Gene 19674 (Tetrahymena)

19674

Species: Tetrahymena
Alias: 3678.m00023, 677, 174.m00058, PreTt19674, 19674, TTHERM_00947540
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
19674.AA Protein None 541 None Fasta, JSON
19674.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
19674.NA RNA None 1626 None Fasta, JSON

Protein domain

Protein domains of 19674.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19674.AA NEK 11-267 47 1.2e-155 523.41 In-house 1-286 (286) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-286/286
Sequence Identity: 47% (136 aa)

FDIIKTLGEGSFAKVYKVVRKSDGQS-----YAMKRCKIGLMKQRDKDNAL-NEVRILASIKNQYVIAYKEAIYDEQSECLFVIMEYAA-GGDLHQQ---
..|||..|.||| ||||| |||||.      |..|. ..| |....|.||. ||||||...|......|......||..||. .|||.  ||||.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

VKSCIKSKTYLDENQIWIWTIQMLYGLKALHDL-----KILHRDLKCANIFLDSRRN----AKIGDLNVSKITQAN--LART-QVGTPYYTSPEVWKDQM
 | . ....|..|.||| | |||. .|| .||      ||||||.|..||||....|    .||||...||. . .  .|.| ||||||| ||||.... 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNNKSDIWSLGCLIYELCAQ--KPPFLAS--DMPSLFKKIGKG-IYERIPSR--YSSELSNLISQCLNINQITRPDCDQLLNLPII
||||||||||||..||.|..  |.|| |.  .||||..|| ||  |..|||.  ||..|.|||||.|. .   ||.|.|.|..|.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 19674.AA S_TKc 11-267 28 1.1e-85 291.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

FDIIKTLGEGSFAKVYKVVRKSDGQSYAMKRCKIGLMKQRDKDNALNEVRILASIKNQYVIAYKEAIYDEQSECLFVIMEYAAG--GDLHQQVKSCIKSK
..|....|.|.|.||||.. |..|. .|.|. |         .....|..|| . .  ... ......|   ..|...|||. |  |||..  |.. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TY--LDENQIWIWTIQMLYGLKALHDLKILHRDLKCANIFLDSRRNAKIGDLNVSKITQANLARTQVGTPYYTSPEVWKDQMYNN-KSDIWSLGCLIYEL
..  ..| ... .. |.. .|. .|...|.||||| .||.||.  . ||.|  ....      .|..|||.| .|||     |.  |.|.||.||..||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CAQKPPFLASDMPSLFKKIGKGIYERIPSRYSSELSNLISQCLNINQITRPDCDQLLN-------LPII
.. .|||   .|  .|||||           |.|. ..|..||. .   || . ..|.        | .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19674.AA NEK1 11-267 39 2.1e-80 273.41 In-house 1-276 (276) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-276/276
Sequence Identity: 39% (109 aa)

FDIIKTLGEGSFAKVYKVVRKSDGQSYAMKRCKIGLMKQRDKDNALNEVRILASIKNQYVIAYKEAIYDEQSECLFVIMEYAAGGDLHQQVKSCIKSKTY
...||..||||| |...| .|.||| |..|  ..  |.. .. ...||| |||  |   ...|||.   . .  |. .|||. |||| |  .    .   
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LDENQIWIWTIQMLYGLKALHDLKILHRDLKCANIFLDSRRNA-----------------KIGDLNVSKI--TQANLARTQVGTPYYTSPEVWKDQMYNN
  | ||  | .|.  .|.  || ||||||.|  |||| . .|                  |.||  ....      .|.| .||||| ||| .  . |||
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGCLIYELCAQKPPFLASDMPSLFKKIGKGIYERIPSRYSSELSNLISQCLNINQITRPDCDQLLNLPII
|||||||||  ||||. | || |  .. |  || .| |  ||..|| ||..|.|| ...|   ||   |.|  |.|
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 19674.AA NEK2 11-267 33 4.3e-79 265.96 In-house 1-319 (319) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-319/319
Sequence Identity: 33% (107 aa)

FDIIKTLGEGSFAKVYKVVRKSDGQSYAMKRCKIGLMKQRDKDNALNEVRILASIKNQYVIAYKEAIYDEQSECLFVIMEYAAGGDLHQQVKSCIKSKTY
 .. .|.|.||| ...|| |||||   . |  . | |    ..   .|. ||   | .... |   | |.|.. | ..||| .|||| | .| | | ..|
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LDENQIWIWTIQMLYGLKALHD---------------------LKILHRDLKCANIFLDSRRN-------------------------------------
..|  ||    |..  |.  |                        |||||.| ||||||.  |                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--AKIGDLNVSKITQ--ANLARTQVGTPYYTSPEVWKDQMYNNKSDIWSLGCLIYELCAQKPPFLASDMPSLFKKIGKGIYERIPSRYSSELSNLISQCL
  .| ||    .. .     | | |||||| |||. ..| || ||||||.||||||.|| .||| |     |  || .| ..|||..||..|. .|.  .
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

NINQITRPDCDQLLNLPII
|..  .||  . .|  | |
NVDHYHRPSIEEILQHPQI
Kinase 19674.AA NEK4 11-267 36 1.8e-64 220.52 In-house 1-257 (257) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-257/257
Sequence Identity: 36% (94 aa)

FDIIKTLGEGSFAKVYKVVRKSDGQSYAMKRCKIGLM--KQRDKDNALNEVRILASIKNQYVIAYKEAIYDEQSECLFVIMEYAAGGDLHQQVKSCIKSK
....|  | ||.  |. |  . |.  | ||  |. |    .|..  |. |...|   |   .. |||    |    |...| .  |||| .. |   .  
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMK--KMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQ--QKN

TYLDENQIWIWTIQMLYGLKALHDLKILHRDLKCANIFLDSRRNAKIGDLNVSKITQ--ANLARTQVGTPYYTSPEVWKDQMYNNKSDIWSLGCLIYELC
  |.|.|.  | .|   .|  .|. .|||||||  ||||  .   ||||. .|.. .  ...|.| .||||| |||..  . |. ||||||||| .||. 
QFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMI

AQKPPFLASDMPSLFKKIGKGIYERIPSRYSSELSNLISQCLNINQITRPDCDQLLNLPII
  |  | | ||.||  .| .|    .|  || .| ||. | |.     ||   ...  | |
TLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 19674.AA CAMK 16-267 19 1.9e-62 199.75 In-house 1-425 (425) Show / Hide 
Range on Protein: 16-267
Range on HMM: 1-425/425
Sequence Identity: 19% (81 aa)

TLGEGSFAKVYKVVRKSDG------------QSYAMKRCKIGLMK--------------------------QRDKDNALNEVRILAS-------IKNQYV
|||.|||.||.....|...            | .|.|  .   .|                          ..|..| ..|..|. .       ..   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IAYKEAIYDEQ-----------------SECLFVIM---EYAAGGDLHQQVKSCIKSKTY---------------LDENQIWIWTIQMLYGLKALHDLKI
|   |.. |..                  .... .|   ||. ||.| . . . |.....               ..| .   .  |.. ... .|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKCANIFLDSR-----------------RNAKIGDLNVSKITQAN-------------------------LARTQVGTPYYTS-PEVWKD----QM
 |||||. || ||..                  | || |   ... . .                         . .|..|||.| . ||| .     .|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNNKSDIWSLGCLIYELCAQKPPFLAS-------------DMPSLFKKIGKGIYERIPSRYSS-----------------------ELSN
          |. |.|.||.|.. | .   .||| ..             ... ||.|| || |. .|.  |                        |  .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISQCLNINQITRPDCDQLLNLPII
||...|. .   |. ..| || | .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 19674.AA Ciliate-E2 11-267 21 2e-62 213.13 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-365/365
Sequence Identity: 21% (81 aa)

FDIIKTLGEGSFAKVYKVVR-----------------------KSDGQSYAMKRC-KIGLMKQRDKDNALNEVR----------ILASIKNQYVIAYKEA
...|| .|.|.|..|||. .                       | ... ||||.  | ..  .  ... ..|..          || .... ..| ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IYDEQSECLFVIMEYAAGGDLHQ-QVKSCIKSKTY------LDENQIWIWTIQMLY---------------GLKALHDLK-ILHRDLKCANIFLDSRRNA
 .... .... .|||. |||| .   ....|..        ..|..|   . | |.               .|. ||  . |.|||.|  ||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDLNVSK---------------------------------ITQANLARTQVGTPYYTSPEVWKDQM---------YNNKSDIWSLGCLIYELCAQKPP
|| |.  ||                                 | | |...|..|||.| .||. . .          |. |.||||||...||..  |||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FLASDMPSLFKKIGKGIYE-R----------------IPSRYSSELSNLISQ----CLNINQITRPD-CDQLLNLPII
|        ...| .. .. .                ..   | |  .||..    .|. ..  |..  .|.|| |..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19674.AA STE 11-267 23 2.3e-62 213.48 In-house 1-359 (359) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-359/359
Sequence Identity: 23% (84 aa)

FDIIKTLGEGSFAKVYKVVRK------SDGQS---------YAMKRCKIGLMKQ---------------RDKDNALNEVRILASIK--NQYVIAYKEAIY
...|. .|.|.| .||| ...      . |.          .|.|. ..   ..                .... |.|..|.   .   .... |  . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE---QSE--CLFVIMEYAAGGDLHQQVK-SCIKSK---------TYLDENQIWIWTIQMLYG-LKALHDLKILHRDLKCANIFLDSRRNAKIGDLNVSK
.|   ...   |...||| .|| | . .|  ... |         ....|.|| . . | | | |. ||...| |||.|.|||.|     .|. |  |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ITQANLA----------------R--TQVGTPYYTSPEVWKDQM------YNNKSDIWSLGCLIYELCAQKPPFLA-SDMPSLFKKIGK-----------
. . ..|                .  | |||| . .||| . .       |. |.|||||||.| |..  |||.   ..|  .| .. .           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GIYERIPS-------------------RYSSELSNLISQCLNINQITRPDCDQLLN--LPII
   |   ..|.                   ..|.|. . |..||...   ||. .|||.   | |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 19674.AA Pkinase 11-267 25 1.7e-59 208.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

FDIIKTLGEGSFAKVYKVVRKSDGQSYAMKRCKIGLMKQRDKDNALN--EVRILASIKNQYVIAYKEAIYDEQSECLFVIMEYAAGG----DLHQQVKSC
. |....|.|||..||| ..|..|. .|.|. |    |   . ....  |..|.....  ... .... .|  .  . ..|||. ||    ||.    . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF----DY

IK--SKTYL--DENQIWIWTIQMLYGLKALHDLKILHRDLKCANIFLDSRRNA----KIGDLNVSK---ITQANLARTQVGTPYYTSPEVWK-DQMYNNK
|.  ... .  .|...  .  |.| ||. .|. .|.||||| .||..|.. .     ||.|  ..|   .     . | .|||.| .||| . .|.|  |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDIWSLGCLIYELCAQKPPFLAS------DMPSLFKKIGKGIYERI-PSRYS-------------------SELSNLISQCLNINQITRPDCDQLLNLPI
.|.||.||..||..  .|||  .      |.  ....|.......  |  .|                   .|.  .|. ||. .   || ..|.|. | 
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

I
.
F
Kinase 19674.AA Ciliate-E2-Unclassified 11-267 26 1.9e-56 193.88 In-house 1-352 (352) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-352/352
Sequence Identity: 26% (93 aa)

FDIIKTLGEGSFAKVYKVVRKSDGQSYAMKRCK-IGLMKQRDKDN---------ALNEVR-------------ILASIKNQYVIAYKEAIYDEQSECLFV
. |||..|.|.|.||||...|...| ||||  | |   ||. . |         ..|.               || .... ...  |.  .... .... 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIV--KMFYCFQDKQNIYI

IMEYAAGGDLHQQVKSC-------------IKSKTYLDENQIW-----IWTIQMLYGLKALHDLK-ILHRDLKCANIFLDSRR---NAKIGDLNVSK---
.|||. ||||.|  |..             .|..  ..|.|.       .. | | ||. ||  . |.|||.|. ||..|.     . || |.  ||   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------ITQANLARTQVGTPYYT----SPEVWKDQMYNNK----SDIWSLGCLIYELCAQKPPFLASDMPS----------------LFKKI
              |.. ... |..|||.|     .||| . | |...    .||||||...||.. ...|| . .  .                |...|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

-GKGIYER------IPSRYSSELSNLIS----QCLNINQITRPDCDQLLNLPII
  | |. .      || . | |  ..|.    ..|. |.  |.. .|.|| |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 19674.AA ULK 11-267 25 9.7e-55 188.18 In-house 1-329 (329) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-329/329
Sequence Identity: 25% (84 aa)

FDIIKTLGEGSFAKVYKVV---RKSDGQSYAMKRCKIGLMKQRDKDN-----------ALNEVRILASIK--------NQYVIAYKEAIYDEQSECLFVI
. ... ||.|||.||||     .| | ..  .  ||. . .. ...|             ||..|.  .|        ..... ...  .. .. ... |
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MEYAAGGDLHQQVKSCIK------SKTYLDENQIWIWTIQMLYGLKALHDLKILHRDLKCANIFLDSRRN------------AKIGDLNVSKITQAN---
|||  |||| |  |   |       | .| |... .  .| | |.|.||. .| |||.| .|| ..                .||.|   .|  . .   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

--LARTQV------GTPYYTSPEVWKDQ----MYNNK-SDIWSLGCLIYELCAQKPPFLASDMPSLF-----KKIGKGIYER-----IPSR---------
  .. |.|      |||.| .|.....|     |... .|||||||..||.   |||| |.   ...     | | ..   .     .| .         
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

YSSELSNLISQCLNINQITRPDCDQLLNLPII
 |.|. .||...| ...  | . ..|.| |..
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 19674.AA ULK 11-267 25 1.4e-52 180.97 In-house 1-324 (324) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-324/324
Sequence Identity: 25% (82 aa)

FDIIKTLGEGSFA-KVYKVV-RKSD--GQSYAMKRCKIGLMKQRDKD--------NALNEVRILASIK------NQYVIAYKEAIYDEQSECLFVIMEYA
. ... ||.|||. ||||    |..  .| .| |   .  |..  ..        .  ||..|.  .|      . ... ...  .. ..  .. |||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

AGGDLHQQVKSCIK-----SKTYLDENQIWIWTIQMLYGLKALHDLKILHRDLKCANIFLDSRRN------------AKIGDLNVSKITQ-----ANLAR
 |||| |  |   |      | .| |... .  .| . |.|.||. .| |||.| .|| .                 .||.|   .|. .     ...  
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TQV------GTPYYTSPEVWKDQ----MYNNK-SDIWSLGCLIYELCAQKPPFLASDMPSLF----KKIGKG------IYE---RIP-----SRYSSELS
|.|      |||.| .|.....|     |... .|||||||..||.   |.|| ..   ...    | | .|      |.    ..|        |.|. 
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

NLISQCLNINQITRPDCDQLLNLPII
.||...| ...  | . ....| |..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 19674.AA TyrKc 11-267 19 3.8e-17 54.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FDIIKTLGEGSFAKVYKVVRKSDGQSYAMKRCKIGLMKQRDKDNALNEVRILASI--KNQYVIAYKEAIYDE-----QSECLFVIMEYAAGGDLHQQVKS
   .|.|||| | .||| . |   .  | | .| .      .   ..| ||. ..  ... ...   .. ..      .| |...|||...|||..  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CIKSKTYLDENQIWIWTIQMLYGLKALHDLKILHRDLKCANIFLDSRRNAKIGDLNVSKITQAN--------LARTQV--GTP-----YYTSPEVWKDQM
. .    |   .   . .|   |   ||. .. |||| . |. ..... .||.|   |.               |..   |.        ..||.... .
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YNNKSDIWSLGCLIYELCAQ-KPPFLA-----SDMPSLFKKIGKGIYERIPSR--------YSSELSNLISQCLNINQITRPDCDQLLNLPII
.. |||.|| | ...|..   ..|         .   ..... .| . ..|           ..|. ....|| . .   ||   ..    ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 19674.AA Pkinase_Tyr 11-98 21 3.2e-07 25.06 Pfam 1-95 (270) Show / Hide 
Range on Protein: 11-98
Range on HMM: 1-95/270
Sequence Identity: 21% (21 aa)

FDIIKTLGEGSFAKVYKVVRK----SDGQSYAMKRCKIGLMKQRD--KDNALNEVRILASI-KNQYVIAYKEAIY-DEQ-SECLFVIMEYAAGGDLH
  ..|.||||.| .||| . |    ....  | | .|     ...  ..  ..|..|. .. ... .. .  ... ... .  ....|||...|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLL
Kinase 19674.AA Pkinase_Tyr 179-206 35 3.6e-05 18.14 Pfam 181-208 (270) Show / Hide 
Range on Protein: 179-206
Range on HMM: 181-208/270
Sequence Identity: 35% (10 aa)

TSPEVWKDQMYNNKSDIWSLGCLIYELC
..||....  .. |||.|| | |..|..
MAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase 19674.AA Pkinase_Tyr 130-157 32 0.179515 5.61 Pfam 127-154 (270) Show / Hide 
Range on Protein: 130-157
Range on HMM: 127-154/270
Sequence Identity: 32% (9 aa)

LHDLKILHRDLKCANIFLDSRRNAKIGD
|.. .. |||| . |. ... . .||.|
LESKNCIHRDLAARNCLVTENNVVKICD