Gene 6435 (Tetrahymena)

6435

Species: Tetrahymena
Alias: 6435, 3722.m00093, TTHERM_00526970, 66.m00234, PreTt06435, 358
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2a

Sequence

Name Sequence Type Origin Length Description Download
6435.AA Protein None 813 None Fasta, JSON
6435.kin_dom Protein Kinase Domain None 269 None Fasta, JSON
6435.NA RNA None 2442 None Fasta, JSON

Protein domain

Protein domains of 6435.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6435.AA Ciliate-E2a 123-391 44 8e-160 474.1 In-house 1-275 (275) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-275/275
Sequence Identity: 44% (122 aa)

YEIITKIGKGKYAKVYKVKRKDTGELFAVKYLHKRKMKDIDDSEAALDNELNILRQLDHPNCLKLVACFQDTNGYYILTELLDESKSLSQEIAKYKNPQF
|..| |||||....||....|.||. ||.|...| || .... .... ||.||.|||||||..||   ..| | ||. .|.. |...| ..| . |. ..
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYC-EGGELYDKIKQCKRFFE

SYKMIKHILGQLI-KGLEYVHSKGIMHRDLKPQNIMFT-ISQSG-ALSQLKLIDFGLAQII--KSQKYIYVHVGTPGFVAPEILANESE-NHR-YDEKCD
 .. |..|. ||. .||.|.|...||||||||.||.|. .|... ..|..|.||||||. |  ...||.....||||.||||.|.|. . .|. ||.|||
EIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCD

LFSIGVIFHILLTGKTVFPGNKFSQVLEKNKLCQIQLSGAR-YEQISQEALDLLGKLLQKDPRRRISAKDALQHPFF
..|.||||.|||.||..|.| .....|..|| |.|....   .|..|.|. ||. |.|.|||  ||.|..||.||.|
MWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 6435.AA Ciliate-E2 123-391 27 2.4e-93 316.44 In-house 1-365 (365) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-365/365
Sequence Identity: 27% (106 aa)

YEIITKIGKGKYAKVYKVKRKDTGELFA-----------------------VKYLHKRKMKDIDDSEAALD---------NELNILRQLDHPNCLKLVAC
|..| |||.| ...|||.|.. ....||                       .|...|.. . |   .  .          ||.|||.||.||| .|.. |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DTNGYYILTELLDESKSLSQEIA-----------KYKNPQFSYKMIKHILGQLIK---------------GLEYVHSKG-IMHRDLKPQNIMFTIS
||  |.| .|. .|.. . ..| . |            | .  .|. | ||.|  |...               .||| |||. |.|||.||.||.|   
FQEKDDNNIYLVMEYC-QGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

QSGALSQLKLIDFGLAQIIKSQ-----------KYIYVH----------------------VGTPGFVAPEILANES-----ENHRYDEKCDLFSIGVIF
       .|.|||||..... .           .|.. .                      .||||..||||| ...     . ..||.|||..|.|||.
-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

HILLTGKTVFPGNKFSQVLEKNKLCQIQLSGAR--------------YEQISQEALDLLGK----LLQKDPRRRIS-AKDALQHPFF
...|.||. |        ....| |.|... .               ....|||. ||. |    .|||||  ||. ....|.||.|
YEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 6435.AA S_TKc 123-391 32 2.8e-87 297.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-231/231
Sequence Identity: 32% (93 aa)

YEIITKIGKGKYAKVYKVKRKDTGELFAVKYLHKRKMKDIDDSEAALDNELNILRQLDHPNCLKLVACFQDTNGYYILTELLDES-KSLSQEIAKYKNPQ
|||. ||||| ..||||.. |.||...|.| ..             . .|..||.. .|||  ||  .||| . .|. .|..| .  .| . | |.. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FSYKMIKHILGQLIKGLEYVHSKGIMHRDLKPQNIMFTISQSGALSQLKLIDFGLAQIIKSQKYIYVHVGTPGFVAPEILANESENHRYDE-KCDL
    |.  ...... |....||| ||.||.||||||.||...        ..|..||||| ..      .  .||| ..|||.|        |.  ||| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDW

FSIGVIFHILLTGKTVFPGNKFSQVLEKNKLCQIQLSGARYEQISQEALDLLGKLLQKDPRRRISAKDALQ-------HPFF
 |.|.|. ..|.|.. ||        . ... .. .        |.||.|.. |.|||||..|..| .|||       ||.|
WSCGCILYEMLCGYPPFP--------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6435.AA CAMK 128-391 19 8.3e-81 259.98 In-house 1-425 (425) Show / Hide 
Range on Protein: 128-391
Range on HMM: 1-425/425
Sequence Identity: 19% (85 aa)

KIGKGKYAKVYKVKRKDTG------------ELFAVKYLHKRKMKD------------------------IDDSEAALDNELNILRQ-------LDHPNC
..|.| ..||.....| |.            . .|.| . |.|.||                         . ... . .|..|...       ||||| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKLVACFQD-----------TNG---------YYILT---ELLDES---KSLSQEIAKYKN-------------PQFSYKMIKHILGQLIKGLEYVHSKG
.||   ..|           |           .|. .   |. .       | . | . ..               |. .  ...  |.. ...| ||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDLKPQNIMFTISQSGAL------------SQLKLIDFGLAQIIKS------------------------QKYIYVHVGTPGFVA-PEILAN-----
|.|||||| ||... . ..               ..|.||||.|.....                         .  .  .|||...| ||.|       
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----ESENHRYDEKCDLFSIGVIFHILLTGKTVFPGN-------------KFSQVLEKNKLCQIQLSGARYEQIS--------------------QEAL
       |.  |..|||  |.|||  |.|.|.  | |                .. .|| . .. .        ||                    ||. 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLLGKLLQKDPRRRISAKDALQHPFF
||. |.||.|| .|......|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 6435.AA AGC 123-391 22 2.8e-80 206.44 In-house 1-395 (395) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-395/395
Sequence Identity: 22% (90 aa)

YEIITKIGKGKYAKVYKVKRK------DTGELFAVKYLHKRK-MKDID--DSEAALDN-----------ELNILRQLD----------HPNCLK-LVACF
.|... |||| . ||| |..|      |||...|.| | |.. .....  . | ..             | ||| ...          ||.  | |  .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDTNG--YYILTELLD--------ESK-SLSQEIAKY-KNPQFSYKMIKHILGQ-------LIKGLEYVHS-KGIMHRD-LKPQNIMFTISQSGALSQLK
|| .    |.. |..              | . . .  |.  |. ....... .       .. .||| || .|| ||| ||| ||...         .|
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-----GHIK

LIDFGLAQIIKS---------------------------------------------------QKYIYVHVG--TPGFVAPEILANESENHRYDEKCDLF
| ||||. ....                                                   ..  .  .|  || ..|||||        |.  ||  
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWW

S--IGVIFHILLTGKTVFPGN------KFSQVLEKNKLCQIQ------LSGARY-----------EQISQEALDLLGKLLQKDPRRRIS----------A
|   |...  .|||.. | |.      .  .  .. .  .|.        . ..           ...|.|| ||. |||.|||..|.           |
SFGLGCLMYEMLTGYPPFYGDNPQENRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGA

KDALQHPFF
..  .||.|
EEIKNHPWF
Kinase 6435.AA Pkinase 123-391 30 4e-76 263.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

YEIITKIGKGKYAKVYKVKRKDTGELFAVKYLHKRKMKDIDDSEAALDNELNILRQLDHPNCLKLVACFQDTNGYYILTELLDES---KSLSQEIAKYKN
|.|. |||.| ...||| ..|.||...||| . ||. |.  | .... .|. |.. |.||| ..|  .|.| . .|. .|...      .|.  |   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PQF--SYKMIKHILGQLIKGLEYVHSKGIMHRDLKPQNIMFTISQSGALSQLKLIDFGLAQI--IKSQKYIYVHVGTPGFVAPEILANESENHRYDEKCD
  |  |.. .|... |...|||| ||.||.||||||.||..  ..    . .|..|||||    . ..   .. .|||...|||..    ..  |. |.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVD

LFSIGVIFHILLTGKTVFPGN------KFSQVLEKNKLCQIQLSGARYEQIS-----------------QEALDLLGKLLQKDPRRRISAKDALQHPFF
 .|.|.|....|.|.. |||          |...... ...  .      ||                 .|..|.. ..|.||| .|..|...||||.|
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 6435.AA Ciliate-E2-Unclassified 123-391 26 3.9e-66 226.03 In-house 1-352 (352) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-352/352
Sequence Identity: 26% (96 aa)

YEIITKIGKGKYAKVYKVKRKDTGELFAVKYLHKRKMKD-----IDDSEAALD----NELN-------------ILRQLDHPNCLKLVACFQDTNGYYIL
|.|| .||.| ..||||...|......| ||..| ....       | |  .     |...             ||....||. .|.. ||||..  || 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TELLDESKSLSQEIAKYKN---------------PQFSYKMIK-----HILGQLIKGLEYVHSKG-IMHRDLKPQNIMFTISQSGALSQLKLIDFGLAQI
.|.. | ..|.| | |.|.                .|. . .|     ... |...|||| |.|. | |||.||.||.|. ...    ..|.||||..  
MEYC-EGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFGISKK

IKSQKYIYVH-----------------VGTPGFV----APEILANESENHRYDEKCDLFSIGVIFHILLTGKTVFPGNKFSQ----------------VL
.... ... .                 .|||..     |||.| ..  .|.  .||| .| |||.. .|.|.  |..|.  |                ..
YQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLY

EKNKLCQIQLSGARY----EQISQEALDLLG----KLLQKDPRRRISAKDALQHPFF
.. | ..|| . .       ..|.|| |..     |.|.|.|  ||.....|.||.|
QNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 6435.AA CAMK-Unique 123-391 22 6.8e-61 199.67 In-house 1-363 (363) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-363/363
Sequence Identity: 22% (83 aa)

YEIITKIGKGKYAKVYKVKRKDTGELFAVKYLHKRKMK-DIDDS---------------EAALDNELNILRQLDHPNCLKLVAC----FQDTN-------
|. .  ||.| . .||... . || ..|.| . | . . .. .                .  |..|..|.. .|||| .||.      |.| .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------GYYILTELLDESKSLSQEIAK---YK---------------NPQFSY--KMIKHILGQLIKGLEYVHSKGIMHRDLKPQNIMFTIS-Q----
         .||..|.... . |...|.|   ..               . .||     .  |  .|   ..| ||..| |||||. |||.  | .    
IKTPRALPYMYIVMEYCQG-GDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

----SGA--LSQLKLIDFGLAQIIK-SQKY--IYVHVGTPGFVAP--------------EILANESENHRYDEKC----DLFSIGVIFHILLTGKTVFPG
    ..    . .||.||||.  .  ....  . . .||| ..||              |..    ....||..|    |. |.||| ...|.|.. | .
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVI----NMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDC

NKFS--------QVLEKNKLCQI-QLSGARYEQ---ISQEALDLLGKLLQKDPRRRISAKDALQHPFF
.             .|. . ...  ..   ..    ||||| |.. .... ||  |.||| .|.|...
ECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 6435.AA ULK 123-391 29 1.5e-59 204.13 In-house 1-324 (324) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-324/324
Sequence Identity: 29% (96 aa)

YEIITKIGKGKYA-KVYKVKRKDT---GELFAVKYLHKRKMKDI-DDSE-----AALDNELNILRQLD---HPN--CLKLVACFQDT--NGYYILTELLD
|... ..||| .. |||| . |.|   ....|.|   | ||...  ..|       |.|| .|...|.   |||  . ||  .|...  | .|| .|. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

ESKSLSQEIAKYKN-------PQFSYKMIKHILGQLIKGLEYVHSKGIMHRDLKPQNIMFTISQSGA-------LSQLKLIDFGLAQIIKS----QKYIY
    |.| | |.|.         .| . ..... |.. |. . |...|.|||.|||||. .  | .          .||. |||.|... .    |  ..
G-GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

VHV------GTPGFVAPEILANESENHRYD-EKCDLFSIGVIFHILLTGKTVFPGNKFSQVL----------------EKNKLCQIQLSGARYEQISQEA
  |      ||| . ||.|| .. |.  |.  |||..|.|.||. .|.||. | .. |..                  .||.  |... .    .||.| 
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPEC

LDLLGKLLQKDPRRRISAKDALQHPFF
 ||. ..||.|.. |||  . ..||.|
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 6435.AA CAMK1 229-391 36 1.3e-58 168.98 In-house 112-276 (276) Show / Hide 
Range on Protein: 229-391
Range on HMM: 112-276/276
Sequence Identity: 36% (61 aa)

HILGQLIKGLEYVHSKGIMHRDLKPQNIMFTISQSGALSQLK--LIDFGLAQIIKSQK-YIYVHVGTPGFVAPEILANESENHRYDEKCDLFSIGVIFHI
||  |... .|| |||||.||||||.|. .     ..  ..|  ..||||..|....  . .  .||||.||||.|.. .    || .||..|||||. |
HIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDS--KIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKACDMWSIGVITYI

LLTGKTVFPGNK-FSQVLEKNKLCQIQLSGARYEQISQE-ALDLLGKLLQKDPRRRISAKDALQHPFF
||.|   | ..   .. .||.| |..         || . | |.. ..| .||  |......|.||..
LLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 6435.AA ULK 123-391 28 1e-57 198.05 In-house 1-329 (329) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-329/329
Sequence Identity: 28% (95 aa)

YEIITKIGKGKYAKVYKVKRKDT----GELFAVKYLHKRKMKDIDDS------EAALDNELNILRQLD--------HPNCLKLVACFQDT--NGYYILTE
|... ..||| ..|||| . |.|    .|..|.| . | ||. . .          |.||  |...|.        |||. ||  .|...  | .|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LLDESKSLSQEIAKYKN---PQ-----FSYKMIKHILGQLIKGLEYVHSKGIMHRDLKPQNIMFTISQSGA-------LSQLKLIDFGLAQIIKSQ---K
. .    |.| | |.|.   ..     .| . ..... |.. |. . |...|.|||.|||||. .  | .          .||. |||.|. . .    .
YCNG-GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

Y-IYVHV------GTPGFVAPEILANESENHRYD-EKCDLFSIGVIFHILLTGKTVFPGNKFSQVL-----EK------------NKLCQIQLSGARYEQ
  ..  |      ||| . ||.|| .. |.  |.  |||..|.|.||. .|.||. | .. |..       .             ..  |.. .|    |
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG-NDPQ

ISQEALDLLGKLLQKDPRRRISAKDALQHPFF
||.|  ||. ..||.|.. |||  . ..||.|
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 6435.AA CDPK 240-391 39 4.9e-52 158.0 In-house 118-271 (271) Show / Hide 
Range on Protein: 240-391
Range on HMM: 118-271/271
Sequence Identity: 39% (63 aa)

YVHSKGIMHRDLKPQNIMFTISQSGA--LSQLKLIDFGLAQIIKSQ-----KYIYVHVGTPGFVAPEILANESENHRYDEKCDLFSIGVIFHILLTGKTV
| ||..|.||||||.||.|..  ...    ..|.||.|.. . ...     |...  .|||  .|||.|     ...|.||||. |.|||  ||| |   
YCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVL-----QKKYNEKCDIWSCGVILYILLCGYPP

FPGNKFSQVLEKNKLCQIQLSGARYEQISQEALDLLGKLLQKDPRRRISAKDALQHPFF
| |   ....|| | .. .. |   . ||.|| ||  |.|..||  |.|| .||||| |
FYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 6435.AA CAMK1 123-204 33 1.9e-30 85.68 In-house 1-90 (276) Show / Hide 
Range on Protein: 123-204
Range on HMM: 1-90/276
Sequence Identity: 33% (30 aa)

YEIITKIGKGKYAKVYKVKRKDT---GELFAVKYLH-KRKMKDIDDS-EAALDNELNILR---QLDHPNCLKLVACFQDTNGYYILTELL
||.. .||.|  ..||....|.|   |. .|.|..  |. ||  |..  .||.||..|..   ..||||. |.   ....| .|. .||.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELV
Kinase 6435.AA CDPK 123-204 38 4.4e-21 61.61 In-house 1-85 (271) Show / Hide 
Range on Protein: 123-204
Range on HMM: 1-85/271
Sequence Identity: 38% (33 aa)

YEIITKIGKGKYAKVYKVKRK-DTGELF-AVKYLHKRKMKDIDDSEAALDNELNILRQLDHPNCLKLVACFQDTNGYYILTE--LL
| |  ..||| .  |.||| |  |..   |.|   |.. || .. .  . ||..||.|||||| .|.   .|| . ||| .|  ..
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQ-QQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYC
Kinase 6435.AA TyrKc 123-391 21 9.9e-14 -0.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 123-391
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YEIITKIGKGKYAKVYKVKRKDTGELFAVKYLHKRKMKDIDDSEAALDNELNILRQL--DHPNCLKLVACFQDT-------NGYYILTELLDESKSLSQE
 . . |.| | . .||| . |   .  ||| |.. .       .... .|..|...|  .||| ..|...  .          ..|..|. .   .| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDY

IAKYKNPQFSYKMIKHILGQLIKGLEYVHSKGIMHRDLKPQNIMFTISQSGALSQLKLIDFGLAQIIKSQ-------KYIYVHV--GTPGFV-----APE
. |...  .. |   ..  |  .| || |||.. ||||   |.. .  .     . |  ||||.  |..        .|. .    |. . .     |||
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

ILANESENHRYDEKCDLFSIGVIFH-ILLTGKTVFPG-----NKFSQVLEKNKLCQIQLSGARYE-----QISQEALDLLGKLLQKDPRRRISAKDALQH
 .      ... .| | .| ||    |.  |..  ||      . ..|.|. |        . ..       ..|  ..  .  . ||  | . ..   |
CI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

PFF
 .|
ECF
Kinase 6435.AA Pkinase_Tyr 123-251 26 6.1e-08 27.53 Pfam 1-137 (270) Show / Hide 
Range on Protein: 123-251
Range on HMM: 1-137/270
Sequence Identity: 26% (38 aa)

YEIITKIGKGKYAKVYKVKRK----DTGELFAVKYLHKRKMKDIDDSE---AALDNELNILRQL-DHPNCLKLVACFQ-DTNG--YYILTELLDESKSLS
 ... |.|.| . .||| . |    .|.   ||| | |    . ....   ... .|..|..|| .||| ..|...   .     .|| .|.     .| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-DLL

QEIAKY--KNPQFSYKMIKHILGQLIKGLEYVHSKGIMHRDL
    |    ..... |.. ..  |  ||.|| .||.. ||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 6435.AA Pkinase 768-802 21 0.007567 11.15 Pfam 258-293 (293) Show / Hide 
Range on Protein: 768-802
Range on HMM: 258-293/293
Sequence Identity: 21% (8 aa)

TKKKKFHPWFIGMIKSMLQENESQRPSIKQLSQM--I
|. .. .....  ||..|. . ..||...|. |   .
TF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 6435.AA CAMK 780-797 38 0.031608 2.17 In-house 401-418 (425) Show / Hide 
Range on Protein: 780-797
Range on HMM: 401-418/425
Sequence Identity: 38% (7 aa)

MIKSMLQENESQRPSIKQ
.|..||| . ..|..|.|
LIRKMLQVDPEKRMTIEQ
Kinase 6435.AA Ciliate-E2 761-798 23 0.084311 1.94 In-house 316-359 (365) Show / Hide 
Range on Protein: 761-798
Range on HMM: 316-359/365
Sequence Identity: 23% (11 aa)

LQKLEEITKK----KKFHPWFIGMIKS----MLQENESQRPS-IKQL
.| .. . .|    ||  .  . .||     ||| ....|.. ..|.
TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI