Gene 21625 (Tetrahymena)

21625

Species: Tetrahymena
Alias: 21625, 3714.m00138, TTHERM_00412070, PreTt21625, 405, 44.m00292
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
21625.AA Protein None 750 None Fasta, JSON
21625.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
21625.NA RNA None 2253 None Fasta, JSON

Protein domain

Protein domains of 21625.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21625.AA NEK 16-276 37 1.2e-131 443.67 In-house 1-286 (286) Show / Hide 
Range on Protein: 16-276
Range on HMM: 1-286/286
Sequence Identity: 37% (108 aa)

YTVSKPIGQGKFSTVYKAETA-NKQV-----FALKKIKIFDMMDPKQREKCL-KEVGLMKPLDHPNIIKYIDSFIHNN--ELIIVTEWAE-KGDLKRL--
|.. | |||| |..|||..   ....     ...|||. ...|..|...... .|| . | |.||||.||.||||...   |.|| |..| .||| ..  
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKIN-MGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-IKMQQQEETPFEELKIWEYMQQIASALNHMHEK-----RIMHRDLKPANIFIAQDDT----LKVGDLGLGREFSSGTIEVYS-KVGTPLYMSPELLHGE
 ||.|.|. ..||| .||....|...||..||..     .|.|||.||.|||.  ...    .|.||.|. ......|   |.  |||| |||||.....
SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

GYDMKSDVWSLGCIVYELSEFKS--PFRNENDKMSLMDLFQNITKG-EYKQISKR--YSEDLQQIIDDMIVVDPTKRIDTEVVLQRCEK
.|. |||.|||||..||.  .|.  ||. . | |... |. .|.|| .|. |...  ||.|||..|  |. .||..| ... .|...  
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAW-D-MNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 21625.AA NEK6 16-267 49 1.3e-103 341.89 In-house 1-252 (252) Show / Hide 
Range on Protein: 16-267
Range on HMM: 1-252/252
Sequence Identity: 49% (126 aa)

YTVSKPIGQGKFSTVYKAE-TANKQVFALKKIKIFDMMDPKQREKCLKEVGLMKPLDHPNIIKYIDSFIHNNELIIVTEWAEKGDLKRLIKMQQQEETPF
. . | ||.|.|| ||.|. . .... ||||..||.||| | |. |.||..|.| |.|||.|||..||| |||| || | |. ||. |.||  ....   
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLI

EELKIWEYMQQIASALNHMHEKRIMHRDLKPANIFIAQDDTLKVGDLGLGREFSSGTIEVYSKVGTPLYMSPELLHGEGYDMKSDVWSLGCIVYELSEFK
 |  || |  |..|||.|||.||.||||.||||.||  .   |.||||||| ||| |    | |||| ||||| .| .||  |||.|||||..||.   .
PERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQ

SPFRNENDKMSLMDLFQNITKGEYKQI-SKRYSEDLQQIIDDMIVVDPTKRIDT
|||    ||| |  | . | . .|  . .  |||.|.| .  .|. ||..| | 
SPFY--GDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase 21625.AA S_TKc 16-278 31 1.6e-81 278.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YTVSKPIGQGKFSTVYKAETAN-KQVFALKKIKIFDMMDPKQREKCLKEVGLMKPLDHPNIIKYIDSFIHNNELIIVTEWAEK--GDLKRLIKMQQQEET
|.. ..||.| |..|||.   . ....|.|.||          |. ..|. ..|  .||||.|..|.| . ..| .|.| ..   |||...|| .. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

P--FEELKIWEYMQQIASALNHMHEKRIMHRDLKPANIFIAQDDTLKVGDLGLGREFSSGTIEVYSKVGTPLYMSPELLHGEGYDM-KSDVWSLGCIVYE
.  | |  .. ||.||..||...|...|.||||||.||.. .  ..|..| || |..       .. .||| ||.||.|   ||.  |.|.||.|||.||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LSEFKSPFRNENDKMSLMDLFQNITKGEYKQISKRYSEDLQQIIDDMIVVDPTKRIDTEVVLQ-----RCEKKI
.   . ||.       .. .|..|            |... ..|. . ..||.||.    .||     .|   .
MLCGYPPFP------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21625.AA Pkinase 16-273 28 5.8e-75 260.16 Pfam 1-290 (293) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-290/293
Sequence Identity: 28% (84 aa)

YTVSKPIGQGKFSTVYKAETANKQV-FALKKIKIFDMMDPKQREKCL-KEVGLMKPLDHPNIIKYIDSFIHNNELIIVTEWAEKG----DLKRLIKMQQQ
|.. ..||.| |..|||.   . .  .|.|.||  .  . |.... .  |. .|| |.||||....|.|  .... .|.|..|.|    ||...|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

EETPF--EELKIWEYMQQIASALNHMHEKRIMHRDLKPANIFIAQDDTL----KVGDLGLGREF-SSGTIEVYSKVGTPLYMSPELLH-GEGYDMKSDVW
....|  .|  .  || ||...|...|...|.||||||.||.| .....    |..| || . |        .. .||| ||.||..  |..|. |.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGCIVYELSEFKSPFRNE---NDKMSLMDLFQNITKGEYKQISKRYS--------------------EDLQQIIDDMIVVDPTKRIDTEVVLQR
|.|||.||.   . ||...    . .. | ....| .....  .   .                    |.....|.... .||.||.  | .|| 
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH
Kinase 21625.AA NEK8 52-264 35 7.1e-73 207.35 In-house 39-266 (278) Show / Hide 
Range on Protein: 52-264
Range on HMM: 39-266/278
Sequence Identity: 35% (82 aa)

MDPKQREKCLKEVGLMKPLDHPNIIKYIDSFIHNNELIIVTEWAEKGDLKRLIKMQQQ----EET-----------PFEELKIWEYMQQIASALNHMHEK
|..|.|   . |. . . |.||||| |.|.|. .| | |. | |. | | ..|  ||     ||.            | |  |  |..|. ||..|||..
MSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQH

RIMHRDLKPANIFIAQD-DTLKVGDLGLGREFSSGTIEVYS--KVGTPLYMSPELLHGEGYDMKSDVWSLGCIVYELSEFKSPFRNENDKMSLMDLFQNI
 | |||||..|||   .   .|.|| |.  . .. .    .   ||||.|||||.  |  |. |||.|.|||. ||.   |  |  .|    |  |   |
NILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASN----LPALVWKI

TKG-EYKQISKRYSEDLQQIIDDMIVVDPTKR
. . .|  || .|| .. . .     .|| .|
MQCRAYEPISDHYSNEMRMLVHNCLQQDPEQR
Kinase 21625.AA CAMK 21-268 20 3.6e-68 218.5 In-house 1-417 (425) Show / Hide 
Range on Protein: 21-268
Range on HMM: 1-417/425
Sequence Identity: 20% (86 aa)

PIGQGKFSTVYKAETA-NK------------QVFALKKIKIFDMMD-------------------------PKQREKCLKEVGLMKP-------LDHPNI
 .|.| |..|....   ..            | .| | |.   . |                         || |.. ..|. .||        ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKYIDSFIH-------------------NNELIIVT---EWAEKG----D-LKRLIKM-----------QQQEETPFEELKIWEYMQQIASALNHMHEKR
|| .. .                     ......|.   | .. |    | . ....               |.  |.|     |..||.||....|.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDLKPANIFIAQDD-----------------TLKVGDLGLGREFSSG-----------------------TIEVYSKVGTPLYMS-PELLHG-----
|.|||||| || . ...                 ..|. | |. ..| .|                       .   .  .||| ||. ||.| |     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EGYDMKSDVWSLGCIVYELSEFKSPFRNENDK---------MSLMDLFQNITKGEYKQISKR-----------------------YSEDLQ
         ..|. |.|.||.|.| | .   ..||. ..|.         |.. .||..|.||.|  ...                         |.. .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QIIDDMIVVDPTKRIDTE
. |  | .|||.||.  |
DLIRKMLQVDPEKRMTIE
Kinase 21625.AA ULK 16-266 26 5.2e-68 232.26 In-house 1-319 (329) Show / Hide 
Range on Protein: 16-266
Range on HMM: 1-319/329
Sequence Identity: 26% (86 aa)

YTVSKPIGQGKFSTVYKAE-TANK----QVFALKKIKIFDMMDPKQR------EKCLK-EVGLMKPLD--------HPNIIKYIDSFIHN--NELIIVTE
| ... .|.| | .|||..   .|    ...| |.| .. |   ..        ..|| |. .|| |.        ||||.|..| |     | . |..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

WAEKGDLKRLIK-MQQQEETP-----FEELKIWEYMQQIASALNHMHEKRIMHRDLKPANIFIAQDD------------TLKVGDLGLGREFSSG---TI
  . |||. .||  . . |.      ..| .. ....||.... ..|...|.|||.||.|| |  ..            .||..| |... ....     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

EVYSKV------GTPLYMSPELLH----GEGYD-MKSDVWSLGCIVYELSEFKSPFRNE-ND--KMSLMDLFQN-------ITKGEYKQI----SKRYSE
  .. |      ||||||.|..|.    .. |.  |.|.|||||| ||.   | ||..  ||  .. ...|..|       | |   .      ..  |.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

DLQQIIDDMIVVDPTKRID
.....|  |...|...||.
ECKDLIRRMLQYDEKDRIS
Kinase 21625.AA ULK 16-266 26 6.8e-67 228.54 In-house 1-314 (324) Show / Hide 
Range on Protein: 16-266
Range on HMM: 1-314/324
Sequence Identity: 26% (83 aa)

YTVSKPIGQGKFS-TVYKAE-TAN---KQVFALKKIKIF-DMMDPKQRE-----KCLK-EVGLMKPLD---HPN--IIKYIDSFIHN--NELIIVTEWAE
| ... .|.| |  .|||..   .   .|..| |.| ..   ......|     . || |. .|| |.   |||  |.|..| |     | . |..|  .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGDLKRLIKMQQQ-----EETPFEELKIWEYMQQIASALNHMHEKRIMHRDLKPANIFIAQDD------------TLKVGDLGLGREFSSGT---IEVYS
 |||. .|| ..      |.  ..| .. ....||.... ..|.. |.|||.||.|| |  ..            .||..| |... . ...      ..
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

KV------GTPLYMSPELLH----GEGYD-MKSDVWSLGCIVYELSEFKSP----FRNENDKMSLMDLFQN-------ITKGEYKQISKR----YSEDLQ
 |      ||||||.|..|.    .. |.  |.|.|||||| ||.   | |    |......   ..| .|       | .   .  ...     |....
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY--IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

QIIDDMIVVDPTKRID
..|  |...|...||.
DLIRRMLQYDEKDRIS
Kinase 21625.AA Ciliate-E2 16-287 24 4.3e-63 215.43 In-house 1-365 (365) Show / Hide 
Range on Protein: 16-287
Range on HMM: 1-365/365
Sequence Identity: 24% (95 aa)

YTVSKPIGQGKFSTVYKAET-ANKQVFALK-----------------KIKIFDMMDPKQREKCLKEVGLMK----------------PLDHPNIIKYIDS
| . | |||| |..|||..   ... ||.|                 ||.   .| ..| |  ..|  .|.                 |.||||||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FI--HNNELIIVTEWAEKGDLKRLIK---MQQQEETP----FEELKIWEYMQQIAS---------------ALNHMHEKR-IMHRDLKPANIFIAQDDTL
|.   .| . .|.| .. |||. .||    ....| .    | | .| ..|.||..               ||...|.|  |.|||.|| ||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KVGDLGLGREFSSGTIE-------------------------------VYSKVGTPLYMSPELLHGEG---------YDMKSDVWSLGCIVYELSEFKSP
|. |.|| ....   ..                               ... .||| ||.|| | |..         || |.|.||||.| ||.   | |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FRNENDKMSLMDLFQNITKGEYK-Q----------------ISKRYSEDLQQIIDD----MIVVDPTKRIDTEVVLQRCEKKINQLKKNPKI
|            .|.| ..... .                . |  |.. ...|      |...|| |||.           ..|....| .
F------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----------GWEQILNHPWF
Kinase 21625.AA NEK1 16-264 33 5.9e-63 215.46 In-house 1-264 (276) Show / Hide 
Range on Protein: 16-264
Range on HMM: 1-264/276
Sequence Identity: 33% (90 aa)

YTVSKPIGQGKFSTVYKA-ETANKQVFALKKIKIFDMMDPKQREKCLKEVGLMKPLDHPNIIKYIDSFIHNNE--LIIVTEWAEKGDLKRLIKMQQQEET
|.. | ||.| |  .... ...  |....| |..  |  .| ||. ..|| . . ..||||.|| .||. |    | || | .. ||| . |. |     
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQ-EKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGK

PFEELKIWEYMQQIASALNHMHEKRIMHRDLKPANIFIA--QDD---------------TLKVGDLGLGREFSSGTIEVYSKVGTPLYMSPELLHGEGYD
.| |  |  .  ||  ||||.| ..|.|||.|. |||    ...               ..|.|| |  |  .. .      .||| | |||.    .|.
LFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

MKSDVWSLGCIVYELSEFKSPFRNENDKMSLMDLFQNITKGEYKQISKRYSEDLQQIIDDMIVVDPTKR
 |||.|||||. |||   | ||    .  ..  |   |..| |  |...||..||  .  |  ..|  |
NKSDIWSLGCVLYELCTLKHPF----EANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHR
Kinase 21625.AA STE 16-268 22 6.9e-55 188.67 In-house 1-349 (359) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-349/359
Sequence Identity: 22% (79 aa)

YTVSKPIGQGKFSTVYKAETAN----------------KQVFALKKIKIFDM--------------MDPKQREKCLKEVGLMKPLD--HPNIIKYIDSFI
..  . ||.| | |||||   .                ....| |.... .               ........ |||. .|| ..  ||||.||.....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HN-------NELIIVTEWAEKGDLKRLIK---MQQQEET-------PFEELKIWEYMQQIASA-LNHMHEKRIMHRDLKPANIFIAQDDTLKVGDLGLGR
..       .|| |. |. . | |  .||   . ... .       .|.|  |  . .||  . |.. |...|.|||.|||||..      |  | |.  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

EFSS----------------GTIEVYSKVGTPLYMSPELLHG------EGYDMKSDVWSLGCIVYELSEFKSPFRNENDK-MSLMDLFQ----------N
 ...                .  . .. |||| .|.|| . .       ||| |.|.||||| . |. . | |. ....  . .| .|           .
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

ITKGEYKQISK-------------------RYSEDLQQIIDDMIVVDPTKRIDTE
| .|.  ..                     ..|..... |.   . || || ...
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS
Kinase 21625.AA Ciliate-E2-Unclassified 16-272 24 1.2e-52 180.96 In-house 1-348 (352) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-348/352
Sequence Identity: 24% (86 aa)

YTVSKPIGQGKFSTVYKAET-ANKQVFALKKIKIFDMMD----------------PKQRE--------KCLKEVGLMKPLDHPNIIKYIDSFIHNNELII
|.. | |||| |..|||..   .||..|.| .| . . .                 ....        | ...  ... ..||.|.|... |   . ..|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQ--ILLNHPHPFIVKMFYCFQDKQNIYI

VTEWAEKGDLKRLIK-------------MQQQEETPFEELKIW-----EYMQQIASALNHMHEK-RIMHRDLKPANIFIAQDD---TLKVGDLGLGREFS
|.| .| |||.  ||             .....   |.| ..       |. || ..|...|.|  | |||.|| ||.. ..     .|. |.|. ..  
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

S---------------GTIEVYSKVGTPLYM----SPELLHGEGYD----MKSDVWSLGCIVYELSEFKSPFRNENDKM------------SLMDLFQNI
.                  . ....||| ||    .||.| |..||     |.|.||||.| ||.   . ||  .|..               . |.|||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

TKGEYKQIS-------KRYSEDLQQIID----DMIVVDPTKRIDTEVVLQ
 ...... .       |. |.  . .|      |....| |||. | .|.
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 21625.AA Pkinase_Tyr 16-210 27 1.1e-22 77.4 Pfam 1-207 (270) Show / Hide 
Range on Protein: 16-210
Range on HMM: 1-207/270
Sequence Identity: 27% (57 aa)

YTVSKPIGQGKFSTVYKAETA-----NKQVFALKKIKIFDMMDPKQ--REKCLKEVGLMKPL-DHPNIIKYIDSFI-HNNE--LIIVTEWAEKGDLKRLI
 |  | .|.| | .|||..       .|.  | |..|  .  ...|  ||. ..|. .|| | .||||....   . .     ..||.| ...|||.   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK--EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KMQQQEETPFEELKIWEYMQQIASALNHMHEKRIMHRDLKPANIFIAQDDTLKVGDLGLGREF-SSGTIEVYSKVGTPL---YMSPELLHGEGYDMKSDV
. .  .. |.    . .. .|||..... ..|.. ||||   |. .. . . |..| || |   . ..  .... |..|    |.|| ..   .  ||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSLGCIVYEL
|| |   .|.
WSFGVLMWEI
Kinase 21625.AA TyrKc 16-274 23 5.5e-17 51.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-274
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

YTVSKPIGQGKFSTVYKAETANKQVFALKKIKIFDMMDPKQREKCLKEVGLMKPL--DHPNIIKYIDSFIHN-------NELIIVTEWAEKGDLKRLIKM
 |  | .| | | .|||..    .  | |..|         ||  ..|  .|. |  .||||.. .   ..          | ||.| ...||||  .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QQQEETPFEELKIWEYMQQIASALNHMHEKRIMHRDLKPANIFIAQDDTLKVGDLGLGREFSSG-TI----EVYSK---VGTP--L---YMSPELLHGEG
 . .   .   .  ... |||.  .. |.|.. ||||   |. .. . | |..| || |.  .. .     ..|.|    |.   |    |.|| .  .|
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

-YDMKSDVWSLGCIVYELSEF-KSPFRNE--NDKMSLMDLFQNITKGEYKQISKR--------YSEDLQQIIDDMIVVDPTKRIDTEVVLQRC
 .  |||||| |   .|.  . ..|  ..  . .||  ...... .|..  . .          .... ||. .    || .|   . . .. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
IFT57 21625.AA IFT57 293-357 37 2.9e-15 51.33 Pfam 1-66 (390) Show / Hide 
Range on Protein: 293-357
Range on HMM: 1-66/390
Sequence Identity: 37% (25 aa)

NEDIYEKLTLLEYHNFFCKPMH--RDPVSKVFFSISDQTPAQNNKKFFYFAELCYWIMSIQKYDKKN
.||.|.|| ||.|.  ||||..  . |.|. .|. .   .   .  |.||..||.| |.. | .|.|
MEDLYDKLKLLNYEQDFCKPHKPYMKPLSRHYFAVP-HKSTNPGEQFYYFTSLCAWLMQLPKAGKHN
IFT57 21625.AA IFT57 378-684 23 1.2e-22 76.08 Pfam 81-390 (390) Show / Hide 
Range on Protein: 378-684
Range on HMM: 81-390/390
Sequence Identity: 23% (76 aa)

AQQLLFDLKKWGLRLPDSLNVQHIRNGYGDTVCFILNDILNRELIRLNF---KFEDPKHTDVQNGQQETENGVLQDPDLNEYMIEEEDIQDEDSIVG-EE
.. .|..|||||. .| ..   ... |.|. .|.||.......|.. .|   ... ||.  .  ...|..     |....   .|.|. ...|.    .|
ISNILQELKKWGIKIPVDFPPNKLKQGCGEHCCYILDCLADQALKKKGFNIVQWKRPKYPQEEKYDEEENVHDEDDAEDILEKVEDEQMMEDDDQDDDDE

EQGDLLNGQYNKRQNGEEAYDYKKIIDEDREMIISNVDPLEWQKECLRVTTEL-QNFDLKIKKNEITAQINE-NDYINNLNRLQKFQR---------AQI
| ....     ..|.  |  |. .....|.. . ||.|. || .|  ||  .| .          .|   ..  |. . ... . .|.         .|.
EEHNYQDLNWYHKQYKRETGDC-NQKPQDKCVMESNIDAEEWKLEVERVAPQLNK----------VTIKTDNNKDWRTHYDQMHQHQKAIEKMWPECKQY

LQEPFVNKIITNWQNQLDQIEKGEQRINQGNIDSINVLKEKVQSKKKFLLDLEQKSEQVKSQIQNFDSMNEQYEKVKKEIVEREKLITGNDQTN--KIKD
|.   |  . . | ..|. |.. |. .|.   ...  ..|. .  ...   . |.|. |... |  .  .|. |.|| |. ||.. ..  |...  |||.
LKK-EVQDLHQDWSKYLEKIQSREKHLNNQFQHMMQEYREARRTLNQVQEQYNQASQGVMERTQELNEISEELEQVKQEMEERGSKMS--DGSPVMKIKQ

AIQKIKTEIKSMTIKIGVLQSNLL
|| |.| ||| | ..|||.|  .|
AITKLKEEIKQMDVRIGVMQHTHL