13026

Species: Tetrahymena
Alias: 4.m00425, 461, PreTt13026, 3707.m00070, 13026, TTHERM_00058410
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E5

Sequence

Name Sequence Type Origin Length Description Download
13026.AA Protein None 557 None Fasta, JSON
13026.kin_dom Protein Kinase Domain None 173 None Fasta, JSON
13026.NA RNA None 1674 None Fasta, JSON

Protein domain

Protein domains of 13026.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13026.AA Ciliate-E5 65-253 42 4.1e-120 392.72 In-house 1-257 (271) Show / Hide
Range on Protein: 65-253
Range on HMM: 1-257/271
Sequence Identity: 42% (109 aa)

IIEKGLLGSGGGGFVLKACSEWNDHLAVKLM-KYSNLEQLKINKREYDILKNINSKYVTKVYQFFTESYESNGYQFIVMERCLYDLKNYIAKKITSKKFL
|||...||.||.|.|.|.||||||....... |..|..|.. |.||..|||..||....||||.....||.. ||||.||||..||..|..|.|...|..
IIENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKWQ

SHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVS---------KVVSEQRK---------------------------------
.|||.|..||||.||||..||||||||||||||||||.|.||||.|.|.|         |.|||||.                                 
KHQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKNR

--------HTNNLIGLTALYSSPEQYQLAN-----------------TSVTHKVTKS
        ||.||.|.|..||||||||. .                 .|...|.||.
KKLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQ

Kinase 13026.AA Ciliate-A1 65-241 33 1.4e-41 139.34 In-house 1-193 (301) Show / Hide
Range on Protein: 65-241
Range on HMM: 1-193/301
Sequence Identity: 33% (66 aa)

IIEKGLLGSGGGGFVLKACSEWNDH--LAVKLMKYSNLEQLKINKREYDILKNINSKYVTKVYQFFTESYESN--GYQFIVMERCLYD-LKNYIAKKITS
  .  |...|. | |..|    |    |..|... .| ||.| |  || ..| ||. .| |.||     |. |    .||.|| |.|  | ||.      
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLY--YNTNNKECMFIIMEYCQYGNLFNYCYQ----

KKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQR----------------KHTNNLI-GLTALYSSPEQYQL
.....  . | .|.|. .|.  .| .||.|.|.|| |||.. | ||| .||| ||.   ..                || .    |.. .| ||||||.
NDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQM

Kinase 13026.AA Ciliate-E1 71-250 25 2.1e-28 89.72 In-house 1-199 (202) Show / Hide
Range on Protein: 71-250
Range on HMM: 1-199/202
Sequence Identity: 25% (52 aa)

LGSGGGGFVLKACSEWND----HLAVKLMK--YSNLEQLKINKREYDILKNIN-SKYVTKVYQFFTESYESNGYQFIVMERCLYDLKNYIA--------K
.|.|. ..|.|| ...|     .. . ...  |.  ......| .| |.| ..  .|. ......    ..|  . |..| | . ||.|.         .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIK--IDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

KITSKKFLSHQD-LYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRKHTNNLIGLTALYSSPEQYQ------LANTSVTH
.. ....  ... . ..  || .||.||||.||||.||||.|||   . . .|.|.|.||.  .. ... .  | |  |..||||.        |  ...
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINY

KV
|.
KS

Kinase 13026.AA Ciliate-B2 138-247 34 2e-25 56.66 In-house 76-185 (197) Show / Hide
Range on Protein: 138-247
Range on HMM: 76-185/197
Sequence Identity: 34% (39 aa)

QFIVMERCLYDLKNYIAKKITSKKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRKHTNNLIGLTALYSSPE
. ..||.| ..||. . |    .|    | || .  ||  || ... .||.||||||.|||.    . .| | |.| . ... .   .  |.|  | |||
DVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQI--KIKGFTKKYASPE

QYQLA--NTSVT
| .    .|.||
QMECDHNQTFVT

Kinase 13026.AA Ciliate-E3 100-245 32 1.5e-23 70.49 In-house 43-186 (202) Show / Hide
Range on Protein: 100-245
Range on HMM: 43-186/202
Sequence Identity: 32% (49 aa)

LEQLKINKREYDILKNINSKYVTKVYQFFTESYESNGYQFIVMERCLY-DLKNYIAKKITSKKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANIL
.||..    |    . |||..| |... .    . |   |||.| |   ||..||  .      .. . .| .| |. .|. ..|.||||| |||| |||
GEQFQKTQQEFQNCQQINSQNVVKCHDQYYD--QQNKMIFIVQEYCSNGDLYHYIK-QQN----KTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNIL

LGLDL---KWKYADLGVSKVVSEQRKHTNNL-IGLTALYSSPEQYQLANTS
..  .     | .|.| ||  .    ||  .  |.| .|..||| . .. |
VDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQIS

Kinase 13026.AA Ciliate-E2 65-240 20 2.2e-20 66.7 In-house 1-260 (365) Show / Hide
Range on Protein: 65-240
Range on HMM: 1-260/365
Sequence Identity: 20% (56 aa)

IIEKGLLGSGGGGFVLKACS------------------------EWNDHLAVKLMKYSNLEQLKINKREYD-------------ILKNINSKYVTKVYQF
..   ..|.|. | | |..                           .   |.| || ...||.|  ....              ||...|.... | | .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FTESYESNGYQFIVMERCLY-DLKNYIAKK---------------ITSKKFLSHQDLY-------YLCLQLSKGLQELHQKN-IIHLDIKPANILLGLDL
| |  ... . ..||| | . ||. || ..               .   |... | |.       . . .. ..|..||.|| ||| |||| |||.    
FQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

KWKYADLGVSKVVSEQRK------------------------------HTNNLIGLTALYSSPEQYQ
  | .|.| || ......                              .. | |  |. | .|| ..
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILN

Kinase 13026.AA Pkinase 65-237 24 2.3e-19 69.54 Pfam 1-181 (293) Show / Hide
Range on Protein: 65-237
Range on HMM: 1-181/293
Sequence Identity: 24% (47 aa)

IIEKGLLGSGGGGFVLKACSEWNDH-LAVKLMKYSNLEQ--LKINKR--EYDILKNINSKYVTKVYQFFTESYESNGYQFIVMERCLY-----DLKNYIA
.  .. .|||. | | |..   . .  ||| .|... .   .... |  |  |.|..|.... . | .|..    ...  .||| |       ||. || 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

KKITSKKFL--SHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKW----KYADLGVSKVVSEQRKHTNNLIGLTALYSSPE
    ... .  | ...   ..|. .||. .|...||| |.||.|||.  .       | .| |..|.... ... .. .  |  | .||
T--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE

Kinase 13026.AA CAMK 70-199 16 3.1e-18 54.7 In-house 1-212 (425) Show / Hide
Range on Protein: 70-199
Range on HMM: 1-212/425
Sequence Identity: 16% (36 aa)

LLGSGGGGFVLKACSE-WN------------DHLAVKLMKYS----------------------------NLEQLKINKREYDILKN-------INSKYV
 ||.|. | | ...    .             . |.| .. .                            . . .|  .||..|.|.       .. . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

TKVYQFFT---------ESYESNGY--------QFIVM---ERCLY-----DLKNYIAKK------------ITSKKFLSHQDLYYLCLQLSKGLQELHQ
 | |...          . ||.  .         ..||   | |       || .|| ..            . ... .. ..  ..  |.  ... .|.
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS

KNIIHLDIKPANILL
.||.|.|.|| ||||
HNIVHRDLKPENILL

Kinase 13026.AA CMGC 65-199 20 4.2e-18 55.2 In-house 1-217 (513) Show / Hide
Range on Protein: 65-199
Range on HMM: 1-217/513
Sequence Identity: 20% (44 aa)

IIEKGLLGSGGGGFVLKACS---------------EWNDHLAVKLMK--YSNLEQLK----------INKREYDILKNIN-----------------SKY
    . .|.|  | | |.                 |.| . |.| .|    . || |          .  ||  |||..|                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VTKVYQFFTESYES-------------NGYQFIVMERCLYDLKNYIAKKIT-----SKKFLSHQD------------LYYLC------LQLSKGLQ--EL
. | | .|. . .              . . ..|.| . .||..|| .. .      .. ||.                |.        |. .||    .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQKN--IIHLDIKPANILL
|...  ||| |.||.|||.
HSHWGNIIHRDLKPENILI

Kinase 13026.AA STE 66-237 23 1.7e-17 58.43 In-house 1-232 (359) Show / Hide
Range on Protein: 66-237
Range on HMM: 1-232/359
Sequence Identity: 23% (55 aa)

IEK-GLLGSGGGGFVLKACSEWND--H--------------LAVKLMKYSNL-----------------EQLKINKREYDILKNIN--SKYVTKVYQFFT
 |. . .|.|..| | ||.   |.  |               |.| |...|                  |...  ..| .|.|. |  .... | |  . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ESYES---NGYQFIVMERCL-YDLKNYIA-KKITSK---------KFLSHQDLYYLCLQLSKG-LQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSK
   .    ... .|.|| .    |   |  |... |         .... . . | | |. || |. ||...||| |||||||||      | .| ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VVSE----------------QRKHTNNLIGLTALYSSPE
 ...                . ...| ..|    . .||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPE

Kinase 13026.AA S_TKc 65-314 20 5.7e-16 57.32 SMART 1-231 (231) Show / Hide
Range on Protein: 65-314
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

IIEKGLLGSGGGGFVLKACSEW-NDHLAVKLMKYSNLEQLKINKREYDILKNINSKYVTKVYQFFTESYESNGYQFIVMERCLY---DLKNYIAKKITSK
     ..|.|. | | |.     . . |.| .|       .  .|| .|||. . ... | | .| .     .. ..||| |     ||. || |. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

KF--LSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQRKHTNNLIGLTALYSSPEQYQLANTSVTH-KVT------
.   ..  .  ... |. ..|. .|...||| |.||.||||      | .| |.....       . ..| |  | .||       . .. |.       
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCG-TPWYMAPEVL-----GYGKCKCDWWSCGC

--------KSLTGVDVTQKWIIKEKISAHNYDKCLNPYYEEFNNCIIKKMMQYEANDRLQIEEVID------VLKRL
        . .      |   . .||             .|. . .|.|..|.. ..|. . |.            .
ILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 13026.AA ULK 65-199 29 1.2e-15 51.23 In-house 1-163 (329) Show / Hide
Range on Protein: 65-199
Range on HMM: 1-163/329
Sequence Identity: 29% (49 aa)

IIEKGLLGSGGGGFVLKACSEWN-----DHLAVKLMKYSNLEQLKIN----------KREYDILKNIN----SKY----VTKVYQFFTESYESNGYQFIV
.. .  ||.|  | | |.  . .        |.| .  . . | . .          |.| .|.| ..    .|.    . | | .| .| . | . .|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-N-NIYII

MERCLY-DLKNYIAKKIT------SKKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILL
|| |   ||..|| |. .       ||.|| |     . |.  |..|||..|||| ||||.|||.
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILI

Kinase 13026.AA Ciliate-A1 279-314 44 5.9e-09 26.56 In-house 267-301 (301) Show / Hide
Range on Protein: 279-314
Range on HMM: 267-301/301
Sequence Identity: 44% (16 aa)

NPYYEEFNNCIIKKMMQYEANDRLQIEEVIDVLKRL
.| .|| .| .|.|||||| | |.. ...|| |. .
EPRFEELQN-LIFKMMQYEPNNRCSLQQCIDCLYIF

Kinase 13026.AA TyrKc 65-311 19 1.7e-07 -101.47 SMART 1-280 (280) Show / Hide
Range on Protein: 65-311
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

IIEKGLLGSGGGGFVLKACSEWNDHLAVKLMKYSNLEQLKINKREYDILKNI--NSKYVTKVYQFFTES---YESNGYQFIVMERCLY-DLKNYIAKKIT
|  .  ||.|  | | |.        ||| .| .   .  .  ||  |....  . . . . |   |..   . . .  .|||| . . |||.|. |.  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SKKFLSHQDLYYLCLQLSKGLQELHQKNIIHLDIKPANILLGLDLKWKYADLGVSKVVSEQ--------RKHTN---NLIG-LTALYSSPEQYQLA----
    |...|| . |.| ..| . ||.||.|| |.   |.|.| ..  | .| | |. . .          ...    .  . |     .||  .      
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

----------------NTSVTHKV---TKSLTGVDVTQKWIIKEKISAHNYDK------CLNPYYEEFNNCIIKKMMQYEANDRLQIEEVIDVL
                .    .        ..  .| ..    .      .|       |    |      |.|.  .....||   .|... .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMY-----QIMKQCWHEDPEDRPTFSEIHECF

Kinase 13026.AA Pkinase_Tyr 108-189 34 0.000785 13.6 Pfam 52-134 (270) Show / Hide
Range on Protein: 108-189
Range on HMM: 52-134/270
Sequence Identity: 34% (29 aa)

REYDILKNI-NSKYVTKVYQFFTESYESNGYQFIVMERCLY-DLKNYIAKKITSKKFLSHQDLYYLCLQLSKGLQELHQKNIIH
||  |.|.. . . . . |   |.  |.| . .|||| . . ||..|  |. ..|. |...||   |.| .||.. |..||.||
REAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH

Kinase 13026.AA ULK 289-309 38 0.018888 4.47 In-house 305-325 (329) Show / Hide
Range on Protein: 289-309
Range on HMM: 305-325/329
Sequence Identity: 38% (8 aa)

IIKKMMQYEANDRLQIEEVID
.|..|.||. .||  .||...
LIRRMLQYDEKDRISWEELFN