27964

Species: Tetrahymena
Alias: PreTt27964, 27964, 90.m00128, TTHERM_00632950, 22
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2

Sequence

Name Sequence Type Origin Length Description Download
27964.AA Protein None 643 None Fasta, JSON
27964.kin_dom Protein Kinase Domain None 378 None Fasta, JSON
27964.NA RNA None 1932 None Fasta, JSON

Protein domain

Protein domains of 27964.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27964.AA Ciliate-E2-Unclassified 33-411 21 2.1e-87 296.69 In-house 3-352 (352) Show / Hide
Range on Protein: 33-411
Range on HMM: 3-352/352
Sequence Identity: 21% (98 aa)

DDKRLGAGGFGEIFRIVEKTQN---------QDQSKMQCLKKVSQQDRSQALNEINSLK-------------ILS---HPNILKFYEYFENQKNIFLVLE
  | .| ||||.... ..| |.         . |...|.... .. . .. ..|.|..|             ||.   ||.|.|....|....||..|.|
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

YIEGLDMIDFIQKDST----------------SISEKVAA-----TIMKQLLEALAYTHDKK-IVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNE
|.||.|....|.| ..                 ..|. |.     ....|.|..| | | |. |.|||||.|||.. ..|.                   
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-------------------

QNFKVKLIDWGFSYNLGLMNQE------------YIESKSLMGTYYYI----SPEQIQKQKYN----SKCDIWAAGVVMYCLLNKQFPFFSNLKFQDRFM
 |...|.||.|.|.... .|..            . .... .||..|.    .|| .|.|.|.     |||||. ||..|..|  ..||..| . |....
-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQL

EYQQVSLSQFHRNMQLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNSQSTVNQTQAEQKDQKPKLTKSQMLNILHQAKIKFENEKSEDIF
..|.. .     |                     | ...   ....|.|.|..... |.                                         
ITQWI-N-----N---------------------A-YRKQLYQNIKQKNIQFPKFPWQQ-----------------------------------------

DKILNEEPSYDDNILSGEAIDLLR----KMLNKNQSQRPSAKDLLRHPWF
          .. ..| ||.|...    |||.||...|......| ||||
----------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 27964.AA Ciliate-E2 35-411 19 2.6e-86 293.04 In-house 5-365 (365) Show / Hide
Range on Protein: 35-411
Range on HMM: 5-365/365
Sequence Identity: 19% (93 aa)

KRLGAGGFGEIFRIVEKTQNQ-------------------DQSKMQCLKKVSQQDRSQALNEINSLK----------------ILSHPNILKFYEYFE--
| .| |.|| ...   . ...                   ...|.  .| .....  | ..||. ..                .|.||||.|.||.|.  
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

NQKNIFLVLEYIEGLDMIDFIQKDSTS----------ISEKVAATIMKQLLE---------------ALAYTHDKK-IVHRDIKCENIMIIKQGETQKSE
...||.||.||..| |. |.|.. ...          ..|| ...||||.|.               || | | |. |.||||| |||..          
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------

NSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLMG-----------------------------TYYYISPEQIQKQK---------YNS
                  .|.||.|.| ..   ||.... |....                             |..| .|| ....|         |. 
------------------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

KCDIWAAGVVMYCLLNKQFPFFSNLKFQDRFMEYQQVSLSQFHRNMQLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNSQSTVNQTQAEQ
|||||..||..|..| ...||                                                                               
KCDIWSLGVILYEMLFGKPPF-------------------------------------------------------------------------------

KDQKPKLTKSQMLNILHQAKIKFENEKSEDIFDKILNEEPSY-DDNILSGEAIDLLRK----MLNKNQSQRPS-AKDLLRHPWF
            ... .| ||.| ......  .. .. .... . . .| |..||..|    ||.|....|.. ....| ||||
------------QQQIKQCKIDFPCPEWQKD-TQ-CI-QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

S_TKc 27964.AA S_TKc 31-411 19 1.7e-70 241.44 SMART 1-231 (231) Show / Hide
Range on Protein: 31-411
Range on HMM: 1-231/231
Sequence Identity: 19% (77 aa)

RADDKRLGAGGFGEIFRIVEKTQNQDQSKMQCLKKVSQQDRSQALNEINSLKILSHPNILKFYEYFENQKNIFLVLEYIEG--LDMIDFIQKDSTS----
    . .| |.||. .. ..|       .   .|...     ....||. ||   |||| |.|..|.. .....|.||..|   |. |.|.|  .     
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-ISEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLMGTYYYISP
 ..| .|. .|.|...||.| |...|.|||.| |||.. .                          .|..| |..  |          ... || .|..|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------------------HIKICDFGLARQL----------TTFCGTPWYMAP

EQIQKQKYNS-KCDIWAAGVVMYCLLNKQFPFFSNLKFQDRFMEYQQVSLSQFHRNMQLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNS
| .   .|.  |||.|. |...| .|  . ||       . .| ....                                                    
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------------------------

QSTVNQTQAEQKDQKPKLTKSQMLNILHQAKIKFENEKSEDIFDKILNEEPSYDDNILSGEAIDLLRKMLNKNQSQRPSAKDLLR-------HPWF
                                                          | ||.|..||.|.|. ..||.| ..|.       ||||
----------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 27964.AA CAMK 36-254 20 4.9e-65 208.22 In-house 1-334 (425) Show / Hide
Range on Protein: 36-254
Range on HMM: 1-334/425
Sequence Identity: 20% (70 aa)

RLGAGGFGEIFRIVEKTQNQDQS-------KMQCLKKV--------------------------------SQQDRSQALNEINSLKILS-------HPNI
 || |.||. .. ..|  ....        . ..  |.                                ...|| . ..||. .| |.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKFYEYFEN-------------------QKNIFLVL---EYIEGL----DMIDFIQKD--------------STSISEKVAATIMKQLLEALAYTHDKKI
.|.||..|.                   .|....|.   ||..|     |. |.|..               .  ..|. |.....|...|..| |...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKCENIMIIKQGETQ---------KSENSSQENSNQNAQNEQNFKVKLIDWGFS--YNLGLMNQ------------------EYIESKSLMGTYYY
||||.|.|||.. . .. .                         ..|...|.||.||.  .. |  |                   |    |   || .|
VHRDLKPENILLDDNNDDSDPVEHDEIFD---------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY

IS-PEQIQK--------------QKYNSKCDIWAAGVVMYCLLNKQFPF
.. || ...              . |. |||.|..||..| .|   .||
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF

Kinase 27964.AA Ciliate-E2a 64-254 33 4.7e-59 172.47 In-house 34-216 (275) Show / Hide
Range on Protein: 64-254
Range on HMM: 34-216/275
Sequence Identity: 33% (67 aa)

KKVSQQD--RSQALNEINSLKILSHPNILKFYEYFENQKNIFLVLEYIEGLDMIDFIQKDSTSISE-KVAATIMKQLL-EALAYTHDKKIVHRDIKCENI
|| .||.  . .  |||| .. |.||||.|.||..|. .|..||.||.|| ...| |... .  .| .... ||.||| ..|.| | ..|.|||.| |||
KKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENI

MIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLMGTYYYIS------PEQIQKQKYNSKCDIWAAGVVMYCLLNKQFP
.. .                 .... ||...|.||.|.. .     ..|. .|   || .|.       .| .....|  |||.| .||..|.||  . |
LFKN----------------CSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQK--CGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPP

F
|
F

Kinase 27964.AA CDPK 35-248 37 7.7e-56 169.84 In-house 5-207 (271) Show / Hide
Range on Protein: 35-248
Range on HMM: 5-207/271
Sequence Identity: 37% (84 aa)

KRLGAGGFGEIFRIVEK-TQNQDQ--SKMQCLKKVSQQDR-SQALNEINSLKILSHPNILKFYEYFENQKNIFLVLE--YIEGLDMIDFIQKDSTSISEK
| || |.||.......|  .||     |.   ..|....   | .|||. || | ||||.|.||... .||...|.|  | .| . .| |.  .   .||
KVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH-FTEK

VAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLM---GTYYYISPEQ
 || ||.|.| |..| |...|||||.| |||.                .|. . ..   . .|.|||| |.. .   |   |.| ..   || |||.||.
EAAYIMRQILSAVNYCHSNNIVHRDLKPENILF---------------DSKKDDSWV-IYNIKVIDWGTSKKFDQN-QKI-EDKKMSQRCGTPYYIAPEV

IQKQKYNSKCDIWAAGVVMYCLL
.||. || ||||| .||..| ||
LQKK-YNEKCDIWSCGVILYILL

Kinase 27964.AA STE 32-411 15 3.4e-54 186.37 In-house 1-359 (359) Show / Hide
Range on Protein: 32-411
Range on HMM: 1-359/359
Sequence Identity: 15% (76 aa)

ADD-KRLGAGGFGEIFRIVEKT-----QNQDQ------SKMQCLKKVS--------------------QQDRSQALNEINSLKILS--HPNILKFYEYFE
 .. ...| |.||. .. . .      ... .       ..   |...                    .... | |.||. .| ..  |||| |.| ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NQ-------KNIFLVLEYIEGLDMIDFIQ-KDSTSIS------------EKVAATIMKQLLEA-LAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQE
.         ......||..|    |.|. | ..  .            |.. |.| .|.|.. |.| |...|.|||||. ||..               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

NSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYI----------------ESKSLMGTYYYISPEQIQK------QKYNSKCDIWAAGVVMYCLLNKQFPF
             |||.| |..   | .....                 ..... ||  . .|| ||.      ..|. |||||  | ..  ... . |.
-------------VKLCDFGVC---GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW

--FSNLK--FQDRFM-----EYQQVSLSQFHRNMQLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNSQSTVNQTQAEQKDQKPKLTKSQM
  .....  |.  |.     .                                                                               
HDMHPMRAMFMIPFNYHMQQQ-------------------------------------------------------------------------------

LNILHQAKIKFENEKSEDIFDKILNEEPSYDDN-------------------ILSGEAIDLLRKMLNKNQSQRPSAKDLLR--HPWF
                 .   .|.|..|    .                    .| | .| ..| |.|. ..||.|..||.  ||..
----------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Pkinase 27964.AA Pkinase 31-254 26 3e-53 188.01 Pfam 1-212 (293) Show / Hide
Range on Protein: 31-254
Range on HMM: 1-212/293
Sequence Identity: 26% (64 aa)

RADDKRLGAGGFGEIFRIVEKTQNQDQSKMQCLKKVSQQDRSQALN-------EINSLKILSHPNILKFYEYFENQKNIFLVLEYIEGL----DMIDFIQ
    ...|.|.||. .. ..|  ..    . ..|... ....   .       ||  .| |.||||...|..||. ..| .|.|| ||     |  |.|.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-KDSTSI--SEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLMG
 ......  ||...  .|.|.|..|.| |...|.|||.| |||.| ..|..                     .||..|.|..  .   .  .   ... |
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------------------CVKICDFGLAKQFD--Y-NNS-MTTFCG

TYYYISPEQIQ-KQKYNSKCDIWAAGVVMYCLLNKQFPF
|..|..|| |.  |.| .|.|.|..|...|..|....||
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF

Kinase 27964.AA ULK 31-411 20 1.9e-48 167.23 In-house 1-329 (329) Show / Hide
Range on Protein: 31-411
Range on HMM: 1-329/329
Sequence Identity: 20% (88 aa)

RADDKRLGAGGFGEIFRIV-EKTQNQDQSKMQCLKKVSQ---QDRSQ-----------ALNEINSLKILS--------HPNILKFYEYFENQ--KNIFLV
   ...|| | ||  ..   .||. . ... ..  |. .   .....             |||  .| |         |||| |.|..||..  .||...
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

LEYIEGLDMIDFIQKDST---------SISEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIK-QGETQKSENSSQENSNQNAQNEQNFKVKLIDW
.|| .| |  ..|.|. .          .||. |  ..||.|... . |...|.||||| .||.| . |. |  |.    .     . .  |  .|. | 
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK----K-----V-HP-NGVLKIADF

GFSYNLGLMNQEYIESKSLM------GTYYYISPEQIQ----KQKYN-SKCDIWAAGVVMYCLLNKQFPFFSNLKFQDR---FMEY--QQVSLSQFHRNM
||.  .   |.|    ..        || .| .|. .|    ...|. .|||||  |...| .|  . ||... ....     ..   ..  . |     
GFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQ-----

QLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNSQSTVNQTQAEQKDQKPKLTKSQMLNILHQAKIKFENEKSEDIFDKILNEEPSYD---
                                                                                       .| .. . ..   
---------------------------------------------------------------------------------------QIKKQPLQFPKDG

-DNILSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
 |...| | .||.|.|| .....| |  .|. ||||
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 27964.AA CAMK-Unique 35-254 24 3.3e-48 157.14 In-house 5-293 (363) Show / Hide
Range on Protein: 35-254
Range on HMM: 5-293/363
Sequence Identity: 24% (72 aa)

KRLGAGGFGEIFRIVE-KTQNQDQSKMQCLKKVSQQDRSQ------------------ALNEINSLKILSHPNILKFYEY----FENQK-----------
. .| |.||....    .|   .. ||  .....   . |                  . .|.. .| ..||||.|.|..    |.  |           
RIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTP

----NIFLVLEYIEGLDMIDFIQKD-------------------STSISE--KVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQ
    ....|.||..| |. | |||                     .. ||    ...|| .||.|.|| |...|||||.| ||||. . .          
RALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN------

ENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIES--KSLMGTYYYISP--------------EQIQKQKYNSKC----DIWAAGVVMYCLLNKQFPF
        .. | ..||.|.| .    . |.   ..  ..  || .|..|              | |  |.| ..|    |||. ||.|| .|    ||
-HHRDFPYDWSNWHIKLCDFGLCC---HYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPF

Kinase 27964.AA CAMKL 77-254 30 2.4e-47 149.06 In-house 62-236 (297) Show / Hide
Range on Protein: 77-254
Range on HMM: 62-236/297
Sequence Identity: 30% (60 aa)

EINSLKILS---HPNILKFYEYFENQKN------IFLVLEYIEGLD--MIDFIQKDS---TSISEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMII
||. .| |.   |||| |.|| .|....      |.||.||..| .  . |.|.|      ...|. |  . .|...|..| |...||||||| |||.. 
EIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLD

KQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLM-NQEYIESKSLMGTYYYISPEQIQK--QKYN-SKCDIWAAGVVMYCLLNKQFPF
..|                       ..|.|| |||     . ...    |   |.. | .|| .|.  ..|.  | |||..||..| ..  ..||
ENGNN---------------------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPF

Kinase 27964.AA MARK 64-161 36 9.9e-29 91.17 In-house 35-137 (262) Show / Hide
Range on Protein: 64-161
Range on HMM: 35-137/262
Sequence Identity: 36% (38 aa)

KKVSQ-QDRSQALNEINSLKILSHPNILKFYEYFE--NQKN-IFLVLEYIEGLDMIDFIQKD-STSISEKVAATIMKQLLEALAYTHDKKIVHRDIKCEN
.| .  | ..    ||. .| |.|||| |.....|  . .. |.|..||..| .. |.|..     ..|. | .| .|...|. | |.| |||||||.||
FKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPEN

IMI
|.|
ILI

Kinase 27964.AA Ciliate-E2a 356-411 28 3.3e-18 50.2 In-house 216-275 (275) Show / Hide
Range on Protein: 356-411
Range on HMM: 216-275/275
Sequence Identity: 28% (17 aa)

FENEKSEDIFDKILNEEPSYDDNI----LSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
|. .. ..|. .. . . ......    .| |..||..|||.|. ..|..|...| ||||
FKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF

Kinase 27964.AA CAMK 362-411 21 1.9e-17 52.1 In-house 353-425 (425) Show / Hide
Range on Protein: 362-411
Range on HMM: 353-425/425
Sequence Identity: 21% (16 aa)

EDIFDKILNEEPSYDDNILSG-----------------------EAIDLLRKMLNKNQSQRPSAKDLLRHPWF
...| ||.. . ....  .|.                       |..||.||||... ..|..... |.|||.
YELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 27964.AA CAMKL 356-411 23 9.2e-15 43.39 In-house 236-297 (297) Show / Hide
Range on Protein: 356-411
Range on HMM: 236-297/297
Sequence Identity: 23% (15 aa)

FENE-------KSEDIFDKILNEEPSYDD--NILSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
|...       .    . .. ..   |..  . .| ...||.||||..| ..||.......|||.
FDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase 27964.AA MARK 362-411 26 1.3e-14 44.3 In-house 214-262 (262) Show / Hide
Range on Protein: 362-411
Range on HMM: 214-262/262
Sequence Identity: 26% (13 aa)

EDIFDKILNEEPSYDDNILSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
.... |||...... .. .| |. .|....|. | ..||.......|||.
KELYKKILRGKYDIPCH-VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase 27964.AA TyrKc 31-411 15 6.6e-13 -14.03 SMART 1-280 (280) Show / Hide
Range on Protein: 31-411
Range on HMM: 1-280/280
Sequence Identity: 15% (63 aa)

RADDKRLGAGGFGEIFRIVEKTQNQDQSKMQCLKKVSQQDRSQA--LNEINSLKIL--SHPNILKFYEYFENQ-------KNIFLVLEYIEGLDMIDFIQ
   .| || | |||... . |        .|.  |. . |  ..  ..|.. .. |  .||||...| .   |       . ...|.|| .. |  |...
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KDSTSISEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLM-----NQEYIESK--
|    .. |    .. |  .  .| |.|...|||. . |... ...                        ||  | | | ...       ...|. .|  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEH

-SLM--GTYYYISPEQIQKQKYNSKCDIWAAGVVMYCLLNKQFPFFSNLKFQDRFMEYQQVS--LSQFHRNMQLAD----TQSQNENECSAAIQISAQTI
 .      .   .|| |.. |...| |.|. ||.|. ..    .  ..  .|  .|. |.|   . | .| .| ..                        
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------

SGSTSEQNQNNQQNQHSNSQSTVNQTQAEQKDQKPKLTKSQMLNILHQAKIKFENEKSEDIFDKILNEEPSYDDNILSGEAIDLLRKMLNKNQSQRPSAK
                                                                      .    . . |  .. ..  . . ..||. .
----------------------------------------------------------------------F---VCCPDEMYQIMKQCWHEDPEDRPTFS

DLLRHPWF
..  |  |
EI--HECF

Kinase 27964.AA CDPK 362-411 37 2.6e-12 34.3 In-house 219-271 (271) Show / Hide
Range on Protein: 362-411
Range on HMM: 219-271/271
Sequence Identity: 37% (20 aa)

EDIFDKILNEEPSYDD---NILSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
..|..|. . . |...   .. | ||.|| ||||.... .| || . | ||||
QEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF

Kinase 27964.AA MARK 216-254 45 1.5e-11 34.24 In-house 167-206 (262) Show / Hide
Range on Protein: 216-254
Range on HMM: 167-206/262
Sequence Identity: 45% (18 aa)

GTYYYISPEQIQKQKYN-SKCDIWAAGVVMYCLLNKQFPF
||. | .|| ..|..|.  | |||. |||.| ..  .|||
GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPF

Kinase 27964.AA Pkinase 364-411 20 2.9e-11 40.93 Pfam 226-293 (293) Show / Hide
Range on Protein: 364-411
Range on HMM: 226-293/293
Sequence Identity: 20% (14 aa)

IFDKILNEEPSYDDNILS--------------------GEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
....|.  ....|   ..                     |..|.....|.|. ..||.|...| ||||
MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 27964.AA CAMK-Unique 356-411 25 1e-07 21.37 In-house 293-363 (363) Show / Hide
Range on Protein: 356-411
Range on HMM: 293-363/363
Sequence Identity: 25% (18 aa)

FENEKSE--------DIFDKILNEEP-SYDDNILSG------EAIDLLRKMLNKNQSQRPSAKDLLRHPWF
|. | ..         ||..|.  .. ..|    .|      ||.|.. . ..  ...| ||| || |.|.
FDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI

Kinase 27964.AA Pkinase_Tyr 34-154 24 2e-06 22.25 Pfam 4-137 (270) Show / Hide
Range on Protein: 34-154
Range on HMM: 4-137/270
Sequence Identity: 24% (33 aa)

DKRLGAGGFGEIFRIVEKTQNQDQSKMQCLKKVSQQDRSQA-------LNEINSLKIL-SHPNILKFYEYFE-NQKN--IFLVLEYIEGLDMIDFIQKD-
.| ||.| |||... . |   .|. |...  |.  .. ..        ..|.. .| | .||||...|      ..   |..|.|| .. |. |. .|  
GKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR

--STSISEKVAATIMKQLLEALAYTHDKKIVHRDI
    ... |    .  |  ....| ..|...|||.
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase 27964.AA Pkinase_Tyr 222-245 41 0.319946 4.76 Pfam 182-205 (270) Show / Hide
Range on Protein: 222-245
Range on HMM: 182-205/270
Sequence Identity: 41% (10 aa)

SPEQIQKQKYNSKCDIWAAGVVMY
.|| |.  |...| |.|. ||.|.
APECINYGKFTTKSDVWSFGVLMW

Efhand 27964.AA efhand 460-488 34 5.7e-07 29.93 Pfam 1-29 (29) Show / Hide
Range on Protein: 460-488
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

ELELIFKKLDKDNSGTLSKEEIKQGFEEM
||. .||..|||..|....|| .......
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL

Efhand 27964.AA efhand 496-524 31 5.8e-07 29.9 Pfam 1-29 (29) Show / Hide
Range on Protein: 496-524
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

DLDQIFDQIDTDKNGFIDYNEFLASTISH
.|...|...|.|..|.||..||..   . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL

EFh 27964.AA EFh 460-488 31 1e-06 29.07 SMART 1-29 (29) Show / Hide
Range on Protein: 460-488
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

ELELIFKKLDKDNSGTLSKEEIKQGFEEM
|.. .|...|||..|....|| |... ..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

EFh 27964.AA EFh 532-560 31 5e-06 27.2 SMART 1-29 (29) Show / Hide
Range on Protein: 532-560
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

YLKKVFKLIDLDKNGSISLNELKNILGSP
 .|..|...| |..| |...|.| .. | 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

Efhand 27964.AA efhand 532-560 31 5e-06 26.51 Pfam 1-29 (29) Show / Hide
Range on Protein: 532-560
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

YLKKVFKLIDLDKNGSISLNELKNILGSP
 ||..||..| |..| |...|..... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL

EFh 27964.AA EFh 496-524 31 2.8e-05 24.79 SMART 1-29 (29) Show / Hide
Range on Protein: 496-524
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

DLDQIFDQIDTDKNGFIDYNEFLASTISH
.....|. .|.|..|.||..||..   | 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

EH 27964.AA EH 450-562 19 0.000141 -0.32 SMART 1-98 (98) Show / Hide
Range on Protein: 450-562
Range on HMM: 1-98/98
Sequence Identity: 19% (23 aa)

SHLVEDNEKKELELIFKKLDKDNSGTLSKEEIKQGFEEMEVELNQQDLDQIFDQIDTDKNGFIDYN-EFLASTISHELISNQNYLKKVFKLIDLDKNG--
   .. ..|.  . || .||....|... .. .  |      |.||.| .| .  |.|..|..| . || .                 ..||.. .||  
PWWISPEDKAKYWQIFHSLDPQQDGFVTGDQARPIFMQ--SGLPQQQLAHIWNLCDIDNDGELDREPEFCVA----------------MHLIYCCMNGNY

SISLNELKNILGSPDQ
.|. .   . . ....
PIPMVLPPWLIPPSKR

EFh 27964.AA EFh 571-599 37 5e-07 30.59 SMART 1-29 (29) Show / Hide
Range on Protein: 571-599
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

VFEDIFSQIDINSDGEISFEEFEKLITSH
 |...|. .| . ||.|.|||| ....| 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

Efhand 27964.AA efhand 571-599 31 8.5e-07 29.29 Pfam 1-29 (29) Show / Hide
Range on Protein: 571-599
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

VFEDIFSQIDINSDGEISFEEFEKLITSH
 ....|...| . ||.|.|||| ..... 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL