Gene 21626 (Tetrahymena)

21626

Species: Tetrahymena
Alias: 21626, 3714.m00139, TTHERM_00412080, PreTt21626, 404, 44.m00293
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
21626.AA Protein None 1164 None Fasta, JSON
21626.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
21626.NA RNA None 3495 None Fasta, JSON

Protein domain

Protein domains of 21626.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21626.AA NEK 46-302 37 5e-137 461.52 In-house 1-286 (286) Show / Hide 
Range on Protein: 46-302
Range on HMM: 1-286/286
Sequence Identity: 37% (107 aa)

FTIVKELGRGSYGVVYRAISNINKKE-----YVVKKINIKHMSNKHQKEAL-KEAQILRKVRHENIIRYYTSFVEHD--CLYIVMEYAD-GGDLQQL---
..|.|..|.||.|.||.. . ...|.     || ||||...|| | ...|. .|..||.. .|.||..|| ||.|..  ||.|||||.. ||||.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LRYRRERKKQFTETEIWEFAYDLIKAVDYLHKN-----NIIHRDIKTLNIFLTKDRK----VKLGDLGVSKIVSSQAALQGT-RVGTPLYLAPELVKQQP
.  .....| | | .||.. . ...|..|.|..     .|.|||||. ||||||...    ||.||.|.||. .. . .. |  |||| |..||.....|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDFKVDIWAIGIVLYHISAL--EPPFQGE--NLIALGFNIVHK-FPKPLPSV--YSPKLVSFINKLLEKNPLQRPKTSELIETFPK
|..|.|||..| |||.. .|  ..||...  |. .| ..|.   ...|.||   ||..| ..|...| |.| ||| .....|.   
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 21626.AA S_TKc 46-302 29 2.8e-87 297.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-302
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

FTIVKELGRGSYGVVYRAISNINKKEYVVKKINIKHMSNKHQKEALKEAQILRKVRHENIIRYYTSFVEHDCLYIVMEYADG--GDLQQLLRYRRERKKQ
..|....|.|..|.||... .  .... .|.|.         . ...| |||.| .|.||...| .|.. |.||.||||.||  ||| .... |. ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FTETEIWEFAYDLIKAVDYLHKNNIIHRDIKTLNIFLTKDRKVKLGDLGVSKIVSSQAALQGTRVGTPLYLAPELVKQQPYDF-KVDIWAIGIVLYHI
  |.| ... ..| ...|..|.|...|||||.|  ||.|..   .|..| |.....        | .||| |.|||..   .|.. |.|.|..|..||  
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

SALEPPFQGENLIALGFNIVHKFPKPLPSVYSPKLVSFINKLLEKNPLQRPKTSELIE-------TFPK
 . .|||.  .. ..  .|.           || . .||.|.|.|.| .||   |. .           
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21626.AA NEK8 73-296 36 1.1e-80 230.03 In-house 30-272 (278) Show / Hide 
Range on Protein: 73-296
Range on HMM: 30-272/278
Sequence Identity: 36% (89 aa)

VVKKINIKHMSNKHQKEALKEAQILRKVRHENIIRYYTSFVEHDCLYIVMEYADGGDLQQLLRYRRERKKQFTET----------------EIWEFAYDL
. | ||   || |    |. | |.| .. | ||| || .| |   | |.||||||| | |..  ..  |. . |.                .|  .    
IWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQN-KLFEEERQLKQVNHCFNIYFNEQMILWYFFQM

IKAVDYLHKNNIIHRDIKTLNIFLTKD-RKVKLGDLGVSKIVSSQAALQG--TRVGTPLYLAPELVKQQPYDFKVDIWAIGIVLYHISALEPPFQGENLI
  || ..|..|| |||.||.|||.|..   ||.|| | ||| ..  . |.  | ||||.|. ||... .||..| |.||.| |||    |.  | ..|| 
CSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLP

ALGFNIVH-KFPKPLPSVYSPKLVSFINKLLEKNPLQRPKTSEL
||   |.  .   |... ||. . . .  .| . | |||  |..
ALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQI
Kinase 21626.AA STE 46-301 25 1.7e-80 273.74 In-house 1-359 (359) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-359/359
Sequence Identity: 25% (92 aa)

FTIVKELGRGSYGVVYRAISN------INKKE---------YVVKKINIKHMSN---------------KHQKEALKEAQILRKVR--HENIIRYYTSFV
.......|.|..|.||.|. .       ....         . .|..|... .|               . ... ||| .|..| .  |.||..|| ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EH-------DCLYIVMEYADGGDLQQLLRYRRERKKQFT----------ETEIWEFAYDLIKA-VDYLHKNNIIHRDIKTLNIFLTKDRKVKLGDLGVSK
         | |.|.||| ||| | .... . ...|...          |..|  ......|.  .|||...|||||||  ||.|     ||| | ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

IVSSQAA----------------LQGTRVGTPLYLAPELVKQ------QPYDFKVDIWAIGIVLYHISALEPPF---QGE---NLIALGF---------N
....  |                   | |||| . ||| ..|      ..||.|.||| .|... .    .||.   .      .|. ..         .
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

IVHKFPKPLPS-------------------VYSPKLVSFINKLLEKNPLQRPKTSELIE---TFP
|| . | |||.                    .||..  |||| |.|.| .||..|.|..    | 
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 21626.AA Pkinase 46-300 27 4.8e-80 277.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

FTIVKELGRGSYGVVYRAISNINKKEYVVKKINIKHMSNKHQKEALK--EAQILRKVRHENIIRYYTSFVEHDCLYIVMEYADGG----DLQQLLRYRRE
..|.. .|.||.|.||...   . |...||.|. .| . . ......  |.||.....|.||.|.| .| ..| .|.||||..||    ||  ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

RKKQF--TETEIWEFAYDLIKAVDYLHKNNIIHRDIKTLNIFLTKDRKV----KLGDLGVSKIV-SSQAALQGTRVGTPLYLAPELVK-QQPYDFKVDIW
|.. |  .| |.  ..| ......|.|...|||||.|  ||.. ..  .    |..| |..| .         |..||| |.|||... .|.|. |||.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AIGIVLYHISALEPPFQGE------NLIALGFNIVH-KFPKPLPSVYS-------------------PKLVSFINKLLEKNPLQRPKTSELIET--F
..|..||     .|||.|.      . ... ..| . ... . |  .|                   . . .||...|.|.| .||   .. .   |
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 21626.AA NEK1 46-291 36 1.7e-79 270.4 In-house 1-265 (276) Show / Hide 
Range on Protein: 46-291
Range on HMM: 1-265/276
Sequence Identity: 36% (96 aa)

FTIVKELGRGSYGVVYRAISNINKKEYVVKKINIKHMSNKHQKEALKEAQILRKVRHENIIRYYTSFVEHDC--LYIVMEYADGGDLQQLLRYRRERKKQ
... | .| ||.| .. . .    ..|| | ||.  |. |   |...|. ||.| .|.||..|. ||.|  |  |||||||.||||| |    .. . | 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FTETEIWEFAYDLIKAVDYLHKNNIIHRDIKTLNIFLT--KDR---------------KVKLGDLGVSKIVSSQAALQGTRVGTPLYLAPELVKQQPYDF
| | .|  .   . .|. . |. .|.|||||. |||||  |.                .||||| |.... ..  ..  | .||| || ||.   .||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KVDIWAIGIVLYHISALEPPFQGENLIALGFNIVHKFPKPLPSVYSPKLVSFINKLLEKNPLQRP
| |||. | |||   .|  ||.. |. .|   |.     |.|. || .| | . ... .||  ||
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRP
Kinase 21626.AA STE20 46-296 32 5.6e-71 242.12 In-house 1-282 (288) Show / Hide 
Range on Protein: 46-296
Range on HMM: 1-282/288
Sequence Identity: 32% (92 aa)

FTIVKELGRGSYGVVYRAISNINKKE----YVVKKINIKHMSN--KHQKEALKEAQILRKVRHENIIRYYTSFVEH----DCLYIVMEYADGGDLQQLLR
.......|.||||.||.|. . ....    . .||.|... .|  ..... .|| .|... .|.||..||.|.. .    |.|.||||| .|| |.....
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

YRRERKK-----QFTETEIWEFAYDLIKAVDYLHKNNIIHRDIKTLNIFLTKDRKVKLGDLGVSKIVSS---QAALQ---GTRVGTPLYLAPELVKQ---
   ...|      ..| .|    ... .. ||||.|.|||||||  || ||.| .||| | ||.  ...   . . |    | |||| ..|||....   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRD-TMQFKRNTFVGTPYWMAPEVIQCMEG

--QPYDFKVDIWAIGIVLYHISALEPPFQGENLIALGFNIV--HK-FPKPL---PSVYSPKLVSFINKLLEKNPLQRPKTSEL
  ..||.|.|||. || .      |||.  ..     | |    . .|.     |. .||..  |..| |.|.| .|| .|.|
PDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQL
Kinase 21626.AA NEK4 46-291 37 6.3e-69 235.31 In-house 1-246 (257) Show / Hide 
Range on Protein: 46-291
Range on HMM: 1-246/257
Sequence Identity: 37% (93 aa)

FTIVKELGRGSYGVVYRAISNINKKEYVVKKINIKHMSNKHQKEALKEAQILRKVRHENIIRYYTSFVEHDC--LYIVMEYADGGDLQQLLRYRRERKKQ
. ..|  |.|||| |.   . . || ||.||.. |  | . .|.|..|||.| . .| ||. |  |.   .   ||||| . .|||| . |   ...| |
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL---KQQKNQ

F-TETEIWEFAYDLIKAVDYLHKNNIIHRDIKTLNIFLTKDRKVKLGDLGVSKIVSSQAALQGTRVGTPLYLAPELVKQQPYDFKVDIWAIGIVLYHISA
|  |  . |       |  |.|. .|.||| || ||||||   .|.||.|.|..    . .  | .||| |. ||.   .|||.| |||..|  .| .  
FLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMIT

LEPPFQGENLIALGFNIVHKFPKPLPSVYSPKLVSFINKLLEKNPLQRP
|   |.  ..  | . |.   | |.| .||. |   . ..||| | .||
LKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRP
Kinase 21626.AA ULK 46-290 27 1.7e-68 233.87 In-house 1-317 (329) Show / Hide 
Range on Protein: 46-290
Range on HMM: 1-317/329
Sequence Identity: 27% (87 aa)

FTIVKELGRGSYGVVYRAISNINK----KEYVVKKINIKHMSNKHQ-------KEALK-EAQILRKVR--------HENIIRYYTSFVEH--DCLYIVME
. . ..|| ||.|.||... ...|    . ...|.| .. |..| .       .. || | .|..|          |.||...|  | .   ...||.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YADGGDLQQLLRYRRE------RKKQFTETEIWEFAYDLIKAVDYLHKNNIIHRDIKTLNIFLTK-DRK-----------VKLGDLGVSKIVSSQ---AA
| .||||.|..  ...      .|| ..| |. .| .... .  .|||.||||||||  || ... . |           .|..| | .| |..    ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LQGTRV------GTPLYLAPELVK----QQPYD-FKVDIWAIGIVLYHISALEPP----FQGEN------LIALGFNI---VHKFPKPLP-----SVYSP
.  | |      ||||| ||....    |.||. .|.||| .|...| .   .||    |. ..      || .....   . |.|   |      . ||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

KLVSFINKLLEKNPLQR
.. ..| ..|.... .|
ECKDLIRRMLQYDEKDR
Kinase 21626.AA ULK 46-290 27 2.4e-67 230.04 In-house 1-312 (324) Show / Hide 
Range on Protein: 46-290
Range on HMM: 1-312/324
Sequence Identity: 27% (87 aa)

FTIVKELGRGSYG-VVYRAISNIN---KKEYVVKKINIKHMSNKHQK-------EALK-EAQILRKVR---HEN--IIRYYTSFVEHDC--LYIVMEYAD
. . ..|| ||.| .||... ...   .. . .|.|..| |..| ..       . || | ||..|     |.|  |...|  | . ..  .||.||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLQQLLRYRRE-----RKKQFTETEIWEFAYDLIKAVDYLHKNNIIHRDIKTLNIFLTK-DRK-----------VKLGDLGVSKIVS---SQAALQGT
||||.|..  ...     .|| ..| |. .| .... .  .|||.||||||||  || ... . |           .|..| | .|.|     .. .  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

RV------GTPLYLAPELVK----QQPYD-FKVDIWAIGIVLYHISALEPPFQGENLIALG-----------------FNIVHKFPKP-LPSVYSPKLVS
 |      ||||| ||....    |.||. .|.||| .|...| .   ..||..     .                   |   .||||    . ||.. .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FINKLLEKNPLQR
.| ..|.... .|
LIRRMLQYDEKDR
Kinase 21626.AA Ciliate-E2 46-298 22 7.9e-67 228.34 In-house 1-361 (365) Show / Hide 
Range on Protein: 46-298
Range on HMM: 1-361/365
Sequence Identity: 22% (83 aa)

FTIVKELGRGSYGVVYRAISNINKKEY------------------VVKKINIKHMSNKHQKEALKEAQILRKVR----------------HENIIRYYTS
. ..| .|.|..|.||..    ..|..                   .|....| |...  .. ..| .|.|...                | |||..| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FV--EHDCLYIVMEYADGGDLQQLLRYRRERK-------KQFTETEIWEFAYDLIK---------------AVDYLHKNN-IIHRDIKTLNIFLTKDRKV
|     ...|.||||..||||..... ..  .       |.||| || .. . ...               |. |||..| |||||||  ||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDLGVSKIVSSQ----------AALQGTR----------------------VGTPLYLAPELVK---------QQPYDFKVDIWAIGIVLYHISALEP
|. |.| ||... .            ..  .                      .||| |.||| ..         |..||.|.|||..|..||     .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFQGENLIALGFNIVHK----FPKPL--------------PSVYSPKLVSFINK----LLEKNPLQRPK-TSELIE
||         ... ..    ||.|               .   |..   .|.|    .|.|.| .|.   .....
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 21626.AA TKL 52-300 18 3.1e-64 219.71 In-house 1-364 (364) Show / Hide 
Range on Protein: 52-300
Range on HMM: 1-364/364
Sequence Identity: 18% (68 aa)

LGRGSYGVVYRAISNINK--------KEYVVKKINIKH-------------------------MSNKHQKEALKEAQILRKVRHENIIRYYTSFVEHDC-
.|.|..|.||... . .         |. .|||.....                         .. . ...  .|. .... ||.||.... .  . .| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LYIVMEYADGGD-LQQLLRYRRERKKQFTETEIWEFAYDLIKAVDYLHKNN--------IIHRDIKTLNIFLTKDRK-----------
            |.|||||..||. | .|.              .  .|.|  ....||| .|        |||||.|. ||.. .. .           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---VKLGDLGVSKIVS-------------------SQAALQGTRVGTPLYLAPELVKQQ----------------PYDFKVDIWAIGIVLYHISALEPPF
   .|..|.| |. .|                   ...   .|..||| ..|||. ..|                .|. |.|... ||||. | . ..|.
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

QGENL----------IALGFNIVHKFPKPLP------------SVYSPKLVSFINKLLEKNPLQRPKTSELIETF
....           . .  ..... . |.|            .   | . . . .  . .| .||  .|.....
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 21626.AA Pkinase_Tyr 46-238 28 5.3e-28 95.47 Pfam 1-205 (270) Show / Hide 
Range on Protein: 46-238
Range on HMM: 1-205/270
Sequence Identity: 28% (58 aa)

FTIVKELGRGSYGVVYRAISN----INKKEYVVKKINIKHMSNK-HQKEALKEAQILRKV-RHENIIRYYTSFV-EHDC--LYIVMEYADGGDLQQLLRY
 |. |.||.|..|.||... .     .| .  ||... ..|.    ... ..||.|...  .|.||.|.|   . . .   .||||||. .|||   || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

RRERKKQFTETEIWEFAYDLIKAVDYLHKNNIIHRDIKTLNIFLTKDRKVKLGDLGVSKIV---SSQ-AALQGTRVGTPL-YLAPELVKQQPYDFKVDIW
.|| |...|  .. .....  |. .||. .|.||||. . |. .|....|| .| | .. .   .    . .|..   |   .|||  .   .  | |.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGKFTTKSDVW

AIGIVLY
. |....
SFGVLMW
Kinase 21626.AA TyrKc 46-300 23 8.9e-23 82.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

FTIVKELGRGSYGVVYRAISNINKKEYVVKKINIKHMSNKHQKEALKEAQILRKV--RHENIIRYYTSFVEH-------DCLYIVMEYADGGDLQQLLRY
 |  |.||.| .|.||... .    .  ||...  .     ... ..||.|..|.  .|.||.| |   ...       . |.|||||...|||.. ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RRERKKQFTETEIWEFAYDLIKAVDYLHKNNIIHRDIKTLNIFLTKDRKVKLGDLGVSKIVSSQ------AALQGTRV--GTP--L---YLAPELVKQQP
.|..   ..  .  .|...  .  .|||..|.||||. . |. ..... || .| | |. . .            ..   |.   |    .|||  .   
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDFKVDIWAIGIVLYHISAL-EPPFQG-----ENLIALGFNIVHKFPKPLPSV--------YSPKLVSFINKLLEKNPLQRPKTSELIETF
. .| |.|. |.... |  . ..|  |      . . .  .. . .  | |           .... . . .  . .| .||  ||..| |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF