27893

Species: Tetrahymena
Alias: 3720.m00060, 74.m00170, PreTt27893, TTHERM_00561320, 27893, 369
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E7

Sequence

Name Sequence Type Origin Length Description Download
27893.AA Protein None 387 None Fasta, JSON
27893.kin_dom Protein Kinase Domain None 244 None Fasta, JSON
27893.NA RNA None 1164 None Fasta, JSON

Protein domain

Protein domains of 27893.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27893.AA Ciliate-E7 59-343 60 1.1e-198 666.38 In-house 1-290 (290) Show / Hide
Range on Protein: 59-343
Range on HMM: 1-290/290
Sequence Identity: 60% (177 aa)

YDLKKQTNDYNASYKCKAYDNKSHQDVFIYYYITFAQYDIYYLKQILKAIEIQKFLNHENIEKIYNFDIISYPEINKMYVVSDFMQTNLSFITQSQQQLT
| .|.        |.||||.....|.. . ||| . |   .|||.|.|||||||||||||.||||||...||.|||.||||||||||||..||||.||||
YQIKREIWYDTYIYFCKAYIDREYQQKQFIYYIFYEQ---CYLKYIIKAIEIQKFLNHENHEKIYNFNFHSYMEINNMYVVSDFMQTNLKYITQSRQQLT

DEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSIKISEFTSCVGNQNQKIRS-YIHKNYYMSPEYIVEKIITE-KSDIWSAGCIFAELINRVK
||||..||||||||||||||.||....|.|||||||..|.||||.|..|.||....|.. ||.|||||||.||||...|. |.|||..||||.|||.|.|
DEHIKWFMYQILRALHYIHSQKIYHTQLTPRFIQINQNCDIKISDFIWCIGNFPHEINKKYINKNYYMSPYYIVEQMETFSKTDIWHVGCIFLELIQRYK

LFSG---HDDFTAITQILQFCGEQNEE--DLKFYKQINREKLSTLMPKEEQIS-LQVRFPNANPLALDLLGKMLTFNLEKRFNALECLQHEYL
.||.   ||....|||...|||.||||  |||.|||.||......|||..... .||.|||||||..|||.|||.||..||||..|||||.|.
FFSDFCCHDYNGVITQYFYFCGSQNEEDLDLKYYKQYNRQYNQLKMPKQYCKQSWQVQFPNANPLLCDLLDKMLVFNEDKRFNVKECLQHPYF

Kinase 27893.AA p38 132-343 37 5.4e-47 158.52 In-house 79-289 (289) Show / Hide
Range on Protein: 132-343
Range on HMM: 79-289/289
Sequence Identity: 37% (80 aa)

EINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSIKISEFTSCVGNQNQKIRSYIHKNYYMSPEYIV
...  |.|. ||.. |. |  .|. |.|.||||  |||||.| ||||| |.   | |  | .| || ..|  |      . ...  |.    | .|| . 
DFQDVYMVTHFMGADLNNIMKCQR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-HCDDEMTGYVATRWYRAPEIML

EKII-TEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINREKLSTLM---PKEEQISLQVRFPNANPLALDLLGKMLTFN
 ..  |.. |||| ||| |||| .  || | |    ...|.. ||   ||   | . |. |.  . .   |. ..  ..  |..|||.|.||| |||   
NWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEE---FWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELD

LEKRFNALECLQHEYL
 .||  | | .||.|.
PDKRITAEEAMQHPYF

Kinase 27893.AA nmo 102-343 29 1.1e-41 125.52 In-house 43-292 (292) Show / Hide
Range on Protein: 102-343
Range on HMM: 43-292/292
Sequence Identity: 29% (75 aa)

KQILKAIEIQKFLNHENIEKIYNFDIISYPEI---NKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCS
| . . . .  | .|.|   .   ||.  |..   . .||| . ||  |  |  | |.|. .|.. |.||||| | |.|||.|.   . |  . .||.| 
KRVFRELKMLCFFKHDN--VLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCV

IKISEFTSCVGNQNQKIRSYIHK---NYYMSPEYIV-EKIITEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINREKLS
.|| .|      . .. .   .     ||  || ..  .  |.  |||| |||||||. |  ||      . .  | .  |    ||.|.  .  .  . 
LKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHML

TLMPKEEQISLQVRFPN---ANPLALDLLGKMLTFNLEKRFNALECLQHEYL
   .|. ...   .      |.  | .|| .|| |. .||  . . |.| ||
RMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL

Kinase 27893.AA ERK7 110-343 29 1.5e-37 125.83 In-house 52-292 (292) Show / Hide
Range on Protein: 110-343
Range on HMM: 52-292/292
Sequence Identity: 29% (71 aa)

IQKFLNHENIEKIYNFDIISYPEINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSIKISEF-----
.| | .|.|| ...|  .|       .|.| .|| | |  . .  . | | | |. |||.|||. |.||....   | |  | ..|.| .|.  |     
LQEFHCHPNIIRLIN--VIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARS

-TSCV--GNQNQKIRSYIHKNYYMSPEYIVE-KIITEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINREKLSTLMPKE
 ..    ..||. .  |.    | .||  .  .  |   | || ||| .|..    .| |   .  | .||.  ..  .||..  .   . ..   |...
IAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQ

EQISLQVRFPNANPLALDLLGKMLTFNLEKRFNALECLQHEYL
.. .|.  .|.. . |.||| ..| || .||  | ..||| | 
KRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV

Kinase 27893.AA ERK1 100-343 35 3e-37 130.06 In-house 40-289 (289) Show / Hide
Range on Protein: 100-343
Range on HMM: 40-289/289
Sequence Identity: 35% (89 aa)

YLKQILKAIEIQKFLNHENIEKIYNFDIISYPEINKM---YVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSD
| .  |. |.| .  .|||| .|   |||  . |..|   |.| . | | |  . .. |.|  .|| .|.||||| | ||||| ..   | |  . .|  
YCQRTLREIKILTRFKHENIINIQ--DIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT

CSIKISEFTSCVGNQNQK-----IRSYIHKNYYMSPEYIVE-KIITEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLK-FYKQIN
| .|| .|        ..     .  |.   .|  || ..  |  |   |||| ||| ||..    .| |      .  ||   |   ..||.    .  
CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKA

REKLSTLMPKEEQISLQVRFPNANPLALDLLGKMLTFNLEKRFNALECLQHEYL
|. |  | |  ......  ||.| . |||||.|||||| .|| .  | | | ||
RNYLQSL-PHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL

Kinase 27893.AA MAPK 236-343 37 1.9e-34 116.43 In-house 212-328 (328) Show / Hide
Range on Protein: 236-343
Range on HMM: 212-328/328
Sequence Identity: 37% (44 aa)

TEKSDIWSAGCIFAELIN-RVKLFSGHDDFTAITQILQFCGEQNEEDLKFYK--QINREKLSTL--MPKEEQISLQVRFPN----ANPLALDLLGKMLTF
|.. |.||.||||||... |  || |.|    ...|....|   ||.... .  .  |. .. |  .||  .....  |||    |||.|.||| |||.|
TKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVF

NLEKRFNALECLQHEYL
. .|| .. |.|||.|.
DPDKRITVEEALQHPYF

Kinase 27893.AA ERK5 102-343 29 1.4e-33 117.91 In-house 43-295 (295) Show / Hide
Range on Protein: 102-343
Range on HMM: 43-295/295
Sequence Identity: 29% (75 aa)

KQILKAIEIQKFLNHENIEKIYNF--DIISYPEINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSI
|  .. . | .   |.||  | .       | |.  .||| | |   |  |  |.| .| ||| .|.||||| | |.|||...   | |  . .|  | .
KRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCEL

KISEF-------TSCVGNQNQKIRSYIHKNYYMSPEYIV-EKIITEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINRE
|| .|       |    ..   . .|.   .|  || ..  .  |   |.|| |||| |.| | ..| |      .  |..  |      ..        
KIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVY

KLSTL-MPKEEQISLQVRFPNANPLALDLLGKMLTFNLEKRFNALECLQHEYL
      .|  .   ..  .| | . |||||..|| |   .|  . . ||| .|
NYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL

Kinase 27893.AA CMGC 223-343 17 4.8e-31 98.52 In-house 290-513 (513) Show / Hide
Range on Protein: 223-343
Range on HMM: 290-513/513
Sequence Identity: 17% (40 aa)

YYMSPEYIVE----------KIITEKSDIWSAGCIFAELINR--------VKLFSGHDD-----------FTAITQILQFCGEQN---------------
.| .|| ..           .  |.. |.||.||||||....          || ||..              . .| . .|  .               
WYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKH

EEDLKFYKQINREKL--------------STL----------MPKEEQISLQVRFPN-----------------------------------ANPLALDL
||.   ...  . ..              |             |.   ....  ||.                                   ..|.|.||
EEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDL

LGKMLTFNLEKRFNALECLQHEYL
| |||... .||  | ..|||.|.
LKKMLQYDPDKRITAEQALQHPYF

Kinase 27893.AA ERK 240-343 43 4.7e-29 102.84 In-house 199-307 (307) Show / Hide
Range on Protein: 240-343
Range on HMM: 199-307/307
Sequence Identity: 43% (47 aa)

DIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQ-NEEDLKFYKQINREKLSTLMPK--EEQISLQVRFPNAN--PLALDLLGKMLTFNLEKRFNA
||||.||||||...|  ||.| |    |..|.|  |    ||||.  . .|  |. . .|.   . .... .|||||  |.|.||| |||.|. .|| ..
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITV

LECLQHEYL
 |||.|.|.
EECLEHPYF

Kinase 27893.AA ERK 100-204 41 8.4e-25 88.72 In-house 46-152 (307) Show / Hide
Range on Protein: 100-204
Range on HMM: 46-152/307
Sequence Identity: 41% (44 aa)

YLKQILKAIEIQKFLN-HENIEKIYNFDIISYP-EINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDC
|.|..|  | ...... |||| .... .. ..| ..|  |.|...|.| |  | .|||.|.|.|.|.||||||..| |||||...   | |. | .||.|
YCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNC

SIKISEF
  ||. |
DLKICDF

Kinase 27893.AA MAPK 108-182 41 4.5e-23 76.46 In-house 55-139 (328) Show / Hide
Range on Protein: 108-182
Range on HMM: 55-139/328
Sequence Identity: 41% (35 aa)

IEIQKFL-NHENIEKIYNFDIIS-----YP--EINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRA--LHYIHSAKIV
| ..... .|||| |...    .     ..  | |  |.|...|.|.|  | .|||.|.|.|||.|||||||.  | ||||| ..
IKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVI

Kinase 27893.AA Pkinase 223-343 24 9.5e-21 74.45 Pfam 176-293 (293) Show / Hide
Range on Protein: 223-343
Range on HMM: 176-293/293
Sequence Identity: 24% (31 aa)

YYMSPEYIV-EKIITEKSDIWSAGCIFAELINRVKLFSGH------DDFTAITQILQFCGEQNEEDLKFYKQINREKLSTLMPKEEQISLQVRFPNANPL
.||.|| |   . .. |.|.||.|||..|....  .|.||      |.   | .|.   | ....|      | ...  .  . .  . .... .|... 
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIM---GPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEE

ALDLLGKMLTFNLEKRFNALECLQHEYL
..|.. ..|... .|| .| ..|||...
CKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 27893.AA MAPK-Unclassified 236-343 25 4.4e-18 61.55 In-house 427-575 (575) Show / Hide
Range on Protein: 236-343
Range on HMM: 427-575/575
Sequence Identity: 25% (38 aa)

TEKSDIWSAGCIFAELINR-----------VKLFSGHD------------D-----FTAITQ---ILQFCGEQNEEDLKFYKQIN-REKLSTLMPKEEQI
. ..||||.||||||....             || | |            |     .  . |   |.   |  .|||. | .. . |. .... .|    
DTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPVH

SLQVRFPNAN---------PLALDLLGKMLTFNLEKRFNALECLQHEYL
  .  |..|          ....|.. ||| ||  ||..| . |.|.| 
FTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF

Kinase 27893.AA MAPK-Unclassified 102-205 41 1.7e-16 55.68 In-house 44-154 (575) Show / Hide
Range on Protein: 102-205
Range on HMM: 44-154/575
Sequence Identity: 41% (47 aa)

KQILKAIEIQKFLNHENIEKIYNFDIISYPEINK-----MYVVSDFMQT---NLSFITQSQQ-QLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQ
| .|  | |.  |||.|| .|   ||.   |         |.| |.|||   .|  | .| |  . ..||| |.||||| | |.||| |.   | |  . 
KRVLREIRILRYLNHPNIIQIQ--DIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLL

INSDCSIKISEFT
|| |||..|  |.
INQDCSVRICDFG

Kinase 27893.AA CMGC 108-182 22 3.3e-16 48.88 In-house 72-206 (513) Show / Hide
Range on Protein: 108-182
Range on HMM: 72-206/513
Sequence Identity: 22% (31 aa)

IEIQKFLN-----------------HENIEKIYNFDIISYPE-------------INKMYVVSDFMQTNLSFITQSQQ---------QLTDEH-------
|.| | ||                 |.|| |.|..   . ..              |..| | ..|...|  . ...|          |.. |       
IKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHR

-----IQFFM------YQILRALH--YIHSAK--IV
     |..||      |||||.|.  |.||..  |.
RPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNII

Kinase 27893.AA S_TKc 59-343 18 9.1e-16 54.29 SMART 1-231 (231) Show / Hide
Range on Protein: 59-343
Range on HMM: 1-231/231
Sequence Identity: 18% (59 aa)

YDLKKQTNDYNASYKCKAYDNKSHQDV---FIYYYITFAQYDIYYLKQILKAIEIQKFLNHENIEKIYNFDIISYPEINKMYVVSDFMQT---NLSFITQ
|.. ..      .  .|....|... |    |              ..|.. |.| |  .|.|| |.| .        ...|.| ... .   .|  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIK

SQQQ------LTDEHIQFFMYQILRALHYIHSAKIV----------FGFLLPRFIQINSDCSIKISEFTSCVGNQNQKIRSYIHKNYYMSPEYIVEKIIT
...       ..  |..|.||||..|| |.|| .|.          .               |||. | ..        ....   .||.|| .     .
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYG

E-KSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINREKLSTLMPKEEQISLQVRFPNANPLALDLLGKMLTFNLEKRFNAL
  |.|.|| |||..|.. .  .|.   .  .. ...                                          | |.|.. |.|... |||  | 
KCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

ECLQ-------HEYL
|.||       |...
EALQDEWDIKCHPWF

Kinase 27893.AA Pkinase 108-182 29 3e-08 30.26 Pfam 51-130 (293) Show / Hide
Range on Protein: 108-182
Range on HMM: 51-130/293
Sequence Identity: 29% (25 aa)

IEIQKFLNHENIEKIYNFDIISYPEINKMYVVSDFMQT-----NLS-FIT-QSQQQL--TDEHIQFFMYQILRALHYIHSAKIV
|.| | |||.|| ..| .        ...|.| ....       |. .|. ...  .  ......|.||||||.| |.|| .|.
IQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII

Kinase 27893.AA TyrKc 72-343 14 4.9e-05 -141.15 SMART 16-280 (280) Show / Hide
Range on Protein: 72-343
Range on HMM: 16-280/280
Sequence Identity: 14% (45 aa)

YKCKAYDNKSHQDVFI-----YYYITFAQYDIYYLKQILKAIEIQKFL--NHENIEKIYNFDIIS---YPEINKMYVVSDFMQTN--LSFITQSQQQLTD
||....     ..| .     .            .. ... ..| . |  .|.|| ..|   . .   . .|  ...|  .|     ....  .. .|. 
YKGTWK-----IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

EHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSIKISEFT-SCVGNQN-------QKIRS--YIHKN-----YYMSPEYIVEKIITEKSDIWSA
..   |..|| .   |.|| ...   |  | . ....  .||| |  |  .          . .|.    ...       |.|| | ... |.|||.|| 
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GCIFAELINRVKLFSGH---DDFTAITQILQFCGEQNEEDLKFY----KQINREKLSTLMPKEEQISLQVRFPNANPLALDLLGKMLTFNLEKRFNALEC
|    |.  . .          .   ......  . .  .   .                           |. . .   ..  .   .. |.| .  |.
GVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI

LQHEYL
  ||..
--HECF