Gene 27964 (Tetrahymena)

27964

Species: Tetrahymena
Alias: PreTt27964, 27964, 90.m00128, TTHERM_00632950, 22
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
27964.AA Protein None 643 None Fasta, JSON
27964.kin_dom Protein Kinase Domain None 378 None Fasta, JSON
27964.NA RNA None 1932 None Fasta, JSON

Protein domain

Protein domains of 27964.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27964.AA Ciliate-E2-Unclassified 33-411 21 2.1e-87 296.69 In-house 3-352 (352) Show / Hide 
Range on Protein: 33-411
Range on HMM: 3-352/352
Sequence Identity: 21% (98 aa)

DDKRLGAGGFGEIFRIVEKTQN---------QDQSKMQCLKKVSQQDRSQALNEINSLK-------------ILS---HPNILKFYEYFENQKNIFLVLE
  | .| ||||.... ..| |.         . |...|.... .. . .. ..|.|..|             ||.   ||.|.|....|....||..|.|
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

YIEGLDMIDFIQKDST----------------SISEKVAA-----TIMKQLLEALAYTHDKK-IVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNE
|.||.|....|.| ..                 ..|. |.     ....|.|..| | | |. |.|||||.|||.. ..|.                   
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-------------------

QNFKVKLIDWGFSYNLGLMNQE------------YIESKSLMGTYYYI----SPEQIQKQKYN----SKCDIWAAGVVMYCLLNKQFPFFSNLKFQDRFM
 |...|.||.|.|.... .|..            . .... .||..|.    .|| .|.|.|.     |||||. ||..|..|  ..||..| . |....
-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQL

EYQQVSLSQFHRNMQLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNSQSTVNQTQAEQKDQKPKLTKSQMLNILHQAKIKFENEKSEDIF
..|.. .     |                     | ...   ....|.|.|..... |.                                         
ITQWI-N-----N---------------------A-YRKQLYQNIKQKNIQFPKFPWQQ-----------------------------------------

DKILNEEPSYDDNILSGEAIDLLR----KMLNKNQSQRPSAKDLLRHPWF
          .. ..| ||.|...    |||.||...|......| ||||
----------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 27964.AA Ciliate-E2 35-411 19 2.6e-86 293.04 In-house 5-365 (365) Show / Hide 
Range on Protein: 35-411
Range on HMM: 5-365/365
Sequence Identity: 19% (93 aa)

KRLGAGGFGEIFRIVEKTQNQ-------------------DQSKMQCLKKVSQQDRSQALNEINSLK----------------ILSHPNILKFYEYFE--
| .| |.|| ...   . ...                   ...|.  .| .....  | ..||. ..                .|.||||.|.||.|.  
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

NQKNIFLVLEYIEGLDMIDFIQKDSTS----------ISEKVAATIMKQLLE---------------ALAYTHDKK-IVHRDIKCENIMIIKQGETQKSE
...||.||.||..| |. |.|.. ...          ..|| ...||||.|.               || | | |. |.||||| |||..          
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------

NSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLMG-----------------------------TYYYISPEQIQKQK---------YNS
                  .|.||.|.| ..   ||.... |....                             |..| .|| ....|         |. 
------------------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

KCDIWAAGVVMYCLLNKQFPFFSNLKFQDRFMEYQQVSLSQFHRNMQLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNSQSTVNQTQAEQ
|||||..||..|..| ...||                                                                               
KCDIWSLGVILYEMLFGKPPF-------------------------------------------------------------------------------

KDQKPKLTKSQMLNILHQAKIKFENEKSEDIFDKILNEEPSY-DDNILSGEAIDLLRK----MLNKNQSQRPS-AKDLLRHPWF
            ... .| ||.| ......  .. .. .... . . .| |..||..|    ||.|....|.. ....| ||||
------------QQQIKQCKIDFPCPEWQKD-TQ-CI-QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
S_TKc 27964.AA S_TKc 31-411 19 1.7e-70 241.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 31-411
Range on HMM: 1-231/231
Sequence Identity: 19% (77 aa)

RADDKRLGAGGFGEIFRIVEKTQNQDQSKMQCLKKVSQQDRSQALNEINSLKILSHPNILKFYEYFENQKNIFLVLEYIEG--LDMIDFIQKDSTS----
    . .| |.||. .. ..|       .   .|...     ....||. ||   |||| |.|..|.. .....|.||..|   |. |.|.|  .     
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-ISEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLMGTYYYISP
 ..| .|. .|.|...||.| |...|.|||.| |||.. .                          .|..| |..  |          ... || .|..|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------------------HIKICDFGLARQL----------TTFCGTPWYMAP

EQIQKQKYNS-KCDIWAAGVVMYCLLNKQFPFFSNLKFQDRFMEYQQVSLSQFHRNMQLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNS
| .   .|.  |||.|. |...| .|  . ||       . .| ....                                                    
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------------------------

QSTVNQTQAEQKDQKPKLTKSQMLNILHQAKIKFENEKSEDIFDKILNEEPSYDDNILSGEAIDLLRKMLNKNQSQRPSAKDLLR-------HPWF
                                                          | ||.|..||.|.|. ..||.| ..|.       ||||
----------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 27964.AA CAMK 36-254 20 4.9e-65 208.22 In-house 1-334 (425) Show / Hide 
Range on Protein: 36-254
Range on HMM: 1-334/425
Sequence Identity: 20% (70 aa)

RLGAGGFGEIFRIVEKTQNQDQS-------KMQCLKKV--------------------------------SQQDRSQALNEINSLKILS-------HPNI
 || |.||. .. ..|  ....        . ..  |.                                ...|| . ..||. .| |.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKFYEYFEN-------------------QKNIFLVL---EYIEGL----DMIDFIQKD--------------STSISEKVAATIMKQLLEALAYTHDKKI
.|.||..|.                   .|....|.   ||..|     |. |.|..               .  ..|. |.....|...|..| |...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKCENIMIIKQGETQ---------KSENSSQENSNQNAQNEQNFKVKLIDWGFS--YNLGLMNQ------------------EYIESKSLMGTYYY
||||.|.|||.. . .. .                         ..|...|.||.||.  .. |  |                   |    |   || .|
VHRDLKPENILLDDNNDDSDPVEHDEIFD---------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY

IS-PEQIQK--------------QKYNSKCDIWAAGVVMYCLLNKQFPF
.. || ...              . |. |||.|..||..| .|   .||
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase 27964.AA Ciliate-E2a 64-254 33 4.7e-59 172.47 In-house 34-216 (275) Show / Hide 
Range on Protein: 64-254
Range on HMM: 34-216/275
Sequence Identity: 33% (67 aa)

KKVSQQD--RSQALNEINSLKILSHPNILKFYEYFENQKNIFLVLEYIEGLDMIDFIQKDSTSISE-KVAATIMKQLL-EALAYTHDKKIVHRDIKCENI
|| .||.  . .  |||| .. |.||||.|.||..|. .|..||.||.|| ...| |... .  .| .... ||.||| ..|.| | ..|.|||.| |||
KKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENI

MIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLMGTYYYIS------PEQIQKQKYNSKCDIWAAGVVMYCLLNKQFP
.. .                 .... ||...|.||.|.. .     ..|. .|   || .|.       .| .....|  |||.| .||..|.||  . |
LFKN----------------CSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQK--CGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPP

F
|
F
Kinase 27964.AA CDPK 35-248 37 7.7e-56 169.84 In-house 5-207 (271) Show / Hide 
Range on Protein: 35-248
Range on HMM: 5-207/271
Sequence Identity: 37% (84 aa)

KRLGAGGFGEIFRIVEK-TQNQDQ--SKMQCLKKVSQQDR-SQALNEINSLKILSHPNILKFYEYFENQKNIFLVLE--YIEGLDMIDFIQKDSTSISEK
| || |.||.......|  .||     |.   ..|....   | .|||. || | ||||.|.||... .||...|.|  | .| . .| |.  .   .||
KVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH-FTEK

VAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLM---GTYYYISPEQ
 || ||.|.| |..| |...|||||.| |||.                .|. . ..   . .|.|||| |.. .   |   |.| ..   || |||.||.
EAAYIMRQILSAVNYCHSNNIVHRDLKPENILF---------------DSKKDDSWV-IYNIKVIDWGTSKKFDQN-QKI-EDKKMSQRCGTPYYIAPEV

IQKQKYNSKCDIWAAGVVMYCLL
.||. || ||||| .||..| ||
LQKK-YNEKCDIWSCGVILYILL
Kinase 27964.AA STE 32-411 15 3.4e-54 186.37 In-house 1-359 (359) Show / Hide 
Range on Protein: 32-411
Range on HMM: 1-359/359
Sequence Identity: 15% (76 aa)

ADD-KRLGAGGFGEIFRIVEKT-----QNQDQ------SKMQCLKKVS--------------------QQDRSQALNEINSLKILS--HPNILKFYEYFE
 .. ...| |.||. .. . .      ... .       ..   |...                    .... | |.||. .| ..  |||| |.| ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NQ-------KNIFLVLEYIEGLDMIDFIQ-KDSTSIS------------EKVAATIMKQLLEA-LAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQE
.         ......||..|    |.|. | ..  .            |.. |.| .|.|.. |.| |...|.|||||. ||..               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

NSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYI----------------ESKSLMGTYYYISPEQIQK------QKYNSKCDIWAAGVVMYCLLNKQFPF
             |||.| |..   | .....                 ..... ||  . .|| ||.      ..|. |||||  | ..  ... . |.
-------------VKLCDFGVC---GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW

--FSNLK--FQDRFM-----EYQQVSLSQFHRNMQLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNSQSTVNQTQAEQKDQKPKLTKSQM
  .....  |.  |.     .                                                                               
HDMHPMRAMFMIPFNYHMQQQ-------------------------------------------------------------------------------

LNILHQAKIKFENEKSEDIFDKILNEEPSYDDN-------------------ILSGEAIDLLRKMLNKNQSQRPSAKDLLR--HPWF
                 .   .|.|..|    .                    .| | .| ..| |.|. ..||.|..||.  ||..
----------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Pkinase 27964.AA Pkinase 31-254 26 3e-53 188.01 Pfam 1-212 (293) Show / Hide 
Range on Protein: 31-254
Range on HMM: 1-212/293
Sequence Identity: 26% (64 aa)

RADDKRLGAGGFGEIFRIVEKTQNQDQSKMQCLKKVSQQDRSQALN-------EINSLKILSHPNILKFYEYFENQKNIFLVLEYIEGL----DMIDFIQ
    ...|.|.||. .. ..|  ..    . ..|... ....   .       ||  .| |.||||...|..||. ..| .|.|| ||     |  |.|.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-KDSTSI--SEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIESKSLMG
 ......  ||...  .|.|.|..|.| |...|.|||.| |||.| ..|..                     .||..|.|..  .   .  .   ... |
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------------------CVKICDFGLAKQFD--Y-NNS-MTTFCG

TYYYISPEQIQ-KQKYNSKCDIWAAGVVMYCLLNKQFPF
|..|..|| |.  |.| .|.|.|..|...|..|....||
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF
Kinase 27964.AA ULK 31-411 20 1.9e-48 167.23 In-house 1-329 (329) Show / Hide 
Range on Protein: 31-411
Range on HMM: 1-329/329
Sequence Identity: 20% (88 aa)

RADDKRLGAGGFGEIFRIV-EKTQNQDQSKMQCLKKVSQ---QDRSQ-----------ALNEINSLKILS--------HPNILKFYEYFENQ--KNIFLV
   ...|| | ||  ..   .||. . ... ..  |. .   .....             |||  .| |         |||| |.|..||..  .||...
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

LEYIEGLDMIDFIQKDST---------SISEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIK-QGETQKSENSSQENSNQNAQNEQNFKVKLIDW
.|| .| |  ..|.|. .          .||. |  ..||.|... . |...|.||||| .||.| . |. |  |.    .     . .  |  .|. | 
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK----K-----V-HP-NGVLKIADF

GFSYNLGLMNQEYIESKSLM------GTYYYISPEQIQ----KQKYN-SKCDIWAAGVVMYCLLNKQFPFFSNLKFQDR---FMEY--QQVSLSQFHRNM
||.  .   |.|    ..        || .| .|. .|    ...|. .|||||  |...| .|  . ||... ....     ..   ..  . |     
GFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQ-----

QLADTQSQNENECSAAIQISAQTISGSTSEQNQNNQQNQHSNSQSTVNQTQAEQKDQKPKLTKSQMLNILHQAKIKFENEKSEDIFDKILNEEPSYD---
                                                                                       .| .. . ..   
---------------------------------------------------------------------------------------QIKKQPLQFPKDG

-DNILSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
 |...| | .||.|.|| .....| |  .|. ||||
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 27964.AA CAMK-Unique 35-254 24 3.3e-48 157.14 In-house 5-293 (363) Show / Hide 
Range on Protein: 35-254
Range on HMM: 5-293/363
Sequence Identity: 24% (72 aa)

KRLGAGGFGEIFRIVE-KTQNQDQSKMQCLKKVSQQDRSQ------------------ALNEINSLKILSHPNILKFYEY----FENQK-----------
. .| |.||....    .|   .. ||  .....   . |                  . .|.. .| ..||||.|.|..    |.  |           
RIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTP

----NIFLVLEYIEGLDMIDFIQKD-------------------STSISE--KVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQ
    ....|.||..| |. | |||                     .. ||    ...|| .||.|.|| |...|||||.| ||||. . .          
RALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN------

ENSNQNAQNEQNFKVKLIDWGFSYNLGLMNQEYIES--KSLMGTYYYISP--------------EQIQKQKYNSKC----DIWAAGVVMYCLLNKQFPF
        .. | ..||.|.| .    . |.   ..  ..  || .|..|              | |  |.| ..|    |||. ||.|| .|    ||
-HHRDFPYDWSNWHIKLCDFGLCC---HYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPF
Kinase 27964.AA CAMKL 77-254 30 2.4e-47 149.06 In-house 62-236 (297) Show / Hide 
Range on Protein: 77-254
Range on HMM: 62-236/297
Sequence Identity: 30% (60 aa)

EINSLKILS---HPNILKFYEYFENQKN------IFLVLEYIEGLD--MIDFIQKDS---TSISEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMII
||. .| |.   |||| |.|| .|....      |.||.||..| .  . |.|.|      ...|. |  . .|...|..| |...||||||| |||.. 
EIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLD

KQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLM-NQEYIESKSLMGTYYYISPEQIQK--QKYN-SKCDIWAAGVVMYCLLNKQFPF
..|                       ..|.|| |||     . ...    |   |.. | .|| .|.  ..|.  | |||..||..| ..  ..||
ENGNN---------------------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPF
Kinase 27964.AA MARK 64-161 36 9.9e-29 91.17 In-house 35-137 (262) Show / Hide 
Range on Protein: 64-161
Range on HMM: 35-137/262
Sequence Identity: 36% (38 aa)

KKVSQ-QDRSQALNEINSLKILSHPNILKFYEYFE--NQKN-IFLVLEYIEGLDMIDFIQKD-STSISEKVAATIMKQLLEALAYTHDKKIVHRDIKCEN
.| .  | ..    ||. .| |.|||| |.....|  . .. |.|..||..| .. |.|..     ..|. | .| .|...|. | |.| |||||||.||
FKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPEN

IMI
|.|
ILI
Kinase 27964.AA Ciliate-E2a 356-411 28 3.3e-18 50.2 In-house 216-275 (275) Show / Hide 
Range on Protein: 356-411
Range on HMM: 216-275/275
Sequence Identity: 28% (17 aa)

FENEKSEDIFDKILNEEPSYDDNI----LSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
|. .. ..|. .. . . ......    .| |..||..|||.|. ..|..|...| ||||
FKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 27964.AA CAMK 362-411 21 1.9e-17 52.1 In-house 353-425 (425) Show / Hide 
Range on Protein: 362-411
Range on HMM: 353-425/425
Sequence Identity: 21% (16 aa)

EDIFDKILNEEPSYDDNILSG-----------------------EAIDLLRKMLNKNQSQRPSAKDLLRHPWF
...| ||.. . ....  .|.                       |..||.||||... ..|..... |.|||.
YELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 27964.AA CAMKL 356-411 23 9.2e-15 43.39 In-house 236-297 (297) Show / Hide 
Range on Protein: 356-411
Range on HMM: 236-297/297
Sequence Identity: 23% (15 aa)

FENE-------KSEDIFDKILNEEPSYDD--NILSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
|...       .    . .. ..   |..  . .| ...||.||||..| ..||.......|||.
FDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 27964.AA MARK 362-411 26 1.3e-14 44.3 In-house 214-262 (262) Show / Hide 
Range on Protein: 362-411
Range on HMM: 214-262/262
Sequence Identity: 26% (13 aa)

EDIFDKILNEEPSYDDNILSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
.... |||...... .. .| |. .|....|. | ..||.......|||.
KELYKKILRGKYDIPCH-VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 27964.AA TyrKc 31-411 15 6.6e-13 -14.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 31-411
Range on HMM: 1-280/280
Sequence Identity: 15% (63 aa)

RADDKRLGAGGFGEIFRIVEKTQNQDQSKMQCLKKVSQQDRSQA--LNEINSLKIL--SHPNILKFYEYFENQ-------KNIFLVLEYIEGLDMIDFIQ
   .| || | |||... . |        .|.  |. . |  ..  ..|.. .. |  .||||...| .   |       . ...|.|| .. |  |...
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KDSTSISEKVAATIMKQLLEALAYTHDKKIVHRDIKCENIMIIKQGETQKSENSSQENSNQNAQNEQNFKVKLIDWGFSYNLGLM-----NQEYIESK--
|    .. |    .. |  .  .| |.|...|||. . |... ...                        ||  | | | ...       ...|. .|  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEH

-SLM--GTYYYISPEQIQKQKYNSKCDIWAAGVVMYCLLNKQFPFFSNLKFQDRFMEYQQVS--LSQFHRNMQLAD----TQSQNENECSAAIQISAQTI
 .      .   .|| |.. |...| |.|. ||.|. ..    .  ..  .|  .|. |.|   . | .| .| ..                        
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------

SGSTSEQNQNNQQNQHSNSQSTVNQTQAEQKDQKPKLTKSQMLNILHQAKIKFENEKSEDIFDKILNEEPSYDDNILSGEAIDLLRKMLNKNQSQRPSAK
                                                                      .    . . |  .. ..  . . ..||. .
----------------------------------------------------------------------F---VCCPDEMYQIMKQCWHEDPEDRPTFS

DLLRHPWF
..  |  |
EI--HECF
Kinase 27964.AA CDPK 362-411 37 2.6e-12 34.3 In-house 219-271 (271) Show / Hide 
Range on Protein: 362-411
Range on HMM: 219-271/271
Sequence Identity: 37% (20 aa)

EDIFDKILNEEPSYDD---NILSGEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
..|..|. . . |...   .. | ||.|| ||||.... .| || . | ||||
QEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 27964.AA MARK 216-254 45 1.5e-11 34.24 In-house 167-206 (262) Show / Hide 
Range on Protein: 216-254
Range on HMM: 167-206/262
Sequence Identity: 45% (18 aa)

GTYYYISPEQIQKQKYN-SKCDIWAAGVVMYCLLNKQFPF
||. | .|| ..|..|.  | |||. |||.| ..  .|||
GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPF
Kinase 27964.AA Pkinase 364-411 20 2.9e-11 40.93 Pfam 226-293 (293) Show / Hide 
Range on Protein: 364-411
Range on HMM: 226-293/293
Sequence Identity: 20% (14 aa)

IFDKILNEEPSYDDNILS--------------------GEAIDLLRKMLNKNQSQRPSAKDLLRHPWF
....|.  ....|   ..                     |..|.....|.|. ..||.|...| ||||
MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 27964.AA CAMK-Unique 356-411 25 1e-07 21.37 In-house 293-363 (363) Show / Hide 
Range on Protein: 356-411
Range on HMM: 293-363/363
Sequence Identity: 25% (18 aa)

FENEKSE--------DIFDKILNEEP-SYDDNILSG------EAIDLLRKMLNKNQSQRPSAKDLLRHPWF
|. | ..         ||..|.  .. ..|    .|      ||.|.. . ..  ...| ||| || |.|.
FDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 27964.AA Pkinase_Tyr 34-154 24 2e-06 22.25 Pfam 4-137 (270) Show / Hide 
Range on Protein: 34-154
Range on HMM: 4-137/270
Sequence Identity: 24% (33 aa)

DKRLGAGGFGEIFRIVEKTQNQDQSKMQCLKKVSQQDRSQA-------LNEINSLKIL-SHPNILKFYEYFE-NQKN--IFLVLEYIEGLDMIDFIQKD-
.| ||.| |||... . |   .|. |...  |.  .. ..        ..|.. .| | .||||...|      ..   |..|.|| .. |. |. .|  
GKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR

--STSISEKVAATIMKQLLEALAYTHDKKIVHRDI
    ... |    .  |  ....| ..|...|||.
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 27964.AA Pkinase_Tyr 222-245 41 0.319946 4.76 Pfam 182-205 (270) Show / Hide 
Range on Protein: 222-245
Range on HMM: 182-205/270
Sequence Identity: 41% (10 aa)

SPEQIQKQKYNSKCDIWAAGVVMY
.|| |.  |...| |.|. ||.|.
APECINYGKFTTKSDVWSFGVLMW
Efhand 27964.AA efhand 460-488 34 5.7e-07 29.93 Pfam 1-29 (29) Show / Hide 
Range on Protein: 460-488
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

ELELIFKKLDKDNSGTLSKEEIKQGFEEM
||. .||..|||..|....|| .......
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 27964.AA efhand 496-524 31 5.8e-07 29.9 Pfam 1-29 (29) Show / Hide 
Range on Protein: 496-524
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

DLDQIFDQIDTDKNGFIDYNEFLASTISH
.|...|...|.|..|.||..||..   . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 27964.AA EFh 460-488 31 1e-06 29.07 SMART 1-29 (29) Show / Hide 
Range on Protein: 460-488
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

ELELIFKKLDKDNSGTLSKEEIKQGFEEM
|.. .|...|||..|....|| |... ..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 27964.AA EFh 532-560 31 5e-06 27.2 SMART 1-29 (29) Show / Hide 
Range on Protein: 532-560
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

YLKKVFKLIDLDKNGSISLNELKNILGSP
 .|..|...| |..| |...|.| .. | 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 27964.AA efhand 532-560 31 5e-06 26.51 Pfam 1-29 (29) Show / Hide 
Range on Protein: 532-560
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

YLKKVFKLIDLDKNGSISLNELKNILGSP
 ||..||..| |..| |...|..... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 27964.AA EFh 496-524 31 2.8e-05 24.79 SMART 1-29 (29) Show / Hide 
Range on Protein: 496-524
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

DLDQIFDQIDTDKNGFIDYNEFLASTISH
.....|. .|.|..|.||..||..   | 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EH 27964.AA EH 450-562 19 0.000141 -0.32 SMART 1-98 (98) Show / Hide 
Range on Protein: 450-562
Range on HMM: 1-98/98
Sequence Identity: 19% (23 aa)

SHLVEDNEKKELELIFKKLDKDNSGTLSKEEIKQGFEEMEVELNQQDLDQIFDQIDTDKNGFIDYN-EFLASTISHELISNQNYLKKVFKLIDLDKNG--
   .. ..|.  . || .||....|... .. .  |      |.||.| .| .  |.|..|..| . || .                 ..||.. .||  
PWWISPEDKAKYWQIFHSLDPQQDGFVTGDQARPIFMQ--SGLPQQQLAHIWNLCDIDNDGELDREPEFCVA----------------MHLIYCCMNGNY

SISLNELKNILGSPDQ
.|. .   . . ....
PIPMVLPPWLIPPSKR
EFh 27964.AA EFh 571-599 37 5e-07 30.59 SMART 1-29 (29) Show / Hide 
Range on Protein: 571-599
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

VFEDIFSQIDINSDGEISFEEFEKLITSH
 |...|. .| . ||.|.|||| ....| 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 27964.AA efhand 571-599 31 8.5e-07 29.29 Pfam 1-29 (29) Show / Hide 
Range on Protein: 571-599
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

VFEDIFSQIDINSDGEISFEEFEKLITSH
 ....|...| . ||.|.|||| ..... 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL