Gene 3425 (Tetrahymena)
3425
Sequence
Protein domains of 3425.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 3425.AA | NEK | 10-295 | 41 | 5.1e-147 | 494.72 | In-house | 1-286 (286) | Show / Hide |
Range on Protein: 10-295 Range on HMM: 1-286/286 Sequence Identity: 41% (129 aa) YKEIEVIGRGNFGSATLVEKLDNKKQ-----YIAKKIVLSSLNPKQQDSAL-QEAQLLKDLNHKNIVSYIESFKEED--LLIIIMEYCERKQIQICFFSV |..|..||.|.||....|.. ..|. |. ||| ......|... |. .|...|| |.| |||.|..|| ||. |.|.|||||. YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEG---------- SKNDIIHKQMQIIEQLLSYYQLHSALKRKKQKKEYFPEMLIVNWFYELALSIKYIHEK-----KILHRDIKTSNIFITRDGT----IKIGDFGISKVLEN . | |... .|..|||..||.|. |..||. ..| .||.|.. ||||||||..|||.|.... .|||||||||||.. -GGDLYQKIKS--------------IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNH TTSVANT-VVGTPYYMSPEVCESKPYTYKSDIWALGCVLYELCAL--EHAFESN--NLLGLIFKIVQQ-NISDIPSF--YSKELNDLIHKLLNKNEQERP ||. |.| .||||||||||||..|||..|||||.|||||||.|.| .|.||.. |...|..||.. . . |||. ||..|..||...|.|. ..|| TTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRP VINDILNDIST .|.||.. SCNQILEMPFI |
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| Kinase | 3425.AA | NEK8 | 135-292 | 48 | 2.5e-87 | 249.35 | In-house | 114-275 (278) | Show / Hide |
Range on Protein: 135-292 Range on HMM: 114-275/278 Sequence Identity: 48% (79 aa) EYFPEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFITRD-GTIKIGDFGISKVLENTTSVANT---VVGTPYYMSPEVCESKPYTYKSDIWALGCVL .||.| .|. | . . ..|.. |||||.|| ||| ||. . .|||||||||.. || . . | ||||||||||| ||.||| |||.||||||| IYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIM-NTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVL YELCALEHAFESNNLLGLIFKIVQ-QNISDIPSFYSKELNDLIHKLLNKNEQERPVINDILND ||.| |. ||| ||. |. ||.| .. .|.. ||.|. |.| .| . . || |. . YEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAM |
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| Kinase | 3425.AA | NEK1 | 128-295 | 44 | 2.5e-83 | 283.17 | In-house | 92-276 (276) | Show / Hide |
Range on Protein: 128-295 Range on HMM: 92-276/276 Sequence Identity: 44% (83 aa) KRKKQKKEYFPEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFIT--RDG---------------TIKIGDFGISKVLENTTSVANTVVGTPYYMSPE .|.| | |.| | .|| . | ..|| .||||||||..||| | ..| ..|.|||||...| .|.. |.|..||||| ||| NRQKRKGKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPE VCESKPYTYKSDIWALGCVLYELCALEHAFESNNLLGLIFKIVQQNISDIPSFYSKELNDLIHKLLNKNEQERPVINDILNDIST |. |||. |||||.|||||||||.| |.||.||. |. ||.| .. ||. ||.|| |. .....| . || .|.|| . ICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | 3425.AA | NEK4 | 130-293 | 48 | 5.8e-73 | 248.71 | In-house | 92-257 (257) | Show / Hide |
Range on Protein: 130-293 Range on HMM: 92-257/257 Sequence Identity: 48% (80 aa) KKQKKEYFPEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFITRDGTIKIGDFGISKVLENTTSVANTVVGTPYYMSPEVCESKPYTYKSDIWALGCV |.|| . .| .|.|| |. |.|||.||||| || |||.|. |||||||||.||.| .| |..|||||||||. ..|| ||||||.||| KQQKNQFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCC LYELCALEHAFESNNLLGLIFKIVQQNISDIPSFYSKELNDLIHKLLNKNEQERPVINDILND--I .||. | |||. .. ||..|.| .| ||..| .|. ..|.| ..|| | ||. | VYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI |
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| Kinase | 3425.AA | S_TKc | 10-299 | 26 | 1.5e-69 | 238.25 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-299
Range on HMM: 1-231/231
Sequence Identity: 26% (79 aa)
YKEIEVIGRGNFGSATLVEKLDNKKQYIAKKIVLSSLNPKQQDSALQEAQLLKDLNHKNIVSYIESFKEEDLLIIIMEYCERKQIQICFFSVSKNDIIHK
|. ...||.| ||. .. . . .... |.| .....| |.|| .|.||| ....| . | | ..||||.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDG------------------
QMQIIEQLLSYYQLHSALKRKKQKK--EYFPEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFITRDGTIKIGDFGISKVLENTTSVANTVVGTPYYM
. |.. .|... .. .||| . ..|.... ..|.|...|.|||.| .||.... .|||.|||....| .|..|||.||
---------DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYM
SPEVCESKPYTY-KSDIWALGCVLYELCALEHAFESNNLLGLIFKIVQQNISDIPSFYSKELNDLIHKLLNKNEQERPVINDILN---DISTQKLF
.|||. .|.. |.|.|..||.|||... . |. . ..||.. |.|. |.| |.|.|. ..|| . ..|. || |
APEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 3425.AA | NEK-Unclassified | 127-284 | 39 | 2.4e-62 | 205.12 | In-house | 84-247 (258) | Show / Hide |
Range on Protein: 127-284 Range on HMM: 84-247/258 Sequence Identity: 39% (65 aa) LKRKKQKKEYFPEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFITRDGTIKIGDFGISKVLENTTSVANTVVGTPYYMSPEVCESKPYTYKSDIWAL .... | | | | | |. . . ||| .||.||| |..||| | | |. .||||||.... | | | |||. .||||||. .|| .||.|.| IQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSL GCVLYELCALEHAFESNNLLGLIFKIVQQNI------SDIPSFYSKELNDLIHKLLNKNEQERP ||..||.|. | .| |.. . .||.| . . || | ..| .| .| | || GCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRP |
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| Kinase | 3425.AA | Ciliate-E2 | 10-295 | 22 | 2.2e-60 | 205.98 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 10-295 Range on HMM: 1-365/365 Sequence Identity: 22% (92 aa) YKEIEVIGRGNFGSATLVEKLDNKKQY------------------IAKKIVLSSLNPKQQDSALQEAQLLK----------------DLNHKNIVSYIES || |..||.||||| .... ..||. .|.. . .....| . .|| .... |||.||. ..|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FK--EEDLLIIIMEYCERKQIQ--ICFFSVSKNDIIH-------KQMQ-IIEQLLS-----YYQLHSALKRKKQKKEYFPEMLIVNWFYELALSIKYIHE |. .. . ..||||. . . | .. ..| .|. |... |..|.|. ... .. | ..|.|. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA----------------------EFYIACIILALEYLHS KK-ILHRDIKTSNIFITRDGTIKIGDFGISK----------------------VLENTTS---------VANTVVGTPYYMSPEVCESKP---------Y |. |.||||| .||.. ||| |||.|| . |.. ..||..|||.||.||. ..|. | KNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGY TYKSDIWALGCVLYELCALEHAFESNNLLGLIFKIVQQNISDIPSF------------------YSKELNDLIHK----LLNKNEQERPV-INDILNDIS .||.|||.||..|||.. .. | ... .|. |.|.. |.| ||| | .|.|....|. ...||| DYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPW T F |
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| Kinase | 3425.AA | Pkinase | 123-293 | 27 | 5.2e-55 | 193.87 | Pfam | 91-293 (293) | Show / Hide |
Range on Protein: 123-293 Range on HMM: 91-293/293 Sequence Identity: 27% (56 aa) LHSALKRKKQKKEYF--PEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFITRDGTI----KIGDFGISKVL-ENTTSVANTVVGTPYYMSPEVCE-S |.. ... ... | .| . ...|... ..|.|...|.|||.| .||.| ..|.| ||.|||..|.. . | ..|..|||.||.|||. . LFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG KPYTYKSDIWALGCVLYELCALEHAFESN------NLLGLIFKIVQ-QNISDIPSFYS-------------------KELNDLIHKLLNKNEQERPVIND ..|..|.|.|..||.|||.. . | . . . .|..| . .. .|.| .| .|. |.| ..|.|. ..|| . . QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ ILND--I ||.. . ILQHPWF |
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| Kinase | 3425.AA | NEK11 | 131-295 | 44 | 4.9e-50 | 172.55 | In-house | 96-259 (259) | Show / Hide |
Range on Protein: 131-295 Range on HMM: 96-259/259 Sequence Identity: 44% (73 aa) KQKKEYFPEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFITRDGTIKIGDFGISKVLENTTSVANTVVGTPYYMSPEVCESKPYTYKSDIWALGCVL || ||| |. || | | . |.||..|||||.| |||. . .||||||.|..| .| |. ||| ||||| . | |||||.| |.| KQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACIL YELCALEHAFESNNLLGLIFKIVQQNISDIPSFYSKELNDLIHKLLNKNEQERPVINDILNDIST ||.| ..||| | | .. .|| . .| | .||| .. ..|||| || ||| YEMCCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM |
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| Kinase | 3425.AA | ULK | 123-283 | 27 | 6.9e-45 | 154.64 | In-house | 107-317 (329) | Show / Hide |
Range on Protein: 123-283
Range on HMM: 107-317/329
Sequence Identity: 27% (59 aa)
LHSALKRKKQ------KKEYFPEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFITRD------------GTIKIGDFGISKVLENT---TSVANTVV
| . .|..| .| ...|. ... |. .. |..|...| ||||| .|| |. . |..||.||| .|...| .. | |
LEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCV
------GTPYYMSPEVCE----SKPYT-YKSDIWALGCVLYELCALEHAFESNNLLGLIFKIVQQN----------ISDIPSF---------YSKELNDL
|||.||.|.. . |||. ||.||| |||..||. . |... .. .|.|.. | ..| |.|. ||
NEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDL
IHKLLNKNEQER
| ..| ..| .|
IRRMLQYDEKDR
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| Kinase | 3425.AA | ULK | 123-283 | 28 | 6.4e-43 | 148.91 | In-house | 104-312 (324) | Show / Hide |
Range on Protein: 123-283
Range on HMM: 104-312/324
Sequence Identity: 28% (59 aa)
LHSALKRKKQ-----KKEYFPEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFITRD------------GTIKIGDFGISKVLENTT---SVANTVV-
| . .|..| .| ...|. ... |. .. |..|...| ||||| .|| |. . |..||.||| .|...| . . | |
LEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVN
-----GTPYYMSPEVCE----SKPYT-YKSDIWALGCVLYELCALEHAFESNNLLGLI--------------FKIVQQNISDIP----SFYSKELNDLIH
|||.||.|.. . |||. ||.||| |||..||. . |.|. .. ..| .|.| . |.|. |||
EKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIR
KLLNKNEQER
..| ..| .|
RMLQYDEKDR
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| Kinase | 3425.AA | STE | 131-284 | 24 | 1.9e-41 | 143.99 | In-house | 143-346 (359) | Show / Hide |
Range on Protein: 131-284
Range on HMM: 143-346/359
Sequence Identity: 24% (52 aa)
KQKKEYFPEMLIVNWFYELALS-IKYIHEKKILHRDIKTSNIFITRDGTIKIGDFGISKVLEN---------------TTS-VANTVVGTPYYMSPEVCE
.. . .||| .| ... .|.|...| ||||| .||.. .|. |||... |.. |.. ||.|||| .|.||| .
QH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ
S------KPYTYKSDIWALGCVLYELCALEHAFES-NNL---------------LGLIFKIVQQNISDIPS-------------------FYSKELNDLI
|.|..|.||| |||.. |.. .. . ... . .. .||.... .|. .|.|..| |
QNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFI
HKLLNKNEQERP
| |.|. ..||
NKCLQKDPNKRP
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| Kinase | 3425.AA | NEK8 | 10-90 | 36 | 1.2e-25 | 70.1 | In-house | 1-83 (278) | Show / Hide |
Range on Protein: 10-90 Range on HMM: 1-83/278 Sequence Identity: 36% (30 aa) YKEIEVIGRGNFGSATLVEKLDNK--KQYIAKKIVLSSLNPKQQDSALQEAQLLKDLNHKNIVSYIESFKEEDLLIIIMEYCE | | |.||| ||...| . .. | | | .. . .|. ..|. | |.|. |.| ||.||...| |. | | |||.. YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYAD |
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| Kinase | 3425.AA | NEK4 | 10-90 | 40 | 8.9e-24 | 82.38 | In-house | 1-83 (257) | Show / Hide |
Range on Protein: 10-90 Range on HMM: 1-83/257 Sequence Identity: 40% (34 aa) YKEIEVIGRGNFGSATLVEKLDNKKQYIAKKIVLSSLNPKQQDSALQEAQLLKDLNHKNIVSYIESFKEEDL--LIIIMEYCE | . |.|.| .| .|| . ||||. ||. | ... |..||||| | | |||.| ||.. |. | |.| .|| YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCE |
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| Kinase | 3425.AA | NEK1 | 10-90 | 37 | 2.1e-23 | 78.14 | In-house | 1-83 (276) | Show / Hide |
Range on Protein: 10-90 Range on HMM: 1-83/276 Sequence Identity: 37% (31 aa) YKEIEVIGRGNFGSATLVEKLDNKKQYIAKKIVLSSLNPKQQDSALQEAQLLKDLNHKNIVSYIESFKEEDL--LIIIMEYCE | .| .|| |.|| | || . ..| | | .. .| .. |. .|. . | |||.| ||| |. | |.||||. YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCD |
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| Kinase | 3425.AA | Pkinase | 10-90 | 30 | 5.9e-20 | 71.65 | Pfam | 1-83 (293) | Show / Hide |
Range on Protein: 10-90 Range on HMM: 1-83/293 Sequence Identity: 30% (25 aa) YKEIEVIGRGNFGSATLVEKLDNKKQYIAKKIVLSSLNPKQQDSALQ--EAQLLKDLNHKNIVSYIESFKEEDLLIIIMEYCE |. ...||.|.||. . . .. |.. |.| ... ..... ... |.|..| |||.||| ....| ..| . ..||||| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCE |
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| Kinase | 3425.AA | STE | 10-90 | 21 | 1.8e-17 | 58.39 | In-house | 1-120 (359) | Show / Hide |
Range on Protein: 10-90 Range on HMM: 1-120/359 Sequence Identity: 21% (26 aa) YKEIEVIGRGNFGSATLVEKL------DNKKQ---------YIAKKIVLSSLNP---------------KQQDSALQEAQLLKDLN--HKNIVSYIESFK .. ||.||.|.||. . . ..... . |.. |.. |. ..... |.| ...|..| |.||| |. .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF EE-------DLLIIIMEYCE | | | |.|||.. KEGHNHKNDDELWICMEYMD |
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| Kinase | 3425.AA | TyrKc | 10-293 | 16 | 8.9e-16 | 32.39 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-293 Range on HMM: 1-280/280 Sequence Identity: 16% (55 aa) YKEIEVIGRGNFG---SATLVEKLDNKKQYIAKKIVLSSLNPKQQDSALQEAQLLKDL--NHKNIVSYIESFKEE-------DLLIIIMEYCE------- . ....|.|.|| .|. . | | . .. . ..||.... | .|.||| . .. . | |.|||.. ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY -RKQIQICFFSVSKNDIIHKQMQIIEQLLSYYQLHSALKRKKQKKEYFPEMLIVNWFYELALSIKYIHEKKILHRDIKTSNIFITRDGTIKIGDFGISKV || .. ... . | |.|.|.. |||. . |. .....|.||.||| |. LRKHRPK----------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD LENT----TSVANTVV----GTP-----YYMSPEVCESKPYTYKSDIWALGCVLYELCALEHAFESN------NLLGLIFKIVQQNISDIPSF------- ... | .. |. |.||. . .| |||.|. | ...|.. . .. . .| .. | . ..| IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFV -YSKELNDLIHKLLNKNEQERPVINDILNDI ..|. ... . . . .|| ..| .. CCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 3425.AA | ULK | 10-90 | 23 | 9.8e-16 | 51.48 | In-house | 1-103 (329) | Show / Hide |
Range on Protein: 10-90 Range on HMM: 1-103/329 Sequence Identity: 23% (25 aa) YKEIEVIGRGNFGSATLVEKLDNKK-----QYIAKKIVLSS-LNPKQQD--------SALQEAQLLKDLN----HKN----IVSYIESFKEEDL--LIII | ....| | || . . ..|. ...| |..... .| |... . .| ...| |. ||| || ... |.. . . || YCLNHCLGKGSFG--KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII MEYCE ||||. MEYCN |
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| Kinase | 3425.AA | ULK | 10-90 | 24 | 1.4e-14 | 48.25 | In-house | 1-100 (324) | Show / Hide |
Range on Protein: 10-90 Range on HMM: 1-100/324 Sequence Identity: 24% (24 aa) YKEIEVIGRGNFG-SATLVEKLDN---KKQYIAKKIVLSSLNPKQQD--------SALQEAQLLKDLN---HKN--IVSYIESFKEEDL--LIIIMEYCE | ....| | || .. .. .... .|.| ....| |... . .| |..| |. |.| || ... |.. . . ||||||. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN |
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| Kinase | 3425.AA | Pkinase_Tyr | 155-236 | 25 | 3.8e-12 | 41.75 | Pfam | 126-210 (270) | Show / Hide |
Range on Protein: 155-236 Range on HMM: 126-210/270 Sequence Identity: 25% (22 aa) YIHEKKILHRDIKTSNIFITRDGTIKIGDFGISKVLENTTSVANTVVGT-----PYYMSPEVCESKPYTYKSDIWALGCVLYELCAL | ..|.. |||. . |. .|.....||.||| .. . .. ..... |.||. . .| |||.|. | ...|.. . YLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | 3425.AA | NEK11 | 10-90 | 39 | 4e-09 | 29.41 | In-house | 1-84 (259) | Show / Hide |
Range on Protein: 10-90 Range on HMM: 1-84/259 Sequence Identity: 39% (33 aa) YKEIEVIGRGNFGSATLVEKLDNKKQ---YIAKKIVLSSLNPKQQDSALQEAQLLKDLNHKNIVSYIESFKEEDLLIIIMEYCE | .| | || || |. . | | ||| | ||||| |.| || . || | | || |||| YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCE |
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| Kinase | 3425.AA | Pkinase_Tyr | 10-90 | 25 | 2.7e-07 | 25.34 | Pfam | 1-90 (270) | Show / Hide |
Range on Protein: 10-90 Range on HMM: 1-90/270 Sequence Identity: 25% (23 aa) YKEIEVIGRGNFGS---ATLVEKLDNKKQYIAKKIVLSSLNPKQ--QDSALQEAQLLKDL-NHKNIVSYIESFK-EEDL--LIIIMEYCE . ....|.|.||. .|. . ||.|. | |.. . ..| ... ..||...| | .|.|||... ... ..|.|||.. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP |
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