Gene 13025 (Tetrahymena)

13025

Species: Tetrahymena
Alias: 4.m00424, PreTt13025, 462, 13025, TTHERM_00058400, 3707.m00069
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E5

Sequence

Name Sequence Type Origin Length Description Download
13025.AA Protein None 647 None Fasta, JSON
13025.kin_dom Protein Kinase Domain None 203 None Fasta, JSON
13025.NA RNA None 1944 None Fasta, JSON

Protein domain

Protein domains of 13025.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13025.AA Ciliate-E5 86-288 45 2.3e-138 453.09 In-house 1-271 (271) Show / Hide 
Range on Protein: 86-288
Range on HMM: 1-271/271
Sequence Identity: 45% (124 aa)

IIENGLLGAGGSGFVLKACSEWNEHLAVKLM-KYSNLEQFESNKREYDILKKFNSNNITKVYQYFTESHESNEYQFIVMERCVYDLKNYIAKKISSNKLL
||||..||.||||.|.|.|||||........ |..|..|.|.|.||..|||.|||..|.||||......|...||||.|||| .||..|..|.|...| .
IIENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKWQ

SHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVS---------KVVSEQRQ---------------------------------
.|| .|..||||.||||..||||||||||||||||||.|.||||.|.|.|         |.||||||                                 
KHQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKNR

--------HTKNLIGFTATYSSPEQYQLMT-----------------TSATHKVTKSSDVYSLGVVFLQLT
        ||.||.|||..||||||||...                 .|...|.||.||.||||.|||.||
KKLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQSDIYSLGIVFLELT
Kinase 13025.AA Ciliate-A1 86-347 29 1.1e-55 188.08 In-house 1-301 (301) Show / Hide 
Range on Protein: 86-347
Range on HMM: 1-301/301
Sequence Identity: 29% (92 aa)

IIENGLLGAGGSGFVLKACSEWNEH--LAVKLMKYSNLEQFESNKREYDILKKFNSNNITKVYQYFTESHESNEYQFIVMERCVYD-LKNYIAKKISSNK
  .  |.. |. | |..|    |.   |..|... .| ||. .|  || ..|  |.||  |.||      .  | .||.|| | |  | ||.      |.
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQ----ND

LLSHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRQ------------------HTKNLIGFTATYSSPEQYQLMT
 ..    | .|.|. .|.  .| .||.|.|.|| |||.. | ||| .||| ||.  || |                    .   | .  | ||||||.  
YMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQL-EQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHY

---TSATHKVTKSSDVYSLGVVFLQLTG-----------VDVTQKWIIKEK----------ISAHNYDRCLNPYYEEFNNCIIKKMMQHEANDRLQIEEV
        |. | ||.||||.... |..           | .    .. ..          |   ..    .| .|| .| .|.|||| | | |.. ...
RDQMFIENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQN-LIFKMMQYEPNNRCSLQQC

IDILKRL
|| |. .
IDCLYIF
Kinase 13025.AA Ciliate-B2 89-281 29 2.1e-37 85.46 In-house 4-197 (197) Show / Hide 
Range on Protein: 89-281
Range on HMM: 4-197/197
Sequence Identity: 29% (59 aa)

NGLLGAGGSGFVLKAC---S-EWNEHLAVKLMKY---SNLEQFESNKREYDILKKFNSNNITKVYQYFTESHESNEYQFIVMERCVYDLKNYIAKKISSN
   .. || ||. .     | .  . ||.| .     .. |....   |. |.| |. |   .| .|      ... . ..||.| ..||. . |     
CKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQH---EIKIMKMFEYNI--NVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQ

KLLSHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRQHTKNLIGFTATYSSPEQYQLM-TTSATHKVTKSSDVYSL
|    | || .  ||  || ... .||.||||||.|||.    . .| | |.| . ... |   .  |||  | |||| .     .   ..   ||.||.
KCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQ--IKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSM

G
|
G
Kinase 13025.AA Ciliate-E1 92-278 27 1.6e-35 113.13 In-house 1-202 (202) Show / Hide 
Range on Protein: 92-278
Range on HMM: 1-202/202
Sequence Identity: 27% (56 aa)

LGAGGSGFVLKACSEWN--EHLAVKLMKYS---NLEQFESNKREYDILKKFNSNNITKVYQYFTESHESNEYQFIVMERCVYDLKNYIA---------KK
.|.|....|.|| ...|  .. |.|. ..    | ..|.....||. ..|   ...  .. . .  ...|  . |..| | . ||.|.          ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

ISSNKLLSHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRQHTKNLIGFTATYSSPEQYQ---LMTTSATHKVTKS
 . .. .. | .  .  || .||.||||.||||.||||.|||   . . .|.|.|.||.  .. .....  |.|  |..||||.   . .   . |... 
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYK

SDVY
||.|
SDIY
Kinase 13025.AA Ciliate-E3 121-288 34 2.9e-32 98.08 In-house 43-202 (202) Show / Hide 
Range on Protein: 121-288
Range on HMM: 43-202/202
Sequence Identity: 34% (60 aa)

LEQFESNKREYDILKKFNSNNITKVYQYFTESHESNEYQFIVMERCVY-DLKNYIAKKISSNKLLSHQILYTLCLQLSKGLQELHQKNIIHLDIKPANIL
.|||     |    ...|| |. |... .    . |.  |||.| |   ||..||  .      .. .|.| .| |. .|. ..|.||||| |||| |||
GEQFQKTQQEFQNCQQINSQNVVKCHDQYYD--QQNKMIFIVQEYCSNGDLYHYIK-QQN----KTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNIL

LGLDL---KWKYADLGVSKVVSEQRQHTKNL-IGFTATYSSPEQYQLMTTSATHKVTKSSDVYSLGVVFLQLT
..  .     | .|.| ||  .    ||  .  |.|  |..||| .    |      | || ||.|.||.|| 
VDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQIS------KESDYYSVGAVFCQLC
Kinase 13025.AA S_TKc 86-347 22 1.3e-30 108.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 86-347
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

IIENGLLGAGGSGFVLKACSEW-NEHLAVKLMKYSNLEQFESNKREYDILKKFNSNNITKVYQYFTESHESNEYQFIVMERCVY---DLKNYIAKKIS--
     ..| |. | | |.     ... |.| .|       |. .|| .|||| .  || | | .| .     .. ..||| |     ||. || |. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

SNKLLSHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRQHTKNLIGFTATYSSPEQYQLMTTSATHKVTK-SSDVY
 .. ..      .. |. ..|. .|...||| |.||.||||      | .| |.....        . .  |  | .||           . .| ..|..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---------GYGKCKCDWW

SLGVVFLQLTG----VDVTQKWIIKEKISAHNYDRCLNPYYEEFNNCIIKKMMQHEANDRLQIEEVID------ILKRL
|.|...  .       .  |   . .||             .|. . .|.|..| . ..|. . |.        .   .
SCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13025.AA STE 87-281 22 1.1e-26 91.26 In-house 1-255 (359) Show / Hide 
Range on Protein: 87-281
Range on HMM: 1-255/359
Sequence Identity: 22% (60 aa)

IEN-GLLGAGGSG-FVLKACS------EWNEH---------LAVKLMKYSNL-----------------EQFESNKREYDILKKFN--SNNITKVYQYFT
 |. . .| |..|  .....       . .|           |.| |...|                  |.... ..| .|.||.|  . || | | .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ES---HESNEYQFIVMERCV-YDLKNYIAKKISSNKLLS----------HQILYTLCLQLSKG-LQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSK
     |..... .|.|| .    |   | .| . .| |.           ... . | |. || |. ||...||| |||||||||      | .| ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VVSE----------------QRQHTKNLIGFTATYSSPEQYQLMTTSAT-HKVTKSSDVYSLG
 ...                . |... ..|    . .||  | .... . .. . ..|..|||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQG-RDKGYDTKCDIWSLG
Kinase 13025.AA Pkinase 86-287 23 8.5e-26 92.3 Pfam 1-205 (293) Show / Hide 
Range on Protein: 86-287
Range on HMM: 1-205/293
Sequence Identity: 23% (51 aa)

IIENGLLGAGGSGFVLKACSEWNEH-LAVKLMKYSNLEQ--FESNKR--EYDILKKFNSNNITKVYQYFTESHESNEYQFIVMERCVY-----DLKNYIA
.   . .|.|..| | |..   ...  ||| .|... .    ... |  |  |.|..|. || . | .|..    . .  .||| |       ||. || 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

KKISSNKLL--SHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKW----KYADLGVSKVVSEQRQHTKNLIGFTATYSSPEQYQLMTTSATH
   .... .  | . .   ..|. .||. .|...||| |.||.|||.  .       | .| |..|.... ...  . .  |  | .||  .        
T--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----GGQ

KVTKSSDVYSLGVVFLQL
. ....|..|.|... ..
YYGPKVDMWSCGCILYEM
Kinase 13025.AA ULK 86-284 26 3e-24 83.0 In-house 1-242 (324) Show / Hide 
Range on Protein: 86-284
Range on HMM: 1-242/324
Sequence Identity: 26% (67 aa)

IIENGLLGAGGSG-FVLKACSEWN----EHLAVKLMKYSNLEQFESN----------KREYDILKKFN---SNN--ITKVYQYFTESHESNEYQFIVMER
.. |  || |  |  | |.  . .    .. |.| .  ... .....          |.|  |.||..   ..|  | | | .| .|..   . .|.|| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH--NNIYIIMEY

CVY-DLKNYIAKKIS-----SNKLLSHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWK-------------YADLGVSKVVS---EQRQH
|   ||..|| |.        .| || |.    . |.  |..|||..|||| ||||.|||.  . ..|              || | .|.|    .. | 
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI-HNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQM

TKNLI------GFTATYSSPE--QYQLMTTSATHKVT-KSSDVYSLGVVF
.. .       | |  | .|.  | |.    .  . . . .|..|||..|
CQTCVNEKRIKG-TPLYMAPQILQGQG----EQKPYYDYKCDIWSLGCIF
Kinase 13025.AA Ciliate-E2 86-287 20 3.1e-24 80.06 In-house 1-289 (365) Show / Hide 
Range on Protein: 86-287
Range on HMM: 1-289/365
Sequence Identity: 20% (60 aa)

IIENGLLGAGGSGFVLKACS------------------------EWNEHLAVKLMKYSNLEQFESNKREYD-------------ILKKFNSNNITKVYQY
.. . ..| |. | | |..                           .   |.| || ...||... ....              ||.. |..|| | | .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FTESHESNEYQFIVMERCVY-DLKNYIAKK-ISSNKL------LSHQILYTLCLQLSK---------------GLQELHQKN-IIHLDIKPANILLGLDL
| |  ..... ..||| | . ||. || .. ...|.       ....   ..  |. .               .|..||.|| ||| |||| |||.    
FQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

KWKYADLGVSKVVSEQRQ-------HTKNLIGF------------------------TATYSSPEQYQLMTTS---ATHKVTKSSDVYSLGVVFLQL
  | .|.| || .....|       . . .  .                        |. | .|| ..    .   . .  ....|..||||.. ..
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 13025.AA ULK 86-284 27 3.3e-24 81.46 In-house 1-246 (329) Show / Hide 
Range on Protein: 86-284
Range on HMM: 1-246/329
Sequence Identity: 27% (69 aa)

IIENGLLGAGGSGFVLKACSEWN-----EHLAVKLMKYSNLEQFESN----------KREYDILKKFN----SNN----ITKVYQYFTESHESNEYQFIV
.. |  || |  | | |.  . .     |  |.| .  . . |.. .          |.| .|.|| .    ..|    | | | .| .|..   . .|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH--NNIYII

MERCVY-DLKNYIAKKIS------SNKLLSHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLK------------WKYADLGVSKVVSEQ---
|| |   ||..|| |.         .| || |.    . |.  |..|||..|||| ||||.|||.  .               | || | .|.|..    
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

RQHTKNLI------GFTATYSSPE--QYQLMTTSATHKVT-KSSDVYSLGVVF
 | ..         | |  | .|.  | |.    .  . . . .|..|||..|
QQMMMTCVNEKRLCG-TPLYMAPQILQGQG----EQKPYYDYKCDIWSLGCIF
Kinase 13025.AA Ciliate-C8 95-284 22 2.3e-22 77.13 In-house 1-238 (238) Show / Hide 
Range on Protein: 95-284
Range on HMM: 1-238/238
Sequence Identity: 22% (53 aa)

GGSGFVLKA----CSEWNEHLAVKLMKYSNLEQFESNKREYDILKKFN-SNNITKVYQYFTESHESNEYQ-----------------FIVMERCVYD---
|. |.||||        ..   ..  .  .  | |. . ||  . .|  .  . .|| .|  . | .. .                 |.|||    .   
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKNYIAKKISSNKLLSHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLD----LKWKYAD------LGVSKVVSEQRQ--HTKNLIGFTAT---
 ||.|. .    .. .| |.   .  |   ..  ||..||.| |||| |.|. .|    .  | .|      .| .  .. .    |.|.  |  ..   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

-------YSSPEQYQLMTTSATHKVTKSSDVYSLGVVF
       |. ||...          .| ||.||.|.|.
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13025.AA TyrKc 86-344 23 5.7e-10 -61.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 86-344
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

IIENGLLGAGGSGFVLKACSEWNEHLAVKLMK-YSNLEQFESNKREYDILKKF--NSNNITKVYQYFTESHE---SNEYQFIVMERCVY-DLKNYIAKKI
|  .  || |  | | |.     .  ||| .| .. .| |    ||  |..|.  .  || . | . |.. .   . |  .|||| . . |||.|. |. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDF---MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

SSNKLLSHQILYTLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQ-------RQHTK----NLIG-FTATYSSPEQYQLMTTS
     |... |   |.| ..| . ||.||.|| |.   |.|.| ..  | .| | |. . .           .|    .  . .     .||        
PK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------

ATHKVTKSSDVYSLGVV-----------FLQ-----LTGVDVTQKWIIKEKISAHNYD------RCLNPYYEEFNNCIIKKMMQHEANDRLQIEEVIDIL
 ..| |  |||.| ||.                   ..  .| ..    .      .|      .|    |      |.|.  .....||   .|.....
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMY-----QIMKQCWHEDPEDRPTFSEIHECF
Kinase 13025.AA ULK 322-343 31 0.18296 0.98 In-house 305-326 (329) Show / Hide 
Range on Protein: 322-343
Range on HMM: 305-326/329
Sequence Identity: 31% (7 aa)

IIKKMMQHEANDRLQIEEVIDI
.|..|.| . .||  .||....
LIRRMLQYDEKDRISWEELFNH
Kinase 13025.AA ULK 322-343 31 0.19057 0.97 In-house 300-321 (324) Show / Hide 
Range on Protein: 322-343
Range on HMM: 300-321/324
Sequence Identity: 31% (7 aa)

IIKKMMQHEANDRLQIEEVIDI
.|..|.| . .||  .||....
LIRRMLQYDEKDRISWEEIFNH