Gene 24670 (Tetrahymena)

24670

Species: Tetrahymena
Alias: 24670, 88.m00138, 3822.m00659, 190, PreTt24670, TTHERM_00628440
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
24670.AA Protein None 755 None Fasta, JSON
24670.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
24670.NA RNA None 2268 None Fasta, JSON

Protein domain

Protein domains of 24670.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24670.AA NEK 59-314 47 9.90000000001e-160 536.94 In-house 1-286 (286) Show / Hide 
Range on Protein: 59-314
Range on HMM: 1-286/286
Sequence Identity: 47% (136 aa)

FHNQKQ-GEGAYSSVYKVKRYGDGQE-----YALKKVKLQNLSEKEKQNAL-NEVRILASIRANNIVGYKEAFLDEMSNSLCIIMEYAN-NGDLFQK---
.  .|. |.|....||||.|  ||..     |..||....|.||||||||. ||||||....  |||.|...|..| .|.|||.|||.. .|||.||   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IVDHQKKGQLFPEQEIWNIFIQMVKGIKSLHDL-----KIFHRDLKSANVFLNKDGT----VKLGDMNVSKVAKKG--LLYT-QTGTPYYASPEVWKDQP
|  ...||..|.| .||..||||....| .||      || |||.|..|.||.|...    ||.|| ..||| ...  ..|| |.|||||.||||....|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDAKSDIWSLGCVLYEMTTL--KPPFRAE--DMEGLYKKVIRG-YYPRIPPH--FSQDLANVIRALLQVAPHLRPSADKILQLPAV
|. |||||||||||||| ||  |.||.|.  .|..||.|...| .||.||.|  .|||| |.|. .||. |..|||...||..| .
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 24670.AA NEK1 59-314 42 3.3e-102 345.85 In-house 1-276 (276) Show / Hide 
Range on Protein: 59-314
Range on HMM: 1-276/276
Sequence Identity: 42% (116 aa)

FHNQKQ-GEGAYSSVYKVKRYGDGQEYALKKVKLQNLSEKEKQNALNEVRILASIRANNIVGYKEAFLDEMSNSLCIIMEYANNGDLFQKIVDHQKKGQL
.| .|| |||..  ...||.  |||.|..|  .. . .|||.....||| |||  .  |||.|||.|  . .  | |.|||...|||.|||     ||.|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FPEQEIWNIFIQMVKGIKSLHDLKIFHRDLKSANVFLN--KDG---------------TVKLGDMNVSKVAKKGLLYTQT--GTPYYASPEVWKDQPYDA
|.| .| . |.|.... .  || || |||.|| |.||   |.|               .|||||  ....    ..| .|  ||||| ||| .  .||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGCVLYEMTTLKPPFRAEDMEGLYKKVIRGYYPRIPPHFSQDLANVIRALLQVAPHLRPSADKILQLPAV
||||||||||||| .||| || |  .  |  |...| || ||||.|..| . .  .... | .|||.  ||. | .
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 24670.AA S_TKc 59-314 29 3.3e-83 283.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 59-314
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

FHNQKQ-GEGAYSSVYKVKRYGDGQEYALKKVKLQNLSEKEKQNALNEVRILASIRANNIVGYKEAFLDEMSNSLCIIMEYANN--GDLFQKIVDHQKKG
..  .. |.||...|||..  ..|...|.|..|         .....|..|| . .  ||| ....| |   ..|...|||...  ||||. |......|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--QLFPEQEIWNIFIQMVKGIKSLHDLKIFHRDLKSANVFLNKDGTVKLGDMNVSKVAKKGLLYTQTGTPYYASPEVWKDQPYDA-KSDIWSLGCVLYEM
  . ||| ... .. |...... .|...| ||||| .|..|..  ..|..|  ....      .|. |||.| .|||    .|.  |.|.||.||.||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

TTLKPPFRAEDMEGLYKKVIRGYYPRIPPHFSQDLANVIRALLQVAPHLRPSADKILQ-------LPAV
 . .|||.  .|. ..||.            |... . || .||. |  ||.| ..||        | .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24670.AA NEK4 60-314 40 1.9e-79 270.27 In-house 3-257 (257) Show / Hide 
Range on Protein: 60-314
Range on HMM: 3-257/257
Sequence Identity: 40% (103 aa)

HNQKQGEGAYSSVYKVKRYGDGQEYALKKVKLQNLSEKEKQNALNEVRILASIRANNIVGYKEAFLDEMSNSLCIIMEYANNGDLFQKIVDHQKKGQLFP
| .  | | |  |. |.   |.  | .||..|.| | .|.. |. |...|   .  ||| ||| .  |    |.|.| . . |||..|    |.|.|. .
HMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL--KQQKNQFLE

EQEIWNIFIQMVKGIKSLHDLKIFHRDLKSANVFLNKDGTVKLGDMNVSKVAK--KGLLYTQTGTPYYASPEVWKDQPYDAKSDIWSLGCVLYEMTTLKP
|. . . |.|   .   .|. .| |||||  |.|| |   .|.||. .|.|      .  |  ||||| |||..  .||| ||||||||| .||| ||| 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFRAEDMEGLYKKVIRGYYPRIPPHFSQDLANVIRALLQVAPHLRPSADKILQLPAV
 | | ||  |  ..| |  | .|| .||||.| .. .|.  |  |||   |.| | .
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 24670.AA NEK8 86-314 35 2.4e-78 223.26 In-house 31-278 (278) Show / Hide 
Range on Protein: 86-314
Range on HMM: 31-278/278
Sequence Identity: 35% (90 aa)

LKKVKLQNLSEKEKQNALNEVRILASIRANNIVGYKEAFLDEMSNSLCIIMEYANNGDLFQKIVDHQKKGQLFPEQ----------------EIWNIFIQ
.| . .  .|||| | |.||...|. .   ||..| . |...  |.| | ||||. | | |.|.. | |  ...|                 .|   |.|
WKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMED--NTLMIEMEYADGGTLYQMIQHQQNK-LFEEERQLKQVNHCFNIYFNEQMILWYFFQ

MVKGIKSLHDLKIFHRDLKSANVFLNKD-GTVKLGDMNVSKV-AKKGLLYT---QTGTPYYASPEVWKDQPYDAKSDIWSLGCVLYEMTTLKPPFRAEDM
|. ..  .|.  | ||||| .|.|.... . ||.||   ||.   | . .|     ||||| |||  . .||..|||.|.|||||||| .||  | |.  
MCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNL

EGLYKKVIRG-YYPRIPPHFSQDLANVIRALLQVAPHLRPSADKILQLPAV
  |  | ...  |  |. | | ..  .....||. |  ||||. |.  | .
PALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 24670.AA Pkinase 59-314 26 5.5e-73 253.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 59-314
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

FHNQKQ-GEGAYSSVYKVKRYGDGQEYALKKVKLQNLSEKEKQNALN--EVRILASIRANNIVGYKEAFLDEMSNSLCIIMEYANNG----DLFQKIVDH
.|  .. |.|....||| .. |.|...|.|..|... .....|....  |..|.....  ||| ....| |  .......|||...|    |||  |   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

QKKGQL-FPEQEIWNIFIQMVKGIKSLHDLKIFHRDLKSANVFLNKDGTV----KLGDMNVSK---VAKKGLLYTQTGTPYYASPEVWK-DQPYDAKSDI
...| . |.|.|. ... |...|.. .|. .| |||||..|......|..    |..|  ..|     ... ..| .|||.|..||| . .|.|. |.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGCVLYEMTTLKPPFRAE------DMEGLYKKVIRGYYPRIPPHFS--------------------QDLANVIRALLQVAPHLRPSADKILQLPAV
||.||.|||| . .|||. .      |.  ..... .. ...  |  .                    ...  .|. .|.. |. ||.|. ||| | .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 24670.AA CAMK 63-314 19 9.3e-66 210.6 In-house 1-425 (425) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-425/425
Sequence Identity: 19% (82 aa)

KQGEGAYSSVYKVKRYGDG------------QEYALKKVKLQNLS--------------------------EKEKQNALNEVRILAS-------IRANNI
. |.|... |.....  ..            |..| | .. . |.                          .| ..| ..|..|. .       ..  ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGYKEAFLD-----------EMSN-------SLCIIM---EYANNG----DLFQKIVDHQKKG-----------QLFPEQEIWNIFIQMVKGIKSLHDLK
.   |.. |             |.        ....|   ||. .|    |||..||.| ..|             |.|.|   .| |.. ... .|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IFHRDLKSANVFLNKD-----------------GTVKLGDMNVSKVAKKG-------------------------LLYTQTGTPYYAS-PEVWKD-----
| |||||  |. |...                 ...|. |   ... ..|                         ...|. |||.|.. ||| .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QPYDAKSDIWSLGCVLYEMTTLKPPFRAE-------------DMEGLYKKVIRGYYPRIPPHFS-----------------------QDLA
         ..|. |.|.||.|..|| | . .|||...             ... |..|...| |  .||.||                       |.  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NVIRALLQVAPHLRPSADKILQLPAV
. || .||| |  |.... .|. | .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 24670.AA NEK2 65-314 31 1.7e-64 216.08 In-house 8-319 (319) Show / Hide 
Range on Protein: 65-314
Range on HMM: 8-319/319
Sequence Identity: 31% (97 aa)

GEGAYSSVYKVKRYGDGQEYALKKVKLQNLSEKEKQNALNEVRILASIRANNIVGYKEAFLDEMSNSLCIIMEYANNGDLFQKIVDHQKKGQLFPEQEIW
|.| . ...||.|  ||   . |  .  .. |||.|   .|. ||   .  ||| |     |. . .| |.|||   ||| | |    |  | ..|. ||
GNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIW

NIFIQMVKGIKSLHD---------------------LKIFHRDLKSANVFLNKDGT---------------------------------------VKLGD
 |. |.    .  |                        | |||.| ||.||  |.                                        |||||
RIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGD

MNVSKVAKKGLLYTQT--GTPYYASPEVWKDQPYDAKSDIWSLGCVLYEMTTLKPPFRAEDMEGLYKKVIRGYYPRIPPHFSQDLANVIRALLQVAPHLR
    .. ..  .. .|  ||||| |||. ..|.|. ||||||.||..||| .|.|||.|     |  |.  | . |||   |..|  .|   . | .  |
FGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHR

PSADKILQLPAV
|| . ||| | .
PSIEEILQHPQI
Kinase 24670.AA STE 59-314 25 1.7e-63 217.29 In-house 1-359 (359) Show / Hide 
Range on Protein: 59-314
Range on HMM: 1-359/359
Sequence Identity: 25% (92 aa)

FHN-QKQGEGAYSSVYKVKRY------GDGQE---------YALKKVKLQNLS---------------EKEKQNALNEVRILASIR--ANNIVGYKEAFL
. . .| |.||. .||| ..         |..         .| |...|.| .               ..|.|. |.|..|.   .    ||| |  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE-----MSNSLCIIMEYANNGDLFQKIVDHQKKGQL----------FPEQEIWNIFIQMVKG-IKSLHDLKIFHRDLKSANVFLNKDGTVKLGDMNVSK
.|       ..|.|.||| ..| | . |    ..|.           |||..|  |  | .||  . ||...| |||.|.||..|     ||| |  |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

-VAK-----------------KGLLYTQTGTPYYASPEVWK------DQPYDAKSDIWSLGCVLYEMTTLKPPFRA-EDMEGLYKKVIR-----------
 ...                 ..  .| .||| . .||| .      |..||.|.|||||||.. || | |||.    .|. .. . .            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GYYPRIPP-------------------HFSQDLANVIRALLQVAPHLRPSADKILQ--LPAV
   |  |..|.                   ..|... . |.  ||  |. ||.|.. |.   | .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 24670.AA ULK 65-314 26 6e-59 202.16 In-house 8-329 (329) Show / Hide 
Range on Protein: 65-314
Range on HMM: 8-329/329
Sequence Identity: 26% (86 aa)

GEGAYSSVYKVKRYGD----GQEYALKKVKLQNLSEKEKQNA--------LNEVRILASIR----ANN----IVGYKEAFLDEMSNSLCIIMEYANNGDL
|.|..  ||| .   .    .. .| |.. .| ...|....          ||..|.  .      .|    || ... | .  .| . ||||| | |||
GKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDL

FQKIVDHQK------KGQLFPEQEIWNIFIQMVKGIKSLHDLKIFHRDLKSANVFLNKD------------GTVKLGDMNVSKVAKKG-----LLYTQT-
.| |  ..|      ... ..|||. ..|.| . | | ||. .| |||.| .|. ....            |..|..|   .|.  ..     ...|.. 
EQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVN

-----GTPYYASPEVWKDQ----PYD-AKSDIWSLGCVLYEMTTLKPPFRAEDMEGLY-----KKV---------IRGYYPRIP-----PHFSQDLANVI
     |||.| .|.....|    ||. .|.|||||||..||| . ||||.|   . .|     | .         |.   ...|     |..|... . |
EKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLI

RALLQVAPHLRPSADKILQLPAV
| .||. .  | | . ... | .
RRMLQYDEKDRISWEELFNHPWF
Kinase 24670.AA ULK 65-297 26 1.9e-58 200.46 In-house 8-307 (324) Show / Hide 
Range on Protein: 65-297
Range on HMM: 8-307/324
Sequence Identity: 26% (80 aa)

GEGAYS-SVYKVKRYGD---GQEYALKKVKLQNLSEKEKQ--------NALNEVRILASIR---ANN--IVGYKEAFLDEMSNSLCIIMEYANNGDLFQK
|.|..   ||| .   .   .| .| |.. ......|...        .  ||..|.  .     .|  || ... | .  .| ..||||| | |||.| 
GKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQY

IVDHQK-----KGQLFPEQEIWNIFIQMVKGIKSLHDLKIFHRDLKSANVFLNKD------------GTVKLGDMNVSKVAKKG-----LLYTQT-----
|  ..|     ... ..|||. ..|.| . | | ||. .| |||.| .|  ....            |..|..|   .|.  ..     ...|.      
IKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRI

-GTPYYASPEVWKDQ----PYD-AKSDIWSLGCVLYEMTTLKPPFRAEDMEGLY-------------KKVIRGYYPRIP-----PHFSQDLANVIRALLQ
 |||.| .|.....|    ||. .|.|||||||..||| . |.||..   . .|             .  |.    ..|     |..|... . || .||
KGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQ

V
.
Y
Kinase 24670.AA Ciliate-E2 57-314 21 1.5e-57 196.1 In-house 1-365 (365) Show / Hide 
Range on Protein: 57-314
Range on HMM: 1-365/365
Sequence Identity: 21% (80 aa)

IDFHNQKQGEGAYSSVYKVKRYGDG-----------------------QEYALKKVKLQNLSEKEK-QNALNEVR----------ILASIRANNIVGYKE
..|...  |.|...||||.|.. ..                       ..||.| .| ... .... .. ..|..          || ..  .||. ..|
YKFIKKI-GQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

AFLDEMSNSLCIIMEYANNGDLFQKIVDH-QKKGQLFP------EQEIWNIFIQMVK---------------GIKSLHDLK-IFHRDLKSANVFLNKDGT
.| ..  |.. ..|||.. ||||. | .. .|... ..      |.|| .|. | ..               ....||  . |.|||.|  |...     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKLGDMNVSKVAKKG---------------------------------LLYTQTGTPYYASPEVWKDQP---------YDAKSDIWSLGCVLYEMTTLKP
.|. |.  || ...                                  . .|. |||.| .||. . ..         || |.||||||..|||| . ||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFRAEDMEGLYKKVIRGYYP-R----------------IPPHFSQDLANVIRA----LLQVAPHLRPS-ADKILQLPAV
||        ... . . .  .                .. . ||.  . |.     .||. |  |.. ...||. |  
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 24670.AA TyrKc 58-312 21 7.4e-16 33.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 58-312
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

DFHNQKQGEGAYSSVYKVKRYGDGQEYALKKVKLQNLSEKEKQNALNEVRILASI--RANNIVGYKEAFLDE-----MSNSLCIIMEYANNGDLFQKIVD
   ..| ||||.  ||| . .   .. | |..|        ..  ..| ||. ..  .  |||    . ...      .  |.|.|||. .||| . . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HQKKGQLFPEQEIWNIFIQMVKGIKSLHDLKIFHRDLKSANVFLNKDGTVKLGDMNVSKVAKKG-------LLYTQT---GTP-----YYASPEVWKDQP
|..|   .. ..  .. .|  .|   ||. .. ||||   |. .....||| .|   |.  . .         |...   |.         .||....  
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDAKSDIWSLGCVLYEMTTL-KPPFRA-----EDMEGLYKKVIRGYYPRIPPH--------FSQDLANVIRALLQVAPHLRPSADKILQLP
.  |||.|| | ...|. |. ..|         . . ....| .||....||.         .... ....   .  |. ||.   | .. 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 24670.AA Pkinase_Tyr 65-204 24 9.4e-05 16.72 Pfam 8-154 (270) Show / Hide 
Range on Protein: 65-204
Range on HMM: 8-154/270
Sequence Identity: 24% (36 aa)

GEGAYSSVYKVKRY----GDGQEYALKKVKLQNLSEKE--KQNALNEVRILASI-RANNIVGYKEAFLDEMSN-SLCIIMEYANNGDLFQKIVDHQKKGQ
||||. .||| . .    ..... | |..  .. ....  ..  ..|..|. .. .  ||| .  . .|.    ...|.|||. .|||     .|   .|
GEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

LFPEQEIWNIFIQMVKGIKSLHDLKIFHRDLKSANVFLNKDGTVKLGD
 .. ... .. .|  ||   |.. .. ||||   |. ......|| .|
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICD
Kinase 24670.AA Pkinase_Tyr 227-282 27 0.000192 15.67 Pfam 182-240 (270) Show / Hide 
Range on Protein: 227-282
Range on HMM: 182-240/270
Sequence Identity: 27% (16 aa)

SPEVWKDQPYDAKSDIWSLGCVLYEMTTL-KPP-FRAEDMEGLYKKV-IRGYYPRIPPH
.||....  .  |||.|| | ...|. |. . | .   . | .|...  .||   .|..
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN