Gene 18676 (Tetrahymena)

18676

Species: Tetrahymena
Alias: 18676, TTHERM_00467740, PreTt18676, 55.m00231, 422, 3710.m00080
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
18676.AA Protein None 1137 None Fasta, JSON
18676.kin_dom Protein Kinase Domain None 262 None Fasta, JSON
18676.NA RNA None 3414 None Fasta, JSON

Protein domain

Protein domains of 18676.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18676.AA NEK2 4-265 49 3.5e-170 571.65 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-319/319
Sequence Identity: 49% (157 aa)

YEILGQIGKGSFGLVQKIKRKSDGKVLVWKEMNYGRMSEREKQQLVAEVNIIRELKHPNIVRYYDRIIEKKDTKIYIIMEYCEGGDVGTLLKKCKKEKDY
||.|. ||.|||| ..|..||||||.|||||..|| | | |.|.||.|.|| |.|||||||||||.|| .. . .||.|||||||| . . |||.||. |
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IAEDVIWKIFTQIILALNECHN----------------RPQG--KILHRDLKPANIFLDAQNN-------------------------------------
. | .||.|..|. .|| ||||                |  |   |||||.||||||||.  |                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--IKLGDFGLSRVMGEQSEFADTHVGTPYYMSPEQIQEKKYNEKSDIWSAGCLLYEMAALKPPFEATNHLSLAIKIKSGKFERLPLRYSEELQKLIESMV
  .||||||| |.    . || | |||||||||||..  |||||||||| |||.|||.||.|||.||| . |. ||| |.|.|.| .||..|...| .| 
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

HIDPEKRPSVQNILELPQI
 .|...|||.  ||. |||
NVDHYHRPSIEEILQHPQI
Kinase 18676.AA NEK 4-265 51 5.5e-165 554.4 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-286/286
Sequence Identity: 51% (148 aa)

YEILGQIGKGSFGLVQKIKRKSDGKV-----LVWKEMNYGRMSEREKQQLV-AEVNIIRELKHPNIVRYYDRIIEKKDTKIYIIMEYCE-GGDVGTL---
|||. .||.|||| | |..||||||.     .|||..|.|.|||.|||...  ||.| ..|||||||.|||..||... ...|.||||| |||   .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LKKCKKEKDYIAEDVIWKIFTQIILALNECHNR--PQGKILHRDLKPANIFLDAQNN----IKLGDFGLSRVMGEQSEFADT-HVGTPYYMSPEQIQEKK
.||.|....|. |..||..|.|..|||...|.|  ||.||||||.||.||||...||    .|.||||.|.|..  ...| | .||||||||||..|.|.
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNEKSDIWSAGCLLYEMAAL--KPPFEAT--NHLSLAIKIKSG-KFERLPLR--YSEELQKLIESMVHIDPEKRPSVQNILELPQI
||.|||||| ||.||||..|  |.||||.  |..||. ||. | .....| .  ||..||.||..| . |||.|||.. |||.|.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 18676.AA NEK1 4-265 45 1.4e-101 343.75 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-276/276
Sequence Identity: 45% (126 aa)

YEILGQIGKGSFGLVQKIKRKSDGKVLVWKEMNYGRMSEREKQQLVAEVNIIRELKHPNIVRYYDRIIEKKDTKIYIIMEYCEGGDVGTLLKKCKKEKDY
|... |||.|||| . . |.|.||...| || |  .|.| |... . ||.| . .||||||.|..  .|      ||.||||.|||     .. |     
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IAEDVIWKIFTQIILALNECHNRPQGKILHRDLKPANIFLD-AQNN----------------IKLGDFGLSRVMGEQSEFADTHVGTPYYMSPEQIQEKK
. || |   |.|| ||||  | |   ||||||.|. ||||   .|                 .|||||| .|.. .  |.| | .||||| ||| .| | 
FSEDQIMHWFCQICLALNHIHDR---KILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKP

YNEKSDIWSAGCLLYEMAALKPPFEATNHLSLAIKIKSGKFERLPLRYSEELQKLIESMVHIDPEKRPSVQNILELPQI
|| ||||||.|| |||  .|| |||| |   |  || .| .  .| .||.||| |. .|  ..|. ||||. ||| | |
YNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 18676.AA NEK8 4-265 37 1.7e-96 276.0 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-278/278
Sequence Identity: 37% (107 aa)

YEILGQIGKGSFGLVQKIKRKSDG--KVLVWKEMNYGRMSEREKQQLVAEVNIIRELKHPNIVRYYDRIIEKKDTKIYIIMEYCEGGDVGTLLKKCKK--
||    .|.|.|| .    ||.|.  .  .||. |  ||||.| |    |...   | ||||. |||  .|  |.   | |||..||    .. . .   
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFME--DNTLMIEMEYADGGTLYQMIQHQQNKL

---EK----------DYIAEDVIWKIFTQIILALNECHNRPQGKILHRDLKPANIFLDAQ-NNIKLGDFGLSRVMGEQSEFAD--THVGTPYYMSPEQIQ
   |.           |  |  |   |.|. .|..  |   |  |||||||..|||..   . .|.||||.| .|.  .  .   | ||||||||||  .
FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMH---QHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCE

EKKYNEKSDIWSAGCLLYEMAALKPPFEATNHLSLAIKIKSG-KFERLPLRYSEELQKLIESMVHIDPEKRPSVQNILELPQI
 |.||.|||.|. || ||||. ||  |||.| . |  || .. ..| .. .|| |.  |...    |||.|||.  |.  | .
GKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 18676.AA S_TKc 4-265 33 2.8e-89 303.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-231/231
Sequence Identity: 33% (93 aa)

YEILGQIGKGSFGLVQKIKRKSDGKVLVWKEMNYGRMSEREKQQLVAEVNIIRELKHPNIVRYYDRIIEKKDTKIYIIMEYCEG--GDVGTLLKKCKKEK
|||| .||||.|| | | . |..|..   |...         ...  |..| .. .|||||..|| . .   ...|..||||.|  ||. ...||.....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

DY--IAEDVIWKIFTQIILALNECHNRPQGKILHRDLKPANIFLDAQNNIKLGDFGLSRVMGEQSEFADTHVGTPYYMSPEQIQEKKYNE-KSDIWSAGC
 .  . | ...... ||..||. ||..   .|.||||||.||.||   .||..||||.|..       .| .|||.||.|| .   .|.  |.|.|| ||
LRFPFPE-HARFYMYQICCALEYCHSH---GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LLYEMAALKPPFEATNHLSLAIKIKSGKFERLPLRYSEELQKLIESMVHIDPEKRPSVQNILE-------LPQI
.||||.. .|||.   .. . .|.            |.|.  .|. . . ||||||..  .|.        | .
ILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18676.AA NEK4 4-265 41 2.8e-88 299.59 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-257/257
Sequence Identity: 41% (109 aa)

YEILGQIGKGSFGLVQKIKRKSDGKVLVWKEMNYGRMSEREKQQLVAEVNIIRELKHPNIVRYYDRIIEKKDTKIYIIMEYCEGGDVGTLLKKCKKEKDY
|... ..||||.| |  .. . |.|  | | |.  . | ||..    |...   ||||||| | .          ||.| .|||||  . ||. | .   
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQ--F

IAEDVIWKIFTQIILALNECHNRPQGKILHRDLKPANIFLDAQNNIKLGDFGLSRVMGEQSEFADTHVGTPYYMSPEQIQEKKYNEKSDIWSAGCLLYEM
. |  .   | || .||   | .   .|||||||  ||||  .| ||.||||.|||. . ...| | .|||||||||    . |. |||||| || .|||
LEEYQVVEWFVQIAMALQYMHEK---HILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEM

AALKPPFEATNHLSLAIKIKSGKFERLPLRYSEELQKLIESMVHIDPEKRPSVQNILELPQI
. ||  |.| .  ||  .|  |.   .|  ||..|| |.  |    |.||||. .|.  | |
ITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 18676.AA Pkinase 4-265 31 6.1e-80 276.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YEILGQIGKGSFGLVQKIKRKSDGKVLVWKEMNYGRMSEREKQQLVA--EVNIIRELKHPNIVRYYDRIIEKKDTKIYIIMEYCEGG----DVGTLLKKC
|.|...||.|||| | | ..|..||. . |.... . .. ..|...   |. | ..|.||||||.||   .  ...||..|||||||    |  ....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

KKEKDYI--AEDVIWKIFTQIILALNECHNRPQGKILHRDLKPANIFLDAQNNI----KLGDFGLSRVM-GEQSEFADTHVGTPYYMSPEQIQ-EKKYNE
 ...  .   |... ....||. .|. ||..   .|.||||||.||..| ...|    |..||||....    .. ..| .|||.||.|| |.  ..|  
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDIWSAGCLLYEMAALKPPFEAT------NHLSLAIKIKSGKFERL-PLRYS-------------------EELQKLIESMVHIDPEKRPSVQNILELP
|.|.||.||.||||.  .|||         ... .  .|.......  |  .|                   ||....|... . ||.|||. . ||. |
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

QI
 .
WF
Kinase 18676.AA STE 4-265 26 4.3e-74 252.48 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-359/359
Sequence Identity: 26% (97 aa)

YEILGQIGKGSFG-LVQKIKRKSD--------------GKVLVWKEMNYGRMS---------------EREKQQLVAEVNIIRELK--HPNIVRYYDRII
.|....||||.||  ......| .              |..   |.||. . .               . |.||.  |..| ....  |||||.||.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----EKKDTKIYIIMEYCEGGDVGTLLK-KCKKEK---------DYIAEDVIWKIFTQIILA-LNECHNRPQGKILHRDLKPANIFLDAQNNIKLGDFG
     .| |....|.|||..|| .  ..| |... |         ... |..| .|  ||. . |.  |.     | |||.|||||.|     .|| |||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LSRVMGE----------------QSEFADTHVGTPYYMSPEQIQE------KKYNEKSDIWSAGCLLYEMAALKPPFEATNHL--SLAIKIKS-------
..  . .                ...  .| |||| .|.|| ||       |.|..|.|||| ||.. |||  |||.   ...   ..| ...       
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------GKFERLPL-------------------RYSEELQKLIESMVHIDPEKRPSVQNILE--LPQI
      |.  .||                    ..|.|..  |.    .||.|||...  |.   | |
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 18676.AA NEK6 4-256 41 7.9e-72 235.63 In-house 1-252 (252) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-252/252
Sequence Identity: 41% (106 aa)

YEILGQIGKGSFGLVQKIKRKSDGKVLVWKEMN-YGRMSEREKQQLVAEVNIIRELKHPNIVRYYDRIIEKKDTKIYIIMEYCEGGDVGTLLKKCKKEKD
..|  .|||| |  | . .   |.|.   | .  .  | .. .|  . |......| |||...||.  ||  . .. |..|  . ||.  ..|  ||.| 
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIE--NNELNIVLELADAGDMSRMIKHFKKQKR

YIAEDVIWKIFTQIILALNECHNRPQGKILHRDLKPANIFLDAQNNIKLGDFGLSRVMGEQSEFADTHVGTPYYMSPEQIQEKKYNEKSDIWSAGCLLYE
 | |  ||| | |.  ||.  | .   ...|||.||||.|. |.  .|||| || |    .   |   |||||||||| |.|. || |||||| ||||||
LIPERTIWKYFVQLCSALEHMHSK---RVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYE

MAALKPPF--EATNHLSLAIKIKSGKFERLPL-RYSEELQKLIESMVHIDPEKRPSV
||||. ||  .  |  ||  ||    .  ||   |||.|..|.  ..| |||.|| .
MAALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase 18676.AA Ciliate-E2 4-265 26 1e-69 237.9 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-365/365
Sequence Identity: 26% (101 aa)

YEILGQIGKGSFGLVQKIKRKSDGKV--LVWKEMNY-----------------GRMSEREKQQLVAEVNIIRELK----------------HPNIVRYYD
|... .||.|.|| | | |.....|   .. .. ..                  .|......|.  | .|.||..                ||||...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

RIIEKKDTKIYIIMEYCEGGDVGTLLKKCKKEKD-------YIAEDVIWKIFTQIIL---------------ALNECHNRPQGKILHRDLKPANIFLDAQ
  .||.|..||..||||.|||   ..|..|| ..       |. |  | .|..||.                ||...|..    |.|||.|| ||..   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF---

NNIKLGDFGLSR-------------VMGEQSEFA-------------------DTHVGTPYYMSPEQIQEKK---------YNEKSDIWSAGCLLYEMAA
  ||. |||||.              ...  .                     .| .|||.||.|| .. ||         |..|.||||.|..||||  
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

LKPPFEATNHLSLAIKIKSGKFERL-----------------PLRYSEELQKLIES----MVHIDPEKRPS-VQNILELPQI
 ||||         ..|| .|..                   ..  |.| . ||      |   |||||..  . ||. | .
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 18676.AA NEK10 4-267 32 4.3e-69 226.86 In-house 1-279 (279) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-279/279
Sequence Identity: 32% (91 aa)

YEILGQIGKGSFGLVQKIKRKSDGK------VLVWKEMNYGR----MSEREK----QQLVAEVNIIRE-LKHPNIVRYYDRIIEKKDTKIYIIMEYCEGG
||.. . | | || | |...|. .        |  || .         ..|.    .... |. ||.| ..||||||||   .| .  ..||.||  || 
YEVYDHLGTGAFGCVYKVRKKAQQHSENPAKLLAMKEIFMHNPAFGKNDKERDKSIEDMISELKIIKEQMRHPNIVRYYRTFVEPQNHRMYIVMELIEGC

DVGTLLKKCKKEKDYIAEDVIWKIFTQIILALNECHNRPQGKILHRDLKPANIFLDAQNNIKLGDFGLSRVMGEQSEFADTHVGTPYYMSPEQIQEKKYN
  . ..   |  ..   |. ||..| |..|||   |     .| ||||.| || .  .. .   |||| .  . ...     |||  |  || .| . | 
PLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHK--EKQIVHRDLTPNNIMMGDKDRVTITDFGLAKQKQPDPSKMTSVVGTILYSCPEIVQSEPYG

EKSDIWSAGCLLYEMAALKPPFEATNHLSLAIKIKSGKFERLPL-RYSEELQKLIESMVHIDPEKRPSVQNILE-LPQINL
|| |.|..|| ||.|. |.|||  || |.|| ||   ... ..   .|.... .| .    ||| || . ..   | .|  
EKADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIVEHFYDPVNEGMWSDDVRFTITRCLTPDPEARPDIVKVSSVLRMIQD
Kinase 18676.AA Ciliate-E2-Unclassified 4-265 25 2.5e-67 230.01 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-352/352
Sequence Identity: 25% (89 aa)

YEILGQIGKGSFGLVQKIKRKSDGKVLVWKEMNYGRMSEREKQQLV-------AEVNII---------RELK-----HPNIVRYYDRIIEKKDTKIYIIM
|.|. |||.|.|| |.| ..|..... . |.|.  ..  . ... .        |.|..         ....     ||.......  ..... .|||.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCEGGDVGTLLKKCKK------------EKDY-IAEDVIW-----KIFTQIILALNECHNRPQGK-ILHRDLKPANIFLDAQN---NIKLGDFGLSRVM
|||||||    .||.||            ...  . |  .      ..| ||...|. .|   . . |.|||.|| ||..| ..   .||. |||.|.  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH---HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

GEQ---------------SEFADTHVGTPYYM----SPEQIQEKKYN----EKSDIWSAGCLLYEMAALKPPFEATNHLS----------------LAIK
...               .. ..| .|||.||    .|| .|...|.    .|.|||| |..||||   ..||...|  .                |  .
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

IKSGKFERLP-------LRYSEELQKLIE----SMVHIDPEKRPSVQNILELPQI
|| ....  .        . |.| . .|.    .|   .|.||.. . ||. | .
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 18676.AA TyrKc 4-263 22 6.1e-21 76.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-263
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

YEILGQIGKGSFGLVQKIKRKSDGKVLVWKEMNYGRMSEREKQQLVAEVNIIREL--KHPNIVRYYDRIIEK-----KDTKIYIIMEYCEGGDVGTLLKK
 . . ..| | || | | . |   .| | .  ..       .. .  | .| ..|  .|||||| |  ....      .  ..|.|||...||    |.|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CKKEKDYIAEDVIWKIFTQIILALN--ECHNRPQGKILHRDLKPANIFLDAQNNIKLGDFGLSRVMGEQ-------SEFADT-HVGTP-----YYMSPEQ
....   .  .   .. .||    .  . .     .. ||||   |. ..... .| .||||||  ..        .    . | |.        |.|| 
HRPK---LCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

IQEKKYNEKSDIWSAGCLLYEMAAL-KPPFEA-----TNHLSLAIKIKSGKFERLPLR--------YSEELQKLIESMVHIDPEKRPSVQNILELP
|...|...|||.|| | ...|.  . ..| .       .   .  ..|.|.  . |           ..|. .....  | |||.||. ..| |. 
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 18676.AA Pkinase_Tyr 130-203 31 3.6e-10 35.05 Pfam 131-207 (270) Show / Hide 
Range on Protein: 130-203
Range on HMM: 131-207/270
Sequence Identity: 31% (25 aa)

KILHRDLKPANIFLDAQNNIKLGDFGLSRVMGEQSEFADTHVGT-----PYYMSPEQIQEKKYNEKSDIWSAGCLLYEM
.. ||||   |. .. .| .| .||||.| . .  .   .....        |.|| |...|...|||.|| | |..|.
NCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEI
Kinase 18676.AA Pkinase_Tyr 4-96 29 1.4e-09 33.1 Pfam 1-100 (270) Show / Hide 
Range on Protein: 4-96
Range on HMM: 1-100/270
Sequence Identity: 29% (30 aa)

YEILGQIGKGSFGLVQKIKRK-----SDGKVLVWKEMNYGRMSERE--KQQLVAEVNIIREL-KHPNIVRYYDRIIEKKDT-KIYIIMEYCEGGDVGTLL
 ... ..|.|.|| | | . |      . .| | | ..    ....  .. . .|..| ..| .||||||.|  ......  .|||.|||...||  . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAV-KMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KK
.|
RK