Gene 13033 (Tetrahymena)

13033

Species: Tetrahymena
Alias: 4.m00432, PreTt13033, 455, TTHERM_00058480, 3707.m00077, 13033
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E5

Sequence

Name Sequence Type Origin Length Description Download
13033.AA Protein None 495 None Fasta, JSON
13033.kin_dom Protein Kinase Domain None 208 None Fasta, JSON
13033.NA RNA None 1488 None Fasta, JSON

Protein domain

Protein domains of 13033.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13033.AA Ciliate-E5 55-262 40 6.00000000001e-132 431.86 In-house 1-271 (271) Show / Hide 
Range on Protein: 55-262
Range on HMM: 1-271/271
Sequence Identity: 40% (109 aa)

LISDQELGRGGSGIVLSGEKMD-RQPIAIKIVKCIKRGQVEGMVKEFNILKSIQSTHVVEAYDLLQYESPNINILITIMDKCECNLTTYLRSIRYQFEKQ
.|..|.||.||||.|..|.... ..||||||.||....|.|....||||||...|.|....|...||...|.|....||..|.|.|.|||..|.||.. .
IIENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMK-W

QYEEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMMGRDKLWKFIDMGIS---------VRLEEQ----------------------------------
|....||.||.||.|||.|||..||.||||||.||..|.|..||.||||||         ....||                                  
QKHQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKN

---------HFISSFGLTQLYSSPEQFKCYMANMQKS-----------SSVKQQINKQSDIYSLGLVFLEMT
         |.....|.||.||||||..||...|...           .|.|..|.|||||||||.||||.|
RKKLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQSDIYSLGIVFLELT
Kinase 13033.AA Ciliate-B2 54-255 33 4.7e-50 115.87 In-house 1-197 (197) Show / Hide 
Range on Protein: 54-255
Range on HMM: 1-197/197
Sequence Identity: 33% (70 aa)

YLISDQELGRGGSGIVLSGEKMDR----QPIAIKIVKCIKRGQVEGMVKEFNILKSIQ-STHVVEAYDLLQYESPNINILITIMDKCECNLTTYLRSIRY
| . .  ...|| |.. .| |.      | .|.||    . .. | . .| .|.|. . . .||.  | .| .. .|..|  ||.|||| |   |  |  
YYLCKY-INKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINE-TIDVL--IMEKCECSLKQELQKIQK

QFEKQQYEEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMMGRDKLWKFIDMGISVRLEEQHFISSFGLTQLYSSPEQFKCYMANMQKSSSVKQQINKQ
|  |.  ..|.| .  ||| ||  ... |||||||||.|| . .    .. | |||   ...  |.  |.|. | |||| .|      .....  .|. |
Q-QKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECD-----HNQTFVTNIDFQ

SDIYSLG
|||||.|
SDIYSMG
Kinase 13033.AA Ciliate-A1 55-325 25 2.1e-36 121.45 In-house 1-301 (301) Show / Hide 
Range on Protein: 55-325
Range on HMM: 1-301/301
Sequence Identity: 25% (78 aa)

LISDQELGRGGSGIVLSGEKMDRQP--IAIKIVKCIKRGQVEGMVKEFNILKSIQSTHVVEAYDLLQYESPNINILITIMDKCECNLTTYLRSIRYQFEK
    | .. |. |.|.  . .. |   ...||..|    |    . |. ..| | .  |.  |..|.|.  |  .   || .|. ..         .. .
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGN-------LFNYCY

QQY---EEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMMGRDKLWKFIDMGISVRLEEQH-------------------FISSFGLTQLYSSPEQFKC
|     .| ||||| |.|.|. |||. ||||.|.|| ||... |. ||..|.|.|  || .                       . |.. .| ||||.. 
QNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQM

YM-ANMQKSSSVKQQINKQSDIYSLGLVFLEMTG-----------VNMDKNIIMQVK--QNQPAAEGLKGIQLNSQF-NKFN--TNVILQMVQFNQESRL
..   | .    .  | ||||.||||..... ..           ||.  | .   .      .   .| |   . . ..|    |.| .| | . . |.
HYRDQMFI----ENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYEPNNRC

NTEYIDKQLQSL
  . .  .|  .
SLQQCIDCLYIF
Kinase 13033.AA Ciliate-E1 61-252 27 3.7e-31 98.8 In-house 1-202 (202) Show / Hide 
Range on Protein: 61-252
Range on HMM: 1-202/202
Sequence Identity: 27% (58 aa)

LGRGGSGIVLSG--EKMDRQPIAIKIVKCI---KRGQVEGMVKEFN-ILKSIQSTH-VVEAYDLLQYESPNINILITIMDKCECNLTTYLR--------S
.|.|...||. .  ..   . .|.||..|.   .  . .   || . |.| ...   ... .| .. .  ...| | |...|.|.|. ||.         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKID--QNYICIIIFECCCCSLKDYLQNHNRLEYWQ

IRYQFEKQQYEEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMMGRDKLWKFIDMGISV--RLEEQHFISSFGLTQLYSSPEQFKCYMANMQKSSSVKQ
.  | ..| ..... .|  |||.||...|. ||.|.||||.||   ...  .. | |||    ..... .  .| |. |..|||   |. ..| .   .|
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQ---YNCPEQ-EHNKNQ

QINKQSDIY
.||..||||
KINYKSDIY
Kinase 13033.AA Ciliate-E3 54-262 30 8.8e-27 80.74 In-house 1-202 (202) Show / Hide 
Range on Protein: 54-262
Range on HMM: 1-202/202
Sequence Identity: 30% (69 aa)

YLISDQELGRGGSGIVLSG-EKMDRQPIAIKIVKCIKRGQ------VEGMVKEFNILKSIQSTHVVEAYDLLQYESPNINILITIMDKCEC-NLTTYLRS
|..... || |. |.|  .      | .|||   | .         .  . .||.  ..| | .||. .| . |   | .| | ... |.  .|..|   
YTVQQI-LGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQY-YDQQNKMIFI-VQEYCSNGDLYHY---

IRYQFEKQQYEEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMMGRDK---LWKFIDMGISVRLEEQH-FISSF--GLTQLYSSPEQFKCYMANMQKSS
|. | .|.| .  ||.|| |.|.|. .||. || | ||||.||  .  .     |. | | |  |      .. .  |.| .|..||| .          
IK-QQNKTQNI--IYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQND----------

SVKQQINKQSDIYSLGLVFLEMT
  .||| | ||.||.| ||... 
--QQQISKESDYYSVGAVFCQLC
Kinase 13033.AA STE 55-261 18 6.8e-21 70.6 In-house 1-261 (359) Show / Hide 
Range on Protein: 55-261
Range on HMM: 1-261/359
Sequence Identity: 18% (52 aa)

LISDQELGRGGSGIVLSGEKMD----------------RQPIAIKIVKCIKRG-----------------QVEGMVKEFNILKSIQ--STHVVEAYDLLQ
.   ...|.|..| |  . ...                 . .|||...  .                   ...   || .|.|  .  . ..|. |.   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YESPN--I-NILITIMDKCEC-NLTTYLRSI-RYQFEKQQY--------EEKIYEICRQLIKG-LNDIHSANILHLDIKPSNIMMGRDKLWKFIDMGISV
.|..|    . |  .|  ..   |.  ...    ... ..         |. |  ||||..|| |. .|| .| | ||||.||..      | .| |.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

RLEE------------------QHFISSFGLTQLYSSPEQFKCYMANMQKSSSVKQQINKQSDIYSLGLVFLEM
.|..                  |.  .  |    . .||  ..   .       ... . ..||.|||.. .||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQG-R-----DKGYDTKCDIWSLGCTIIEM
Kinase 13033.AA S_TKc 55-327 18 8.2e-20 73.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-327
Range on HMM: 1-231/231
Sequence Identity: 18% (54 aa)

LISDQELGRGGSGIVLSGEKMD-RQPIAIKIVKCIKRGQVEGMVKEFNILKSIQSTHVVEAYDLLQYESPNINILITIMDKCEC---NLTTYLRSIRYQF
    ...|.|. | |  . . .  .  ||||.|       | . .| .|||. .  ..|  ||  |      . |  .|. |.    .| .|... ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

EKQQYEEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMMGRDKLWKFIDMGISVRLEEQHFISSFGLTQLYSSPEQFKCYMANMQKSSSVKQQINK-QS
 .... | .  ...|....|. .|| .|.| |.||.||.. .    | .| |.. .|      ..|  |  | .|| .               . .|  .
LRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---------------GYGKCKC

DIYSLGLVFLEMTG----VNMDKNIIMQVKQNQPAAEGLKGIQLNSQFNKFNTNVILQMVQFNQESRLNTEYIDK----QLQSLYL
|..|.| .. ||         . . ....                     .    | .. |.. | |.    . .      .  ..
DWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13033.AA CMGC 55-190 14 1.5e-16 49.99 In-house 1-217 (513) Show / Hide 
Range on Protein: 55-190
Range on HMM: 1-217/513
Sequence Identity: 14% (32 aa)

LISDQELGRGGSGIVLSGEKMDR---------------QPIAIKIVKCIKRGQVEGM------------VKEFNILKSIQ-----------------STH
   .. .|.|  |.| ..   ..               . .|||..|  .  . ..               |  ||| ..                   .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVEAYDLLQYESPN-------------INILITIMDKCECNLTTYLRSIRY--------QFEKQQ----------YEEKIYE----ICRQLIKGLN--DI
.|  || .... ..              | |  ... ....|  |... .          ..  .          .  | .     ...|...||.   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--ILHLDIKPSNIMM
||..  |.| |.||.||..
HSHWGNIIHRDLKPENILI
Kinase 13033.AA Pkinase 55-261 21 1.9e-16 59.2 Pfam 1-205 (293) Show / Hide 
Range on Protein: 55-261
Range on HMM: 1-205/293
Sequence Identity: 21% (49 aa)

LISDQELGRGGSGIVLSGEKMDR-QPIAIKIVKCIKRGQVEGMVK------EFNILKSIQSTHVVEAYDLLQYESPNINILITIMDKCEC-----NLTTY
.   . .|.|..| |  . . .  .  |.||.|  ||.. ... .      |  |.|.... ..|. ||  .. ...| .   .|. ||.      | .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK--KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYM---VMEYCEGGLYVMDLFDY

LRSIRYQFEKQQ--YEEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMMGRDKLW----KFIDMGISVR--LEEQHFISSFGLTQLYSSPEQFKCYMAN
..    . ..     |. .  ...|...||. .|| .|.| |.||.||.. ..       | .| |..    .  ..  ..|  |  | .||  .     
IST---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----

MQKSSSVKQQINKQSDIYSLGLVFLEM
        | . . .|..|.|... ||
------GGQYYGPKVDMWSCGCILYEM
Kinase 13033.AA Ciliate-C8 64-258 24 2e-16 55.61 In-house 1-238 (238) Show / Hide 
Range on Protein: 64-258
Range on HMM: 1-238/238
Sequence Identity: 24% (59 aa)

GGSGIVLS-GEKMDRQPIAIKIVKCIKRGQVEG----MVKEFNILKSIQSTHVVEAYD--LLQYESPNIN-----------------ILITIMDKCE--C
|. |.||.   |   . .|.|...| .  |  .     ...  | .  |.  ||. ||   |. |                           | ||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLTTYLRSIRYQFEKQQYEEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMMGRD-------KLWK-----FIDMGISVRLEEQHFISSF--GLTQL--
|| .|.   | .    . ..|. .|  | | ..| .|  ||.| ||||.|.    |       || .       .    .. .. |..|.   |  |   
NLKQYFDRCRKKQSYPSQQMKE-IIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIE

--------YSSPEQFKCYMANMQKSSSVKQQINKQSDIYSLGLVF
        |. ||. |    .  .  | |      ||.||.|||.
MYFCGNWGYFAPEVEKKQSRIQSDIFSKK------SDSYSVGLVL
Kinase 13033.AA Ciliate-E2-Unclassified 54-261 20 1.8e-15 50.13 In-house 1-263 (352) Show / Hide 
Range on Protein: 54-261
Range on HMM: 1-263/352
Sequence Identity: 20% (56 aa)

YLISDQELGRGGSGIVLSGEKMDRQPIA-----IKIVKCIKRGQVEGM---------VKEFN-------------ILKSIQSTHVVEAYDLLQYESPNIN
| |  . .|.|| |.|   .. . .  .     .| .. .|. |.. .         ... .             ||..... ..|  ..  | .    |
YKI-IKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDK---QN

ILITIMDKCE-CNLTTYLRSI-----------RYQFEKQQY-EEKIY-----EICRQLIKGLNDIHSAN-ILHLDIKPSNIMMGRDK---LWKFIDMGIS
| | .|..||  .|  |...            . . ....  |...       ...|...||. .|. | |.| ||||.||..  ..     | || |||
IYI-VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

VRLEE----------------QHFISSFGLTQLYS----SPEQFKCYMANMQKSSSVKQQINKQSDIYSLGLVFLEM
 ....                |. ...|  |  |     .|| ..    . .|.        ...||.||| .. ||
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA--------YKCDIWSLGVILYEM
Kinase 13033.AA ULK 55-190 24 6.3e-15 49.46 In-house 1-159 (324) Show / Hide 
Range on Protein: 55-190
Range on HMM: 1-159/324
Sequence Identity: 24% (40 aa)

LISDQELGRGGSG-IVLSGEKMDR----QPIAIKIVK---CIKRGQV-------EGMVKEFNILKSIQ---STH--VVEAYDLLQYESPNI-NILITIMD
 . ...|| |  |  |  |....     | .|.|..     .|  .        .   .| .|.| .    . .  .|. ||   .|..|  || | ||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDW--FETSNHNNIYI-IME

KCEC-NLTTYLRSIRYQ----FEKQQYEEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMM
 |.. .| .|.   ...    ..|   |... ....|.. |. ..|. || | ||||.||..
YCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI
Kinase 13033.AA TyrKc 55-322 18 2e-06 -119.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-322
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

LISDQELGRGGSGIVLSGEKMDRQPIAIKIVKCIKRGQVEGMVKEFNILKSI--QSTHVVEAYDLLQYES------PNINILITIMDKCECNLTTYLRSI
.  ...||.|  |.|  |.    .. |.| .|  .   .| . .| .|....  .  ..|  |     ..      . . |.   |..   .|  |||. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLRKH

RYQFEKQQYEEKIYEICRQLIKGLNDIHSANILHLDIKPSNIMMGRDKLWKFIDMGISVRLEEQ--------HFISSF--GLTQL----YSSPEQFKCYM
| .       ..  ..| |  .| . .|| |. | |.   |.. |...  |  | | |  ...            ..   |   .      .|| .    
RPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

ANMQKSSSVKQQINKQSDIYSLGLVFLEMT--GVNMDKNIIMQVKQNQPAAEGLKGIQLNSQFNK--------FNTNVILQMVQFNQE---SRLNTEYID
         .   . .||..| | .  |.   |     ..| |.. || . | .|      |             . .   | |  .|   .| . . | 
--------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

KQL
...
ECF
Kinase 13033.AA ULK 242-261 38 0.034055 3.66 In-house 225-245 (324) Show / Hide 
Range on Protein: 242-261
Range on HMM: 225-245/324
Sequence Identity: 38% (8 aa)

KQQIN-KQSDIYSLGLVFLEM
... . . .||.||| .| ||
QKPYYDYKCDIWSLGCIFYEM