Gene 7312 (Tetrahymena)

7312

Species: Tetrahymena
Alias: 3739.m00062, TTHERM_00729110, 314, 118.m00140, PreTt07312, 7312
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
7312.AA Protein None 1373 None Fasta, JSON
7312.kin_dom Protein Kinase Domain None 401 None Fasta, JSON
7312.NA RNA None 4122 None Fasta, JSON

Protein domain

Protein domains of 7312.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7312.AA Ciliate-E2-Unclassified 228-628 22 3.9e-96 325.68 In-house 1-352 (352) Show / Hide 
Range on Protein: 228-628
Range on HMM: 1-352/352
Sequence Identity: 22% (105 aa)

ELIGEKLGEGSQGDVRKCIHKK-----------SQQVYAVKMIRNGDTEIILSAITSF-----------KIAKN--LNHPSIIKPYELFINQETEKIYYV
  |....|.|..|.|.||.|||           ..|.|..| |.| | ||...... .           ||...  ||||.... ..... | ...|| |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCEYGSLQDYIENLWSLSPHKRDHRSMSKMKTTSTDNLEDESNSLDSQKNLNFEGASNKATKKKDRKKKQKKRRQEDNQAKEDDHLIKLYQQLGSSDN
|||||.|.|..||.. ....                                                                    .|          
MEYCEGGDLWQYIKKRKKQK--------------------------------------------------------------------QK----------

LKQQQNEIVNNNLNAQDEDDTKIDSQKKIEGSEEKSVRNKSQKRKVQFNSSYQSKIDHDLIK--RILKEIITAVEYLHSEG-ICHRDLKPDNILISNDLQ
    .|....|... .  .. .. .                                   .|  .....|. . ||||... |.|||.||.|||..|. .
----GNDLFHNMKQRKIFTEQQAKY-----------------------------------KKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK

--NIKIIDFEISKRFKYFRQN------KTGVLKVCEMWTRTGTLDFQ----SPEMFESAGYT----EAVDIWAIGVIAYYLLTGRLPFDQEYISD----K
  .|||||| |||. ......      |....| ..|||..||. ..    .||.... .|     ...|||. |||.|..|.|..||...   .    .
NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLI

IEFIRN-----AQYNQDYIK--------------DLDDISKDFIR----RMLRKDPAERLTASEALSHPWF
...| |      .|.. . |              ....  ||||.    .|| |.| .|.|....| ||||
TQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 7312.AA Ciliate-E2 228-628 20 2.6e-95 322.96 In-house 1-365 (365) Show / Hide 
Range on Protein: 228-628
Range on HMM: 1-365/365
Sequence Identity: 20% (104 aa)

ELIGEKLGEGSQGDVRKCIHKKSQ-----------------------QVYAVKMIRNGDTEIILSAITSFK-------------IAKNLNHPSIIKPYEL
  . .|.|.|..|.|.|| ..| |                       . ||.|.... . |.|.. |  ..             | ..|||| ||| || 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FINQETEKIYYVMEYCEYGSLQDYIENLWSLSPHKRDHRSMSKMKTTSTDNLEDESNSLDSQKNLNFEGASNKATKKKDRKKKQKKRRQEDNQAKEDDHL
|... ...||.|||||..|.|.|||.| .  ..|...                                                               
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE---------------------------------------------------------------

IKLYQQLGSSDNLKQQQNEIVNNNLNAQDEDDTKIDSQKKIEGSEEKSVRNKSQKRKVQFNSSYQSKIDHDLIKRILKEIIT---------------AVE
                                                             . .  ....  ||.| |.|.                |.|
-------------------------------------------------------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALE

YLHSEG-ICHRDLKPDNILISNDLQNIKIIDFEISKRFKYFRQNKTGVLKVCEMWTRTG------------------------TLDFQSPEMFESAG---
||||.. |.|||.||.|||.      |||||| .||... ..||.|. .. |....  .                        |. ...||.... .   
YLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDN

------YTEAVDIWAIGVIAYYLLTGRLPFDQEYISDKIEFIRNAQYNQDYI----------------KDLDDISKDFIRR----MLRKDPAERLT-ASE
      |....|||..||| |..|.|..||        .. | . ... .                  |....  ||.|..    || ||| .|.| ...
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ

ALSHPWF
.| ||||
ILNHPWF
Kinase 7312.AA CAMK 233-628 17 7.1e-82 263.48 In-house 1-425 (425) Show / Hide 
Range on Protein: 233-628
Range on HMM: 1-425/425
Sequence Identity: 17% (96 aa)

KLGEGSQGDVRKCIHKKSQ------------QVYAVKMIR-------------------------------NGDTEIILSAITSFKIAKN----LNHPSI
.||.|| | |..||||...            | .|.|.|                                  | . ... |   |  ..    |.|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKPYELFINQE-----------------TEKIYYVM---EYCEYG----SLQDYIENL--------WSLSPHKRDHRSMSKMKTTSTDNLEDESNSLDSQ
|| || . . .                 ....| ||   |||. |     | |||                                             
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQ---------------------------------

KNLNFEGASNKATKKKDRKKKQKKRRQEDNQAKEDDHLIKLYQQLGSSDNLKQQQNEIVNNNLNAQDEDDTKIDSQKKIEGSEEKSVRNKSQKRKVQFNS
                                                                                                 .  
------------------------------------------------------------------------------------------------FDIV

SYQSKIDHDLIKRILKEIITAVEYLHSEGICHRDLKPDNILISNDL----------------QNIKIIDFEISKRFKY--------FRQNKTGVLKV---
    ... .  .|. . |. ||.|.|| .|.||||||.|||....                  |||||||  ...|.           .... . .    
-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWT

-----CEMWTRTGTLDFQS-PEMFES--------------AGYTEAVDIWAIGVIAYYLLTGRLPFDQEYISDKIE-------------FIRNAQY--NQ
       |.|. ||. . . ||....               .|....|.|..||| | .|.|..||. .. .. .|              |....|    
TPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPP

DYIKD--------------------LDDISKDFIRRMLRKDPAERLTASEALSHPWF
.|...                    ...  ||.||.||..|| .|.|....|.|||.
PYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 7312.AA Pkinase 228-628 22 9.2e-71 246.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 228-628
Range on HMM: 1-293/293
Sequence Identity: 22% (100 aa)

ELIGEKLGEGSQGDVRKCIHKKSQQVYAVKMIRNGDTEIILSAI----TSFKIAKNLNHPSIIKPYELFINQETEKIYYVMEYCEYG----SLQDYIENL
  ||.|.|.|| | |.||.||......||| |.  ...     .    .  .| |.|||| |.. |. | .    .|| |||||| |    .| |||.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

WSLSPHKRDHRSMSKMKTTSTDNLEDESNSLDSQKNLNFEGASNKATKKKDRKKKQKKRRQEDNQAKEDDHLIKLYQQLGSSDNLKQQQNEIVNNNLNAQ
                                                                                                    
----------------------------------------------------------------------------------------------------

DEDDTKIDSQKKIEGSEEKSVRNKSQKRKVQFNSSYQSKI--DHDLIKRILKEIITAVEYLHSEGICHRDLKPDNILISNDLQN---IKIIDFEISKRFK
                                  ... ..  . . .|.....|. ..||.||.||.||||||.||||.|. ..   .||.|| ..| |.
----------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD

YFRQNKTGVLKVCEMWTRTGTLDFQSPEMFE-SAGYTEAVDIWAIGVIAYYLLTGRLPFDQE----YISDKIEFIRNAQYNQDYIKDLDDIS--------
          .   |.|..||... .||    . .|. .||.|..|.| |..|.||.||...       |... |..  . .       ..|        
--------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH

--------------KDFIRRMLRKDPAERLTASEALSHPWF
              ||||...|.|||..|.|| ..| ||||
WHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 7312.AA AGC 227-628 16 3.8e-68 174.35 In-house 1-395 (395) Show / Hide 
Range on Protein: 227-628
Range on HMM: 1-395/395
Sequence Identity: 16% (86 aa)

YELIGEKLGEGSQGDVRKCIHK------KSQQVYAVKMIRNGD---------TEIILSA------------ITSFKIAKNLN-------HPSIIK-PYEL
.|..   .|.|| | |. . .|       ....||.|...  .          | ....               .. ... .       || |.|  .  
FEFL-KVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYS

FINQETEKIYYVMEYCE----------YGSLQDYIENLWSLSPHKRDHRSMSKMKTTSTDNLEDESNSLDSQKNLNFEGASNKATKKKDRKKKQKKRRQE
| ... ...| ||||..           . |  .. .                                                               
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGR--------------------------------------------------------------

DNQAKEDDHLIKLYQQLGSSDNLKQQQNEIVNNNLNAQDEDDTKIDSQKKIEGSEEKSVRNKSQKRKVQFNSSYQSKIDHDLIKRILKE-------IITA
                                                                 |        . . | . .. .. |       |. |
-----------------------------------------------------------------R-------KEGRFDEERARFYAAEMQKICGCIVLA

VEYLHS-EGICHRD-LKPDNILISNDLQNIKIIDFEISKRFKY-----------------------------------FRQNK------TGVLK-VCEMW
.|||||  || ||| |||.|||. .|  .||. ||  .|...                                    ...|.      |   |     |
LEYLHSHMGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKRDRTW

TRTG--TLDFQSPEMFESAGYTEAVDIWA--IGVIAYYLLTGRLPFDQE----------YISDKIEFIRNAQ----YNQDYI----------KDLDDISK
|  |  | .. .||..    |. |.|.|.   |.. | .|||. ||  .             .. . |.| .     .. .           . ...  |
TFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAK

DFIRRMLRKDPAERLT----------ASEALSHPWF
|.|...| |||..||.          |.|  .||||
DLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 7312.AA Ciliate-A9 464-628 25 9.2e-65 153.06 In-house 127-392 (392) Show / Hide 
Range on Protein: 464-628
Range on HMM: 127-392/392
Sequence Identity: 25% (70 aa)

IKRILKEIITAVEYLHSEGICHRDLKPD--------------------------------------------------NILIS--NDLQNIKIIDFEISK
| .| | |. || |.|. .|||||||||                                                  ||||.  |||. .||.|| .||
ISQIMKCIMSAVMYMHQKNICHRDLKPDRQINKCIQLFISSFIHLFINHHNYCKQQNKQTNKQTNEKINQVKIFILTENILIGDKNDLTQVKIADFGLSK

------RFKYFRQNKTGVLKVCEMWTRTGTLDFQSPEMFESAGYTEAVD-------------------------------------------IWAIGVIA
      | .|| | ...      | . .||| . .|| | ...|.  ||                                           .|. | |.
SFVKSQRVQYFTQWTYH-----SMYQQCGTLIYMAPEFFINKQYSQPVDHAVSMKSRKRLIYLFLQLIILFLNSLKSQNQFILYRQFKQQVDMWSCGIIM

YYLLT-GRLPFDQ--EYISDKIEFIRNAQYNQDYIKDLD---DISKDFIRRMLRKDPAERLTASEALSHPWF
| ||. |. ||    | ..|.  |.   | |.  .. .|   .. |.|| .|....| .| .|...| ||| 
YMLLCMGKHPFWCPYEKNDDEDYFKMKIQCNPQ-WEFWDNCSNNAKNFIQKMTNINPSNRYNAFQCLKHPWI
Kinase 7312.AA CAMK1 466-628 38 1.2e-52 151.29 In-house 112-276 (276) Show / Hide 
Range on Protein: 466-628
Range on HMM: 112-276/276
Sequence Identity: 38% (67 aa)

RILKEIITAVEYLHSEGICHRDLKPDNILISNDLQN--IK--IIDFEISKRFKYFRQNKTGVLKVCEMWTRTGTLDFQSPEMFES---AGYTEAVDIWAI
.| |.|. ||||.|| ||.|||||| |.| ..   .  ||  |.|| .||.|.              | |. ||.... ||..|     .|  |.|.| |
HIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN---------LMKTACGTPGYVAPEVLECKKDKPYDKACDMWSI

GVIAYYLLTGRLPFDQEY-ISDKIEFIRNAQYNQDYIKD-LDDISKD----FIRRMLRKDPAERLTASEALSHPWF
||| | ||.|  ||  |  ..   | | ...|  .....  |.||.     ||. || .|| .|.|....| |||.
GVITYILLCGYPPFYDENVDNELFEKIKKCEY--EFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 7312.AA S_TKc 228-628 17 9.2e-52 179.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 228-628
Range on HMM: 1-231/231
Sequence Identity: 17% (75 aa)

ELIGEKLGEGSQGDVRKCIHKKSQQVYAVKMIRNGDTEIILSAITSFKIAKNLNHPSIIKPYELFINQETEKIYYVMEYCEYGSLQDYIENLWSLSPHKR
  |..|.|.|. | |.||.|||.....|.|.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

DHRSMSKMKTTSTDNLEDESNSLDSQKNLNFEGASNKATKKKDRKKKQKKRRQEDNQAKEDDHLIKLYQQLGSSDNLKQQQNEIVNNNLNAQDEDDTKID
                                                                             .. ..||             . .
-----------------------------------------------------------------------------EHIRREIQILKK--------HHP

SQKKIEGSEEKSVRNKSQKRKVQFNSSYQSK--------------------IDHDLIKRILKEIITAVEYLHSEGICHRDLKPDNILISNDLQNIKIIDF
   |. .. .          .. .   | .                     ..   .......|. |.||.|| ||.||||||.|||...   .|||.||
NIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDF

EISKRFKYFRQNKTGVLKVCEMWTRTGTLDFQSPEMFESAGYTE-AVDIWAIGVIAYYLLTGRLPFDQEYISDKIEFIRNAQYNQDYIKDLDDISKDFIR
 .....                 |  ||... .||..   ||.  ..|.|..|.| | .|.|. ||.     .  . ...           ..  |||||
GLARQL----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------SPEAKDFIR

RMLRKDPAERLTASEALS-------HPWF
..|.|||..|.|| |||        ||||
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 7312.AA CAMK-Tt 466-628 37 5e-50 171.33 In-house 228-396 (396) Show / Hide 
Range on Protein: 466-628
Range on HMM: 228-396/396
Sequence Identity: 37% (64 aa)

RILKEIITAVEYLHSEGICHRDLKPDNILISNDLQNIKIIDFEISKRFKYFRQNKTGVLKV---CEMWTRTGTLDFQSPEMFESAG-YTEAVDIWAIGVI
.| | |. |..|.|.. .||||||| |||   | ...|| || .||   . ...| . |       ||| |||. |  || |.    | | .|.|  |.|
KIFKQILDAIKYMHENYVCHRDLKPNNILCNEDGTCVKITDFNVSKFCDHYKNYKKDNLMNHQNIKMWTYTGTVAFSAPEIFNEDCCYDETIDMWSAGCI

AYYLLTGRLPFDQEYISDKIEFIRNAQYNQD--YIKDLDDISKDFIRRMLRKDPAERLTASEALSHPWF
 | .| |. ||. ||. | |. | .|.|| .    ..  .  || |.. |  .| .| .  ..| ||| 
LYTMLCGQEPFQAEYVHDLIKKICQADYNFPSHVWQHISEEAKDLIKKCLTINPEQRIKPDQMLQHPWI
Kinase 7312.AA RSK 467-628 34 6.9e-45 155.44 In-house 109-278 (278) Show / Hide 
Range on Protein: 467-628
Range on HMM: 109-278/278
Sequence Identity: 34% (63 aa)

ILKEIITAVEYLHSEGICHRDLKPDNILISNDLQN---IKIIDFEISKRFKYFRQNKTGVLKVCE--MWTRT--GTLDFQSPEMFE----SAGYTEAVDI
.. ||. |||.||. || ||||||.|||  ..  |   ||..||  .| |            .|.   || |  .|...  |||        |...|.|.
YMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF------------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDW

WAIGVIAYYLLTGRLPFDQ---EYISDKIEFIRNAQYNQDYI--KDLDDISKDFIRRMLRKDPAERLT-----ASEALSHPWF
|  ||. | .|||..|| .   .  .. .. |........    . | .  ||.||.|| .||. ||.     |.| ..||||
WSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 7312.AA CAMKL 534-628 28 1.5e-30 94.59 In-house 195-297 (297) Show / Hide 
Range on Protein: 534-628
Range on HMM: 195-297/297
Sequence Identity: 28% (30 aa)

GTLDFQSPEMFES--AGYT-EAVDIWAIGVIAYYLLTGRLPFDQEYI-------SDKIEFIRNAQYNQDYIK-DLDDISKDFIRRMLRKDPAERLTASEA
|.. ...||.|..    |   .||||..||| | ...|.||||.. .         . . . . .  .. |  ...   .|.||.|| ..| .| |. . 
GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI

LSHPWF
..|||.
MNHPWM
Kinase 7312.AA MARK 534-628 30 3.9e-22 69.31 In-house 167-262 (262) Show / Hide 
Range on Protein: 534-628
Range on HMM: 167-262/262
Sequence Identity: 30% (30 aa)

GTLDFQSPEMFESAGYT-EAVDIWAIGVIAYYLLTGRLPFDQEY--ISDKIEFIRNAQYN-QDYIKDLDDISKDFIRRMLRKDPAERLTASEALSHPWF
||. . .||.|..  |.  .||||. ||. |....|..|||     . .  . |.. .|   ..   . .  ...|.|.|  .| || |..| ..|||.
GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH---VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 7312.AA CAMKL 458-507 47 9e-21 62.89 In-house 123-173 (297) Show / Hide 
Range on Protein: 458-507
Range on HMM: 123-173/297
Sequence Identity: 47% (24 aa)

KIDHDLIKRILKEIITAVEYLHSEGICHRDLKPDNILISNDLQ-NIKIIDF
... .  .|. . |. ||.|.|| ||.|||.||.|||....   |||||||
RMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDF
Kinase 7312.AA Ciliate-A9 227-318 25 1.7e-19 42.33 In-house 1-114 (392) Show / Hide 
Range on Protein: 227-318
Range on HMM: 1-114/392
Sequence Identity: 25% (30 aa)

YELIGEKLGEGSQGDVRKCIHKK--SQQVYAVKMIRNGDTEI--ILSAITSFKIAKNLNHPSIIKPYE---------------------LFINQETEKIY
.|.| ...|||. | | .|. ..    |.|||| |.. . .   |       || . ..||.|.| ..                      |.  .. .|.
FEPI-KIIGEGAFGCVIQCRDIQQEDKQEYAVKVIQKNKMKMDCIEFQDQEAKILQQHDHPNIVK-FKNIKNINTQKETKQLNYIFQISKFCESDQ-NIH

YVMEYCEYGSLQDYIEN
.||||   |.||  ...
IVMEYMKCGTLQQLMKE
Kinase 7312.AA MARK 465-507 56 2.2e-19 60.21 In-house 107-150 (262) Show / Hide 
Range on Protein: 465-507
Range on HMM: 107-150/262
Sequence Identity: 56% (25 aa)

KRILKEIITAVEYLHSEGICHRDLKPDNILISNDL-QNIKIIDF
.|| . |. ||.|.|| .|.|||.||.||||  .  .|||||||
RRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDF
Kinase 7312.AA CAMK-Tt 227-305 30 7.9e-17 54.29 In-house 1-117 (396) Show / Hide 
Range on Protein: 227-305
Range on HMM: 1-117/396
Sequence Identity: 30% (36 aa)

YELIGEKLGEGSQGDVRKCIHKKSQQVYAVKMIRNGDTE-II--------------------------------------LSAITSFKIAKNLNHPSIIK
||.. | ||||  | |.| . .  .||.|.||.|  | | |.                                      .  |  ||. . |||| |.|
YEEQ-EILGEGCVGLVKKVKRISDGQVFACKMVRTRDEEEIMNHQSYNSEISSGQHKCQSTGELFEITKFTYFKSISQSKMQVIREFKNIRELNHPNIVK

PYELFINQETEKIYYVME
 |||.| .   .|| .||
VYELYIDETKGRIYTIME
Kinase 7312.AA CAMKL 227-318 31 3.3e-16 48.09 In-house 1-116 (297) Show / Hide 
Range on Protein: 227-318
Range on HMM: 1-116/297
Sequence Identity: 31% (37 aa)

YELIGEKLGEGSQGDVRKCIH-KKSQQVYAVKMIRNGDTEIILSAITSFK-----------------IAKNLN---HPSIIKPYELFINQET----EKIY
|...   ||.|| | |. ..| .  .. .|.|.|      | .  ... .                 | | ||   || ||| || . ..|.    .|||
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDK--KKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY

YVMEYCEYGS--LQDYIEN
 |||||. |.  |.|||..
LVMEYCSGGEMDLFDYIVK
Kinase 7312.AA MARK 229-318 31 5.9e-15 45.5 In-house 2-95 (262) Show / Hide 
Range on Protein: 229-318
Range on HMM: 2-95/262
Sequence Identity: 31% (30 aa)

LIGEKLGEGSQGDVRKCIHKKSQQVYAVKMIR---NGDTEIILSAITSFKIAKNLNHPSIIKPYELFINQETEK--IYYVMEYCEYGSLQDYIEN
 ..  .|.|| . |....||.... .|.|..      | . . .     .| | |.|| ||| .. .  |.||.  || .|||.. |.| |||..
KMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIE-QDTEQHQIYLIMEYASGGELYDYIKA
Kinase 7312.AA TyrKc 228-628 17 2e-13 -5.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 228-628
Range on HMM: 1-280/280
Sequence Identity: 17% (74 aa)

ELIGEKLGEGSQGDVRKCIHKKSQQVYAVKMIRNGDTEIILSAITSFKIAKNL--NHPSIIKPYELFINQ-----ETEKIYYVMEYCEYGSLQDYIENLW
   |.|||||  | |.|.. |  .|| ||||....    .   .   .| ..|  .|| |.. |   . |     . | .. ||||...|.|.||. .  
ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

SLSPHKRDHRSMSKMKTTSTDNLEDESNSLDSQKNLNFEGASNKATKKKDRKKKQKKRRQEDNQAKEDDHLIKLYQQLGSSDNLKQQQNEIVNNNLNAQD
                                                                                                    
PK--------------------------------------------------------------------------------------------------

EDDTKIDSQKKIEGSEEKSVRNKSQKRKVQFNSSYQSKIDHDLIKRILKEIITAVEYLHSEGICHRDLKPDNILISNDLQNIKIIDFEISKRF-------
                                      . ..    .   |    ||||| .. ||||   |.|.....  .|| ||  |.         
--------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQG

---KYFRQNKTGVLK--VCEMWTRTGTLDFQSPEMFESAGYTEAVDIWAIGVIAYYLLT-GRLPFDQ-----EYISDKIEFIRNAQYNQDYIK-------
   .| |. ...  |  .   |.        .|| .    .|.. |.|. ||  . ..| |  |           .. ||....  .             
ESKDYYRKKEHKGGKTMLPIRWM--------APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFV

-DLDDISKDFIRRMLRKDPAERLTASEALSHPWF
   |.. .  ...  . ||..| | ||   |  |
CCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 7312.AA CAMK1 227-307 27 8.7e-11 27.52 In-house 1-90 (276) Show / Hide 
Range on Protein: 227-307
Range on HMM: 1-90/276
Sequence Identity: 27% (26 aa)

YELIGEKLGEGSQGDVRKCIHKKS---QQVYAVKMIRNGDTEIILSAI----TSFK----IAKN---LNHPSIIKPYELFINQETEKIYYVMEYC
|| .|...|.|. ..|..|.||..   .. ||.|.| .   . .        ....    | |.   ..|| ||| || .  ......| |||..
YE-FGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK--KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWY--ESDNHFYLVMELV
Kinase 7312.AA Pkinase_Tyr 227-507 16 2.7e-09 32.11 Pfam 1-155 (270) Show / Hide 
Range on Protein: 227-507
Range on HMM: 1-155/270
Sequence Identity: 16% (49 aa)

YELIGEKLGEGSQGDVRKCIHK-----KSQQVYAVKMIRNGDTEI---ILSAITSFKIAKNL-NHPSIIKPYELFI-NQETEKIYYVMEYCEYGSLQDYI
 ... .|||||. |.|.|.. |     . ..| ||||...| ..    . . .   || |.| .|| |.. |   .  .|  .|| ||||...|.| || 
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

ENLWSLSPHKRDHRSMSKMKTTSTDNLEDESNSLDSQKNLNFEGASNKATKKKDRKKKQKKRRQEDNQAKEDDHLIKLYQQLGSSDNLKQQQNEIVNNNL
 .                                                                                                  
RKHR------------------------------------------------------------------------------------------------

NAQDEDDTKIDSQKKIEGSEEKSVRNKSQKRKVQFNSSYQSKIDHDLIKRILKEIITAVEYLHSEGICHRDLKPDNILISNDLQNIKIIDF
                                     . . ....  .  .  .|  . |||.| .. ||||   |.|.....  .|| ||
-------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDF
Kinase 7312.AA RSK 230-260 30 3e-06 19.09 In-house 1-33 (278) Show / Hide 
Range on Protein: 230-260
Range on HMM: 1-33/278
Sequence Identity: 30% (10 aa)

IGEK--LGEGSQGDVRKCIHKKSQQVYAVKMIR
. ..  .| |.   .|||.|....|.||.| ..
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLK