pfam 1-19 (293) Show / Hide 
Range on Protein: 408-426
Range on HMM: 1-19/293
Sequence Identity: 47% (9 aa)

FTFYRQIGEGSFGEVYLVK
... |.||.||||.||. .
YHIGRKIGSGSFGCVYKCH
Kinase 24302.AA PKA 408-426 42 0.001604 12.83 In-house 1-19 (263) Show / Hide 
Range on Protein: 408-426
Range on HMM: 1-19/263
Sequence Identity: 42% (8 aa)

FTFYRQIGEGSFGEVYLVK
| ... .| |||| |.|..
FEIIQTLGTGSFGRVMLCR
Kinase 24302.AA RSK 411-426 31 0.014661 5.62 In-house 1-16 (278) Show / Hide 
Range on Protein: 411-426
Range on HMM: 1-16/278
Sequence Identity: 31% (5 aa)

YRQIGEGSFGEVYLVK
 .. |.|..|.|.|..
LKVLGQGGYGKVFLCR