Gene 2122 (Tetrahymena)

2122

Species: Tetrahymena
Alias: 97.m00108, 2122, TTHERM_00657380, 3724.m00016, PreTt02122, 355
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
2122.AA Protein None 936 None Fasta, JSON
2122.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
2122.NA RNA None 2811 None Fasta, JSON

Protein domain

Protein domains of 2122.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2122.AA NEK 40-296 44 9.40000000001e-154 517.09 In-house 1-286 (286) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-286/286
Sequence Identity: 44% (128 aa)

YRELEQIGKGTSGTVFLVKSKQDKKF-----YIAKKIILTNLNEQERQAVE-QELILLKKLKHPHIVGYKENFLEPY--YMIIIMEYCE-QGDLSFH---
|.....||.|  |.|..|..|.|.|      |. ||| ..|..|.|.|.   .| ..||.||||.||.|.. |.|    ...|.|||||  |||. .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKQKLKENDHFPENIILNWFIQLTMALDFIHEK-----HVLHRDVKSSNIFLTSSGS----IKLGDFGISKVLHSTADKAQT-LIGTPYYLSPEVCENKP
||.. .....|.|..|..||||. .||...|..     ..|||| |..|||||....    .|.||||||||| .|.|.|.| ..|||||.|||||.|||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YTYQSDIWALGCVLFEMCAL--KHPFVSE--SLMALVVKIIRE-PNPNIPNM--YSSDLNCLVQILLAKKPESRPRTKQILSFPFV
|.. ||||.|||||.|||.|  |||| ..  ....|..||...   | || .  ||.||. |.. .| | ||.|| ..|||..||.
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 2122.AA NEK1 40-296 44 2.1e-116 392.99 In-house 1-276 (276) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-276/276
Sequence Identity: 44% (123 aa)

YRELEQIGKGTSGTVFLVKSKQDKKFYIAKKIILTNLNEQERQAVEQELILLKKLKHPHIVGYKENFLEPYY--MIIIMEYCEQGDLSFHIKQKLKENDH
| .. |||.|. | ..|||.| | . |  | | ...  |.||...  | ..|.|.||| ||.||| | |  .    |.||||. |||   |...   .  
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FPENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLT--SSG---------------SIKLGDFGISKVLHSTADKAQTLIGTPYYLSPEVCENKPYTY
|.|  |..||.|. .|| .|| . .|||| ||.|||||  ..|                .|||||||...| .| . |.| |||||||||| |.||||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

QSDIWALGCVLFEMCALKHPFVSESLMALVVKIIREPNPNIPNMYSSDLNCLVQILLAKKPESRPRTKQILSFPFV
 ||||.||||| | |.||||| . .. .|| ||.. . | ||. || .|  ||  .. . |..|| . |||. ||.
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 2122.AA NEK4 40-296 46 1.4e-102 347.05 In-house 1-257 (257) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-257/257
Sequence Identity: 46% (121 aa)

YRELEQIGKGTSGTVFLVKSKQDKKFYIAKKIILTNLNEQERQAVEQELILLKKLKHPHIVGYKENF-LEPY-YMIIIMEYCEQGDLSFHIKQKLKENDH
|  . ..|||  | |.||....||| |. ||. | |   .||.| |.|  || .|||| || ||| .  |   .. |.| .|| |||    ||  . |. 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQ--QKNQF

FPENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLTSSGSIKLGDFGISKVLHSTADKAQTLIGTPYYLSPEVCENKPYTYQSDIWALGCVLFEMCAL
 .|. ...||.|  ||| ..||||.|||| |  |||||    ||.||||||.||   .| |.|.||||||.|||.  |.|| | ||||.||| ..||  |
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

KHPFVSESLMALVVKIIREPNPNIPNMYSSDLNCLVQILLAKKPESRPRTKQILSFPFV
|| |    .  |. .||    | .|  || ||  ||  .| |.|. ||   .|.  |..
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 2122.AA NEK8 46-296 39 4.7e-89 254.38 In-house 7-278 (278) Show / Hide 
Range on Protein: 46-296
Range on HMM: 7-278/278
Sequence Identity: 39% (108 aa)

IGKGTSGTVFLVKSKQDK--KFYIAKKIILTNLNEQERQAVEQELILLKKLKHPHIVGYKENFLEPYYMIIIMEYCEQGDLSFHI---KQKLKENDH---
.|.|  | . |   | |   .  | | | .. . | |||.   |  .|..| || |..| ..|.|     | |||.. | |   |   . || |.     
VGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLK

---------FPENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLTSS-GSIKLGDFGISKVLHSTADKAQT---LIGTPYYLSPEVCENKPYTYQSDI
         |.|  ||  |.|   |. ..|.. .|||| |  |||.| . . .|.|||||||.. .|  ..||   ..|||||.||| || |||   ||.
QVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIM-NTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDM

WALGCVLFEMCALKHPFVSESLMALVVKIIR--EPNPNIPNMYSSDLNCLVQILLAKKPESRPRTKQILSFPFV
|||||||.||| ||  |  . | |||.||..  . .| |.  ||...  ||  .|.. || ||   ||.. | .
WALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEP-ISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 2122.AA S_TKc 40-296 29 7.6e-84 285.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

YRELEQIGKGTSGTVFLVKSKQDKKFYIAKKIILTNLNEQERQAVEQELILLKKLKHPHIVGYKENFLEPYYMIIIMEYCEQ--GDLSFHIKQKLKENDH
|. |..||||. |.|.... | ... .  |.|          . ...|. .||| .||.|| ... | .  .. ..||||..  |||  .||.. ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FPENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLTSSGSIKLGDFGISKVLHSTADKAQTLIGTPYYLSPEVCENKPYTY-QSDIWALGCVLFEM
  |||  .  .. |.  ||...|.....|||.| .||.|..   ||..|||....|        |..|||.|..|||.   .|..  .|.|..||.|.||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CALKHPFVSESLMALVVKIIREPNPNIPNMYSSDLNCLVQILLAKKPESRPRTKQILS-------FPFV
.. . ||     |... |.|.          |...  ... .| | || ||   ..|         |..
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2122.AA NEK-Unclassified 40-296 34 2.9e-80 265.42 In-house 1-258 (258) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-258/258
Sequence Identity: 34% (90 aa)

YRELEQIGKGTSGTVFLVKSKQDKKFYIAKKIILTNLNEQERQAVEQELILLKKLKHPHIVGYKENFLEPYYMIIIMEYCEQGDLSFHIKQKLKENDHFP
|  .  .|.|  | |.||. .  |.  . .  |      . ||     .|.| .|.||||| | . | |   .    .||. |.|   |. . | |. | 
YDKITTLGQGGGGAVYLVRHQISKRHLVQQ--ISKRKKKKKRQ---NKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

ENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLTSSGSIKLGDFGISKVLHSTADKAQTLIGTPYYLSPEVCENKPYTYQSDIWALGCVLFEMCALKH
| .|  |.||. ||. .|| . ..||| | .||||| .  . .||||||...  | |||.| .||. ..|||||. .||  .||.|.|||...|||.   
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

PFVSESLMALVVKIIREPN-------PNIPNMYSSDLNCLVQILLAKKPESRPRTKQILSFPFV
 |   ..  .  || ...|       | .   || ||  ..  .| . .. ||    |.. ...
FFDTHNMGEVYMKIKQDDNRLEEALEP-VSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase 2122.AA Pkinase 40-296 25 5.5e-73 253.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

YRELEQIGKGTSGTVFLVKSKQDKKFYIAKKIILTNLNEQERQAVEQ--ELILLKKLKHPHIVGYKENFLEPYYMIIIMEYCEQG----DLSFHIKQKLK
|. ...||.|..|.|.. . | . | .  |.| . . .....|.     |. ..|.|.||.|| ... | .. .. ..||||| |    ||. .|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

ENDHF--PENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLTSSGSI----KLGDFGISKVL-HSTADKAQTLIGTPYYLSPEVCE-NKPYTYQSDIW
..  |  .|. . ... |.  .|...|.. ..|||.|..||.. . | |    |..|||..|.. .     ..|. |||.|..|||.  ...|.. .|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGCVLFEMCALKHPFVSE------SLMALVVKIIR-EPNPNIPNMYS-------------------SDLNCLVQILLAKKPESRPRTKQILSFPFV
..||.|.||.  . || ..      . |.....| . ..  ..|. .|                   ...  ..  .|.|.|..||  .|||  |..
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 2122.AA NEK2 40-296 31 3.9e-69 231.94 In-house 1-319 (319) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-319/319
Sequence Identity: 31% (99 aa)

YRELEQIGKGTSGTVFLVKSKQDKKFYIAKKIILTNLNEQERQAVEQELILLKKLKHPHIVGYKENFL--EPYYMIIIMEYCEQGDLSFHIKQKLKENDH
|  |. ||.|  |..  |. | |.|  . | |   ...| |.|.   |  .|..|||| || |       .     |.||||| ||||  ||   ||   
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FPENIILNWFIQLTMALDFIHE------------------KH---VLHRDVKSSNIFLTSSGS-------------------------------------
..| .|.  . ||. ||  .|                   .    .|||| |  |||| . ..                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--IKLGDFGISKVLHSTADKAQTLIGTPYYLSPEVCENKPYTYQSDIWALGCVLFEMCALKHPFVSESLMALVVKIIREPNPNIPNMYSSDLNCLVQILL
  .||||||  ..|      |.| .||||| |||. .  .|   ||||..||...|||||. ||   .  .| .||       ||  ||..|| ..   .
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

AKKPESRPRTKQILSFPFV
. ....|| .  ||  |..
NVDHYHRPSIEEILQHPQI
Kinase 2122.AA NEK11 40-296 39 3.5e-68 232.81 In-house 1-259 (259) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-259/259
Sequence Identity: 39% (103 aa)

YRELEQIGKGTSGTVFLV---KSKQDKKFYIAKKIILTNLNEQERQAVEQELILLKKLKHPHIVGYKENFLEPYYMIIIMEYCEQGDLSFHIKQKLKEND
|    ..| |  |||.||   | |.     . | |    ||  |      |  || .|.|| || .   |.|     || ||||  ||  .|.   .   
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

HFPENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLTSSGSIKLGDFGISKVLHSTADKAQTLIGTPYYLSPEVCENKPYTYQSDIWALGCVLFEMCA
 |||| |. ||||| .  |..||. .||||.|| ||||     .|.||||.|..|    | | || ||| |.|||    . |  .||||.| |.|.||| 
IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNN-LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCC

LKHPFVSESLMALVVKIIREPNPNIPNMYSSDLNCLVQILLAKKPESRPRTKQILSFPFV
. | |   . ...|..|.    | .|. |  .|| ..  .| | |  ||   .||  |..
MDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase 2122.AA STE 40-296 24 1.6e-66 227.31 In-house 1-359 (359) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-359/359
Sequence Identity: 24% (88 aa)

YRELEQIGKGTSGTVFLVKSKQ---------------DKKFYIAKKIILTNLN---------------EQERQAVEQELILLKKLK--HPHIVGYKENFL
.. .|.||||..|||.. . .                 ....  |.. | | |               ..|.| ...|. ..||..  ||.|| |   ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EPY-------YMIIIMEYCEQGDLSFHIKQKLKEND----------HFPENIILNWFIQLTMA-LDFIHEKHVLHRDVKSSNIFLTSSGSIKLGDFGISK
          .  |.|||.. | |.  ||.| . ..          .|||..|     |.  . |...|..|. |||.|..||.|     .|| |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLHS---------------TAD-KAQTLIGTPYYLSPEVCEN------KPYTYQSDIWALGCVLFEMCALKHPFVSESLM-ALVVKIIR-----------
 | .               | . | .|..||| . .||| ..      |.|....||| |||.. ||.  |.|.  .. | |.  ...            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---EPNPNIPN-------------------MYSSDLNCLVQILLAKKPESRPRTKQILS--FPFV
   .| | .|.                    .|....  ..  | | |. || ..| |.   ||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 2122.AA Ciliate-E2 40-296 21 1.7e-64 220.27 In-house 1-365 (365) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

YRELEQIGKGTSGTVFLVKSKQDKKFY------------------IAKKIILTNLNEQERQAVEQELILLK----------------KLKHPHIVGYKEN
|  ...||.|. |.|...| ....| .                   .|.. . ...... ....||. ...                .|.||.|. ..| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FL--EPYYMIIIMEYCEQGDLSFHIKQK-LKENDHFP------ENIILNWFIQLT---------------MALDFIHEKH-VLHRDVKSSNIFLTSSGSI
|      .. ..||||..|||  .||.. .|.| ...      |. |.. . |..                || ..|.|. ..||| | .||..     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGISKVLHS-------------------------------TADKAQTLIGTPYYLSPEVCENKP---------YTYQSDIWALGCVLFEMCALKHP
|. |||.|| ..                                  . ..|..|||.|..||. ..|.         |.|..|||.||..|.||.  |.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FVSESLMALVVKIIREPNPNIPNM------------------YSSDLNCLVQI----LLAKKPESRPR-TKQILSFPFV
|          ..| . . ..|.                    | .   | .     .| |.|| |.   .|||  |. 
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 2122.AA ULK 40-296 24 7.7e-64 218.41 In-house 1-329 (329) Show / Hide 
Range on Protein: 40-296
Range on HMM: 1-329/329
Sequence Identity: 24% (81 aa)

YRELEQIGKGTSGTVFLVKSKQDK---KFYIAKKIIL---TNLNEQERQ------AVEQELILLKKLK--------HPHIVGYKENFLEP--YYMIIIME
|   ...|||. |.|.  . |..|   . ..| |.|.    | ...|..       ...|  ..||||        ||.|| ... | ..   .  ||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEQGDLSFHIKQKLK------ENDHFPENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLTSS------------GSIKLGDFGISKVLHST---AD
||..|||.  ||.. |      |. ...|..... |.|.  .. ..|.. . ||| | .|| ..              | .|..||| .|.. .    ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KAQTLI------GTPYYLSPEVCE----NKPYT-YQSDIWALGCVLFEMCALKHPFVSESLMALVVKIIREP--------------NPNIP-----NMYS
 ..|        |||.| .|.. .    .|||. | .||| |||...||   | ||..   . .. .||..               ....|     .  |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

SDLNCLVQILLAKKPESRPRTKQILSFPFV
...  | . .| .... |    .... |..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 2122.AA Pkinase_Tyr 40-237 21 3.9e-18 62.06 Pfam 1-210 (270) Show / Hide 
Range on Protein: 40-237
Range on HMM: 1-210/270
Sequence Identity: 21% (46 aa)

YRELEQIGKGTSGTVFLVKSK---QDKKFYIAKKIILTNLNEQE--RQAVEQELILLKKL-KHPHIVGYKENFL---EPYYMIIIMEYCEQGDLSFHIKQ
 . ....|.|  |.|.. . |   ...|   | |..  .  ...  |..  .|. ..|.| .||.|| .    .   || ...|.|||.. |||  . ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

KLKENDHFPENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLTSSGSIKLGDFGISKVL--HSTA-DKAQTLIGTPYYLSPEVCENKPYTYQSDIWAL
.  ......   .|.. .|  ..... ..|.  |||.   |. .|... .| .||| .. .   ..   |..        ..||.  .. .| .||.|. 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GCVLFEMCAL
| ...|.. .
GVLMWEIFTY
Kinase 2122.AA TyrKc 40-294 18 7.8e-17 49.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-294
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

YRELEQIGKGTSGTVFLVKSKQDKKFYIAKKIILTNLNEQERQAVEQELILLKKL--KHPHIVGYKENFLEP-------YYMIIIMEYCEQGDLSFHIKQ
 . ....| |  |.|.. . |       | | .  .     |..  .|. ...||  .||.||      ...         . |.|||.. |||  ... 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KLKENDHFPENIILNWFIQLTMALDFIHEKHVLHRDVKSSNIFLTSSGSIKLGDFGISKVLHST--------ADKAQTLIGTP-----YYLSPEVCENKP
. ..   ..    |.. .|     ...|.|.. |||    |. ... . .| .||| |. ...           ....  |.        ..||.   . 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTYQSDIWALGCVLFEMCAL----KHP-----FVSESLMALVVKIIREPNPNI--PNM----YSSDLNCLVQILLAKKPESRPRTKQILSFP
.| .||.|. | ...|.. .               . ....| .  | | |    | |     ....  . .   . .||.||. ..| .. 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF