Gene 24495 (Tetrahymena)

24495

Species: Tetrahymena
Alias: PreTt24495, TTHERM_00139680, 3698.m00260, 546, 10.m00544, 24495
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
24495.AA Protein None 559 None Fasta, JSON
24495.kin_dom Protein Kinase Domain None 269 None Fasta, JSON
24495.NA RNA None 1680 None Fasta, JSON

Protein domain

Protein domains of 24495.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Zf-MYND 24495.AA zf-MYND 96-134 45 8.6e-16 53.89 Pfam 1-39 (39) Show / Hide 
Range on Protein: 96-134
Range on HMM: 1-39/39
Sequence Identity: 45% (19 aa)

CQNCKQQDKKVS--SCAGCKEVYYCSVECQKADW-KNHKKPC
| .|..   . .   |..|| |.|||.|||||.| . ||| |
CHHCGK---ALKLYRCSRCKSVWYCSRECQKAHWKPYHKKEC
Kinase 24495.AA Ciliate-E2-Unclassified 159-427 24 2.2e-87 296.59 In-house 1-352 (352) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-352/352
Sequence Identity: 24% (85 aa)

FEKIDNCGQGNFSVIQKMKEISTGKI----YAIKVIEKKRLKQLGKEKDIIMEKHVLKKL------------------SGSPYVIELFDTFSDELCLYMQ
...|  .|||.|....|.........    |..|....|..... |. .|..|.. ....                  . .|... .|..| |. ..|. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEFVDGGELWNYCRIF-----------------GLIGTSLVR-----YFFAKLLVALEFIHSKG-IIHRDIKTENVLVTKDDK--NIKFCDFGTSRDALD
||...||.||.|....                   .    ..     ..|| .|..||..|.|. ||||||| ||.|.... |  .|| .||| |.   .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

DSIQGAGTG-----RPGKKMFEHFVGTPNFM----APECVRNKASE----YSSDIFSLGGLVFQLQTGFPPFLGRSEYL---------------IFLQSE
.. .  ...     .. ..|. .|.||||.|    |||. ...  .    |..||.||| . ... .| .|| .....                ...|  
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KQDPIFQEELW------QNQDDLKDLIL----KMMKKEMTERITIPEIKKHPYF
|| .|.. . .      . ..  ||.|     ||.|| . .|||...|..||.|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 24495.AA Ciliate-E2 159-427 24 8.8e-83 281.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

FEKIDNCGQGNFSVIQKMKEISTG-----------------------KIYAIKVIEKKRLKQLGKEKDII----------MEKHVLKKLSGSPYVIELFD
...|  .|||||... |.| ....                       ||||.|...|. ..|. .|..|.          .|| .|..|. .|..|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE

TFS--DELCLYMQMEFVDGGELWNYCRIFGLIG-----------TSLVRYFFAKLLV---------------ALEFIHSKG-IIHRDIKTENVLVTKDDK
.|   |. ..|. ||...||.|. |.... .                ..|.....|                |||..|||. ||||||| ||.|.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

NIKFCDFGTSRDALDDSIQGAGTGRPGKKMFEHF----------------------VGTPNFMAPECVRNKA---------SEYSSDIFSLGGLVFQLQT
 || .|||.|... ||.... . ..  |.. . .                      .|||..|||| ...|            |..||.||| . ... .
-IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GFPPFLGRSEYLIFLQSEKQDPIFQEEL--------------WQNQDDL-KDLILK----MMKKEMTERIT-IPEIKKHPYF
| |||        . | ....  |...               |.. ..  |||| |    |..|.  .||| . .|..||.|
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 24495.AA AGC 159-427 22 8.7e-75 191.92 In-house 1-395 (395) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-395/395
Sequence Identity: 22% (92 aa)

FEKIDNCGQGNFSVIQKMKEI------STGKIYAIKVIEKKR-LKQLG--KEKDIIME------------KHVLKKLSG---------SPYVIE-LFDTF
|| .   |.| |.     ..       .|||.||.||..||.  ...   ... .. |            ...|.|...         .|...  |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

SDELC--LYMQME----FVD-----GG-ELWNYCR---IFGLIGTSLVRYFFAK-------LLVALEFIHS-KGIIHRD-IKTENVLVTKDDKNIKFCDF
 |.    ||. ||    .|      || ||. . .     |    . .|...|        .. |||..|| .|||||| .| ||.| ..|  .|| .||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-GHIKLTDF

GTSRDALDD-----------------------------------------SIQGAGTGRPGKKMFEH-FVG--TPNFMAPECVRNKASEYSSDIFS--LG
| .    .|                                           .   | | .|.   . |.|  ||..|||| .      .. |. |  ||
GLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQ-E-DDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLG

GLVFQLQTGFPPFLGRS----------EYLIFLQSEKQD-PIFQEELWQNQ------------DDLKDLILKMMKKEMTERIT----------IPEIKKH
 | ... || ||| | .          .. .| . .. .  |.... . .             ...|||| |...|. ..|..          . |||.|
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

PYF
|.|
PWF
Kinase 24495.AA S_TKc 159-427 29 6.3e-73 249.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-231/231
Sequence Identity: 29% (83 aa)

FEKIDNCGQGNFSVIQKMKEISTGKIYAIKVIEKKRLKQLGKEKDIIMEKHVLKKLSGSPYVIELFDTFSDELCLYMQMEFVDG--GELWNYCRIFGL--
.|...  |.| |..  | ....||.|.|||.|           ..|. |  .|||  . |... |.|.| |  .||| ||..||  |.|  | .  |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IGTSLVRYFFAKLLVALEFIHSKGIIHRDIKTENVLVTKDDKNIKFCDFGTSRDALDDSIQGAGTGRPGKKMFEHFVGTPNFMAPECVRNKASEYS
    .    .|.... .. |||..||.||||||.| ||.|...   .|| |||| .|                     .|.|||..|||| .  . .  .
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------------------TTFCGTPWYMAPEVL--GYGKCK

SDIFSLGGLVFQLQTGFPPFLGRSEYLIFLQSEKQDPIFQEELWQNQDDLKDLILKMMKKEMTERITIPEIKK-------HPYF
.|. |.| ... . .| |||    ....| .                ...||.| |...|. ..|.|. |. .       ||.|
CDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24495.AA CAMK 166-427 19 1e-59 190.78 In-house 3-425 (425) Show / Hide 
Range on Protein: 166-427
Range on HMM: 3-425/425
Sequence Identity: 19% (84 aa)

GQGNFSVIQKMKEISTG------------KIYAIKVIEKKRLK-------------------------QLGKEKDIIMEKHVLKKLSG------SPYVIE
|.|.|..  . ....|.            . .|||.|.||.||                         .  ..| .  | ...|||.|       | .| 
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

LFDTFSD-------------------ELCLYMQM---EFVDGGEL----WNYCRIFGL---------------IGTSLVRYFFAKLLVALEFIHSKGIIH
|.... |                   . ..|| |   |...||||     .| .  |                .  . .|..|  .. |....||..|.|
LYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVH

RDIKTENVLVTKDD----------------KNIKFCDFGTSRDALDDSIQGAG------------TGRPGKKMFEHFVGTPNFMA-PECVRN--------
||.| ||.|.....                 ||| .||| ..   ... .               | .   .... |.||| .|| || ..         
RDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQN

------KASEYSSDIFSLGGLVFQLQTGFPPFLGR-------------SEYLIFLQSEKQDPIFQEELWQN---------QD------------DLKDLI
      .   ...|. |.| . . . .|.||| |              ..| .| .  | .  | .. . .          |            . ||||
ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLI

LKMMKKEMTERITIPEIKKHPYF
 ||.... ..|.|| ....|| .
RKMLQVDPEKRMTIEQCLNHPWM
Kinase 24495.AA Pkinase 159-427 25 2.2e-59 208.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

FEKIDNCGQGNFSVIQKMKEISTGKIYAIKVIEKKRLKQLGKEKDII-MEKHVLKKLSGSPYVIELFDTFSDELCLYMQMEFVDGG----ELWNYCR--I
....   |.|.|..  | ....||||.|.|.|.|.. |   .. ..  .| ...|.| ..|....|.|.| |.  .|| ||...||    .|. | .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

FGLI--GTSLVRYFFAKLLVALEFIHSKGIIHRDIKTENVLVTKDDKN---IKFCDFGTSRDALDDSIQGAGTGRPGKKMFEHFVGTPNFMAPECVR-NK
 | .      .. ..  .| .||..||.||||||.| ||.|. ... .   .| |||| .. .              .  . .|.|||..|||| .| ..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRGGQ

ASEYSSDIFSLGGLVFQLQTGFPPFLGR------SEYLIFLQSEKQDPIFQEELW-QNQ-----------------DDLKDLILKMMKKEMTERITIPEI
   ...|..|.| ..... .| ||| |.      ... .. .  . .. |... |  .                  ...||.| .. .| ...|.|...|
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

KKHPYF
..||.|
LQHPWF
Kinase 24495.AA PDK1 159-379 32 2.8e-51 155.06 In-house 1-253 (307) Show / Hide 
Range on Protein: 159-379
Range on HMM: 1-253/307
Sequence Identity: 32% (83 aa)

FEKIDNCGQGNFSVIQKMKEIST----GKIYAIKVIEKKRLKQLGKEKDIIMEKHVLKKLSGS----PYVIELFDTFSDELCLYMQMEFVDGGELWNYCR
|  . | | | .|   . .|..|    .|.||||. ||. .    | | .. || .. .|...    | .. |. || || |||  .|.. .|.|  | .
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

I--FGLIGTSLVRYFFAKLLVALEFIHSKGIIHRDIKTENVLVTKDDKNIKFCDFGTS---RDALDD--SIQ-------------GAG-TGRPGKKMFEH
   ||    . .|.. | .. |||..||.||||||.| ||.|..|| . |.  ||||.   . .|..  |.|             | . .  ..      
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMH-IMITDFGTAGFDK-ILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKS

FVGTPNFMAPECVRNKASEYSSDIFSLGGLVFQLQTGFPPFLGR-----SEYLIF
||||  .  ||   .|   .|.|| .|| ...|...| ||| |      .||..|
FVGTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTF
Kinase 24495.AA RSK 161-427 28 3e-48 166.59 In-house 2-278 (278) Show / Hide 
Range on Protein: 161-427
Range on HMM: 2-278/278
Sequence Identity: 28% (84 aa)

KID-NCGQGNFSVIQKMKEISTGKIYAIKVIEKKRLKQLGK-EKDIIMEKHVLKKLSGSPYVIELFDTFSDELCLYMQMEFVDGGELWNYCR---IFGLI
| .   |.| ... .|     ||.||| ||..|. ..|  |  ..   |  .|.   ..| ...|...| .|. ||. ||.. ||||    .   .|| .
KVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCF

GTSLVRYFFAKLLVALEFIHSKGIIHRDIKTENVLVTKDDKN---IKFCDFGTSRDALDDSIQGAGTGRPG-KKMFEHFVGTPNFMAPECVR----NKAS
  . ... .|.. .|.|..|..||||||.| ||.| . .. |   || .||| .. .           |.  ...   |..| ..|||| ..    ... 
SEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF-----------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGH

EYSSDIFSLGGLVFQLQTGFPPFLG---RSEYLIFLQSEKQD--PIFQ--EELWQNQDDLKDLILKMMKKEMTERIT-----IPEIKKHPYF
  . |..||| | . . ||.||| |    .   |. . .| .  . .   ..|    .. |||| ||....   |..     . |||.||.|
DKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYL---SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 24495.AA STE 159-427 22 1.1e-46 161.39 In-house 1-359 (359) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-359/359
Sequence Identity: 22% (81 aa)

FEKIDNCGQGNFS-VIQKMKE--------------ISTGKIYAIKVIEKKRLKQ--------------LGKEKDIIMEKHVLKKLSG-SPYVIELFDTFS
.|.|.  |.|.|  | ..|.               ..||.|.|||...... ..                ....|..|  ..||..  .|.... .... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DEL-------CLYMQMEFVDGGELWNYCR-IFGLIGT-------------SLVRYFFAKLLVA-LEFIHSKGIIHRDIKTENVLVTKDDKNIKFCDFGTS
.|         |.. ||..||| |    .  .|  ..             |...|.   .| . |...||..|||||||  |.|.      .| ||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

RDALDDSIQGAGTG-------RPGKKMFEHFVGTPNFMAPECVRN--KA--SEY--SSDIFSLGGLVFQLQTGFPPFLGRSEY--LIFLQSE--------
    |..  . . .         ....  .||||| .|||| ...  ..  ..|  ..|| ||| ..  . || ||.   .    .   . .        
GQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------KQDPIFQEELWQNQ----------------DDLKDLILKMMKKEMTERITIPEIKK--HPYF
      .. | ....| ||.                ...|| | |  .|.  .| |  .  |  || .
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 24495.AA CAMKL 159-427 25 1.3e-46 146.74 In-house 1-297 (297) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-297/297
Sequence Identity: 25% (78 aa)

FEKIDNCGQGNFSVIQKMKE-ISTGKIYAIKVIEKKRLK-QLGKEKD-----------IIMEKHVLKKLS--GSPYVIELFDTFSDELC------LYMQM
.. ..  |.|.|.. .  .  . ||. .|||.|.||...    ..|            |  | . .|.|.  . | .| |.... .. .      .|. |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFVDGGE--LWNYCRIF----GLIGTSLVRYFFAKLLVALEFIHSKGIIHRDIKTENVLVTKDDK-NIKFCDFGTS---RDALDDSIQGAGTGRPGKKMF
| ..|||  | .| .      | .  .  | .|  .. |....||.||.||||| ||.|...... ||| .||| |   |.             .  ...
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC----------IFGPGQKL

EHFVGTPNFMAPECVRN--KASE-YSSDIFSLGGLVFQLQTGFPPFLGRS-------EYLIFLQSEKQDPIFQEELWQNQDDLKDLILKMMKKEMTERIT
. | |.|..|||| .    |  . .  || |.| . . . .|  || . .        .  ..  ....  .     .   |..||| ||...  ..|.|
KTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPT

IPEIKKHPYF
| .|..|| .
IHQIMNHPWM
Kinase 24495.AA ULK 159-427 23 1.6e-43 149.79 In-house 1-329 (329) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-329/329
Sequence Identity: 23% (79 aa)

FEKIDNCGQGNFSVIQKMKEIST----GKIYAIKVIEKKRLKQLGKEKD-------IIMEKHVLKKLS---GSPY----VIELFDTFSDELC--LYMQME
.....  |.| | .  | . . |    ....|.|.|.|. ..|  .| .       .. |  ..|||    ....    ...|.| | .  .  .|. ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FVDGGELWNYCRIFGLIGTSL----------VRYFFAKLLVALEFIHSKGIIHRDIKTENVLVTKDDKN-----------IKFCDFGTSRDALDD--SIQ
. .|| | .|    .  . .           .. ||  .| .. ..|...||||||| .|.|.....             .| .||| ..   .|  ..|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

GAGTGRPGKKMFEHFV------GTPNFMAPECVRNK-----ASEYSSDIFSLGGLVFQLQTGFPPFLG--RSEYLIFLQSEKQDP------IFQEELWQN
          |.  .|      ||| .|||. . ..      ..| .||.||| . ... .| ||| .  ...|| ..|.....|      | .. |  .
----------MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFP

--------QDDLKDLILKMMKKEMTERITIPEIKKHPYF
         ...|||| .|.... ..||...|. .|| |
KDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 24495.AA ULK 159-427 22 1.1e-41 144.76 In-house 1-324 (324) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-324/324
Sequence Identity: 22% (75 aa)

FEKIDNCGQGNFS-VIQKMKEIST---GKIYAIKVIEKKRLKQLGKE-------KDIIMEKHVLKKLS--GSPY--VIELFDTFSDELC--LYMQMEFVD
.....  |.| |  .  | . . |   ....|.|.|.|| ...  .|       . .. |  ..|||    .|.  ...|.| | .  .  .|. ||. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGELWNYCRIFGL--IGTSL---------VRYFFAKLLVALEFIHSKGIIHRDIKTENVLVTKDDKN-----------IKFCDFGTSRDALDDSIQGAGT
|| | .|    .     | .         .. ||  .. .. ..|...||||||| .| |.....             .| .||| ..   ... .    
GGDLEQYIKKNKKLPE-T-EEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME----

GRPGKKMFEHFV------GTPNFMAPECVRNK-----ASEYSSDIFSLGGLVFQLQTGFPPFLGR-SEYL----IFLQS-------EKQDPIFQE---EL
    . |.  .|      ||| .|||. . ..      ..| .||.||| . ... .| .|| .. ...       ..        .|. ||      . 
----QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKD

WQNQDDLKDLILKMMKKEMTERITIPEIKKHPYF
 .  ...|||| .|.... ..||...|| .|| |
PKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 24495.AA PDK1 401-427 32 9.9e-11 28.56 In-house 274-307 (307) Show / Hide 
Range on Protein: 401-427
Range on HMM: 274-307/307
Sequence Identity: 32% (11 aa)

KDLILKMMKKEMTERIT-------IPEIKKHPYF
|||. |  ... ..|.|       ...||.||.|
KDLVKKLLVRDPNDRLTSCDECGGYQQIKAHPFF
Kinase 24495.AA TyrKc 159-427 21 5.1e-10 -60.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 159-427
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

FEKIDNCGQGNFSVIQKMKEISTGKIYAIKVIEKKRLKQLGKEKDIIMEKHVLKKL-SGSPYVIELFDTFSDE-------LCLYMQMEFVDGGELWNYCR
 ....  | |.| .. | . .      |.|.. .        ..|.. |  ...||    | .. |.   ...         |.. ||....| | .| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

IFGL-IGTSLVRYFFAKLLVALEFIHSKGIIHRDIKTENVLVTKDDKNIKFCDFGTSRDALDD-------SIQGAGTGRPGKKMFEHFVGTPNFMAPECV
  .  . ..   .|        |..|||..||||. . |.||...   .| .||| |||  ||       .   . ... || |.         ||||| 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML-----PIRWMAPECI

RNKASEYSSDIFSLGGLVFQLQT-GFPPFLG-----RSEYLIFLQSEKQDPIFQEEL------WQNQDDLKDLILKMMKKEMTERITIPEIKKHPYF
. .     ||..| | . . . | | .|  |      | . .. . .. .   | .           |.. .....  . .  .| |  ||  | .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 24495.AA Pkinase_Tyr 270-313 43 2.6e-05 18.59 Pfam 123-165 (270) Show / Hide 
Range on Protein: 270-313
Range on HMM: 123-165/270
Sequence Identity: 43% (19 aa)

ALEFIHSKGIIHRDIKTENVLVTKDDKNIKFCDFGTSRDALDDS
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GMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDD