1924

Species: Tetrahymena
Alias: TTHERM_01114180, 240.m00047, PreTt01924, 1924, 791
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
1924.AA Protein None 932 None Fasta, JSON
1924.kin_dom Protein Kinase Domain None 211 None Fasta, JSON
1924.NA RNA None 2799 None Fasta, JSON

Protein domain

Protein domains of 1924.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1924.AA NEK 4-254 41 2.3e-117 396.21 In-house 1-286 (286) Show / Hide
Range on Protein: 4-254
Range on HMM: 1-286/286
Sequence Identity: 41% (120 aa)

YDKVKLVCKIEMGDVFLVEEK-TSKH---------RIFIDER-EQQTYHPE-NEAKLLEQLDHPNIIKMQEHFYHKK--YFCLIMEFAE-KGDLNKL---
|...| . .   | |..|. | ..||         .| ...  |...     ||...|.||.||||.|  ..|....  ..| .||..| .||| ..   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ILNLKQKEEYLNEKQVLDLFCQLCLAVKYLHDR-----KYIHRDIKIHNIFLSNENI----VKLGDFGISIQLDKSEIYAKT-QLGTPYYLSPEVVQGKN
| . ||| .|. |.|..| |.|.|||.||.|||     | .|||||  ||||...|.    ||.|||||| .|...  .|.| | |||||.||||.|.| 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDQKVDIWMIGCFLYEICEL--SRPFQGA--TWSEVDYKIQNI-EPEPIDES--YSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI
|..|.|||..|| |||.| |   .||..    . .  .||..  ...|| .   ||| ||||. ..|||||.||||.|.|.||| |
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase 1924.AA NEK1 44-254 41 1.5e-78 267.26 In-house 47-276 (276) Show / Hide
Range on Protein: 44-254
Range on HMM: 47-276/276
Sequence Identity: 41% (96 aa)

NEAKLLEQLDHPNIIKMQEHFYHKKY--FCLIMEFAEKGDLNKLILNLKQKEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLS--NEN---
||...|. ..||||.| .| |    .     .||... |||.. | . | |     | | .. |||.|||... |||| .|||||  ||||.  .     
NEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGS

------------IVKLGDFGISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEICELSRPFQGATWSEVDYKIQNIEPEPIDESYS
            .||||||||.  |  .  ||.| .|||||||||  | | |..| |||  || ||| | |..||... |     ||      ||   ||
GSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYS

QFLQNLVKKLLQKDPQQRPSINDIIEMPEI
. ||.||.......|. |||.|.| | | |
YELQSLVSQMFKRNPRHRPSVNQILERPFI

Kinase 1924.AA NEK8 44-254 39 5.1e-71 201.95 In-house 49-278 (278) Show / Hide
Range on Protein: 44-254
Range on HMM: 49-278/278
Sequence Identity: 39% (91 aa)

NEAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEKGDLNKLILNLKQ---KEE------------YLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIH
||  .|  |.|||||   .||   .     || |. | |  .|.  .     ||            | ||...|. | | |.|| ..|.    |||.|  
NEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQ

NIFLSNE-NIVKLGDFGISIQL-DKSEIY-AKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEICELSRPFQGATWSEVDYKIQNI-EPEPIDESYS
|||.    ..||.||||||  . .|.  . .|| .|||||.||| ..|| |.|| |.| .|| ||| | | | | ..  ...  ||    . |||.. ||
NIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYS

QFLQNLVKKLLQKDPQQRPSINDIIEMPEI
  .  ||  .||.||.||||   |  || .
NEMRMLVHNCLQQDPEQRPSASQIMAMPLC

Kinase 1924.AA NEK4 4-254 40 4.3e-69 235.87 In-house 1-257 (257) Show / Hide
Range on Protein: 4-254
Range on HMM: 1-257/257
Sequence Identity: 40% (107 aa)

YDKVKLVCKIEMGDVFLVEEKTSKHR-----IFID--EREQQTYHPENEAKLLEQLDHPNIIKMQEHFYHKKY--FCLIMEFAEKGDL-NKLILNLKQKE
|. .| | |   |.|.|| ..  | .     .|    .|. ..   | ||.|| || ||||..  | .        . .| | | ||| .||    .|| 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRR-ERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL---KQQKN

EYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFGISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEIC
. | |.||.. | |  .|  |.|... .||| |  ||||   ||.|.||||||  |. .  .||| .|||||.|||.   . || | ||| .|| .||. 
QFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMI

ELSRPFQGATWSEVDYKIQNIEPEPIDESYSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI
 |   |.        |.| .  | |.   ||| |||||...|.| |..|||| ||. || |
TLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI

Kinase 1924.AA S_TKc 4-254 26 1.4e-64 221.73 SMART 1-231 (231) Show / Hide
Range on Protein: 4-254
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

YDKVKLVCKIEMGDVFLVEEKTSKHRI---FIDEREQQTYHPENEAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEK--GDLNKLILNLKQ--KEEYL
|...... |  .| |... .| ....     |.       | ..| ..|.. .||||.|. ..|.. ......||...   ||| ..| . .   .  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFGISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQ-KVDIWMIGCFLYEICEL
.| ..  ...|.|.|..|.|... ||||.|  ||.|..   .|..|||.. ||       .|. |||.|..|||.    |.  |.|.| .|| ||| .  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

SRPFQGATWSEVDYKIQNIEPEPIDESYSQFLQNLVKKLLQKDPQQRPSINDIIE-------MPEI
  ||.     ...  ...|         ..... ...|.|||||..||.. .. .       .| .
YPPFP-----QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 1924.AA Ciliate-E2 4-254 24 2.1e-60 206.05 In-house 1-365 (365) Show / Hide
Range on Protein: 4-254
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

YDKVKLVCKIEMGDVFLVEE--------------------------------KTSKHR-IFIDEREQQTY----HPE----NEAKLLEQLDHPNIIKMQE
|...|. ..   |.|....                                 |. |.. |.. ..|.. .    . .    || ..||||.||||||| |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

HFY--HKKYFCLIMEFAEKGDLNKLILNLKQKE-------EYLNEKQVLDLFCQLCL---------------AVKYLHDRK-YIHRDIKIHNIFLSNENI
.|.   .... |.||... ||| ..| | |.|.       .|..||...... |..                |..||| ..  ||||||  ||..     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKLGDFGISIQLDKSEI-------------------------------YAKTQLGTPYYLSPEVVQGKN---------YDQKVDIWMIGCFLYEICELSR
.|. |||.| ..|....                                ..|..|||.|..||...||.         || |.||| .|. ||| .   .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFQGATWSEVDYKIQNIE------PEP--------------IDESYSQFLQNLVKK----LLQKDPQQRPS-INDIIEMPEI
||           .|.|.      |.|              . .. ||  ..| ||    .|||||..|.. ...|.. | .
PF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 1924.AA Pkinase 33-254 25 5.9e-58 203.64 Pfam 36-293 (293) Show / Hide
Range on Protein: 33-254
Range on HMM: 36-293/293
Sequence Identity: 25% (67 aa)

DEREQQTYHPEN--EAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEKG----DLNKLILNLKQKEEYL--NEKQVLDLFCQLCLAVKYLHDRKYIHRD
.|.... ..  .  |....  |.||||... . |. |.. ...||..|.|    ||  .|    ...  .   |... . . |.. ...|.|... ||||
HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRD

IKIHNIFLSNENIV----KLGDFGISIQ--LDKSEIYAKTQLGTPYYLSPEVVQ-GKNYDQKVDIWMIGCFLYEICELSRPFQGA----TWSEVDYKIQN
.|  ||...|.. .    |..|||.. |  . ...  ..|  |||.|..|||.. |. |..|||.| .|| ||| .    ||.|.    .  . ...|..
LKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICR

IEPEPIDESYS-----------------------QFLQNLVKKLLQKDPQQRPSINDIIEMPEI
| . |......                       . .. ..|..|.|||..||.. .| . | .
IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 1924.AA ULK 43-254 26 3.5e-55 189.65 In-house 58-324 (324) Show / Hide
Range on Protein: 43-254
Range on HMM: 58-324/324
Sequence Identity: 26% (71 aa)

ENEAKLLEQLD---HPN--IIKMQEHFYHK--KYFCLIMEFAEKGDLNKLILNLKQ-----KEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNI
.|| ... .|.   |||  |.|. . |. .  .....|||. . ||| ..| . |      .. .|.|....  | |.| . |.||....||||||  ||
KNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNI

FLSNEN------------IVKLGDFGISIQLD---KSEIYAKTQL------GTPYYLSPEVVQ----GKNYD-QKVDIWMIGCFLYEICELSRPFQGATW
 ..| .            ..|..||| . ..|   ...   .|..      |||.| .|...|    .|.|.  |.||| .|| .||.   . ||..   
LIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-F

SEVD----------------YKIQNIEPEP--IDESYSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI
.. .                 | |.|.. .   |   |. ...| ...||.|. .| |. .|...| .
NDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 1924.AA NEK-Unclassified 4-254 33 7.7e-55 179.86 In-house 1-258 (258) Show / Hide
Range on Protein: 4-254
Range on HMM: 1-258/258
Sequence Identity: 33% (86 aa)

YDKVKLVCKIEMGDVFLVEEKTSKHRIF--IDEREQQTYHPENEAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEKGDLNKLILNLKQKEEYLNEKQV
|||.  . .   | |.||  . ||  .   |  | ..     |   .| || || |.   . |.         .. . |.| ..|     | | ..|  .
YDKITTLGQGGGGAVYLVRHQISKRHLVQQISKRKKKKKR-QNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRI

LDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFGISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEICELSRPFQG
   . |.  || | | || |||| |  ||||  . .| .||||||  .|     |.|  ||. ..||||.| . |. . |.|  || .||.|     |  
MQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDT

ATWSEVDYKIQNIEP------EPIDESYSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI
    || .||   .       ||.   ||  ||.... .|....|||||  .|.|.. |
HNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI

Kinase 1924.AA CAMK 43-250 21 1.3e-54 174.01 In-house 79-421 (425) Show / Hide
Range on Protein: 43-250
Range on HMM: 79-421/425
Sequence Identity: 21% (74 aa)

ENEAKLLEQ-------LDHPNIIKMQEHFYH-------------------KKYFCLIM---EFAEKG----DLNKLILNLKQKE-----------EYLNE
..| ... .       ||||||||. |..                     .|.....|   |... |    ||   |   ...             ...|
RREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE

KQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNE-----------------NIVKLGDFGISIQLDKSE-----------------------IYAKT
...  .| |.| ||.|.|... .|||.|  || |..                  | .|. ||| ....|..|                          ||
REARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT

QLGTPYYLS-PEVVQGKN--------------YDQKVDIWMIGCFLYEICELSR--PFQGATWSEVDY-------------KIQNIEPEPIDES------
. |||.| . |||..||               |..|.|.| .|. ||    |.   ||.| . .|                ||.. . . ...       
FCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM--LCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISC

-----------------YSQFLQNLVKKLLQKDPQQRPSINDIIE
                  ||  ..|..|.||.||..|..| .. .
NYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN

Kinase 1924.AA ULK 43-254 26 1.5e-54 187.58 In-house 58-329 (329) Show / Hide
Range on Protein: 43-254
Range on HMM: 58-329/329
Sequence Identity: 26% (71 aa)

ENEAKLLEQLD--------HPNIIKMQEHFYHK--KYFCLIMEFAEKGDLNKLILNLKQ------KEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIK
.|| |.. .|.        ||||.|. . |. .  ... .|||. . ||| ..| . |       .. .|.|....  |.|.. . |.||....||||||
KNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIK

IHNIFLSNEN------------IVKLGDFGISIQLDKS--EIY-AKTQL------GTPYYLSPEVVQ----GKNYD-QKVDIWMIGCFLYEICELSRPFQ
  || ..| .            ..|..||| . ..|..  |.  ..|..      |||.| .|...|    .|.|.  |.||| .|| .||.     ||.
PQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY

GATWSEVD-----YKIQN-------IEPEPIDES-------YSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI
.   .. .       |.|       |. .|..          |. ...| ...||.|. .| |. .....| .
AW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 1924.AA NEK11 45-254 38 2.3e-50 173.63 In-house 51-259 (259) Show / Hide
Range on Protein: 45-254
Range on HMM: 51-259/259
Sequence Identity: 38% (81 aa)

EAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEKGDLNKLILNLKQKEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFG
||.|| .|.|| |..    |  .  ||.| |. |  ||   |   ||      | |... | || | | |.|.|. .|||.|  |||| | |..|.||||
EAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKN-NLLKIGDFG

ISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEICELSRPFQGATWSEVDYKIQNIEPEPIDESYSQFLQNLVKKLLQKDPQQRPS
.|  |  |   | |  ||| |.||| .. . || | ||| . | |||.| .   | |. .  .  .|   .   . . | . |  .. ..| |.|  |||
VSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPS

INDIIEMPEI
  ||. .| .
AIDILKIPYM

Kinase 1924.AA Pkinase_Tyr 44-207 26 1.2e-22 77.28 Pfam 52-224 (270) Show / Hide
Range on Protein: 44-207
Range on HMM: 52-224/270
Sequence Identity: 26% (45 aa)

NEAKLLEQL-DHPNIIKMQEHFY-HKKY--FCLIMEFAEKGDLNKLILNLKQKEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVK
.|||.. || .||||...    . ...    ...||....||| .   . .  .. |. |. |.   | . .  ||.....||||.   |. ....|.||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LGDFGISIQLDKSEIY--AKTQLGTPY-YLSPEVVQGKNYDQKVDIWMIGCFLYEICELS-RP-FQGATWSEV
 .||| .  . . . |  ...    |   ..||. . . .  | |.|. |  ..||. .   | ..| . .||
ICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEV

Kinase 1924.AA TyrKc 7-252 20 1.2e-16 46.25 SMART 1-280 (280) Show / Hide
Range on Protein: 7-252
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

VKLVCKIEMG---DVFLVEE------KTSKHRIFIDEREQQTYHPENEAKLLEQL--DHPNIIKMQEHFYHK-------KYFCLIMEFAEKGDLNKLILN
..|  |.  |    |.. .       |. |.        ..  .  .||... .|  .||||...     ..       .  ...||....|||.. . .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFM--REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LKQKEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFGISIQLDKS-------EIYAKTQ--LGTP----YYLSPEVVQGKN
 . |   |. |. |.   | .    |||....||||.   |. ......|| .||| |  ..         . | |..   |        ..||. . . 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDQKVDIWMIGCFLYEICEL-SRPFQG-----ATWSEVDYKIQNIEPEPIDES--------YSQFLQNLVKKLLQKDPQQRPSINDIIEMP
.  | |.|. |  ..||. .   |  |      ...||  .... .  |. ..         .. . .. |.  . || .||. ..|.|  
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF