Gene 5729 (Tetrahymena)

5729

Species: Tetrahymena
Alias: 63, PreTt05729, 5729, 435.m00014, TTHERM_01513280
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
5729.AA Protein None 505 None Fasta, JSON
5729.kin_dom Protein Kinase Domain None 329 None Fasta, JSON
5729.NA RNA None 1518 None Fasta, JSON

Protein domain

Protein domains of 5729.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5729.AA AGC 211-385 29 6.8e-112 290.08 In-house 127-395 (395) Show / Hide 
Range on Protein: 211-385
Range on HMM: 127-395/395
Sequence Identity: 29% (82 aa)

G-DLYMNMK---YKQKFTDREVLFYCSE-------IIVALEYLHS-KGIIYRD-LKPENVLLTKQGHIKLADFGLSKIKNYKD-----------------
| .|.. ..    ...|.  .. ||..|       |. ||||||| .|||.|| |||||.||...|||||.||||.|. . ..                 
GCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNK

---------------------------------ERSQSKCG--TPDYIAPEIVLGQNGHDESCDFWS--LGSVIYELYHGYPPFFCK-------------
                                 .| .. ||  ||.|.||||.     .. .|| ||  || ..||.  |||||. .             
KYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPM

DKQKQIIDSM---NKEVLIS----------KKLSEEAQDLIRKFLQPNPENRIGSQG------GFQEIKSHPFF
.. ..|.. .   |..| .           ...|.||.|||.|.|...||.|.|..|      |..|||.||.|
EMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 5729.AA Ciliate-E2-Unclassified 57-385 27 2.6e-105 356.16 In-house 1-352 (352) Show / Hide 
Range on Protein: 57-385
Range on HMM: 1-352/352
Sequence Identity: 27% (111 aa)

FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQH---------ALNEKN-------------ILASNNHPFLLKLYYSFQDDQKLYLIT
.||.|.||||.||.||..... .|. ||||...|..|.. ||...         ..|.|.             || ...|||..|..| |||.|..|...
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYVQGGKLIINQSFGATQKLFYPLILFFLIGFIYFGGSPNFSRNLLFIQFFTSKSIDIVTNQQQLSCIQLFLKIIKGDLYMNMKYKQKFTDREVL-----
||..||.|.   .   .||                                                      ....||..|||....||.....     
EYCEGGDLWQYIKKRKKQK------------------------------------------------------QKGNDLFHNMKQRKIFTEQQAKYKKAK

FYCSEIIVALEYLHSKG-IIYRDLKPENVLLTKQG---HIKLADFGLSK---------------IKNYKDERSQSKCGTPDYI----APEIVLG-QNGHD
||. .|...|||||.|. ||.||.||||.|....|   .||..|||.||               ....|.......|||| |.    |||.  | ...| 
FYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHS

--ESCDFWSLGSVIYELYHGYPPFFCKDKQK----------------QIIDSMNKEVLISK--------KLSEEAQDLIRKFLQPNPENRIGSQGGFQEI
  ..||.|||| ..||.  ||.||..... .                .. . ..|.. ..|        ..|.||.|.|...|| ........  .|..|
KAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI

KSHPFF
. ||.|
LNHPWF
Kinase 5729.AA Ciliate-E2 57-385 28 1.5e-96 327.04 In-house 1-365 (365) Show / Hide 
Range on Protein: 57-385
Range on HMM: 1-365/365
Sequence Identity: 28% (124 aa)

FKIVKKIGQGNFG-----TVYHVYC------------------EADKKDYAMKIIHKNRIRDEKQKQHAL----------NEKNILASNNHPFLLKLYYS
.|..|||||||||     .|. | .                  ....| |||||..|| |.  ||..| .          |||||| ..|||...|.|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DDQKLYLITEYVQGGKLIINQSFGATQKLFYPLILFFLIGFIYFGGSPNFSRNLLFIQFFTSKSIDIVTNQQQLSCIQLFLKIIKGDLYMNMKYKQ
||  ||...||..||.||| |        ..... .                                                   . . .|...|  .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE--------------------------------------------------K-D-KYFTEKEIK

KFTDREVL-------FYCSEIIVALEYLHSKG-IIYRDLKPENVLLTKQGHIKLADFGLSKI--------------KNYKDER-----------------
...   .        ||. .||.||||||||. ||.||.||||.|.     ||..||||||.              |.|.. .                 
YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQN

-SQSKCGTPDYIAPEIVLG--------QNGHDESCDFWSLGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLIS------------------KKLSEEAQ
  .. |||| | ||||. |        |.|.|..||.|||| ..||.  |.|||        ..  ..... ..                  ||.|.|..
MFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECK

DLIRK----FLQPNPENRIGSQGGFQEIKSHPFF
|||.|     || .||.||.   |...|. ||.|
DLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
Kinase 5729.AA Akt 211-385 45 7.4e-79 251.69 In-house 85-264 (264) Show / Hide 
Range on Protein: 211-385
Range on HMM: 85-264/264
Sequence Identity: 45% (83 aa)

GDLYMNMKYKQKFTDREVLFYCSEIIVALEYLHSKGIIYRD-LKPENVLLTKQGHIKLADFGLSKIKN-YKD-ERSQSKCGTPDYIAPEIVLGQNGHDES
|.|.  ...|..|.  .  |||.||| |.|.||||.||||| |||||.|. |.|||.|.||||.| .|  || .. .. |||| |.|||| .| |||. .
GELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK-ENIIKDHDKTKTFCGTPEYLAPEILNG-NGHTKA

CDFWS-LGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLIS--KKLSEEAQDLIRKFLQPNPENRIG-SQGGFQEIKSHPFF
.|.|. || |.||...| |||. .|...     .|..| .   ...| |..|||.. |. .|..| |   .. ||||.||.|
VDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 5729.AA S_TKc 57-385 30 7.4e-73 249.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 57-385
Range on HMM: 1-231/231
Sequence Identity: 30% (102 aa)

FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASNNHPFLLKLYYSFQDDQKLYLITEYVQG-GKLIINQSFGATQKLF
..|..|||.| ||.|| ..   ... .|.|||.          .|...| .|| . .||.. |||..||| ..||...||. | .               
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDL---------------

YPLILFFLIGFIYFGGSPNFSRNLLFIQFFTSKSIDIVTNQQQLSCIQLFLKIIKGDLYMNMKYKQK------FTDREVLFYCSEIIVALEYLHSKGIIY
                                                       |||.  .| ...      |.  .. ||. .|. ||||.||.|||.
-------------------------------------------------------GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIH

RDLKPENVLLTKQGHIKLADFGLSKIKNYKDERSQSKCGTPDYIAPEIVLGQNGHDE-SCDFWSLGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLISK
|||||||.||..  |||..||||...         . ||||.|.|||..    |..  .|| ||.| ..||.. |||||     ...... .        
RDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------

KLSEEAQDLIRKFLQPNPENRIGSQGGFQ---EIKSHPFF
  |.|| |.||| || .||.|..    .|   .||.||.|
--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5729.AA AktR 211-385 44 7.5e-73 248.34 In-house 86-268 (268) Show / Hide 
Range on Protein: 211-385
Range on HMM: 86-268/268
Sequence Identity: 44% (82 aa)

GDLYMNMKYKQKFTDREVLFYCSEIIVALEYLHSK-GIIYRDLKPENVLLTKQGHIKLADFGLSK--IKNYKDERSQSKCGTPDYIAPEIVLGQNGHDES
|.|.   | |.||.  ...|| ..|. ||||||..  |||||||||| || . ||.|..||||||  ... .||. .| |||| |.|||... . ||. |
GELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKS

CDFWSLGSVIYELYHGYPPFFCKD----KQKQIIDSMNKEVLISKKLSEEAQDLIR-KFLQPNPENRIG-SQGGFQEIKSHPFF
.|.|..| .|||.  |.|||. |.     ||..|   .... .....|....|||  | |. ||..|.| .  |..||||||.|
VDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 5729.AA SGK 211-385 44 6.4e-72 221.25 In-house 110-283 (283) Show / Hide 
Range on Protein: 211-385
Range on HMM: 110-283/283
Sequence Identity: 44% (78 aa)

GDLYMNMKYKQKFTDREVLFYCSEIIVALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSKIKNYKDERSQSKCGTPDYIAPEIVLGQNGHDESCDF
|..   ..  ..|   .. || .||. |||||||. ||||||||||.||  |||..| ||||.| .  . .   . |||| | |||. ..| .|| . | 
GEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ-PHDRTVDW

WSLGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLISKKLSEEAQDLIRKFLQPNPENRIGSQGGFQEIKSHPFF
|.||.| ||. .| |||....||      .|..  | .  | .| |||   || .|..| |.  .| |||.||||
WCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 5729.AA RSK 211-385 40 8.9e-70 238.13 In-house 86-278 (278) Show / Hide 
Range on Protein: 211-385
Range on HMM: 86-278/278
Sequence Identity: 40% (78 aa)

GDLYMNMKYKQK---FTDREVLFYCSEIIVALEYLHSKGIIYRDLKPENVLLTK---QGHIKLADFGLSKI-KNYKDERSQSKCGTPDYIAPEIVL---G
|.|..  . ..    |. .|. || .||..|.|.||..|||.|||||||.|..    .||||| |||..|. .. . .. .. |.| .|.|||..    .
GELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQ

QNGHDESCDFWSLGSVIYELYHGYPPFFC-KD-KQKQIIDSMNKEV--LISK---KLSEEAQDLIRKFLQPNPENRIGS-QGGFQEIKSHPFF
|.|||..|| |||| ..||.  |.|||    |  .|.|.. . |    | ..   .||.||.||||| |. .|..|.|.  .. .|||.||.|
QGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 5729.AA MAST 230-385 34 3.7e-68 218.71 In-house 103-334 (334) Show / Hide 
Range on Protein: 230-385
Range on HMM: 103-334/334
Sequence Identity: 34% (79 aa)

FYCSEIIVALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSKI---------------------------KNYKDERS-------------------
.| .|.. .||||||.||. |||||.|.|... |||||.||||||.                           || .| ..                   
MYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQQQ

-------------------QSKCGTPDYIAPEIVLGQNGHDESCDFWSLGSVIYELYHGYPPFFCKDKQ---KQIIDSM-N-KEVLIS------KKLSEE
                   .. ||||||||||. |||  |  . | ||.| ..||.  |.|||. .. .    .|.  . | .|          ...|.|
QEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPE

AQDLIRKFLQPNPENRIGSQGGFQEIKSHPFF
|||||.|.|||.|. |.|...| .|.|.||||
AQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 5729.AA Pkinase 211-385 29 1.9e-55 195.34 Pfam 85-293 (293) Show / Hide 
Range on Protein: 211-385
Range on HMM: 85-293/293
Sequence Identity: 29% (64 aa)

G----DLYMNMK--YKQKF--TDREVLFYCSEIIVALEYLHSKGIIYRDLKPENVLLTKQGHI----KLADFGLSKIK-NYKDERSQSKCGTPDYIAPEI
|    ||.  ..  .. .|  ...|. ||. .|. .|||.||.|||.|||||||.|. ..|||    |..||||.| . . ...  .. ||||.|.|||.
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

VLGQNGHDESCDFWSLGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLISKKLS-------------------------------EEAQDLIRKFLQPNP
..|..... ..| ||.| ..||.. |.|||   ..  . .. ... ..| ....                               ||..|.|.. |...|
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFP--GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

ENRIGSQGGFQEIKSHPFF
. |..    ...|. ||.|
KKRPT----AEQILQHPWF
Kinase 5729.AA PKA 210-328 49 4.7e-48 165.96 In-house 84-200 (263) Show / Hide 
Range on Protein: 210-328
Range on HMM: 84-200/263
Sequence Identity: 49% (59 aa)

KGDLYMNMKYKQKFTDREVLFYCS-EIIVALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSKIKNYKDERSQSKCGTPDYIAPEIVLGQNGHDESC
.|..   .  ...|.  . .||   .|. |||||||. |||||||||| |. |.||||..||| .  |. .| |... ||||.|.||||... |||  | 
GGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFA--KKVDD-RTWTLCGTPEYLAPEIIQSKNGHGKSV

DFWSLGSVIYELYHGYPPFF
| |.|| .|||.  |||||.
DWWALGILIYEMLAGYPPFY
Kinase 5729.AA AGC 57-142 30 6.9e-43 107.52 In-house 1-130 (395) Show / Hide 
Range on Protein: 57-142
Range on HMM: 1-130/395
Sequence Identity: 30% (40 aa)

FKIVKKIGQGNFGTVYHVYCE------ADKKDYAMKIIHKNR---IRDEKQKQHALNE------------KNILASNN----------HPFLLK-LYYSF
|...| ||.| ||.|| |         . .| ||||.. | .   |..... .|...|            .|||.  |          |||. | |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDQK--LYLITEYVQ---------GG-KL
||...  ||.. ||..         ||  |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCEL
Kinase 5729.AA AktR 57-142 44 1.6e-32 114.37 In-house 1-88 (268) Show / Hide 
Range on Protein: 57-142
Range on HMM: 1-88/268
Sequence Identity: 44% (39 aa)

FKIVKKIGQGNFGTVYHVYCE-ADKKDYAMKIIHKNRIRDEKQKQHALNEKNILA-SNNHPFLLKLYYSFQDDQKLYLITEYVQGGKL
|.. | .|.|.||.|| |     ..| ||||.|.|  |....|..|...|.||..  .||||. ||.|.||.. ||..| ||..||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGEL
Kinase 5729.AA SGK 57-142 33 1.7e-31 94.2 In-house 1-112 (283) Show / Hide 
Range on Protein: 57-142
Range on HMM: 1-112/283
Sequence Identity: 33% (37 aa)

FKIVKKIGQGNFGTVYHVYCEAD------------------KKDYAMKIIHKNRIR-------DEKQKQHALNEK-NILASNNHPFLLKLYYSFQDDQKL
|.. |.||.|.|| || |  ..|                  .| ||||.. |. |.         |.  | . |. .||   .|||. .| |.|| ..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLITEYVQGGKL
|.  .||.|| .
YFVMDYVNGGEM
Kinase 5729.AA Akt 57-140 42 2.7e-30 93.99 In-house 1-85 (264) Show / Hide 
Range on Protein: 57-140
Range on HMM: 1-85/264
Sequence Identity: 42% (36 aa)

FKIVKKIGQGNFGTVYHVYCEADKKDY-AMKIIHKNRIRDEKQKQHALNEKNILASNNHPFLLKLYYSFQDDQKLYLITEYVQGG
| ..| .|.| || |. |   ...| | |||.. |..| . .|..|.. |.|||   ||||. .|.||||. .|||....|..||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGG
Kinase 5729.AA PKA 57-140 44 3.7e-29 103.2 In-house 1-85 (263) Show / Hide 
Range on Protein: 57-140
Range on HMM: 1-85/263
Sequence Identity: 44% (38 aa)

FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASNNHPFLL-KLYYSFQDDQKLYLITEYVQGG
|.|.. .|.| ||.|. .    ... ||||.. |..| ..||..| .|||||| . .|||.  |.|..||||..||.. |||.||
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGG
Kinase 5729.AA NDR 57-140 44 1.9e-26 78.05 In-house 1-86 (350) Show / Hide 
Range on Protein: 57-140
Range on HMM: 1-86/350
Sequence Identity: 44% (38 aa)

FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASNN--HPFLLKLYYSFQDDQKLYLITEYVQGG
|.|.| ||.| || |. | .   .. |||||. |  . .  |  | ..|. |.|. .  .|.  ||||||||.| |||. ||. ||
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGG
Kinase 5729.AA NDR 220-274 47 1.2e-25 75.48 In-house 98-152 (350) Show / Hide 
Range on Protein: 220-274
Range on HMM: 98-152/350
Sequence Identity: 47% (26 aa)

KQKFTDREVLFYCSEIIVALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSK
.. ||. .  || .|...|.|..|. |.| ||.||.| |. |.||||| ||||..
MDIFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCT
Kinase 5729.AA Pkinase 57-142 35 2.3e-23 83.67 Pfam 1-91 (293) Show / Hide 
Range on Protein: 57-142
Range on HMM: 1-91/293
Sequence Identity: 35% (32 aa)

FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHAL-NEKNILASNNHPFLLKLYYSFQDDQKLYLITEYVQGG----KL
..|..|||.|.||.||. .   . | .|.||| | .....|...|.. .|  |... |||. ..||..|.|....|...||..||     |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL
Kinase 5729.AA RSK 60-140 39 7.6e-23 80.55 In-house 1-86 (278) Show / Hide 
Range on Protein: 60-140
Range on HMM: 1-86/278
Sequence Identity: 39% (34 aa)

VKKIGQGNFGTVYHVYCE---ADKKDYAMKIIHKNRIRD-EKQKQHALNEKNILASNN-HPFLLKLYYSFQDDQKLYLITEYVQGG
.|  ||| .| |. .      . .. ||||...|. |.  .|   |.. | |||.  . |||. .|.|.||...|||||.||. ||
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGG
Kinase 5729.AA NDR 285-328 52 3.6e-22 64.61 In-house 240-283 (350) Show / Hide 
Range on Protein: 285-328
Range on HMM: 240-283/350
Sequence Identity: 52% (23 aa)

SKCGTPDYIAPEIVLGQNGHDESCDFWSLGSVIYELYHGYPPFF
|  |||||.|||......|....||.|||| . ||.  |||||.
STVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFC
Kinase 5729.AA NDR 349-385 60 4e-22 64.45 In-house 313-350 (350) Show / Hide 
Range on Protein: 349-385
Range on HMM: 313-350/350
Sequence Identity: 60% (23 aa)

KLSEEAQDLIRKFLQPNPENRIGSQG-GFQEIKSHPFF
.||.||.||||... |.|..|.||.| |..||||||||
NLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase 5729.AA MAST 57-140 35 2.5e-21 65.2 In-house 1-84 (334) Show / Hide 
Range on Protein: 57-140
Range on HMM: 1-84/334
Sequence Identity: 35% (30 aa)

FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASNNHPFLLKLYYSFQDDQKLYLITEYVQGG
|...| |. | .| || |     .. .|||.| |.   . .. ..   |.||||    ||  |..|||| ...|... ||..||
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGG
Kinase 5729.AA TyrKc 57-385 17 2.2e-13 -6.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 57-385
Range on HMM: 1-280/280
Sequence Identity: 17% (66 aa)

FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASN--NHPFLLKLYYSFQDD-------QKLYLITEYVQGGKL----I
 .  ||.| |.||.||.        . | | ....       ..  ..| .|. .   .|| ...||    ..       . |....||. .| |     
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

INQSFGATQKLFYPLILFFLIGFIYFGGSPNFSRNLLFIQFFTSKSIDIVTNQQQLSCIQLFLKIIKGDLYMNMKYKQKFTDREVLFYCSEIIVALEYLH
 ..                                                                            .. .. | .|  |    ||||
KHRPK--------------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLH

SKGIIYRDLKPENVLLTKQGHIKLADFGLSKIKNYKD---ERSQSKC-----GTPD-----YIAPEIVLGQNG-HDESCDFWSLGSVIYELY-HGYPPFF
||..| |||   |.|.......| .|||||.    .|   |... .      |. .       |||    . |   .  | || | ...|..  | .|  
SKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYP

C----KDKQKQIIDSMNKE-VLISKKL---------SEEAQDLIRKFLQPNPENRIGSQGGFQEIKSHPFF
     . . ...|    .   .   .          ..|  .....  . .||.|      |.||  | .|
GMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR----PTFSEI--HECF
Kinase 5729.AA Pkinase_Tyr 57-140 24 7.5e-09 30.61 Pfam 1-92 (270) Show / Hide 
Range on Protein: 57-140
Range on HMM: 1-92/270
Sequence Identity: 24% (23 aa)

FKIVKKIGQGNFGTVYHVYCE----ADKKDYAMKIIHKNRIRDEKQ--KQHALNEKNILASN-NHPFLLKLYYSFQ-DDQK--LYLITEYVQGG
 .. ||.|.|.||.||. ..      .| . | |.. |.   ...|  ..  ..| .|. .  .|| ...||     ...   .|...||...|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG
Kinase 5729.AA Pkinase_Tyr 238-290 37 4.2e-07 24.68 Pfam 123-175 (270) Show / Hide 
Range on Protein: 238-290
Range on HMM: 123-175/270
Sequence Identity: 37% (20 aa)

ALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSKIKNYKDERS-QSKCGTP
..|||.||..| |||   |.|.|.....| .||||..   |.|.   ... |..
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGK
Kinase 5729.AA PKA 350-385 35 6e-06 23.74 In-house 224-263 (263) Show / Hide 
Range on Protein: 350-385
Range on HMM: 224-263/263
Sequence Identity: 35% (14 aa)

LSEEA---QDLIRKFLQPNPENRIGSQG-GFQEIKSHPFF
..  |    |||.| ||.... |.|..  | . || |..|
FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF