17883

Species: Tetrahymena
Alias: TTHERM_01083090, 17883, PreTt17883, 805, 224.m00053
External Links: Tetrahymena Genome Database (TGD) ,
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
17883.AA Protein None 422 None Fasta, JSON
17883.kin_dom Protein Kinase Domain None 283 None Fasta, JSON
17883.NA RNA None 1269 None Fasta, JSON

Protein domain

Protein domains of 17883.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17883.AA Ciliate-E7 51-333 59 4.4e-217 727.46 In-house 1-290 (290) Show / Hide
Range on Protein: 51-333
Range on HMM: 1-290/290
Sequence Identity: 59% (172 aa)

YQILRLIWRDTNISFCLAAIDREYGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQHENIN-SNLHIMMESKNLYIVKELMDINLKDVTFSRQELTDEH
|||.|.||.||.|.||.|.|||||.||.||..|..|.|.|||||.||...|..||..||.|. .|.|..||..|.|.|...|..|||..|.|||.|||||
YQIKREIWYDTYIYFCKAYIDREYQQKQFIYYIFYEQCYLKYIIKAIEIQKFLNHENHEKIYNFNFHSYMEINNMYVVSDFMQTNLKYITQSRQQLTDEH

IKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGFIH--SNFPHEVN--YYNKKGYYPPQRILELPENLSKTDIWHVGVIILQLLYGYPFFE
||||.||||.||...|||..|||.||.|.|....|||.||..||.  .|||||.|  |.||..|..|..|.|..|..|||||||||.|.|.|...|.||.
IKWFMYQILRALHYIHSQKIYHTQLTPRFIQINQNCDIKISDFIWCIGNFPHEINKKYINKNYYMSPYYIVEQMETFSKTDIWHVGCIFLELIQRYKFFS

KRNRGGRNGVLQAYFYSIGSPSEE--DLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF
.......|||...|||..||..||  ||..||.|..||.|||...||||.|||.|||||||||||||||||||||||||..|||..||||
DFCCHDYNGVITQYFYFCGSQNEEDLDLKYYKQYNRQYNQLKMPKQYCKQSWQVQFPNANPLLCDLLDKMLVFNEDKRFNVKECLQHPYF

Kinase 17883.AA ERK 68-333 36 1e-71 244.6 In-house 17-307 (307) Show / Hide
Range on Protein: 68-333
Range on HMM: 17-307/307
Sequence Identity: 36% (108 aa)

AAIDRE-----YGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQ-HENINSNLHIMMES-----KNLYIVKELMDINLKDVTFSRQELTDEHIKWFVYQ
.||| |      |||| ||.|. .   ..| ....| ||...||  |||| ....|||..     ...|.| |||.. |  . .|.|||.|.|.. |.||
SAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQELSDDHCQYFMYQ

ILKALNFLHSQNVYHTELTARDILLKENCDLKITGFIHSNFPH-EVNYYNKKG-------------YYPPQRILELPENLSKTDIWHVGVIILQLLYGYP
|| .| ..||.||.|. |  . ||. .||||||  |. ..... ...   . .             | .|. .| .... ...|||..|.|.  .| . |
ILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE-CNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKP

FFEKRNRGGRNGV--LQAYFYSIGSP-SEEDLSQYKDYTEQYEQLKSLNQ--YCKKSWQDQFPNAN--PLLCDLLDKMLVFNEDKRFSLKECFLHPYF
.|.     |.. |  ... |  ||.| ||||| ||... . .. .|.|.   . .|.|.. |||||  |. .|||.|||||..||| . .||  ||||
LFP-----GKDYVHQINRIFQIIGTPHSEEDL-QYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF

Kinase 17883.AA MAPK 68-189 38 1.2e-28 96.03 In-house 17-158 (328) Show / Hide
Range on Protein: 68-189
Range on HMM: 17-158/328
Sequence Identity: 38% (54 aa)

AAIDRE------YGQKVFIKVIKLEECILKYIIQAIRSIKIENHF-QHENINSNLHIMMES-----------KNLYIVKELMDINLKDVTFSRQELTDEH
.|||..      .|.|| || |      . .   ..| ||. .|| .|||| . |.|.. .           . .||| |||. .|  .  |.|.|.|.|
SAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQPLSDDH

IKWFVYQILKA--LNFLHSQNVYHTELTARDILLKENCDLKI
|. |.||||..  | ..|| || |  |    ||. |||||||
IQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKI

Kinase 17883.AA MAPK 215-333 33 1e-24 82.25 In-house 203-328 (328) Show / Hide
Range on Protein: 215-333
Range on HMM: 203-328/328
Sequence Identity: 33% (44 aa)

ILE--LPENLSKTDIWHVGVIILQLLY-GYPFFEKRNRGGRNGV--LQAYFYSIGSPSEEDLSQYK--DYTEQYEQLKSL---NQYCKKSWQDQFPN---
.|   . ..  . |.|.|| |   .|  . |.|      |.. .  ..  .  .|.||||.... .  .   .|  ..||    .| ||.|.. |||   
MLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP-----GKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNY--IQSLGNLPKYPKKPWEKMFPNANF

-ANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF
 |||. .|||.|||||. ||| . .|.  ||||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase 17883.AA ERK5 51-192 36 3.8e-22 77.84 In-house 1-147 (295) Show / Hide
Range on Protein: 51-192
Range on HMM: 1-147/295
Sequence Identity: 36% (54 aa)

YQILRLIWRDTNISFCLAAIDREYGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQHENINSNLHIMM------ESKNLYIVKELMDINLKDVTFSRQE
|.|.  |        | .|. |  ||.| || |      .      .| .||  ||.|.||     |.|      | |. |.| .||.  |  .  | | 
YKIIEKIGNGAYGVVC-SARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQP

LTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGF
.| |||..|.||||. | ..|| .| | .|    .|  |||.|||  |
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDF

Kinase 17883.AA nmo 98-192 37 2e-21 62.08 In-house 47-146 (292) Show / Hide
Range on Protein: 98-192
Range on HMM: 47-146/292
Sequence Identity: 37% (37 aa)

RSIKIENHFQHENINSNLHIMMESKN-----LYIVKELMDINLKDVTFSRQELTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGF
| .|.   |.|.|. | | |.   .      .|.| |||   |  .  | |.|. .|.| |.||||. | .||| |. | ..   ..|.  || |||  |
RELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDF





Kinase 17883.AA CMGC 226-333 17 2.8e-20 62.49 In-house 317-513 (513) Show / Hide
Range on Protein: 226-333
Range on HMM: 317-513/513
Sequence Identity: 17% (35 aa)

DIWHVGVIILQLLYG--------YPFFE---------KRNRGGRNGVLQAYFYSIGSPS---------------EEDLSQYKD-----------------
|.| || |.  .. |        .|.|          | |       |.  |  .|.|.               ||.  ....                 
DMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDK-NGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMT

---YTEQYEQLKS---LNQYCKKSWQDQFPN-----------------------------------ANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF
   .  .. ...|   . .. .|.|...||.                                   ..|.. |||.|||... ||| . ...  ||||
NHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase 17883.AA ERK1 51-192 35 9.8e-17 59.25 In-house 1-144 (289) Show / Hide
Range on Protein: 51-192
Range on HMM: 1-144/289
Sequence Identity: 35% (52 aa)

YQILRLIWRDTNISFCLAAIDREYGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQHENINSNLHIMMES-----KNLYIVKELMDINLKDVTFSRQEL
|  |. |  .   ... .|.|.  .|.| || |   |    |    .| ||| . |.||||     |.  .     . .|||..||.  |  .    |.|
YTNLQYI-GEGAYGMVCSAYDTVHKQRVAIKKISPFEHQT-YCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKL-LKTQHL

TDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGF
  .|| .|.||||. | ..|| || | .|    .||   |||||  |
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF

Kinase 17883.AA CMGC 69-192 20 1e-16 50.55 In-house 18-248 (513) Show / Hide
Range on Protein: 69-192
Range on HMM: 18-248/513
Sequence Identity: 20% (47 aa)

AID--------------REYGQKVFIKVIKLEECILKYII----------QAIRSIKIENHFQ-----------------HENINSNLHIMMESK-----
..|              .|....| || ||...                  |.| |||  |..                 |.|| . . | . ..     
CRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNE

------------NLYIVKELMDINLKDVTFSRQ---------ELTDEH------------IKWFV------YQILKALN--FLHSQN--VYHTELTARDI
            .||.| |.|| .|...  . |         .|.. |            || |.      ||||..|.  ..||..  . |. |    |
YEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENI

LLKENCDL--------------------KITGF
|. .||.|                    ||  |
LINHNCELITRMMWKSEDWNPCQKNGRLKICDF

Kinase 17883.AA S_TKc 51-333 22 4.5e-16 58.76 SMART 1-231 (231) Show / Hide
Range on Protein: 51-333
Range on HMM: 1-231/231
Sequence Identity: 22% (69 aa)

YQILRLIWRDTNISFCLAAIDREYGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQHENINSNLHIMMESKNLYIVKELMDI---NLKDVTFSRQE---
|.|||.|      . .  ..... |..| ||.||         ....| |.|  . .|.||   . .. . ..||.| |..|    .|.|.  .|.    
YEILRKI-GKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGFIHSNFPHEVNYYNKKG---YYPPQRILELPENLS-KTDIWHVGVIILQL
   ..  |.. ..|||..||...||... |  |    ||| |   .||. |  . .      .   |   | .|  .         | |.| .|.|.  .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

LYGYPFFEKRNRGGRNGVLQAYFYSIGSPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFL-------H
|.||| |.          .|. |  ||                                       | ..|...|.|... .|| .  |..        |
LCGYPPFP---------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PYF
|.|
PWF

Kinase 17883.AA p38 284-333 40 2.5e-14 45.08 In-house 240-289 (289) Show / Hide
Range on Protein: 284-333
Range on HMM: 240-289/289
Sequence Identity: 40% (20 aa)

LKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF
..|. |. ..  .. |..|||.  |||.|||.  .||| . .|   ||||
IQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF

Kinase 17883.AA p38 118-189 34 2.7e-13 41.49 In-house 77-147 (289) Show / Hide
Range on Protein: 118-189
Range on HMM: 77-147/289
Sequence Identity: 34% (25 aa)

MMESKNLYIVKELMDINLKDVTFSRQELTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKI
|.. .. |.| ..|.  |. .    | |.|.||.  |||||..| . || .. |  |    | . |.|.|.|
MNDFQDVYMVTHFMGADLNNI-MKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRI

Kinase 17883.AA ERK1 226-333 37 2.8e-13 46.12 In-house 186-289 (289) Show / Hide
Range on Protein: 226-333
Range on HMM: 186-289/289
Sequence Identity: 37% (41 aa)

DIWHVGVIILQLLYGYPFFE-KRNRGGRNGVLQAYFYSIGSPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSL
||| || |.  .|   | |  |      | .|      .||||..||          . |.||    | .|.  ||.| .   ||||||| || .||  .
DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGV----LGSPSQDDLNCIIN-EKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITV

KECFLHPYF
 |   ||| 
EEALAHPYL

Kinase 17883.AA MAPK-Unclassified 122-189 31 1.4e-12 41.28 In-house 79-150 (575) Show / Hide
Range on Protein: 122-189
Range on HMM: 79-150/575
Sequence Identity: 31% (23 aa)

KNLYIVKELMDI---NLKDVTFSRQ-ELTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKI
. .||| ..| .   .|. .  |.|  . ..||. | ||||. |  ||| .. |  |    .|. ..| ..|
DDIYIVMDYMQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRI

Kinase 17883.AA ERK7 107-192 31 5.2e-12 37.05 In-house 57-144 (292) Show / Hide
Range on Protein: 107-192
Range on HMM: 57-144/292
Sequence Identity: 31% (28 aa)

QHENINSNLHIMMESKN--LYIVKELMDINLKDVTFSRQELTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGF
.|.|| . . ..  . .  .|.| | |.  |  |    . | | | .  .||.|.|. ..|| || |  | .  |||  .| .|.  |
CHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDF

Kinase 17883.AA Pkinase 69-171 21 2.1e-11 41.4 Pfam 18-131 (293) Show / Hide
Range on Protein: 69-171
Range on HMM: 18-131/293
Sequence Identity: 21% (25 aa)

AIDREYGQKVFIKVIKLEECILKYIIQAIR--SIKIENHFQHENINSNLHIMMESKNLYIVKELMDI-----NLKDVTF--SRQEL--TDEHIKWFVYQI
.... .|..| .|.||...   .  ....|   |.| ....|.||   ..........|.| |...       |.|.    ..  .  .....| ..|||
CHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQI

LKALNFLHSQNVYH
|..|...||... |
LRGLEYCHSMGIIH

Kinase 17883.AA ERK7 226-333 28 2.3e-10 31.32 In-house 189-292 (292) Show / Hide
Range on Protein: 226-333
Range on HMM: 189-292/292
Sequence Identity: 28% (31 aa)

DIWHVGVIILQLLYGYPFFEKRNRGGRNGVLQ--AYFYSIGSPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFS
| | .| |. ..| | | |      |   . |      .|. |..||.   .        |...||  .|. .. .|.. .   ||| ..|||| .|| .
DMWSIGCILGEMLRGKPMFP-----GTSTMNQIEKILETIPKPTQEDIEAIGSHY-AWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLT

LKECFLHPYF
 ...  ||| 
AEQALQHPYV

Kinase 17883.AA Pkinase 223-333 17 2.7e-10 37.51 Pfam 191-293 (293) Show / Hide
Range on Protein: 223-333
Range on HMM: 191-293/293
Sequence Identity: 17% (20 aa)

SKTDIWHVGVIILQLLYGYPFFEKR-NRGGRNGVLQAYFYSIG----SPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFN
.| |.| .|.|. ..| |.| |  . .  . .  .| ..   |    ...... | . ..  .. . .       .  .   .|... ..|.....| ..
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------F-HWTF-HNWSEECKDFIKWCLCKD

EDKRFSLKECFLHPYF
  || . .... ||.|
PKKRPTAEQILQHPWF

Kinase 17883.AA nmo 308-333 50 8.6e-09 22.52 In-house 267-292 (292) Show / Hide
Range on Protein: 308-333
Range on HMM: 267-292/292
Sequence Identity: 50% (13 aa)

DLLDKMLVFNEDKRFSLKECFLHPYF
.|| .||.|. ||| | |.   ||| 
HLLCRMLHFDPDKRISCKDALAHPYL

Kinase 17883.AA MAPK-Unclassified 290-333 38 1.2e-08 26.83 In-house 532-575 (575) Show / Hide
Range on Protein: 290-333
Range on HMM: 532-575/575
Sequence Identity: 38% (17 aa)

YCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF
.|| .  ||    |..  |...|||.||  ||..  .  .||||
FCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF

Kinase 17883.AA TyrKc 63-333 16 8e-06 -128.68 SMART 1-280 (280) Show / Hide
Range on Protein: 63-333
Range on HMM: 1-280/280
Sequence Identity: 16% (56 aa)

ISF------------CLAAIDREYGQKVFIKVIKLEECILKYIIQAIRS-IKIENHF--QHENINSNLHIMMES-------KNLYIVKELMD-INLKDVT
|..            ...  .    ..| .|..| .       ...... ..|  ..  .|.||   . . ...       . |.|| |.|.  .|||  
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

FSRQE-LTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGFIHSNFPHEVNYYNK------KGYYPPQR--ILE--LP------ENL
 .... |. ..   | .|| .  ..|||.|. |  | || .|..||   ||. |  |      . |..      | || ..        ||      | .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS-----RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

------SKTDIWHVGVII-------LQLLYG-----YPFFEKRNRGGRNGVLQAYFY----SIGSPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFP
      .|.|.|  || .        |  .|      . .| ...  . . .    .    |                                    |.
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------FV

NANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF
 . . . ..  .   .. ..| . .|.  | .|
CCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 17883.AA ERK5 293-333 31 1.9e-05 15.78 In-house 255-295 (295) Show / Hide
Range on Protein: 293-333
Range on HMM: 255-295/295
Sequence Identity: 31% (13 aa)

KSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF
| |.  .| | .   ||| .||.|   .| .  .   ||. 
KDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL