Gene 1405 (Tetrahymena)

1405

Species: Tetrahymena
Alias: 253.m00030, 784, TTHERM_01144900, 1405, PreTt01405
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
1405.AA Protein None 787 None Fasta, JSON
1405.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
1405.NA RNA None 2364 None Fasta, JSON

Protein domain

Protein domains of 1405.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1405.AA NEK 29-283 47 2.8e-157 528.78 In-house 1-286 (286) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-286/286
Sequence Identity: 47% (135 aa)

FEILKKLGQGAHGVVYKVRRKKDQNT-----YVLKQILAGGMQQKQRKECI-NEAILLNKLNSPYIVRYYDSFLENN--QLCIVMEYCE-QGDLENF---
.||.||.|||..|.|||||||.|..      ||.|.|  |.|..|...... ||...| .|..|.||.|||||.|..  .|||||||||  |||...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKNQM--GRPLVEKKIWKFFFQIAEGLLELHTR-----NILHRDIKTMNLFLTGNEQ----IRIGDLGVAKQLENNKSHAHS-QVGTPYYMSPEIIQDIP
||.|   | .. |..||..|.|.. .| ..| |     .|||||||..|.||| |      ..|||.|..|.|......|.. |||||||||||..|. |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNEKSDVWSLGCVLYQLATF--KRPFEAT--NQGSLVLKIQKA-QYIPISSN--YSPQLHRLIELCLTKEHQKRYSIKQLLTDPEI
||.|||.||||||||...|.  |.||||.  |. ||..||.|  || ||.|.  ||..|..||...|.|....|.|..|.| .| |
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 1405.AA NEK8 35-283 39 1.8e-98 281.75 In-house 7-278 (278) Show / Hide 
Range on Protein: 35-283
Range on HMM: 7-278/278
Sequence Identity: 39% (107 aa)

LGQGAHGVVYKVRRKKDQ--NTYVLKQILAGGMQQKQRKECINEAILLNKLNSPYIVRYYDSFLENNQLCIVMEYCEQGDLENFIKNQMGRPLVEKK---
.|.|| |..   ||| ||     ..|||   .|  |.|    ||  .| .|. | |. |||.|.|.|.| |.|||.. | |. .|  | .  . | .   
VGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLK

--------------IWKFFFQIAEGLLELHTRNILHRDIKTMNLFLTGN-EQIRIGDLGVAKQLENNKSHAH-S--QVGTPYYMSPEIIQDIPYNEKSDV
              |  .|||.  ..  .|. ||||||.|| | |.|     . ||| | .| . | |.|.  .   ||||||||||. .  |||.|||.
QVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIM-NTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDM

WSLGCVLYQLATFKRPFEATNQGSLVLKIQKA-QYIPISSNYSPQLHRLIELCLTKEHQKRYSIKQLLTDPEI
|.|||||| ... || |||.|.  ||.||     | |||. ||. .. |.. || .. ..| |  |.. .| .
WALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 1405.AA NEK1 29-283 42 3.9e-96 325.7 In-house 1-276 (276) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-276/276
Sequence Identity: 42% (117 aa)

FEILKKLGQGAHGVVYKVRRKKDQNTYVLKQILAGGMQQKQRKECINEAILLNKLNSPYIVRYYDSFLENNQ--LCIVMEYCEQGDLENFIKNQ--MGRP
....|..|.|. | ...|..| |  .||.| |    ||.| | |  ||...| |.  | ||.|..|| || .  | ||||||. |||   |..|   | .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LVEKKIWKFFFQIAEGLLELHTRNILHRDIKTMNLFLT--GNE---------------QIRIGDLGVAKQLENNKSHAHSQVGTPYYMSPEIIQDIPYNE
  |  |  .| ||  .|   | |.|||||||. |.|||   |                 ...|| |.|. | .  ..|   .||||| ||||.|  ||| 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDVWSLGCVLYQLATFKRPFEATNQGSLVLKIQKAQYIPISSNYSPQLHRLIELCLTKEHQKRYSIKQLLTDPEI
|||.|||||||| | | |.|||| |   ||||| .. | ||.. ||  |. |.   . .  . | |. |.|. | |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 1405.AA S_TKc 29-283 31 1.6e-88 301.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

FEILKKLGQGAHGVVYKVRRKKDQNTYVLKQILAGGMQQKQRKECINEAILLNKLNSPYIVRYYDSFLENNQLCIVMEYCEQ--GDLENFIKNQMGRP--
.|||.|.|.|| |.|||.| ||..  . .|.|          .  ..|  .| | . |.||..||.| . . |..|||||..  |||  .||.. ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LVEKKIWKFFFQIAEGLLELHTRNILHRDIKTMNLFLTGNEQIRIGDLGVAKQLENNKSHAHSQVGTPYYMSPEIIQDIPYNE-KSDVWSLGCVLYQL
  . |  ..... ||...|  .| ..|.|||.|  |..|.   .| |.| |.|.||       ....|||.||.||..   .|.  |.|.||.||.|| .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ATFKRPFEATNQGSLVLKIQKAQYIPISSNYSPQLHRLIELCLTKEHQKRYSIKQLLT-------DPEI
.. . ||.   |  ...|. .          ||..  .|. ||.|. .||... ..|.       .| .
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1405.AA NEK4 29-283 40 1.1e-86 294.36 In-house 1-257 (257) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-257/257
Sequence Identity: 40% (105 aa)

FEILKKLGQGAHGVVYKVRRKKDQNTYVLKQILAGGMQQKQRKECINEAILLNKLNSPYIVRYYDSF-LENN-QLCIVMEYCEQGDLENFIKNQMGRPLV
....|  |.| .| |. || ..|   ||.| .      ...||.   || || .|  | || | .|.  ||.  |.||| .|| ||| .  | | .  | 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EKKIWKFFFQIAEGLLELHTRNILHRDIKTMNLFLTGNEQIRIGDLGVAKQLENNKSHAHSQVGTPYYMSPEIIQDIPYNEKSDVWSLGCVLYQLATFKR
|. .   | ||| .|. .| ..||||| || |.|||    |.|||.|... |.|    |   .|||||||||.    ||. |||.||||| .| ..| | 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFEATNQGSLVLKIQKAQYIPISSNYSPQLHRLIELCLTKEHQKRYSIKQLLTDPEI
 |.| .  ||. .| . |  |.. |||..|  |.   | |  .|| || ...  | |
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 1405.AA Pkinase 29-283 28 2.4e-75 261.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-293/293
Sequence Identity: 28% (83 aa)

FEILKKLGQGAHGVVYKVRRKKDQNTYVLKQILAGGMQQKQRKECIN--EAILLNKLNSPYIVRYYDSFLENNQLCIVMEYCEQG----DLENFIKNQMG
..|..|.|.|. |.||| ..|... ....|.|   .   ..... ..  |. ....||.|.|||.||.| ... ...|||||| |    ||  .|. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RPL--VEKKIWKFFFQIAEGLLELHTRNILHRDIKTMNLFLTGNEQI----RIGDLGVAKQL-ENNKSHAHSQVGTPYYMSPEIIQ-DIPYNEKSDVWSL
...   |. . ... ||..||  .| ..|.|||.|  |...  | .|    .|.| |.|||. . |.| ... .|||.||.||.|. . .|  |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVLYQLATFKRPFEAT------NQGSLVLKIQKAQYIPISSNYS--------------------PQLHRLIELCLTKEHQKRYSIKQLLTDPEI
||.||.... . ||         .|  .. .| ....   ... .                    . .  .|. ||.|  .||....|.| .| .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 1405.AA STE 29-283 24 5.3e-75 255.49 In-house 1-359 (359) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-359/359
Sequence Identity: 24% (88 aa)

FEILKKLGQGAHGVVYKVRRKK---------------DQNTYVLKQILAGGMQQ---------------KQRKECINEAILLNKLN--SPYIVRYYDSFL
.|...|.|.|| |.||| ...|                .. .  ||.     ..               ..... ..|  ...|.|  .|.||.||....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EN-------NQLCIVMEYCEQGDLENFIKNQMGRPLV------------EKKIWKFFFQIAEG-LLELHTRNILHRDIKTMNLFLTGNEQIRIGDLGVAK
 .       ..|.|.|||.. | |. .||. .|..              |. | .. .|| .| |  ||  .| |||||  | .|     . . | ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLEN----------------NKSHAHSQVGTPYYMSPEIIQ------DIPYNEKSDVWSLGCVLYQLATFKRPFEATNQGSLVLKIQKA-----------
||..                ....  . |||| .|.||.||      | .|..|.|.|||||..  .|| | |.   .  .  . |..            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----QYIPISS-------------------NYSPQLHRLIELCLTKEHQKRYSIKQLLT--DPEI
    .  |. .                   ..|| ..  |..||.|. .|| . .|||    | |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 1405.AA NEK6 29-274 40 1.2e-74 245.12 In-house 1-252 (252) Show / Hide 
Range on Protein: 29-274
Range on HMM: 1-252/252
Sequence Identity: 40% (103 aa)

FEILKKLGQGAHGVVYKVRRKKDQNTYVLKQI-LAGGMQQKQRKECINEAILLNKLNSPYIVRYYDSFLENNQLCIVMEYCEQGDLENFIK--NQMGRPL
|.| ||.|.|    ||. .   |. .  ||.. .   | .| |..|| |  || .|| | ...||.||.|||.| ||.|  . ||.   ||   . .| .
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLI

VEKKIWKFFFQIAEGLLELHTRNILHRDIKTMNLFLTGNEQIRIGDLGVAKQLENNKSHAHSQVGTPYYMSPEIIQDIPYNEKSDVWSLGCVLYQLATFK
 |. |||.| |..  |  .| . ..|||||  | |.|.|  ...||||. .    .   ||| |||||||||| |..  || |||.|||||.|| .|  .
PERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQ

RPF--EATNQGSLVLKIQKAQYIPISSN-YSPQLHRLIELCLTKEHQKRYSI
 ||  .  |  ||  ||.. .| |. .. || || .|. .|.  . ..|  |
SPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase 1405.AA NEK2 29-283 34 1.4e-73 247.12 In-house 1-319 (319) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-319/319
Sequence Identity: 34% (109 aa)

FEILKKLGQGAHGVVYKVRRKKDQNTYVLKQILAGGMQQKQRKECINEAILLNKLNSPYIVRYYDSFL--ENNQLCIVMEYCEQGDLENFI---KNQMGR
 |.|. .|.|  |...||||| |    | | |  | || | .   ..|  .| .|  |.||||||     .|  | ||||||| |||   |   ...  .
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

PLVEKKIWKFFFQIAEGLLELHT------------------RN---ILHRDIKTMNLFLTGNEQ------------------------------------
 . |. ||. .||.   | | |                    .   |||||||  |.||  ..                                     
-MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYS

---IRIGDLGVAKQLENNKSHAHSQVGTPYYMSPEIIQDIPYNEKSDVWSLGCVLYQLATFKRPFEATNQGSLVLKIQKAQYIPISSNYSPQLHRLIELC
   .  || | |. |.   | ||. |||||||||| ... .||||||.||.||..| ... . ||.||||  |  ||..  . .| . ||  |  .| . 
QVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFM

LTKEHQKRYSIKQLLTDPEI
.   |..| ||  .| .| |
INVDHYHRPSIEEILQHPQI
Kinase 1405.AA Ciliate-E2 29-283 23 3.7e-70 239.38 In-house 1-365 (365) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

FEILKKLGQGAHGVVYKVRRKKDQNTY-----------------VLKQILAGGMQQKQRKECINEAILLN-----------------KLNSPYIVRYYDS
....||.|||..|.|||....|.|. .                 | ..| |  ...|. .| |.  | ..                 .||.|.|...|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FL--ENNQLCIVMEYCEQGDLENFIKNQ----------MGRPLVEKKIWKFFFQIAE---------------GLLELHTRN-ILHRDIKTMNLFLTGNEQ
|    .| . .|||||..|||. .|||.             ...||.| ... ||..               .| .|| .| |.|||||  |...     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IRIGDLGVAKQLENN------KSHA-------------------------HSQVGTPYYMSPEIIQDIP---------YNEKSDVWSLGCVLYQLATFKR
| | |.| .|.. ..      |...                         ....|||.||.|||..  .         |..|.|.||||..||.. . |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFEATNQGSLVLKIQKAQYIPIS------------------SNYSPQLHRLIEL----CLTKEHQKRYS-IKQLLTDPEI
||         ....| . | ..                   . |..   ||      .| |. .||.. ..|.|  | .
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 1405.AA ULK 29-283 29 5.9e-70 238.71 In-house 1-329 (329) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-329/329
Sequence Identity: 29% (96 aa)

FEILKKLGQGAHGVVYKVRRKKD----QNTYVLKQILAGGMQQKQRKE--------CINEAILLNKLN----SPY----IVRYYDSFLEN--NQLCIVME
... ..||.|. |.||| | ||.    .  .. |.|.   |.||.            .||  .. ||.    ...    ||..|| | .   | . |.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEQGDLENFIKNQ--------MGRPLVEKKIWKFFFQIAEGLLELHTRNILHRDIKTMNLFLTGNE------------QIRIGDLGVAKQLENN---KS
||..||||..||..         .. | |... .|| ||..|. ||| .|| |||||  |  .. .             .. |.| | ||...|.   . 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

HAHSQV------GTPYYMSPEIIQ----DIPYN-EKSDVWSLGCVLYQLATFKRPFEATNQGSLV-LKIQKAQYIPISSN------------------YS
 ....|      |||.||.|.|.|     .||.  |.|.|||||..|.. . | ||.|    ... ..|||   .|  ..                   |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PQLHRLIELCLTKEHQKRYSIKQLLTDPEI
|... ||  .|...  .| |. .|.  | .
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 1405.AA ULK 29-283 28 9.6e-70 238.02 In-house 1-324 (324) Show / Hide 
Range on Protein: 29-283
Range on HMM: 1-324/324
Sequence Identity: 28% (94 aa)

FEILKKLGQGAHG-VVYKVRRKKD---QNTYVLKQILAGGMQQKQRK--------ECINEAILLNKLN---SPY--IVRYYDSFLEN--NQLCIVMEYCE
... ..||.|. | .||| | ||.   .  .  |.|   .|..|. .          .||  .. ||.   .|.  ||..|| | .   | ..|.||||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

QGDLENFIKNQMGRP-------LVEKKIWKFFFQIAEGLLELHTRNILHRDIKTMNLFLTGNE------------QIRIGDLGVAKQLENN---KSHAHS
.||||..||.. . |       | |... .|| ||..|. ||| .|| |||||  |. .. .             .. |.| | ||...||   .   ..
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QV------GTPYYMSPEIIQ----DIPYN-EKSDVWSLGCVLYQLATFKRPFEATNQGSLVLK--------------IQKAQYIPIS----SNYSPQLHR
.|      |||.||.|.|.|     .||.  |.|.|||||..|.. . | ||..    ...|.              |.. .  . .     . ||... 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIELCLTKEHQKRYSIKQLLTDPEI
||  .|...  .| |. ...  | .
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 1405.AA Pkinase_Tyr 29-219 29 2e-27 93.48 Pfam 1-205 (270) Show / Hide 
Range on Protein: 29-219
Range on HMM: 1-205/270
Sequence Identity: 29% (62 aa)

FEILKKLGQGAHGVVYKVRRK----KDQNTYVLKQILAGGMQQKQ--RKECINEAILLNKL-NSPYIVRYYDSFL-ENNQ--LCIVMEYCEQGDLENFIK
 ...||||.|| |.||| . |    ... .   | .   |  ..|  |.. ..|| .. .| . | |||.|   . .  .  ..|||||.. ||| .. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

NQ--MGRPLVEKKIWKFFFQIAEGLLELHTRNILHRDIKTMNLFLTGNEQIRIGDLGVAKQLENNKSHAHSQVGT-----PYYMSPEIIQDIPYNEKSDV
..   ..||  | . .. .|||.|.  |. .|. |||. . |  .| | ...|.| | |. .  |..   .....        |.|| |..  ...||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSLGCVLY
|| | ...
WSFGVLMW
Kinase 1405.AA TyrKc 29-285 23 1.4e-17 61.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 29-285
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FEILKKLGQGAHGVVYKVRRKKDQNTYVL-KQILAGGMQQKQRKECINEAILLNKL--NSPYIVRYYDSFLEN-------NQLCIVMEYCEQGDLENFIK
 . .|||| || |.||| . |    . |  | . ..      |.. ..|| .. ||  . | ||| |   ..         .|.|||||.. ||| ....
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NQMGRPLVEKKIWKFFFQIAEGLLELHTRNILHRDIKTMNLFLTGNEQIRIGDLGVAKQLENN-------KSHAHSQ-VGTP-----YYMSPEIIQDIPY
.  .. |  |.  .| .|||.|   || .|. |||. . |  .. | ...|.| | .. ...        .   ...  |.        |.|| |..  .
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NEKSDVWSLGCVLYQLATF-KRPFEA-----TNQGSLVLKIQKAQYIPISSN--------YSPQLHRLIELCLTKEHQKRYSIKQLLTDPEIEM
..|||||| | ... . |. . | .       .   .. ....  . |.  |         .. ...... |   .  .| . ...      ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF