Gene 20296 (Tetrahymena)

20296

Species: Tetrahymena
Alias: PreTt20296, TTHERM_00455670, 3712.m00059, 53.m00198, 412, 20296
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
20296.AA Protein None 842 None Fasta, JSON
20296.kin_dom Protein Kinase Domain None 267 None Fasta, JSON
20296.NA RNA None 2529 None Fasta, JSON

Protein domain

Protein domains of 20296.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20296.AA NEK 14-280 47 6.5e-153 514.31 In-house 1-286 (286) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-286/286
Sequence Identity: 47% (139 aa)

YKEIELIGRGTQGSAMLVECRSDKKR-----YVSKKVILTNLSEKDQNNAI-QELKLLREMKHPNIVKFIESYKEKN--KVIIIMEYCE-YGDLSQL---
|..|. ||.| .|.. .|...||.|      || ||. ..|.|||.. ||. .| ..|...|||||||...|. |..  . .|.|||||  |||.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKQKSAKGEQIEESIILQWFIQICSALSFIHSK-----KVIHRDIKSSNIFLTKSNC----VKIGDFGISKQLENSMDKANT-LVGTPYYLSPEVCQNKP
||..  ||. .||..|. ||||.|.|| ..|..     |..|||||..||||||.|.    ||||||||||.|....|.|.| .||||||.|||||||||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YTYKSDMWSLGCVIYELCSLKVTNLTIYITKHPFQSN--SLMSLVMKIATE-KAPKIPQN--YSLMTNGFIRSLLQKIPEKRPSAQDILNNQNI
|..|||.||||||.||.|.||         ||||...  ...||.|||  . . |.||..  ||   . .|...||| ||.|||...||..  |
YNNKSDIWSLGCVLYEMCTLKP--------KHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 20296.AA NEK1 14-280 43 1.9e-111 376.54 In-house 1-276 (276) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-276/276
Sequence Identity: 43% (125 aa)

YKEIELIGRGTQGSAMLVECRSDKKRYVSKKVILTNLSEKDQNNAIQELKLLREMKHPNIVKFIESYKEKNK--VIIIMEYCEYGDLSQLIKQKSAKGEQ
| .|  || |. | |.||  ..| . || |   ... .||.  ..  | ..|. ||||||||. ||  |  .    |.||||. ||| | |...  ||  
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IEESIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLT--KSN---------------CVKIGDFGISKQLENSMDKANTLVGTPYYLSPEVCQNKPYTY
. |  |..||.||| || .||..|..||||||.|||||  |.                 ||.|||||.. | ..|. |.| .||||||||| ||||||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDMWSLGCVIYELCSLKVTNLTIYITKHPFQSNSLMSLVMKIATEKAPKIPQNYSLMTNGFIRSLLQKIPEKRPSAQDILNNQNI
|||.|||||| |||| |          ||||..|..  ||.||     |.||. ||      . ..... |. |||...||    |
KSDIWSLGCVLYELCTL----------KHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 20296.AA NEK4 14-280 43 2.4e-96 326.4 In-house 1-257 (257) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-257/257
Sequence Identity: 43% (118 aa)

YKEIELIGRGTQGSAMLVECRSDKKRYVSKKVILTNLSEKDQNNAIQELKLLREMKHPNIVKFIESYKEKNK--VIIIMEYCEYGDLSQLIKQKSAKGEQ
|  .  .|.|  |   ||  | |||.|| ||. | | | ...  | .| .||  .||||||.. ||..  |     |.| .|| ||| .  ||.  |.. 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQ--KNQF

IEESIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLTKSNCVKIGDFGISKQLENSMDKANTLVGTPYYLSPEVCQNKPYTYKSDMWSLGCVIYELCSL
.||. .. ||.||  || ..| |...||| |  |||||| | .||||||||. |.|. | | |..|||||.|||.  |.|| ||||.||||| .||.  |
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

KVTNLTIYITKHPFQSNSLMSLVMKIATEKAPKIPQNYSLMTNGFIRSLLQKIPEKRPSAQDILNNQNI
          || |.   . ||. .|   . | .|.|||      .. .|.| |.||||  ||.    |
----------KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 20296.AA NEK8 14-277 36 1.7e-87 249.84 In-house 1-275 (278) Show / Hide 
Range on Protein: 14-277
Range on HMM: 1-275/278
Sequence Identity: 36% (104 aa)

YKEIELIGRGTQGSAMLVECRSDK--KRYVSKKVILTNLSEKDQNNAIQELKLLREMKHPNIVKFIESYKEKNKVIIIMEYCEYGDLSQLIKQKSAKGEQ
|  |  .|||  |...|   ..|   .  . | . .. .|||  . |  |  .|    ||||.  ...  | |   | |||.. | | |.|    .| . 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

IEE---------------SIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLTKS-NCVKIGDFGISKQL--ENSMDKANTLVGTPYYLSPEVCQNKPYT
 |.                 ||  |.|.|||....|.. . |||.|  |||.|.. . |||||||||| .  . .|  . |.||||||.||| |. ||| 
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

YKSDMWSLGCVIYELCSLKVTNLTIYITKHPFQSNSLMSLVMKIAT-EKAPKIPQNYSLMTNGFIRSLLQKIPEKRPSAQDILNN
 |||||.||||.||.|.|| .          |    |  ||.|| .  .   |.  ||.     ....||. ||.||||  |. .
QKSDMWALGCVLYEMCCLKRA----------FEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAM
Kinase 20296.AA S_TKc 14-280 28 1.4e-80 274.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-231/231
Sequence Identity: 28% (79 aa)

YKEIELIGRGTQGSAMLVECRSDKKRYVSKKVILTNLSEKDQNNAIQELKLLREMKHPNIVKFIESYKEKNKVIIIMEYCEY--GDLSQLIKQKSAKG--
|. ...||.|. |. ...  .......  |..          .....|...|.. .||||||..... . ... ..||||.   ||| ..||..  .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

EQIEESIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLTKSNCVKIGDFGISKQLENSMDKANTLVGTPYYLSPEVCQNKPYTY-KSDMWSLGCVIYEL
 .. |  .  .. |||.|| ..||...||||.| .||.|..  ..||.|||...||       .|..|||.|..|||.   .|.. |.|.||.||..||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CSLKVTNLTIYITKHPFQSNSLMSLVMKIATEKAPKIPQNYSLMTNGFIRSLLQKIPEKRPSAQDILN-------NQNI
.. .                  | ...|.            . . . ||| .||| |||||.| ..|.        . .
LCGYPPFP-------------QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20296.AA STE 14-280 25 5.3e-77 262.12 In-house 1-359 (359) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-359/359
Sequence Identity: 25% (92 aa)

YKEIELIGRGTQGSAMLVECRS-----DKKRY---------VSKKVILTNLSE----------------KDQNNAIQELKLLREMK--HPNIVKFIESYK
.. || ||.|. |.  .  ..      ....          .  |..  . ..                ..... ..|.|......  ||||||.. .| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EK-------NKVIIIMEYCEYGDLSQLIKQKSAKGEQ----------IEESIILQWFIQICSA-LSFIHSKKVIHRDIKSSNIFLTKSNCVKIGDFGISK
 .       ... |.|||...| |...||.|  .|..          ..||.|     ||. . |...||...||||||..||.|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLENSMD----------------KANTLVGTPYYLSPEVCQN------KPYTYKSDMWSLGCVIYELCSLKVTNLTIYITKHPFQSNSL------MSLVM
||..||.                | ||.|||| . .||| |.      |.|..|.|.|||||.| |..  |.   . . ..  |. .        . .. 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

KIATEKAPKIPQ-------------------NYSLMTNGFIRSLLQKIPEKRPSAQDILN--NQNI
.|  .. |..|.                   ..|   . ||.  ||| |.|||.|.. |.     |
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 20296.AA NEK-Unclassified 14-280 35 2.3e-75 248.94 In-house 1-258 (258) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-258/258
Sequence Identity: 35% (97 aa)

YKEIELIGRGTQGSAMLVECRSDKKRYVSKKVILTNLSEKDQNNAIQELKLLREMKHPNIVKFIESYKEKNKVIIIMEYCEYGDLSQLIKQKSAKGEQIE
|  |  .| |  |   ||     |.  | ...       | ||  |    .|  ..|| || . .|. |  |.    .||. |.| ..|. .  | | ..
YDKITTLGQGGGGAVYLVRHQISKRHLV-QQISKRKKKKKRQNKII----ILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

ESIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLTKSNCVKIGDFGISKQLENSMDKANTLVGTPYYLSPEVCQNKPYTYKSDMWSLGCVIYELCSLK-
| .| ||.||.  |. .||..|.|||| | .|||||..  | .||||||. ..   ||| | |||. ..|||||| .||  .|| |||||.|||.|    
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

VTNLTIYITKHPFQSNSLMSLVMKIATEKA-------PKIPQNYSLMTNGFIRSLLQKIPEKRPSAQDILNNQNI
            |   .. .. |||  . .       | . . ||      || .|.. ...|||| .|.    |
F-----------FDTHNMGEVYMKIKQDDNRLEEALEP-VSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase 20296.AA Pkinase 14-280 25 6.5e-74 256.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

YKEIELIGRGTQGSAMLVECRSDKKRYVSKKVILTNLSEKDQNNAIQ--ELKLLREMKHPNIVKFIESYKEKNKVIIIMEYCEYG----DLSQLIKQKSA
|. .. ||.|. |.  .   ... |... |.. . . ... . ...   |........|||||...... .|... ..||||| |    ||. .|.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KGEQI--EESIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLT-KSNC---VKIGDFGISKQL-ENSMDKANTLVGTPYYLSPEVCQ-NKPYTYKSDMW
..  .  .|  .  .. ||...| ..||...||||.|..||..  . ..   |||.|||..||. . .   ..|..|||.|..|||.. ...|..|.|||
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGCVIYELCSLKVTNLTIYITKHPFQSN------SLMSLVMKIATEKAPKIPQNYS--------------------LMTNGFIRSLLQKIPEKRPSAQD
|.||..||...           . ||..       . | .. .|   . .   .. .                         ||...|.| |.|||.|..
SCGCILYEMLC----------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

ILNNQNI
||.   .
ILQHPWF
Kinase 20296.AA Ciliate-E2 14-280 23 2.8e-72 246.43 In-house 1-365 (365) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

YKEIELIGRGTQGSAMLVECRSDKKRY------------------VSKKVILTNLSEKDQNNAIQELKLLREMK----------------HPNIVKFIES
|| |..||.|..||  ... ....|..                   .|.. . ...... ..  ||....||..                ||||.|..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YK--EKNKVIIIMEYCEYGDLSQLIKQK---------SAKGEQIEESIILQWFIQICS---------------ALSFIHSKK-VIHRDIKSSNIFLTKSN
..   .|.. ..||||..||| ..||..         . . ... |  |.. . ||..               || ..|||. .|||||| .||..    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

CVKIGDFGISKQLENSMD-------------------------------KANTLVGTPYYLSPEVCQNKP---------YTYKSDMWSLGCVIYELCSLK
 .|| |||.||.. ....                                .||..|||.|..||. ..|.         |.||.|.||||...||... |
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

V------TNLTIYITKHPFQSNSLMSLVMKIATEKAPKIPQNYSLMTNGFIRS----LLQKIPEKRPS-AQDILNNQNI
        .  | . .  .|.. .  ..     .   |.... |. .  .|.     .||| ||||.. ...|||.. .
PPFQQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKW---KSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 20296.AA Ciliate-E2-Unclassified 14-280 24 1e-66 227.95 In-house 1-352 (352) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-352/352
Sequence Identity: 24% (89 aa)

YKEIELIGRGTQGSAMLVECRSDK--------KRYVSKKVILTNLSEKDQNNAIQELK----------------LLREMKHPNIVKFIESYKEKNKVIII
|| |. ||.| .|.  .......|        | . ..|. . . .. . .| ..|..                .|. ..||.|||...  . |....|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCEYGDLSQLIKQKSA----KGE---------QIEESIIL-----QWFIQICSALSFIHSKK-VIHRDIKSSNIFLTKSN---CVKIGDFGISKQLEN
|||||.|||.| ||...     ...         ...|  ..     ..| ||...|...|.|. .|||||| .||......   ..|| ||||||....
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

S---------------MDKANTLVGTPYYL----SPEVCQNKPYT----YKSDMWSLGCVIYELCSLKVTNLTIYITKHPFQSNS---------------
.                ....| .|||.|.    .||| |.. |     ||.|.||||...||..            ..||..|.               
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML----------FGYYPFYDNNCEQHQQLITQWINNA

----LMSLVM--KIATEKAP------KIPQNYSLMTNGFIRSLLQKIPEKRPSAQDILNNQNI
    | .  .  .|   |.|      ......  . | .....|.| |.||.....||| . .
YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 20296.AA ULK 14-280 25 1.2e-65 224.36 In-house 1-329 (329) Show / Hide 
Range on Protein: 14-280
Range on HMM: 1-329/329
Sequence Identity: 25% (88 aa)

YKEIELIGRGTQGSAMLVECRS----DK---KRYVSKKVILTNLSEKDQNN---------AIQELKLLREMK--------HPNIVKFIESYKEK--NKVI
|  .. .| |. |    . ..     .|   . .|  |.|. .   ...|.          ..| |.....|        ||||||... ....  | . 
YCLNHCLGKGSFG----KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIY

IIMEYCEYGDLSQLIKQKSA------KGEQIEESIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLTKSN------------CVKIGDFGISKQLENS-
||||||. |||.|.||..        ..  ..|....| |.||.... ..|....|||||| .|| ... .            ..||.||| .|...|. 
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

M--DKANTLV------GTPYYLSPEVCQ----NKPYT-YKSDMWSLGCVIYELCSLKVTNLTIYITKHPFQSNSLMSLVMKIATEKAP----------KI
|  . . | |      |||.| .|.. |    .|||. ||.|.|||||..||.   |.          ||...  .... .| ..             |.
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKP----------PFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQ

PQN---------YSLMTNGFIRSLLQKIPEKRPSAQDILNNQNI
| .          |  .  .|| .||. ...| | ....|.  .
PLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 20296.AA ULK 14-208 28 4.1e-63 216.0 In-house 1-245 (324) Show / Hide 
Range on Protein: 14-208
Range on HMM: 1-245/324
Sequence Identity: 28% (70 aa)

YKEIELIGRGTQG-SAMLVECRSD---KKRYVSKKVILTNLSEKDQN--------NAIQELKLLREMK---HPN--IVKFIESYKEK--NKVIIIMEYCE
|  .. .| |. |      ..  .   .. .  |.. . ....| ..        . ..| ......|   |||  |||... ....  | . ||||||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

YGDLSQLIKQKSA-----KGEQIEESIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLTKSN------------CVKIGDFGISKQLENSM---DKANT
 |||.|.||..       ..  ..|....| |.|||... ..|....|||||| .|| ... .            ..||.||| .|...| .   ..  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LV------GTPYYLSPEVCQ----NKPYT-YKSDMWSLGCVIYEL
.|      |||.| .|.. |    .|||. ||.|.|||||..||.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM
Kinase 20296.AA Pkinase_Tyr 59-211 26 1.9e-31 107.16 Pfam 51-210 (270) Show / Hide 
Range on Protein: 59-211
Range on HMM: 51-210/270
Sequence Identity: 26% (43 aa)

IQELKLLREM-KHPNIVKFIESYK-EKNK--VIIIMEYCEYGDLSQLIKQKSAKGEQIEESIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLTKSNCV
..|.|..... .|||||...     ..    ..|.|||...|||    ....  ....  . .||. .||...... .||. ||||.   |. .|..|.|
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVV

KIGDFGISKQLENSMDKANT-LVGT-----PYYLSPEVCQNKPYTYKSDMWSLGCVIYELCSL
||.||| .. .   ... .   ...        ..||. ... .| ||| || | ...|....
KICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase 20296.AA TyrKc 14-283 18 2.3e-19 71.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-283
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

YKEIELIGRGTQGSAMLVECRSDKKRYVSKKVILTNLSEKDQNNAIQELKLLREM--KHPNIVKFIESYKEK-------NKVIIIMEYCEYGDLSQLIKQ
 . .. .|.|  |  .. . .    . |  |..  .     .   ..|......   .|||||...    ..         . |.|||...||| . .. 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KSAKGEQIEESIILQWFIQICSALSFIHSKKVIHRDIKSSNIFLTKSNCVKIGDFGISKQLENS--------MDKANTLVGTP-----YYLSPEVCQNKP
.  |   .  .  |.. .||..  ...|||..||||.   |. ... ..|||.||| |. ...         . .. .  |.        ..||. . . 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTYKSDMWSLGCVIYELCSLKVTNLTIYITKHPFQS-----NSLMSLVMKIATEKAPKIPQN---------YSLMTNGFIRSLLQKIPEKRPSAQDILNN
.| ||| || | ...|....          . |         |   .. .. . . ...|.|          . | .  ...  .  ||.||. ..|   
FTTKSDVWSFGVCMWEIFTY---------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI---

QNIKKL
  ....
--HECF