Gene 29162 (Tetrahymena)

29162

Species: Tetrahymena
Alias: TTHERM_00865320, 3751.m00466, 29162, 154.m00120, 290, PreTt29162
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
29162.AA Protein None 500 None Fasta, JSON
29162.kin_dom Protein Kinase Domain None 298 None Fasta, JSON
29162.NA RNA None 1503 None Fasta, JSON

Protein domain

Protein domains of 29162.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29162.AA Ciliate-E2-Unclassified 78-375 24 1.1e-92 314.25 In-house 1-352 (352) Show / Hide 
Range on Protein: 78-375
Range on HMM: 1-352/352
Sequence Identity: 24% (93 aa)

YEELEKIGEGSHSIVKKCLNKLNN-----------KMYAVKIIRTDDLEIINQAKTEYQ-----------IVKE--LNHDNILKVFEMFVNEKTGYVRLI
|. ...||.|....|.|| .| ..           ..|..|.|.. | ||.|..|.. .           | ..  |||.....| .... ... .. ..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEYSDAITLKQFIEKSFN---------------KRLTEQISS-----KITIQILSALSYLHQNK-IVHRDIKPSNILIHPESL--RVTLIDFGISRFFND
.|| .  .|.|.|.|. .               |..||| ..     ... |||..|.|||... |.||||||.|||.. .    .. .||||||.. ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------SHELCTPTGTPLYK----APEMIRGDPYNET----ADCWSLGITLFEMLTGLKPFNYTYRTINQILQKKKQVNRVPKNIHITTN
                .....| .||| |.    |||...|  |...    .|.||||. |.|||.|  ||... ....|.|..... |    |      
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N----N------

PLIPIHPFILKPLTYKENEMIIKMENQSFTNNQKY----KSLSQQAQDLLK----QLLNPNLNNRIQPQEGLKHPFV
       .      |...   ...... . ....     | .|..|.|...    ..|. |.|.||.... |.||. 
-------A------YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 29162.AA Ciliate-E2 78-375 21 3.9e-86 292.46 In-house 1-365 (365) Show / Hide 
Range on Protein: 78-375
Range on HMM: 1-365/365
Sequence Identity: 21% (91 aa)

YEELEKIGEGSHSIVKKCLNKLNNKM-----------------------YAVKIIRTDDLEIINQAKTEYQ-------------IVKELNHDNILKVFEM
|. ..|||.|....|.|| .....|.                       ||.||.. ...|.|.| . ...             | ..|||.||.| .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FVNEKTGYVRLITEYSDAITLKQFIEKSFNKR---------LTEQISSKITIQILS---------------ALSYLHQNK-IVHRDIKPSNILIHPESLR
| .... .. |..|| .  .|...|...  ||         .||.  ..|. |||.               || |||... |.||||||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

VTLIDFGISRFFNDS---------HELCTPTG------------------------TPLYKAPEMIRGDP---------YNETADCWSLGITLFEMLTGL
. .||||.|....|.         .....  .                        || |.|||...| .         |.. .| ||||..|.|||.| 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

KPFNYTYRTINQILQKKKQVNRVPKNIHITTNPLIPIHPFILKPLTYKENEMIIKMENQSFTNNQ--------------KYKSLSQQAQDLLKQ----LL
 ||                                                ........   ...              ..|..||...||.|.    .|
PPF------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRML

NPNLNNRIQ-PQEGLKHPFV
. . ..||. ... |.||. 
QKDPEKRITGWEQILNHPWF
Kinase 29162.AA S_TKc 78-375 25 3.3e-80 273.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 78-375
Range on HMM: 1-231/231
Sequence Identity: 25% (80 aa)

YEELEKIGEGSHSIVKKCLNKLNNKMYAVKIIRTDDLEIINQAKTEYQIVKELNHDNILKVFEMFVNEKTGYVRLITEYSDA--ITLKQFIEKSFNKR--
|| |.|||.|. . |.|| .|  .. .|.|||.       .... | || |. .|.|| | ...|..   ... ...|| |    .|...|.|   ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LTEQISSKITIQILSALSYLHQNKIVHRDIKPSNILIHPESLRVTLIDFGISRFFNDSHELCTPTGTPLYKAPEMIRGDPYNE-TADCWSLGITLFEM
  ..|    ... ||..|| |.|...|.|||.||.|||.     .. ..|||..|..       |  ||| | |||..   .|.   .| ||.|..|.||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTGLKPFNYTYRTINQILQKKKQVNRVPKNIHITTNPLIPIHPFILKPLTYKENEMIIKMENQSFTNNQKYKSLSQQAQDLLKQLLNPNLNNRIQPQEGL
|.|  ||     .......| .                                                    |..| |.....|. . ..|.   | |
LCGYPPFP----QMQMMFKKIG----------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

K-------HPFV
.       ||..
QDEWDIKCHPWF
Kinase 29162.AA CAMK 83-375 17 1.7e-75 242.55 In-house 1-425 (425) Show / Hide 
Range on Protein: 83-375
Range on HMM: 1-425/425
Sequence Identity: 17% (82 aa)

KIGEGSHSIVKKCLNKLNN------------KMYAVKIIRTDDLE----------------------------IINQAKTEYQIVKE-------LNHDNI
..|.|| ..||.| .|...            . .|.||| .. |                                . . |..| |        |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKVFEMFV------------NEKTG------YVRLIT---EYSDAI----TLKQFIEKSFN-------------KRLTEQISSKITIQILSALSYLHQNK
.| .|..             . ...      .. ...   || .       | ..| .  .             .|.||.  ...  ||.||. |.|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKPSNILI-HPES---------------LRVTLIDFGISRFFNDSH------------------------ELCTPTGTPLYKA-PEMIRG-----
|||||.|| |||. . ..                 . .|||| ...|....                         . |. ||| | | ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------DPYNETADCWSLGITLFEMLTGLKPFN--YTYRTINQILQKKKQVNRVPKNIHITTNPLIPIHPFILKPLTYKENEMIIKMENQSFTNNQK
         ..|.. .|.||.|. |. ||.|  ||.  .  .... . . .                           ... ..|.  |  .  ..   .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D-E-W---------------------------IGMNDYELFEKIMKGKYDFPPP

YKS---------------------LSQQAQDLLKQLLNPNLNNRIQPQEGLKHPFV
| |                     .||...||....|... ..|.  .. |.||..
YFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 29162.AA Pkinase 78-375 26 9.9e-67 232.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 78-375
Range on HMM: 1-293/293
Sequence Identity: 26% (85 aa)

YEELEKIGEGSHSIVKKCLNKLNNKMYAVKIIRTDDLEIINQAKT-----EYQIVKELNHDNILKVFEMFVNEKTGYVRLITEYSDAI----TLKQFIEK
|. ..|||.|| . |.|| .| ..|..|||||. .  |  .. .|     | || |.|||.||.. ...| .   ... ...|| .       |. .|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

SFNKRL--TEQISSKITIQILSALSYLHQNKIVHRDIKPSNILIHPESLRV----TLIDFGISRF--FNDSHELCTPTGTPLYKAPEMIR-GDPYNETAD
. ....  .|.   ..  |||..| |.|...|.|||.||.||||. .   .     ..|||....     .. . |..||| | ||| || | .|   .|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

CWSLGITLFEMLTGLKPFNYTYRTINQILQKK---KQVNRVPKNIHITTNPLIPIHPFILKPLTYKENEMIIKMENQSFTNNQKYKSLSQQAQDLLKQLL
 ||.|..|.|||.|             . . .   .  ..  . |  .  | .. . . . .  | .  .. . .   | .  . . .|. ..|..| .|
MWSCGCILYEMLCGR-----------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCL

NPNLNNRIQPQEGLKHPFV
... . |. ... |.||..
CKDPKKRPTAEQILQHPWF
Kinase 29162.AA CAMKL 78-375 24 4.8e-65 206.46 In-house 1-297 (297) Show / Hide 
Range on Protein: 78-375
Range on HMM: 1-297/297
Sequence Identity: 24% (81 aa)

YEELEKIGEGSHSIVKKCLN-KLNNKMYAVKIIRTDDLEIINQAKT---------------EYQIVKELN---HDNILKVFEMFVNEKT----GYVRLIT
|. .. .|.|| . || ... .......|.|||  . .  . ..|                |.|| | ||   | || | .|.. ....    ... |..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYSDAIT--LKQFIEKSFNKR--LTEQISSKITIQILSALSYLHQNKIVHRDIKPSNILIHPESL-RVTLIDFGISRFFND-----SHELCTPTGTPLYK
|| .     | ..|.|  ..|  ..|    ..  ||.||..|.|...|||||||| |||.       . .|||| | .. .      . | |  |.| | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEMIRG--DPYN-ETADCWSLGITLFEMLTGLKPFN---YTYRTINQILQKKKQVNRVPKNIHITTNPLIPIHPFILKPLTYKENEMIIKMENQSFTNN
|||.. |  .||.   .|.||.|..|. |..|  ||.   |  .                                    .  . .    .....  .. 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-K------------------------------------QGKDNI-YLYWKIMCG-YYP

QKYKSLSQQAQDLLKQLLNPNLNNRIQPQEGLKHPFV
 .....| ...||....|..| . |.  .. ..||..
PIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 29162.AA STE 78-375 22 1.3e-61 211.04 In-house 1-359 (359) Show / Hide 
Range on Protein: 78-375
Range on HMM: 1-359/359
Sequence Identity: 22% (90 aa)

YEELEKIGEGSHSIVKKCLNKL---------------NNKMYAVKIIRTDDL-----------------EIINQAKTEYQIVKELN--HDNILKVFEMFV
.| .||||.|.   | |..|.                .....|.|... ..                  |...| . | .| |..|  |.|| | . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NEK-----TGYVRLITEYSDAITLKQFIE------KSFN------KRLTEQISSKITIQILSA-LSYLHQNKIVHRDIKPSNILIHPESLRVTLIDFGIS
.|       ... .. || |. .| ..|.      |..|      .|. |.. ..|. ||| . |.|||...|.||||||.|||.      | |.|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

RFFNDS----------------HELC-TPTGTPLYKAPEMIRG------DPYNETADCWSLGITLFEMLTGLKPFNYTYRT--INQILQKKKQVN-----
  ..||                 . . | .||| . |||.|..      ..|.. .| ||||.|. ||.||  |.   . .  . .|..... ..     
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

-----RVPKNI-HIT-----------TNPLIPIHPFILKPLTYKENEMIIKMENQSFTNNQKYKSLSQQAQDLLKQLLNPNLNNRIQPQEGLK--HPFV
       |.   |.            | .                                  ...|.  .| ... |. . |.|  ... ||  |||.
CIVNGPPPPLPDHLSQNEMISYGGSGT-T--------------------------------YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 29162.AA CAMK-Unique 78-278 22 9e-57 185.85 In-house 1-294 (363) Show / Hide 
Range on Protein: 78-278
Range on HMM: 1-294/363
Sequence Identity: 22% (66 aa)

YEELEKIGEGSHSIVKKCLNKLNNKMYAVKIIRT-DDLEIINQA-------------------KTEYQIVKELNHDNILKVFEM----FVNEK-------
|. .. ||.|. ..|..|... . | .|.|...  .. .... .                   | | || | ..| ||.|...     |. .|       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

------TGYVRLITEYSDAITLKQFIEK------------------SFNKRLTE--QISSKITIQILSALSYLHQNKIVHRDIKPSNILIHPE-------
        |  ...|| .. .|.. | |                    . ...|    .. |  ..|||..|.|...|||||.|. ||..  .       
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------SLRVTLIDFGISRFFNDSHELC---TPTGTPLYKAP--------------EMIRGDPYNETA----DCWSLGITLFEMLTGLKPFN
         ... |.|||... .| ...     |  |||.|.||              |.| ...| .      |.|||| ....||.|  ||.
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFD
Kinase 29162.AA ULK 78-375 25 5.6e-52 179.0 In-house 1-329 (329) Show / Hide 
Range on Protein: 78-375
Range on HMM: 1-329/329
Sequence Identity: 25% (91 aa)

YEELEKIGEGSHSIVKKCLNKLN----NKMYAVKIIRTDDLEIINQA----------KTEYQIVKELN----HDN----ILKVFEMFVNEKTGYVRLITE
|.  ...|.||   | |  || .    |...|.|.|  . . ..|.           | | .| |.|.    | |    | | ...| . .  .. .|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YSDAITLKQFIEKS--------FNKRLTEQISSKITIQILSALSYLHQNKIVHRDIKPSNILIH------------PESLRVTLIDFGISRFFNDS----
| .  .|.|.|.|         ..|||.||.  .. .|||... .||...|.||||||.|||||            | . .. . ||| .......    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNMEQ

HELCTPT------GTPLYKAPEMIRGD----PYNET-ADCWSLGITLFEMLTGLKP----FNYTY-RTINQILQKKKQVNRVPKNIHITTNPLIPIHPFI
  ..| .      ||||| ||. . |     ||..  .| ||||. ..|||.|  |    || .| . |.. .....  .                    
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQ-------------------

LKPLTYKENEMIIKMENQSFTNNQ--KYKSLSQQAQDLLKQLLNPNLNNRIQPQEGLKHPFV
             ....| .  ..  . . .|.. .||....|  . . ||  .| ..||..
-------------QIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 29162.AA ULK 78-375 25 2.6e-51 176.81 In-house 1-324 (324) Show / Hide 
Range on Protein: 78-375
Range on HMM: 1-324/324
Sequence Identity: 25% (93 aa)

YEELEKIGEGSHS-IVKKCLNKLN---NKMYAVKIIR-----TDDLE-----IINQAKTEYQIVKELN---HDN--ILKVFEMFVNEKTGYVRLITEYSD
|.  ...|.||    | |  || .   |. .|.|.|       . .|     .... | | ||.|.|.   | |  | | ...| .    .. .|.|| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

AITLKQFIEKS-------FNKRLTEQISSKITIQILSALSYLHQNKIVHRDIKPSNILIH------------PESLRVTLIDFGISRFFN---DSHELC-
  .|.|.|.|        ..|||.||.  .. .||.... .||...|.||||||.|||||            | . .. . ||| .....    .  .| 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQMCQ

TPT------GTPLYKAPEMIRGD----PYNET-ADCWSLGITLFEMLTGLKP-FNYTYRTIN----QILQKKKQVNRVPKNIHITTNPLIPIHPFILKPL
|        ||||| ||. . |     ||..  .| ||||. ..|||.|  | |.. ... .    . ....|                           
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGK-E-------------------------

TYKENEMIIKMENQSFTNNQ--KYKSLSQQAQDLLKQLLNPNLNNRIQPQEGLKHPFV
 .      |...|| .  .   | . .|.. .||....|  . . ||  .| ..||..
-Q-----QIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 29162.AA CMGC 78-277 21 3.9e-47 152.38 In-house 1-342 (513) Show / Hide 
Range on Protein: 78-277
Range on HMM: 1-342/513
Sequence Identity: 21% (74 aa)

YEELEKIGEGSHSIVKKCLNKLNN--------------KMYAVKIIRTDDLEIINQ-----------AKTEYQIVKELN-----------------HDNI
|| ..|||||. ..| || .|..|              ...|.|.|. .  |.  .           |  | .| |.||                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

LKVFEMFVNEKTG---------------YVRLITEYSDAITLKQFIEKSF-------NKRLTEQI------------SSKIT------IQILSALS--YL
.| ...|. ...                .. |..|| |  .|.|.|..         .. |.|                ...       ||| .|   |.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMD-HDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQNK--IVHRDIKPSNILIHPE-------------------SLRVTLIDFGISRFFND----------------------SHELCTPTGTPLYKAPEMIR
|...  |.|||.||.|||| ..                   . |. ..||| .|....                      .. . .   |  |.||| . 
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GDP----------YNETADCWSLGITLFEMLTG-------LKPF
|..          |... | ||.|  ..||.||       .||.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase 29162.AA NEK 78-272 34 7.4e-47 161.98 In-house 1-219 (286) Show / Hide 
Range on Protein: 78-272
Range on HMM: 1-219/286
Sequence Identity: 34% (75 aa)

YEELEKIGEGSHSIVKKCLNKLNNKM-----YAVKIIRTDDL--EIINQAK-TEYQIVKELNHDNILKVFEMFVNEKTGYVRLITEYSD-AITLKQF---
||...|||.||.. | |.  | ..|.     |. | | .. .  .   .|   | .| |.|.|.|| | .. |. |. ..   . || .   .| |.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IEKSF--NKRLTEQISSKITIQILSALSYLHQN-----KIVHRDIKPSNILIHPESLR---VTLIDFGISRFFNDS-HELCT-PTGTPLYKAPEMIRGDP
|.|    .| . | .  .. ||...|| |.|..     ||.||||||.|| .  .  .   | . |||||. .|..   ..|  .||| | .||.... |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNETADCWSLGITLFEMLT
||. .| ||||  |.|| |
YNNKSDIWSLGCVLYEMCT
Kinase 29162.AA TyrKc 78-319 20 4e-13 -10.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 78-319
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YEELEKIGEGSHSIVKKCLNKLNNKMYAVKIIRTDDLEIINQAKTEYQIVKEL--NHDNILKVFEMFVNEKT-----GYVRLITEYSDAITLKQFIEKSF
 . ..|.|||   .| |.  |    . ||| .. |    .     | .| ..|  .|.||.. .   . ..      . . ...|| .   ||... |. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

NKRLTEQISSKITIQILSALSYLHQNKIVHRDIKPSNILIHPESLRVTLIDFGISRFFNDS------HELCTPTGTPLYK--------APEMIRGDPYNE
.| |. .   .. .|| .  .|||.....|||.   |.|.. | ..|   ||| ||.  |       ..  .....   |        ||| |.   ...
PK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVG-ENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

TADCWSLGITLFEMLTGLKPFNYTY----RTINQILQKKKQVNRVPKNIH-------ITTNPLIPI-----HP---------FILKPL
  | || |....|..|  ..  .       .  ..... || .| |.  .       . .  .  |     |           | . .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 29162.AA CMGC 332-375 25 3e-09 25.58 In-house 457-513 (513) Show / Hide 
Range on Protein: 332-375
Range on HMM: 457-513/513
Sequence Identity: 25% (15 aa)

NQSFTNNQKYKS----------------LSQQAQDLLKQLLNPNLNNRIQPQEGLKHPFV
...| |. .| .                ...|| ||||..|  . ..|| ... |.||. 
AMVF-NW-IY-EEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 29162.AA CAMK-Unique 338-375 21 2.2e-07 20.2 In-house 323-363 (363) Show / Hide 
Range on Protein: 338-375
Range on HMM: 323-363/363
Sequence Identity: 21% (9 aa)

NQKYKS---LSQQAQDLLKQLLNPNLNNRIQPQEGLKHPFV
.... .    ||.| |..|....  .. |.   |.|.|...
WKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 29162.AA Pkinase_Tyr 245-277 34 0.00396 11.22 Pfam 182-216 (270) Show / Hide 
Range on Protein: 245-277
Range on HMM: 182-216/270
Sequence Identity: 34% (12 aa)

APEMIRGDPYNETADCWSLGITLFEMLT-GLKP-F
||| |.   ...  | || |....|..| | .| .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY
Kinase 29162.AA Pkinase_Tyr 78-203 21 0.00479 10.94 Pfam 1-137 (270) Show / Hide 
Range on Protein: 78-203
Range on HMM: 1-137/270
Sequence Identity: 21% (30 aa)

YEELEKIGEGSHSIVKKCLNK----LNNKMYAVKII--RTDDLE-IINQAKTEYQIVKEL-NHDNILKVFEMFVNEKTGY--VRLITEYSDAITLKQFIE
 . ..|.|||.   |.|.  |     ..   |||..   ... . ..     | .| |.| .|.||.. .   . .. .   . ...||     |. .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVR-LYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KS--FNKRLTEQISSKITIQILSALSYLHQNKIVHRDI
|    ...|| .   .. .|| ....||......|||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL