Gene 7740 (Tetrahymena)

7740

Species: Tetrahymena
Alias: 3759.m00357, PreTt07740, 7740, TTHERM_00821800, 279, 140.m00055
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
7740.AA Protein None 801 None Fasta, JSON
7740.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
7740.NA RNA None 2406 None Fasta, JSON

Protein domain

Protein domains of 7740.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7740.AA NEK 6-262 45 7.29999999999e-154 517.45 In-house 1-286 (286) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-286/286
Sequence Identity: 45% (129 aa)

FEIIEKLGEGAYSQVYKVKRTIDQQI-----YALKKVNLTNLSLKEKENAL-NEVRIIASIRHPNVVSFKESFLSDDGEFLYLVMEYAD-DGDVLEK---
.|||.|.|.|....||||.|..|...     |..||.|..|.| |||.||. ||||| ....|||.|....||. .....|. ||||..  ||  .|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKKHIRTGTRLREDYIWSVFIQSVKGLQVLHSL-----NIYHRDIKNANLFLYKDGT----TKIGDFNVSKQAKMG--LLYT-QTGTPYYASPEVWSDQP
|||.   |. . |..|| .||| ...|. .|.      .| ||||| .|.|| |...     |||||..||. . .  ..|| |.|||||.||||....|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YTSSSDIWSLGCVLYELATLSP--PFNGE--SMKELYGKIMSG-VYKKISPK--YSLELSNMVSNMLQIDPKKRFSCSQILQLPYI
|.. ||||||||||||..||.|  ||...  .|..|| ||| |  |..|...  || .|.|..|.||| ||..| ||.|||..|.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 7740.AA NEK1 6-262 41 1.6e-96 326.95 In-house 1-276 (276) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-276/276
Sequence Identity: 41% (114 aa)

FEIIEKLGEGAYSQVYKVKRTIDQQIYALKKVNLTNLSLKEKENALNEVRIIASIRHPNVVSFKESFLSDDGEFLYLVMEYADDGDVLEKIKKHIRTGTR
...| ..|||..  ...||.. | | |..|  |... . ||.|...||| | |  .|||.|..||||    .  || ||||.| ||   ||..  | |  
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LREDYIWSVFIQSVKGLQVLHSLNIYHRDIKNANLFLY--KDG---------------TTKIGDFNVSK--QAKMGLLYTQTGTPYYASPEVWSDQPYTS
  || | . |.| ...|.  |. .| |||||  |.||   |.|               . |.||| ...  .  | .  |  ||||| ||| .  .||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

SSDIWSLGCVLYELATLSPPFNGESMKELYGKIMSGVYKKISPKYSLELSNMVSNMLQIDPKKRFSCSQILQLPYI
 ||||||||||||| ||. ||.. ..| |  || .| | .|.| || ||.. || |....|. |.|  |||. | |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 7740.AA S_TKc 6-262 31 3.4e-89 303.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

FEIIEKLGEGAYSQVYKVKRTIDQQIYALKKVNLTNLSLKEKENALNEVRIIASIRHPNVVSFKESFLSDDGEFLYLVMEYADD--GDVLEKIKKHIRTG
.||..|.|.||...|||.. . ...|.|.|...         |....|..|  . .|||.| ....| .   ..||.||||.|   ||... |||. | |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TR--LREDYIWSVFIQSVKGLQVLHSLNIYHRDIKNANLFLYKDGTTKIGDFNVSKQAKMGLLYTQTGTPYYASPEVWSDQPYTS-SSDIWSLGCVLYEL
.|  . |  ..... | ...|. .||..| |||.| .|..| .  . ||.|| ...|      .|. |||.| .|||    .|.  ..|.||.||.|||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ATLSPPFNGESMKELYGKIMSGVYKKISPKYSLELSNMVSNMLQIDPKKRFSCSQILQ-------LPYI
..  |||    |.... ||.           | |. ......|| ||.|| .. ..||        |..
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 7740.AA NEK4 6-262 38 9.9e-77 261.23 In-house 1-257 (257) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-257/257
Sequence Identity: 38% (99 aa)

FEIIEKLGEGAYSQVYKVKRTIDQQIYALKKVNLTNLSLKEKENALNEVRIIASIRHPNVVSFKESFLSDDGEFLYLVMEYADDGDVLEKIKKHIRTGTR
....   | | |  |. |. ..|   | .||..| | | .|.  |. |...    .|||.|..|||. ...| ||| || . . ||  .| |.  . .  
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQ--QKNQF

LREDYIWSVFIQSVKGLQVLHSLNIYHRDIKNANLFLYKDGTTKIGDFNVSKQAK--MGLLYTQTGTPYYASPEVWSDQPYTSSSDIWSLGCVLYELATL
| |  .   |.|   .|| .|  .| ||| |  |.|| |    ||||| .|.       .  |  ||||| |||... .||   |||||||| .||..||
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

SPPFNGESMKELYGKIMSGVYKKISPKYSLELSNMVSNMLQIDPKKRFSCSQILQLPYI
   |.   |  |  .|. |    ..|.|| .| |.|  ||.  |.|| |  .|.| |||
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 7740.AA Pkinase 6-262 26 6.4e-76 263.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

FEIIEKLGEGAYSQVYKVKRTIDQQIYALKKVNLTNLSLKEKENALN--EVRIIASIRHPNVVSFKESFLSDDGEFLYLVMEYADDG----DVLEKIKKH
..|..|.|.|....||| ..  ...|.|.|.... . . ........  |..| ....|||.| ....| .  .  .|.||||.. |    |  . |.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

IRTGTRL--REDYIWSVFIQSVKGLQVLHSLNIYHRDIKNANLFLYKDGTT----KIGDFNVSK---QAKMGLLYTQTGTPYYASPEVWS-DQPYTSSSD
 . ....   |. . ... | ..||. .|| .| |||.| .|... ..|..    ||.|| ..|     . . ..| .|||.|..|||   .|.|....|
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSLGCVLYELATLSPPFNGE------SMKELYGKIMSGVYKKISPKYS--------------------LELSNMVSNMLQIDPKKRFSCSQILQLPYI
.||.||.|||...  ||| |.      ...... .||.. ..  .|. .                     |.   ....|. ||||| .. |||| |..
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 7740.AA CAMK 11-262 19 4.8e-75 241.08 In-house 1-425 (425) Show / Hide 
Range on Protein: 11-262
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

KLGEGAYSQVYKVKRTIDQ------------QIYALKKVNLTNLS--------------------------LKEKENALNEVRIIAS-------IRHPNV
.||.|....|...... ..            | .| | .. . |.                           | ..| ..|..|  .       ..|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSFKESFLSDD-----------------GEFLYLVM---EYADDG----DVLEKIKKH------------IRTGTRLREDYIWSVFIQSVKGLQVLHSLN
... | . ...                  ...|.||   ||.. |    |....|..|            .    |. |.    .| | . ... .||.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IYHRDIKNANLFLYKD-----------------GTTKIGDFNVSKQAKMG-------------------------LLYTQTGTPYYAS-PEVWSD-----
| |||.|  |. | ..                 .. || ||  ... . |                         ...|. |||.|.. ||| .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QPYTSSSDIWSLGCVLYELATLSPPFNGE-------------SMKELYGKIMSGVYKKISPKYSL-----------------------ELS
         ..|. ..|.||.|..|| . .  |||.|.             ...||. |||.| |  ..|. |                        |  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NMVSNMLQIDPKKRFSCSQILQLPYI
.....||| ||.||....|.|. | .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 7740.AA Ciliate-E2 6-262 22 3.3e-65 222.77 In-house 1-365 (365) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

FEIIEKLGEGAYSQVYKVKRTIDQQIY------------------ALKKVNLTNLSLKEKENALNEVRII----------------ASIRHPNVVSFKES
...|.|.|.|....|||.|.  .|. .                  . |.... ... ...|. ..| .|.                 .. |||.. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLSDDGEFLYLVMEYADDGDVLEKIK--KHIRTGT-----RLREDYIWSVFIQSVK---------------GLQVLHSLN-IYHRDIKNANLFLYKDGTT
| . | . .||||||.. || .. ||  |. |.       .. |  |  .. | ..               .|. ||| | | |||||  |...      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDFNVSKQAK-----------MG----------------------LLYTQTGTPYYASPEVWSDQP---------YTSSSDIWSLGCVLYELATLSPP
|| ||  ||...           ..                      . .|. |||.| .||. . ..         |. ..||||||..|||. .  ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FNGESMKELYGKIMSGVYKK-------------ISPKYSLELSNMVSN----MLQIDPKKRFS-CSQILQLPYI
|    ...   .  .   ..             .  | |.|  .. ..    ||| ||.||..  .|||. |..
F----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 7740.AA STE 6-262 26 2.5e-64 220.05 In-house 1-359 (359) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-359/359
Sequence Identity: 26% (95 aa)

FEIIEKLGEGAYSQVYKVKRTI---------------DQQIYALKKVNLTNLS---------------LKEKENALNEVRIIASIR--HPNVVSFKESFL
.|.|||.|.||. .||| ..                  ..|.| |..|| | .                .|... |.|..|    .  |||.| .  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SDD-----GEFLYLVMEYADDGDVLEKIKKHIRTGTRLR----------EDYIWSVFIQSVKG-LQVLHSLNIYHRDIKNANLFLYKDGTTKIGDFNVSK
 ..     .. |...||| | | . . ||.   .| .|           |. |  .  | .|| |. |||..| ||||| || .|      |. || |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QAK-----------------MG-LLYTQTGTPYYASPEVWS------DQPYTSSSDIWSLGCVLYELATLSPPF-NGESMKELYGKIMS-----------
|                   |.   .| .||| . .||| .      |..|. ..|||||||.. |.||  ||. ..  |. .. ....           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GVYKKISP-------------------KYSLELSNMVSNMLQIDPKKRFSCSQILQ--LPYI
   |   .. .                   |.| |. . ... ||.||.|| . || |.   | |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 7740.AA ULK 6-262 25 5.1e-61 209.02 In-house 1-329 (329) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-329/329
Sequence Identity: 25% (83 aa)

FEIIEKLGEGAYSQVYKVKRTID----QQIYALKKVNLTNLSLKEKENA--------LNEVRIIASIR--------HPNVVSFKESFLSDDGEFLYLVME
......||.|.. .||| .  ..    ....| |.. .  .. |..|.          ||..|.  .         |||.| ... | ...   .|..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YADDGDVLEKIKKHIR------TGTRLREDYIWSVFIQSVKGLQVLHSLNIYHRDIKNANLFLYKD------------GTTKIGDFNVSKQAKMG-----
| ..||  . |||. .      .. || |. . ..|.| . |.. ||. || ||||| .|  . ..            |. ||.||  .|.   .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LLYTQT------GTPYYASPEVWSDQ----PYTSS-SDIWSLGCVLYELATLSPPFNGESMKELY-GKIMSGVYK-------------KIS-----PKYS
...|..      |||.| .|.....|    ||... .|||||||..||. .  |||..    ..|  .|.. . .             ..      |. |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

LELSNMVSNMLQIDPKKRFSCSQILQLPYI
 |. .  . |||.|.|.|.|  .... | .
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 7740.AA NEK2 6-262 28 1.2e-60 202.91 In-house 1-319 (319) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-319/319
Sequence Identity: 28% (91 aa)

FEIIEKLGEGAYSQVYKVKRTIDQQIYALKKVNLTNLSLKEKENALNEVRIIASIRHPNVVSFKESFLSDDGEFLYLVMEYADDGDVLEKIKKHIRTGTR
 |. . .|.| . ...||.|  |  | . |  .  ..  ||.    .|. |    .|||.| .         . ||.||||   ||    |||     ..
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LREDYIWSVFIQSVKGLQVLHS------------------LN---IYHRDIKNANLFLYKDGT-------------------------------------
. | .|| .. |    ||. |                    .   | ||||| ||.||  |.                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--TKIGDFNVSKQAKMGLLYTQT--GTPYYASPEVWSDQPYTSSSDIWSLGCVLYELATLSPPFNGESMKELYGKIMSGVYKKISPKYSLELSNMVSNML
   | |||   .  .   .. .|  ||||| |||. ..|.|   |||||.||..||...|.||| . . ..| .||  | .  |   || .|.  .. |.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

QIDPKKRFSCSQILQLPYI
 .|...| |   ||| | |
NVDHYHRPSIEEILQHPQI
Kinase 7740.AA ULK 6-262 26 1.8e-60 207.25 In-house 1-324 (324) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-324/324
Sequence Identity: 26% (86 aa)

FEIIEKLGEGAYS-QVYKVKRTID---QQIYALKKVNLTNLSLKEKE--------NALNEVRIIASIR---HPN--VVSFKESFLSDDGEFLYLVMEYAD
......||.|..  .||| .  ..   .|..| |.... ... |..|        .  ||..|.  .    |||  .| ... | ...  ..|..||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DGDVLEKIKKHIR-----TGTRLREDYIWSVFIQSVKGLQVLHSLNIYHRDIKNANLFLYKD------------GTTKIGDFNVSKQAK---MG--LLYT
.||  . |||. .     .. || |. . ..|.| . |.. ||. || ||||| .|. . ..            |. ||.||  .|.     |   ...|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QT------GTPYYASPEVWSDQ----PYTSS-SDIWSLGCVLYELATLSPPFNGESMKELYGK--------------IMSGVYKKIS----PKYSLELSN
.       |||.| .|.....|    ||... .|||||||..||. . ..||..    ..| .              |     .. .    || | |. .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

MVSNMLQIDPKKRFSCSQILQLPYI
  . |||.|.|.|.|  .|.. | .
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 7740.AA Ciliate-E2-Unclassified 6-262 23 2.9e-57 196.56 In-house 1-352 (352) Show / Hide 
Range on Protein: 6-262
Range on HMM: 1-352/352
Sequence Identity: 23% (85 aa)

FEIIEKLGEGAYSQVYKVKR-----------TIDQQIYALKKVNLTNLSLKEKENALNEVR-------------IIASIRHPNVVSFKESFLSDDGEFLY
..||...|.|....|||...            ...|||. |...  .  .. .....|.               |  .. ||..| . . | ..  . .|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDK--QNIY

LVMEYADDGDVLEKIK-------------KHIRTGTRLREDYIW-----SVFIQSVKGLQVLHSLN-IYHRDIKNANLFLYKDG---TTKIGDFNVSK--
.||||...|| .. ||             ...... .. |  .        | | ..||. ||. | | |||||  |... ..|     || ||  ||  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

---------------QAKMGLLYTQTGTPYYA----SPEVWSDQPYTSS----SDIWSLGCVLYELATLSPPFNGESMKE----------------LYGK
               . |  ...|..|||.|     .|||   | |  |    .||||||..|||. .  .||.... ..                || .
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

IMSGVYKKIS-------PKYSLELSNMVS----NMLQIDPKKRFSCSQILQLPYI
|. . ... .        . | |  ....     ||. .|.|| . .|||. |..
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 7740.AA TyrKc 6-260 24 2.3e-15 25.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

FEIIEKLGEGAYSQVYKVKRTIDQQIYALKKVNLTNLSLKEKENALNEVRIIASI--RHPNVVSFKESFLSDDG------EFLYLVMEYADDGDVLEKIK
 . ..||||||. .||| . .   .  | |...        .|  ..| ||  ..  .|||.| .     ...|      | |..||||.. || .. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KHIRTGTRLREDYIWSVFIQSVKGLQVLHSLNIYHRDIKNANLFLYKDGTTKIGDFNVSKQAKMG-------LLYTQT---GTP-----YYASPEVWSDQ
|| ..   |  .   |  .|  .| . ||| |. |||.   |  . ...| ||.||  |.  . .         |...   |.         .||.. . 
KHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYTSSSDIWSLGCVLYELATL-SPPFNG-----ESMKELYGKIMSGVYKKISPK--------YSLELSNMVSNMLQIDPKKRFSCSQILQLP
 .|. ||.|| | ...|. |.  .|  |      | .|.. ....| . .. |          . |. .. .   . ||..| . |.| .. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 7740.AA Pkinase_Tyr 175-222 33 7.9e-07 23.75 Pfam 182-232 (270) Show / Hide 
Range on Protein: 175-222
Range on HMM: 182-232/270
Sequence Identity: 33% (17 aa)

SPEVWSDQPYTSSSDIWSLGCVLYELATLS-PP-FNGESMKELYGKI-MSG
.||....  .|. ||.|| | ...|. |.   | . | |  |.| .|  .|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG
Kinase 7740.AA Pkinase_Tyr 6-99 27 3e-06 21.57 Pfam 1-101 (270) Show / Hide 
Range on Protein: 6-99
Range on HMM: 1-101/270
Sequence Identity: 27% (28 aa)

FEIIEKLGEGAYSQVYKVKRT----IDQQIYALKKVNLTNLSLKE--KENALNEVRIIASI-RHPNVVSFKESFLSDDGE-FLYLVMEYADDGDVLEKIK
 ....||||||. .||| . .     ...  | |..   . . ..  .|  ..|..|  .. .|||.|..    .....   .|.||||.  || |.  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KH
||
KH