Gene 29897 (Tetrahymena)

29897

Species: Tetrahymena
Alias: 29897, 895, PreTt29897, TTHERM_00185750, 14.m00464
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
29897.AA Protein None 891 None Fasta, JSON
29897.kin_dom Protein Kinase Domain None 275 None Fasta, JSON
29897.NA RNA None 2676 None Fasta, JSON

Protein domain

Protein domains of 29897.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29897.AA NEK 456-730 38 7.1e-123 414.51 In-house 1-286 (286) Show / Hide 
Range on Protein: 456-730
Range on HMM: 1-286/286
Sequence Identity: 38% (116 aa)

YTLVEMIGKGAFGTVYLVRKG--GNK-----YALKQIPFSNVDLRDKDG--KPQEEVKINENNLEEYFKEVKIYKTLKHPNIVTYYESFIEDD--CLCIV
|.....||.|.||.||.||.   |..     |..|.| ..| . ..|.   .                .||.| | |||||||.||.||||..  |||||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQN----------------NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIV

MEFVE-GFNLSEL---IKLQIEKQDHFSEKQIWKVVVNLSSVLKYLHYDK----KIVHRDLNPANIMIDNEFN----VKLADFGLAKTLNQSVNMLQS-F
||. | | .|...   || | .| ..|.|.|||.. . ... |||.|. |    ||.|||. |.||..... |    ||. |||..| ||... |... .
MEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQ

VGTLMYSCPEIVQNRPYSEKADVWSFGCVLYELMML--KPPFQSG--NPLMLAKKIVDL-EYEAITKANAPQYSQELIEIVSRCLTVEEKERPSILEILS
|||  | .||..||.||..|.|.||.||||||...|  |.||..   | . |..||.   .|. | . .  .|||.| ...|..|... ..|||. .||.
VGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHR--MYSQDLQNLISQMLQKDPEQRPSCNQILE

SISS
    
MPFI
Kinase 29897.AA NEK10 456-730 40 2.2e-93 308.24 In-house 1-279 (279) Show / Hide 
Range on Protein: 456-730
Range on HMM: 1-279/279
Sequence Identity: 40% (117 aa)

YTLVEMIGKGAFGTVYLVRKGGNKY--------ALKQIPFSN--VDLRDKDGKPQEEVKINENNLEEYFKEVKIYKT-LKHPNIVTYYESFIE--DDCLC
| . .  | |||| || |||             |.| | . |  . . ||.          .  .|.   |.|| |  ..||||| ||  |.|   . . 
YEVYDHLGTGAFGCVYKVRKKAQQHSENPAKLLAMKEIFMHNPAFGKNDKE---------RDKSIEDMISELKIIKEQMRHPNIVRYYRTFVEPQNHRMY

IVMEFVEGFNLSELIKLQIEKQDHFSEKQIWKVVVNLSSVLKYLHYDKKIVHRDLNPANIMIDNEFNVKLADFGLAKTLNQSVNMLQSFVGTLMYSCPEI
|||| .||  | |..    ||..||.|..||.... .   | |||  |.|||||| | |||. ..  |   ||||||        . | ||| .||||||
IVMELIEGCPLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHKEKQIVHRDLTPNNIMMGDKDRVTITDFGLAKQKQPDPSKMTSVVGTILYSCPEI

VQNRPYSEKADVWSFGCVLYELMMLKPPFQSGNPLMLAKKIVDLEYEAITKANAPQYSQELIEIVSRCLTVEEKERPSILEILS---SISS
||. || ||||||.|||.||..  |.||| | | | || |||.  |. .   |   .|...  ...||||   . || |... |    |. 
VQSEPYGEKADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIVEHFYDPV---NEGMWSDDVRFTITRCLTPDPEARPDIVKVSSVLRMIQD
Kinase 29897.AA S_TKc 456-733 29 2.6e-83 283.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 456-733
Range on HMM: 1-231/231
Sequence Identity: 29% (86 aa)

YTLVEMIGKGAFGTVYLVRKGG--NKYALKQIPFSNVDLRDKDGKPQEEVKINENNLEEYFKEVKIYKTLKHPNIVTYYESFIEDDCLCIVMEFVEG--F
|.... |||||||.||..|. .   ..|.|.|.                        |   .|..| |  .|||||..|..| . |.|..|||...|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG

NLSELIKLQIEKQDH--FSEKQIWKVVVNLSSVLKYLHYDKKIVHRDLNPANIMIDNEFNVKLADFGLAKTLNQSVNMLQSFVGTLMYSCPEIVQNRPYS
.| ..|| .  .  .  |.| ......  . . |.|.|   .|.|||| |.||..|.  ..|..|||||. |        .|.||. |  ||..   .|.
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYG

E-KADVWSFGCVLYELMMLKPPFQSGNPLMLAKKIVDLEYEAITKANAPQYSQELIEIVSRCLTVEEKERPSILEILS----SISSQLV
  |.|.||.||.|||..  .|||.  .. |. |||.               |.|.......||... ..||.. |.|       . . .
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 29897.AA STE 456-726 25 5.9e-71 242.05 In-house 1-353 (359) Show / Hide 
Range on Protein: 456-726
Range on HMM: 1-353/359
Sequence Identity: 25% (94 aa)

YTLVEMIGKGAFGTVYLVRKG-----------------GNKYALKQIPFSNVDLRDKD--GKPQEE-VKINENNLEEYFKEVKIYKTLK--HPNIVTYYE
....|.||||||||||. ..                  |. .| ||....| .  | .   . | |  ..|....... ||.|| | ..  |||||.|| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG

SFIED-------DCLCIVMEFVEGFNLSELIKLQIEKQD----------HFSEKQIWKVVVNLSSV-LKYLHYDKKIVHRDLNPANIMIDNEFNVKLADF
... .       | |.|.||...|  |...||   ....          .|.|.|| .... .    |.|||  . |.|||. ||||..     |||.||
CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDF

GLAKTLNQSVN----------------MLQSFVGTLMYSCPEIVQN------RPYSEKADVWSFGCVLYELMMLKPPFQSGNPL----MLAKK-------
|... |..|.                 . ..||||  .  ||..|.       .|..|.|.||.||.. |.   |||.  ..|.    | ...       
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

----IVDLEYEAIT-KANAP--------------QYSQELIEIVSRCLTVEEKERPSILEILS
    ||. .   .  .   .              ..|.|... ...||. . ..||.  . |.
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
Kinase 29897.AA Ciliate-E2 456-730 22 4.8e-69 235.68 In-house 1-365 (365) Show / Hide 
Range on Protein: 456-730
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

YTLVEMIGKGAFGTVYLV--RKGGNKYALKQIPFSNVDLRD-----KDGKPQEEVKINENNLEEYFKEVKIYK----------------TLKHPNIVTYY
| ....||.|.||.||..  .| ....|.|.|   ..  |       ..|  .   ...|..|. ..| .|..                .|.||||. .|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

ESFI--EDDCLCIVMEFVEGFNLSELIKLQIEKQD-------HFSEKQIWKVVVNLSS---------------VLKYLHYDKKIVHRDLNPANIMIDNEF
|.|.   |... .|||...| .| ..|| .  |..        |.||.| ..   . .                |.|||  ..|.|||. | ||..    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NVKLADFGLAKTLNQS-------------------------------VNMLQSFVGTLMYSCPEIVQNRP---------YSEKADVWSFGCVLYELMMLK
 .|..||||.| ....                                || ....||..| .|||... .         |..|.|.||.|..|||... |
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFQSGNPLMLAKKIVDLEYEAITKA-----------NAPQYSQELIEIVSR----CLTVEEKERPS-ILEILSSISS
|||      .  .|  ....    .            .  . ||| . . ..    .| .....|.. . .||     
PPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 29897.AA Pkinase 456-728 27 2.1e-67 235.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 456-728
Range on HMM: 1-293/293
Sequence Identity: 27% (87 aa)

YTLVEMIGKGAFGTVYLVRKGGNK--YALKQIPFSNVDLRDKDGKPQEEVKINENNLEEYFKEVKIYKTLKHPNIVTYYESFIEDDCLCIVMEFVEGF--
|.... ||.|.||.||. .. |.   .|.|.|   ... ..|..|.|. ...          |..| | |.|||||..|..| ..| ...|||..||   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKII---KKR-HEKSWKDQTHRRL---------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY

--NLSELIKLQIEKQDHF--SEKQIWKVVVNLSSVLKYLHYDKKIVHRDLNPANIMIDNEFNV----KLADFGLAKTL-NQSVNMLQSFVGTLMYSCPEI
   |...|.   ...  |  ||... ...  . . |.|.|  ..|.|||| |.||.|||. ..    |..|||||| . . .   ...|.||. |  ||.
VMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

VQ-NRPYSEKADVWSFGCVLYELMMLKPPFQSG------NPLMLAKKIVDLEYEAI-----------------TKANAPQYSQELIEIVSRCLTVEEKER
.. ...|. |.|.||.||.|||..  .|||..       ... . ..| . ...                   .. . .  |.|.......||..  |.|
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKR

PSILEILSS--I
|.. .|| .  .
PTAEQILQHPWF
Kinase 29897.AA ULK 456-726 27 8.4e-66 224.93 In-house 1-320 (324) Show / Hide 
Range on Protein: 456-726
Range on HMM: 1-320/324
Sequence Identity: 27% (91 aa)

YTLVEMIGKGAFG-TVYLVR---KG--GNKYALKQIP---FSNVDLRDKDGKPQEEVKINENNLEEYFKEVKIYKTLK---HPN--IVTYYESFIEDDC-
| | ...|||.|| .||  |   ..  . ..| |.|.   ...  ...       .    .  ..   .|..| |.||   |||  || .|. | .... 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE------G----QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHN

-LCIVMEFVEGFNLSELIKLQIE-----KQDHFSEKQIWKVVVNLSSVLKYLHYDKKIVHRDLNPANIMIDNEFN------------VKLADFGLAKTLN
 ..|.||. .| .|...|| . .     ..  .||... ..   . . .|.|| ...|.|||. |.||.| | .             .|.||||.||...
NIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELH-KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD

---QSVNMLQSFV------GTLMYSCPEIVQNR----PYS-EKADVWSFGCVLYELMMLKPPFQSG-NPLML-AKKIVD--------LEYEAITKA---N
   .. .|.|..|      || .| .|.|.|..    ||.  |.|.||.||..||.   |.||.|  |.. |  .| ..         ... | .    .
NNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPK

APQYSQELIEIVSRCLTVEEKERPSILEILS
.|. |.|.... .|.|...||.| |. ||..
DPKISPECKDLIRRMLQYDEKDRISWEEIFN
Kinase 29897.AA ULK 456-726 27 5.6e-65 222.18 In-house 1-325 (329) Show / Hide 
Range on Protein: 456-726
Range on HMM: 1-325/329
Sequence Identity: 27% (91 aa)

YTLVEMIGKGAFGTVYLVR---KG---GNKYALKQIP---FSNVDLRDKDGKPQEEVKINENNLEEYFKEVKIYKTLK--------HPNIVTYYESFIED
| | ...|||.||.||  |   ..   . |.| |.|.   ...    .       .    .  ..   .|.|| |.||        ||||| .|. | ..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQE------G----QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETS

--DCLCIVMEFVEGFNLSELIKLQIE------KQDHFSEKQIWKVVVNLSSVLKYLHYDKKIVHRDLNPANIMIDNEFN------------VKLADFGLA
  ... |.||. .| .|...|| . .      .. ..||... ..   . . .|.|| ...|.|||. |.||.|.| .             .|.||||.|
NHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELH-KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA

KTLNQS---VNMLQSFV------GTLMYSCPEIVQNR----PYS-EKADVWSFGCVLYELMMLKPPFQSGNPLMLA-KKIVDLEYEAITKA---------
|... .    .|....|      || .| .|.|.|..    ||.  |.|.||.||..||.   ||||..  .  .  ..| .|     . .         
KHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQ

-----NAPQYSQELIEIVSRCLTVEEKERPSILEILS
     |.|| |.|.... .|.|...||.| |. |...
FPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFN
Kinase 29897.AA CAMK 461-726 19 9.3e-60 190.92 In-house 1-421 (425) Show / Hide 
Range on Protein: 461-726
Range on HMM: 1-421/425
Sequence Identity: 19% (81 aa)

MIGKGAFGTVYLVRKGGNK--------------YALKQIPFSNVDL-----------RDKDGKPQEEVKINENNLEEYFKEVKIYKT-------LKHPNI
 .|.|.||.|.|..   ..              .| | |. . ..            .|| ..   . ......... ..|..| |.       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTYYESFIE-------------------DDCLCIVM---EFVEGF----NLSELIKLQ------------IEKQDHFSEKQIWKVVVNLSSVLKYLHYDK
.  || .                     |.....||   |...|      | . |. .            . .  .|.|..  ...  . | ..|.| ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCH-SH

KIVHRDLNPANIMIDNE-----------------FNVKLADFGLAKTLNQSVN-----------------------MLQSFVGTLMYSC-PEIVQN----
.|||||| | ||..|.                  .|.|..|||.|. .... |                       ... |.||. | . ||...     
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------RPYSEKADVWSFGCVLYELMMLKPPFQSG-------------NPLMLAKKIVDLEYEAITKANAP-------------------QYSQEL
          ..|..|.|.|| |..|| .   .|||..              |.  | .||   .|. . .   |                   . ||| 
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

IEIVSRCLTVEEKERPSILEILS
.  ....|.|. ..|..| ..|.
KDLIRKMLQVDPEKRMTIEQCLN
Kinase 29897.AA TKL 462-728 20 3.7e-59 202.85 In-house 1-364 (364) Show / Hide 
Range on Protein: 462-728
Range on HMM: 1-364/364
Sequence Identity: 20% (79 aa)

IGKGAFGTVYLV-RKG---------GNKYALKQIPFSNVDLRDK------------DGKPQEEVKINENNLEEYFKEVKIYKTLKHPNIVTYYESFIEDD
||.|.||.||    .|         |.  | |...  |.|...|            |   | . . .. . ..  .|... . |.||||| .. . .. .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSD-M-QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

C-------------LCIVMEFVEGFN-LSELIKLQIEKQDHFSEKQIWKVVVNLSSVLKYLHYDKK-------IVHRDLNPANIMIDNEFN---------
|             ||||||...| . |. |.             |. . .   .. . ||| ..        |.||||...||..|. ..         
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

-----VKLADFGLAKTLNQSVN-------------------MLQSFVGTLMYSCPEIVQNR----------------PYSEKADVWSFGCVLYELMMLKP
     .|..||||.....|| |                   .. . .||. .  ||. ..                 .||||.||.||| ||.|..  ..
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

PFQSGNPLMLA---------KKIVDLEYEAITK---------ANAPQYSQELIEIVSRCLTVEEKERPSILEILSSI
|..  .. .           ....|  .    .          . |.  ......  .|   . ..||| .|||. .
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 29897.AA NEK1 456-730 36 8.8e-56 191.63 In-house 1-276 (276) Show / Hide 
Range on Protein: 456-730
Range on HMM: 1-276/276
Sequence Identity: 36% (109 aa)

YTLVEMIGKGAFGTVYLVRK--GGNKYALKQIPFSNVDLRDKDGKPQEEVKINENNLEEYFKEVKIYKTLKHPNIVTYYESFIEDDC--LCIVMEFVEGF
|.   .||.|.|| ..||..   |  |..| | .               .|  | . ||  .||.| . .||||||.|.|||.|  |  | ||||. .| 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINV---------------MKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGG

NLSELIKLQIEKQDHFSEKQIWKVVVNLSSVLKYLHYDKKIVHRDLNPANIMID---NEF--------------NVKLADFGLAKTLNQSVNMLQSFVGT
 |   |. |  |   ||| ||    . ..  |.. | |.|| |||. . ||      |                 |||.||| |..|| ..   .  .||
DLMQKINRQKRKGKLFSEDQIMHWFCQICLALNHIH-DRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGT

LMYSCPEIVQNRPYSEKADVWSFGCVLYELMMLKPPFQSGNPLMLAKKIVDLEYEAITKANAPQYSQELIEIVSRCLTVEEKERPSILEILSSISS
  |  ||| ||.||  | |.|| |||||||. || ||...|   |  ||.   |  |     | ||.|| . ||  . .  . |||.  ||.. . 
PYYLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPI----PPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 29897.AA Ciliate-E2-Unclassified 456-725 23 1.3e-54 187.76 In-house 1-347 (352) Show / Hide 
Range on Protein: 456-725
Range on HMM: 1-347/352
Sequence Identity: 23% (82 aa)

YTLVEMIGKGAFGTVYLVRKGGNK--YALKQIPFSNVDLRDKDGKPQEEVKINENNLEEYF--------KEVK-IYKTLKHPNIVTYYESFIEDDCLCIV
|.... ||.|.||.||....  .|  ||.|..  .... . .  . . | . ... ...          |. . | . ..||.|| ... |  .....||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEFVEGFNLSELIKLQIE------------KQDH-FSEKQIW-----KVVVNLSSVLKYLHYDKKIVHRDLNPANIMIDNE---FNVKLADFGLAKTLNQ
||..|| .|.. || .              ||.. |.|.|.      .    . . |.|||. ..|.|||. | ||..||.   ...|..|||..| ..|
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

S---------------VNMLQSFVGTLMYS----CPEIVQNRPYS----EKADVWSFGCVLYELMMLKPPFQSGN---PLMLAKKIVDL-----EYEAIT
.                .|...|.||..|      ||. |.  |.    .|.|.||.|..|||... ..||.. |      | .... .     ... . 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNI

KAN------AP------QYSQELIEIVS----RCLTVEEKERPSILEIL
|..      .|      . |.| .....    ..| .  ..|... .||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase 29897.AA TyrKc 456-728 20 3.2e-17 55.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 456-728
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

YTLVEMIGKGAFGTVYLVRKGGNKYALKQIPFSNVDLRDKDGKPQEEV---KINENNLEEYFKEVKIYKTL--KHPNIVTYYESFIED-------DCLCI
 || ...| ||||.||. .                          ..|   ...|. .|.  .| .| . |  .|||||  |   ...       . |.|
ITLGKKLGEGAFGEVYKGTWK------------------------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI

VMEFVEGFNLSELIKLQIEKQDHFSEKQIWKVVVNLSSVLKYLHYDKKIVHRDLNPANIMIDNEFNVKLADFGLAKTLNQS--------VNML----QS-
|||.... .| . ..   .|   .. |.  .  .  ..   ||| .|...||||   |....... || .||||.. .           . .     .. 
VMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLH-SKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

FVGTLMYSCPEIVQNRPYSEKADVWSFGCVLYELMML-KPPFQS-----GNPLMLAKKIVDLEYEAITKANAPQY---------SQELIEIVSRCLTVEE
..  .    ||  . . ...| |||||| ...|.. . ..|         ..  . ... . ..  .     |..         ..|. .| ..|   . 
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQ-----PPNDYPMSFVCCPDEMYQIMKQCWHEDP

KERPSILEILSSI
..||.  || . .
EDRPTFSEIHECF
Kinase 29897.AA Pkinase_Tyr 514-621 29 9.4e-12 40.43 Pfam 51-161 (270) Show / Hide 
Range on Protein: 514-621
Range on HMM: 51-161/270
Sequence Identity: 29% (33 aa)

FKEVKIYKTL-KHPNIVTYYESFI-EDDC--LCIVMEFVEGFNLSELIKLQIEKQDHFSEKQIWKVVVNLSSVLKYLHYDKKIVHRDLNPANIMIDNEFN
..|.|| |.| .||||| .|   . ...   ..||||.... .| .  . . | ..... |.. .  .  .. . ||. .|...||||   |....... 
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENNV

VKLADFGLAKTL
|| .|||||...
VKICDFGLARDI
Kinase 29897.AA Pkinase_Tyr 640-667 35 9.4e-07 23.49 Pfam 183-210 (270) Show / Hide 
Range on Protein: 640-667
Range on HMM: 183-210/270
Sequence Identity: 35% (10 aa)

PEIVQNRPYSEKADVWSFGCVLYELMML
||  ... ...| |||||| ...|.. .
PECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase 29897.AA Pkinase_Tyr 456-472 47 0.002267 12.04 Pfam 1-17 (270) Show / Hide 
Range on Protein: 456-472
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

YTLVEMIGKGAFGTVYL
 |. ...|.||||.||.
ITFGKKLGEGAFGEVYK