Gene 9015 (Tetrahymena)
9015
Group:
Other
Family:
Ciliate-E3
Sequence
Protein domains of 9015.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 9015.AA | Ciliate-E3 | 79-270 | 37 | 4.6e-120 | 375.75 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 79-270 Range on HMM: 1-202/202 Sequence Identity: 37% (76 aa) YDVLDIIACSKYSVVFKAFSSTLNTEVAIKVQTCRNQAV------LKDLQKQFIMFQDQEDKNLLKIHQIYYDEQTEMLFVIMDLCINGDLYHFVRRDQN |.|..|..|.....|.|||....|..||||...|.||.. ....|..|...|.....|..|.|..|||.|..|.|.....|.||||||... .|| YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIK-QQN LSLQTTYDLCAQAIRSLLILHQKNIIHGDLNPSNFLIDSSY---TLKFSYQGASKFLYNNL--KHAFYDPFTIYYSSKEQLDQQSPSNESDLYSLGVVLL ......||.|.|.|......|.|||||.|..|.|.|.|... ..|....|.||.|..|. .|..|...|..|...||.|||..|.|||.||.|.|.. KTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFC DII ... QLC |
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| Kinase | 9015.AA | Ciliate-E1 | 85-260 | 25 | 6.8e-20 | 61.74 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 85-260 Range on HMM: 1-202/202 Sequence Identity: 25% (52 aa) IACSKYSVVFKAFSSTLN-TEVAIKVQTCR---NQAVLKDLQKQFI-MFQDQEDKNLLKIHQIYYDEQTEMLFVIMDLCINGDLYHFV------------ |. . .|.||||.. | .||.|.. |. || . |..|. . ... .. .....| ......| . |...| .. . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ RRDQNLSLQTTYDLCAQAIRSLLILHQKNIIHGDLNPSNFLIDSSYTLKFSYQGASKFLYNNLKHAF-YDPFTIYYSSKEQ--------LDQQSPSNESD . ..... | . |.| | .|||.||||.|..|.| ||... .... .| |||| || .. |. .| ||...|| ..| . .|| QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSD LY .| IY |
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| Kinase | 9015.AA | Ciliate-A1 | 79-267 | 25 | 5.7e-18 | 57.73 | In-house | 1-219 (301) | Show / Hide |
Range on Protein: 79-267
Range on HMM: 1-219/301
Sequence Identity: 25% (55 aa)
YDVLDIIACSKYSVVFKAFSSTLNTE--VAIKVQTCRNQAVLKD-LQKQFIMFQDQEDKNLLKIHQIYYDEQ-TEMLFVIMDLCINGDLYHFVRRDQNLS
| | | ..|| .|. . |. ...|. | | .|. .| .. | ... |.|| .. | | || | | | .. ..
YHVVQLIDKGSFGVVMRAYDIQ-NQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQNDYMK
LQTTYDLCAQAIRSLLILHQKNIIHGDLNPSNFLIDSSYTLKFSYQGASKFLYNNL------------------KHAFYDPFTIYYSSKEQ---------
|..|.| | .. .| .||.| || | | || |. | || | | | . || | ||
KEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQM
LDQQSPSNESDLYSLGVVLL
. . ||.||||....
FIENKIYKQSDMYSLGCIIC
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| Kinase | 9015.AA | Ciliate-E5 | 92-208 | 30 | 3e-15 | 45.87 | In-house | 14-135 (271) | Show / Hide |
Range on Protein: 92-208 Range on HMM: 14-135/271 Sequence Identity: 30% (38 aa) VVFKAFSSTLNTEVAIKVQTCRNQAVLKDLQKQFIMFQDQEDKNLLKIHQIYYDE--QTEMLFVIMDLCINGDLYHFV----RRDQNLSLQTTYDLCAQA .| |..| .. .|||. | ||. ..|.|. | .. .. .| ||| . . . .| ||..| || . .....| | .| | MVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKC-DLHTYLNKIIYQMKWQKHQDIYQICLQL IRSLLILHQKNIIHGDLNPSNFL .. | .||||||| | |.| | VKGLQDIHQKNIIHLDIKPANIL |
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| Kinase | 9015.AA | TKL | 85-270 | 17 | 4.6e-14 | 47.05 | In-house | 1-283 (364) | Show / Hide |
Range on Protein: 85-270
Range on HMM: 1-283/364
Sequence Identity: 17% (51 aa)
IACSKYSVVFKAFSSTLN--------TEVAIKVQTCRN-QAVLKDLQK------------------QFIMFQDQEDKNLLK-----IHQIYY-DEQTEM-
| ...|.|. . ..||.|. .| . | .|. .| | .| . ... | |.. . . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------LFVIMDLCINGDLYHFVRRDQNLSLQTTYDLCAQAIRSLLILHQ--------KNIIHGDLNPSNFLIDSSYT--------------LK
|. .|..| .|.|.|.. .. . ... .. | . ||. ..||| ||...| |.|. .| .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
FSYQGASKFLY-------------------NNLKHAFYDPFTIYYSSKEQLDQQ----------------SPSNESDLYSLGVVLLDII
. | |.|. || |. |... . | |..| . | .| || |.|| |.
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL
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| Kinase | 9015.AA | Ciliate-E2 | 79-266 | 14 | 9.1e-14 | 43.62 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 79-266 Range on HMM: 1-286/365 Sequence Identity: 14% (42 aa) YDVLDIIACSKYSVVFKAFSSTLNTEVAIKVQTCRN--------------QAVLKDLQKQFIMFQDQEDKN-----------------------LLKIHQ |... .| ...|.|. . ..|||... .. |. ..| ... .. . ..|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE IYYDEQTEMLFVIMDLCINGDLYHFVR------------RDQNLSLQTTYDLCAQAIR---------------SLLILHQKN-IIHGDLNPSNFLIDSSY ....... .. .|..| |||... . ...... .. .| .. | ||.|| ||| |. |.| |. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- TLKFSYQGASKFLYNNLK--------HAFYDPF------------------------TIYYSSKEQLDQQS---------PSNESDLYSLGVVL .| . | ||.. .. . . . . | .| . | | .. . ..|..||||.| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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| Kinase | 9015.AA | Ciliate-E2-Unclassified | 79-266 | 18 | 1.1e-13 | 43.9 | In-house | 1-260 (352) | Show / Hide |
Range on Protein: 79-266 Range on HMM: 1-260/352 Sequence Identity: 18% (48 aa) YDVLDIIACSKYSVVFKAFSSTLNTEV-----AIKVQTCRNQAVLKD---------LQKQ---------FIMFQD--QEDKNLLKIHQIYYDEQTEMLFV | .. .| ...|.|. . . .. ..|.| . . ... .... .|| |. . ....... .|...... .. YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIM-QQILLNHPHPFIVKMFYCFQDKQNIYI IMDLC-----------------INGDLYHFVRRDQNLSLQTTY-----DLCAQAIRSLLILHQKN-IIHGDLNPSNFLIDSSY---TLKFSYQGASKFLY .|..| . .||.| .... .. | . ...|| . | ||.|| ||| |. |.| |.|.. .| . | ||.. VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ N-------------NLKHAFYDPF--TIYYS----SKEQLDQQSPSNE----SDLYSLGVVL . ..|. .. | |..| . | |..| .... .| .||||.| QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL |
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| Kinase | 9015.AA | S_TKc | 79-335 | 17 | 3.3e-13 | 16.73 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 79-335 Range on HMM: 1-231/231 Sequence Identity: 17% (48 aa) YDVLDIIACSKYSVVFKAFSSTLNTEVAIKVQTCRNQAVLKDLQKQFIMFQDQEDKNLLKIHQIYYDEQTEMLFVIMDLCIN--GDLYHFVRRDQN---- |..|..| ...|.|. . .||||. ..... . . .|. |.. ...| . |...|..| . |||... .. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LSLQTTYDLCAQAIRSLLILHQKNIIHGDLNPSNFLIDSSYTLKFSYQGASKFLYNNLKHAFYDPFTIYYSSKEQLDQQSPSN-ESDLYSLGVVLLDI .. .. ...| .. | .|...||| || |.| |.|. ..| . | ...| | .| . | | . . ..| .|.|..| FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM IGLRV--ENKIEELINLQSRNIDQLLLLKDKLEGRYHFLFEIALNLIKNDRQILRAD-----QSVEILE-------QSYN . . . ....... . |...| |..|. | |.|. . LCGYPPFP-QMQMMFKKIG--------------------SPEAKDFI---RKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 9015.AA | CAMK | 84-216 | 11 | 2.5e-10 | 28.77 | In-house | 1-236 (425) | Show / Hide |
Range on Protein: 84-216 Range on HMM: 1-236/425 Sequence Identity: 11% (28 aa) IIACSKYSVVFKAFSSTLN------------TEVAIKV----------------------QTCRN------QAVLKDLQKQFIMFQDQE-------DKNL .. ...|.... . ..||||. ..|.. . .| ... . . .|. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LKIHQIYYDEQ-----------------TEMLFVIM---DLCING----DLYHFVRRDQN---------------LSLQTTYDLCAQAIRSLLILHQKNI .|....| |.. ..... .| ..| .| ||. .... . .. . . . | . . .|..|| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI IHGDLNPSNFLIDSS-----------------YTLK .| || | | |.|.. ...| VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIK |
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| Kinase | 9015.AA | CMGC | 79-216 | 15 | 4.5e-10 | 28.33 | In-house | 1-244 (513) | Show / Hide |
Range on Protein: 79-216 Range on HMM: 1-244/513 Sequence Identity: 15% (39 aa) YDVLDIIACSKYSVVFKAFS--------------STLNTEVAIKVQT---------------------CRNQAVLKDL--QKQFIM------FQDQEDKN |.... | . |.||.|.. | .|||| .| || | ... . ... ..| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHNN LLKIHQIYYDEQTE---------------MLFVIMDLCINGDLYHFVRRDQN----------------------------LSLQTTYDLCAQAIRSLL-- ..|.. |.|..... |. ..... |||.. .. |. ... . | .|.| IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYM-DHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK ILHQKN--IIHGDLNPSNFLIDSS--------------------YTLK .|... ||| || |.| ||.. ..|| YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLK |
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| Kinase | 9015.AA | KHS | 79-223 | 23 | 6.1e-10 | 29.48 | In-house | 1-143 (258) | Show / Hide |
Range on Protein: 79-223 Range on HMM: 1-143/258 Sequence Identity: 23% (35 aa) YDVLDIIACSKYSVVFKAFSSTLNTEVAIKVQTCRNQAVLKDLQKQFIMFQDQEDKNLLKIHQIYYDEQTEMLFVIMDLCINGDLYHFVRRDQNLS-LQT |..| . | |.|| .. .|.|| . .. .|. .|..| . |.. . | . . |...|. | | | . .|| || YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYL--RRDKLWICMEYCGGGSLQDIYHVTGPLSELQI TYDLCAQAIRSLLILHQKNIIHGDLNPSNFLIDSSYTLKFSYQGAS .| .| .... | ||.. .| |. | |. .. | | | AY-VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVS |
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| Kinase | 9015.AA | TyrKc | 79-313 | 17 | 1.8e-08 | -85.73 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 79-313 Range on HMM: 1-280/280 Sequence Identity: 17% (49 aa) YDVLDIIACSKYSVVFKAFSSTLNTEVAIKVQTCRNQAVLKDLQKQFIMFQDQ--EDKNLLKIHQIYYDEQT-----EMLFVIMDLCINGDLYHFVRRDQ .... . . .|.|. . ..||.| .... | ..|. . . . .|..... . ... | |...| .. .||| .. |. . ITLGKKLGEGAFGEVYKGTWK---IQVAVK--MLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR N-LSLQTTYDLCAQAIRSLLILHQKNIIHGDLNPSNFLIDSSYTLKFSYQGASKFLYNN--------LKHAFY---DP--FTIYYSSKEQLDQQSPSNES . |.... . | |. . ||.||.|| || | |... .| | | | |...|. ... . | . | .. . .| PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS DLYSLGVVL-----------LD-----IIGLRVENKIEELINLQSRNID-------------QLLLL--KDKLEGRYHFLFEIALNL | .| ||.. . . .| ..... . | |. . . . | | | || . DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS-EIHECF |
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| Kinase | 9015.AA | Pkinase | 134-216 | 25 | 4e-06 | 22.92 | Pfam | 60-152 (293) | Show / Hide |
Range on Protein: 134-216 Range on HMM: 60-152/293 Sequence Identity: 25% (24 aa) KNLLKIHQIYYDEQTEMLFVIMDLCING----DLYHFVR--RDQNL--SLQTTYDLCAQAIRSLLILHQKNIIHGDLNPSNFLIDSSYTL----K .| .... ...| ... ..|..| .| ||..... |. .. | .. . . | .| | .|...||| || |.|.|||. ... | PNIVRLYDWFED-KDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK |
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| Kinase | 9015.AA | Ciliate-E5 | 257-270 | 57 | 0.042392 | 2.39 | In-house | 258-271 (271) | Show / Hide |
Range on Protein: 257-270 Range on HMM: 258-271/271 Sequence Identity: 57% (8 aa) SDLYSLGVVLLDII || ||||.| | SDIYSLGIVFLELT |
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| MORN | 9015.AA | MORN | 622-644 | 52 | 5.8e-09 | 37.31 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 622-644 Range on HMM: 1-23/23 Sequence Identity: 52% (12 aa) YTGEWKNNLREGHGMYKWANGTI | |||||....||| |.|..|. YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 9015.AA | MORN | 620-641 | 59 | 8.8e-09 | 36.42 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 620-641 Range on HMM: 1-22/22 Sequence Identity: 59% (13 aa) NKYTGEWKNNLREGHGMYKWAN ..|.|||.|..| ||| | ||| DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 9015.AA | MORN | 645-667 | 30 | 1.4e-05 | 25.04 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 645-667 Range on HMM: 1-23/23 Sequence Identity: 30% (7 aa) YIGEYFQNAKNGKGTLKFHNGER | ||. .. ..|.|.... .| | YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 9015.AA | MORN | 668-690 | 43 | 1.6e-05 | 24.82 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 668-690 Range on HMM: 1-23/23 Sequence Identity: 43% (10 aa) YEGYFKDNNFNGKGIYYFTDGVR ||| .|.. ..|.|.|.. || | YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 9015.AA | MORN | 599-621 | 39 | 4.6e-05 | 23.15 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 599-621 Range on HMM: 1-23/23 Sequence Identity: 39% (9 aa) YEGSFVDGLYEGKGVYYYLGGNK |||....|. .|.|||.. |.. YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 9015.AA | MORN | 576-598 | 34 | 0.000144 | 21.34 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 576-598 Range on HMM: 1-23/23 Sequence Identity: 34% (8 aa) YIGEVQQKVPHGQGKMYFHKGNR | || .. ..||.|.... |.| YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 9015.AA | MORN | 597-618 | 40 | 0.000254 | 21.28 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 597-618 Range on HMM: 1-22/22 Sequence Identity: 40% (9 aa) NRYEGSFVDGLYEGKGVYYYLG .||||....|. |.|||.. DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 9015.AA | MORN | 643-664 | 27 | 0.000543 | 18.81 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 643-664 Range on HMM: 1-22/22 Sequence Identity: 27% (6 aa) TIYIGEYFQNAKNGKGTLKFHN .|.||.. . . |.|.. . | DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 9015.AA | MORN | 666-687 | 31 | 0.000567 | 18.67 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 666-687 Range on HMM: 1-22/22 Sequence Identity: 31% (7 aa) ERYEGYFKDNNFNGKGIYYFTD |||| .... . |.|.|.... DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 9015.AA | MORN | 574-595 | 27 | 0.11531 | 1.39 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 574-595 Range on HMM: 1-22/22 Sequence Identity: 27% (6 aa) GYYIGEVQQKVPHGQGKMYFHK |.|| . .||.|.... DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 9015.AA | MORN | 691-712 | 30 | 1.303649 | 6.98 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 691-712 Range on HMM: 1-23/23 Sequence Identity: 30% (7 aa) FEGEFDDGKAL-NGEFYLANGLK .|||. .|| .| .. ..| . YEGEWKNGKMHGHGVYTWPDGDR |
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