Gene 8589 (Tetrahymena)

8589

Species: Tetrahymena
Alias: TTHERM_00188390, PreTt08589, 563, 8589, 15.m00300, 3697.m00012
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
8589.AA Protein None 696 None Fasta, JSON
8589.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
8589.NA RNA None 2091 None Fasta, JSON

Protein domain

Protein domains of 8589.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8589.AA NEK 8-264 47 1.9e-158 532.72 In-house 1-286 (286) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-286/286
Sequence Identity: 47% (135 aa)

YQELEIIGRGNFGSATLVKEIATQIL-----FIAKKIILAGLKEREQESAK-QEAELLKSLKHPNIVAYKDSFMIDG--TLIIIMEYCE-EGDIAFH---
|.... ||.|.||....|. . ..       .. ||| . ...|.|.. |  .|. .||.|||||||.|.|||. ..  .|.|.||||| .|| . .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKRKKNKQEYFSERVILNWFLQIAFALIYIHDK-----KILHRDIKTSNIFVTSNGT----VKIGDFGISRVLEHTQDQAQT-VVGTPYYMSPEVCESKP
||..|.| .||.|..|..|| |.. || |.||.     ||||||||..||| |.|..    |||||||||.||.||.| |.| .||||||||||||..||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YTQKSDVWALGCVVYELCTL--KHAFNSN--NLLGLVYKIVKE-QVEDIPEI--YSNELKNLVKQMFIKDDALRPNLRQVLASPFL
|..|||.|.||||.||.|||  ||.|...  |...|..||.|. | . ||.   ||..|.||. ||. ||  .||. .|.|. ||.
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 8589.AA NEK1 8-264 47 3.4e-127 428.88 In-house 1-276 (276) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-276/276
Sequence Identity: 47% (132 aa)

YQELEIIGRGNFGSATLVKEIATQILFIAKKIILAGLKEREQESAKQEAELLKSLKHPNIVAYKDSFMIDGT--LIIIMEYCEEGDIAFHIKRKKNKQEY
| .. .|| |.|| | |||. .   ..  | | .   .| | | .. |. .|. .||||||.||.||   |   | |.||||. ||..  |.|.| |   
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FSERVILNWFLQIAFALIYIHDKKILHRDIKTSNIFVT--SNG---------------TVKIGDFGISRVLEHTQDQAQTVVGTPYYMSPEVCESKPYTQ
|||  |..|| ||  || .|||.||||||||..||| |  .||               .||.|||||.|.| || . |.|..||||| ||| |. |||..
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDVWALGCVVYELCTLKHAFNSNNLLGLVYKIVKEQVEDIPEIYSNELKNLVKQMFIKDDALRPNLRQVLASPFL
|||.|.|||| ||||||||.|..||.  || ||..  .  ||  ||.||..||.||| ..  .||   |.| .||.
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 8589.AA NEK8 8-264 43 2.5e-115 330.74 In-house 1-278 (278) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-278/278
Sequence Identity: 43% (121 aa)

YQELEIIGRGNFGSATLVKEIATQ--ILFIAKKIILAGLKEREQESAKQEAELLKSLKHPNIVAYKDSFMIDGTLIIIMEYCEEGDIAFHIKRKKN----
|     .||| ||...|    . |   | | | | . .. |.|  .|  | ..|. | ||||..| |.|| |.|| | |||.. |  .  | . .|    
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

--K---------QEYFSERVILNWFLQIAFALIYIHDKKILHRDIKTSNIFVTSN-GTVKIGDFGISRVLEHTQDQAQT---VVGTPYYMSPEVCESKPY
  .          .|| |. ||  | |.  |. ..|.. |||||.|| ||| |   . ||||||||| ..  |   .||   ||||||||||| ||.|||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMN-TKYHMQTTKTVVGTPYYMSPEMCEGKPY

TQKSDVWALGCVVYELCTLKHAFNSNNLLGLVYKIVK-EQVEDIPEIYSNELKNLVKQMFIKDDALRPNLRQVLASPFL
 ||||.|||||| ||.|.|| ||   ||. || ||.     |.|.. ||||.. || .   .| . || . |..| | .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 8589.AA NEK4 8-264 45 1.7e-107 363.43 In-house 1-257 (257) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-257/257
Sequence Identity: 45% (117 aa)

YQELEIIGRGNFGSATLVKEIATQILFIAKKIILAGLKEREQESAKQEAELLKSLKHPNIVAYKDSFMIDGT--LIIIMEYCEEGDIAFHIKRKKNKQEY
|. .  .|.| .|  .||..      .. ||. |     ||.  | .||.||  ||||||| ||.|. |.    | |.| .|| ||     |..||  . 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKN--QF

FSERVILNWFLQIAFALIYIHDKKILHRDIKTSNIFVTSNGTVKIGDFGISRVLEHTQDQAQTVVGTPYYMSPEVCESKPYTQKSDVWALGCVVYELCTL
 .|. ...|| ||| || |.|.|.||||| || ||| |    .|||||||||||.   | |.|..|||||||||.  ..||  |||.|.||| |||. ||
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

KHAFNSNNLLGLVYKIVKEQVEDIPEIYSNELKNLVKQMFIKDDALRPNLRQVLASPFL
||||.  ..  |.|.|.. |   .|  || .|.|||.||  |    || .....  |..
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 8589.AA S_TKc 8-264 29 3.7e-86 293.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

YQELEIIGRGNFGSATLVKEIATQILFIAKKIILAGLKEREQESAKQEAELLKSLKHPNIVAYKDSFMIDGTLIIIMEYCEE--GDIAFHIKRKKN--KQ
|. |..||.| ||.  ..... |. ..  |.|          |....| ..||. .||||| ..|.|   . | ..||||.   ||   .||...   ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

EYFSERVILNWFLQIAFALIYIHDKKILHRDIKTSNIFVTSNGTVKIGDFGISRVLEHTQDQAQTVVGTPYYMSPEVCESKPYTQ-KSDVWALGCVVYEL
 .|.| ..  .. ||. || |.|...|.|||.| .||....  ..||.|||..|.|        |..|||.||.|||.   .|.  |.|.|..||..||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CTLKHAFNSNNLLGLVYKIVKEQVEDIPEIYSNELKNLVKQMFIKDDALRPNLRQVLA-------SPFL
.. .  |     . ...|...          | |.|....... || . ||   ..|.        |..
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 8589.AA Pkinase 8-264 27 8e-85 292.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

YQELEIIGRGNFGSATLVKEIATQILFIAKKIILAGLKEREQESAKQ--EAELLKSLKHPNIVAYKDSFMIDGTLIIIMEYCEEG----DIAFHIK-RKK
|. ...||.|.||.  . ... |....  |.| . . |. .....    |....|.|.||||| ..|.|. .. . ..||||| |    | . .|. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NKQEYFSERVILNWFLQIAFALIYIHDKKILHRDIKTSNIFVTSNGTV----KIGDFGISRVL-EHTQDQAQTVVGTPYYMSPEVCE-SKPYTQKSDVWA
..   |||... ....||. .| |.|...|.|||.| .||.. .||..    ||.|||..... .  .  ..|..|||.||.|||.  ...|..|.|.|.
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCVVYELCTLKHAFNSN------NLLGLVYKIVKEQVEDI-PEIYS-------------------NELKNLVKQMFIKDDALRPNLRQVLASPFL
.||..||... .  | .       . . ....| . ...   |. .|                    |.| ..| .. || . ||. .|.| .|..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 8589.AA NEK-Unclassified 58-264 38 8.8e-78 257.05 In-house 46-258 (258) Show / Hide 
Range on Protein: 58-264
Range on HMM: 46-258/258
Sequence Identity: 38% (83 aa)

LLKSLKHPNIVAYKDSFMIDGTLIIIMEYCEEGDIAFHIKRKKNKQEYFSERVILNWFLQIAFALIYIHDKKILHRDIKTSNIFVTSNGTVKIGDFGISR
.|  |.|| || | |||     |    .||. |.    |...  | | | |  |  |. |.  |. ||| .||.||| |..||| |   || .|||||||
ILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISR

VLEHTQDQAQTVVGTPYYMSPEVCESKPYTQKSDVWALGCVVYELCTLKHAFNSNNLLGLVYKIVKEQV------EDIPEIYSNELKNLVKQMFIKDDAL
...|| | |.| |||. .||||||. .||  .||||.|||..||.||   .|   |.. . .||...        | .   ||  | .... |  ..   
IMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQ

RPNLRQVLASPFL
||    ..  .. 
RPSATEIVEQDYI
Kinase 8589.AA NEK2 8-264 31 1.3e-71 240.34 In-house 1-319 (319) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-319/319
Sequence Identity: 31% (102 aa)

YQELEIIGRGNFGSATLVKEIATQILFIAKKIILAGLKEREQESAKQEAELLKSLKHPNIVAYKDSFMID---GTLIIIMEYCEEGDIAFHIKRKKNKQE
|. |. ||.| ||.   |. . .  ... | |    . | |      |  .|. ||||||| | |   ||    || |.||||| || .  ||. ..   
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYD-WIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQ

YFSERVILNWFLQIAFALIYIHD------------------KK---ILHRDIKTSNIFVTSNGT------------------------------------
|. | .|.  ..|.  ||  .|                   .    |||||||  |||  ...                                     
YMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYS

---VKIGDFGISRVLEHTQDQAQTVVGTPYYMSPEVCESKPYTQKSDVWALGCVVYELCTLKHAFNSNNLLGLVYKIVKEQVEDIPEIYSNELKNLVKQM
   || ||||  |.|.| .  |.| ||||||||||. .  .|  |||.|..||..||.|.|.  |   | . |  || .   . ||..|| .|  ..  |
QVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFM

FIKDDALRPNLRQVLASPFL
   |.  ||.    |..|..
INVDHYHRPSIEEILQHPQI
Kinase 8589.AA ULK 8-264 26 6.3e-71 241.95 In-house 1-329 (329) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-329/329
Sequence Identity: 26% (87 aa)

YQELEIIGRGNFGSATLVKE--IAT----QILFIAKKIILAGLKEREQE--------SAKQEAELLKSLK--------HPNIVAYKDSFMID--GTLIII
|.  ...| | ||  .  |   . |    ......|.| .  ... ..|        . |.| ...| ||        ||||| ..| |. .    . ||
YCLNHCLGKGSFG--KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MEYCEEGDIAFHIKRKKN------KQEYFSERVILNWFLQIAFALIYIHDKKILHRDIKTSNIFVTSN------------GTVKIGDFGISRVLEHT---
||||. ||    ||..|.      .. ..||  ... | ||. .. ..|...| ||||| .|| .. .            |..||.||| .....     
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

QDQAQTVV------GTPYYMSPEVCE----SKPYT-QKSDVWALGCVVYELCTLKHAFNSNNLLGLV-YKIVKE-------------QVEDIP-----EI
|....| |      |||.||.|.. .     |||.  |.|.| |||. ||. . |  |...    .. ..| |.             |  ..|      .
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

YSNELKNLVKQMFIKDDALRPNLRQVLASPFL
 |.|.|.| ..|...|   | .  .... |..
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 8589.AA STE 8-264 23 4.3e-69 235.84 In-house 1-359 (359) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-359/359
Sequence Identity: 23% (86 aa)

YQELEIIGRGNFGSATLVKEI------ATQIL--------FIAKKIIL------------AGLKE------REQESAKQEAELLKSLK--HPNIVAYKDS
.. .|.||.|.||.  . . .       |. .        ..| |..             .   |       |... ..| ...| ..  ||||| | ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

FMIDG-------TLIIIMEYCEEGDIAFHIKRKKNKQE----------YFSERVILNWFLQIAFA-LIYIHDKKILHRDIKTSNIFVTSNGTVKIGDFGI
.. .|       .| |.|||.. | .   ||.|. ...          .|.| .|     ||  . | |.|...| ||||| .||..     ||. |||.
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGV

SRVLEH---------------TQD-QAQTVVGTPYYMSPEVCES------KPYTQKSDVWALGCVVYELCTLKHAFNS-NNL---------------LGL
.  |..               |.. . .|.|||| .|.||| .       |.|. |.|.| |||.. |..| |. .   ...               . .
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

VYKIVKEQVEDIPE-------------------IYSNELKNLVKQMFIKDDALRPNLRQVLA--SPFL
. .||...   .|.                    .| |.|. ... ..||   ||.  | |    ||.
L-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 8589.AA Ciliate-E2 8-264 25 5.6e-68 232.16 In-house 1-365 (365) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-365/365
Sequence Identity: 25% (96 aa)

YQELEIIGRGNFGSATLVKEIATQILF----------------------IAKKII-LAGLKEREQESA--K---------QEAELLKSLKHPNIVAYKDS
|  ...||.|||||  ..| . .| .|                      .|.||.   .... .||    .         .| ..|..|.||||. ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FM--IDGTLIIIMEYCEEGDIAFHIK--RKKNKQE-----YFSERVILNWFLQIAF---------------ALIYIHDKK-ILHRDIKTSNIFVTSNGTV
|    | .. ..||||. ||   .||  .|| ..|     ||.|. |.. . ||.                || |.| |. |.||||| .||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDFGISR-----------------VLEHT---------------QDQAQTVVGTPYYMSPEVCESKP---------YTQKSDVWALGCVVYELCTLKH
|| |||.|.                  ..                 |....|..|||.||.||. ..|.         |. |.|.|.||.. ||... |.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

AFNSNNLLGLVYKIVKEQVEDIP------------------EIYSNELKNLVKQ----MFIKDDALRPN-LRQVLASPFL
 |         ... |..  |.|                  .  |.| |.| |.    |. ||   |..   |.|  |..
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 8589.AA ULK 8-264 26 2e-67 230.29 In-house 1-324 (324) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-324/324
Sequence Identity: 26% (86 aa)

YQELEIIGRGNFGSATLVKE--IAT---QILFIAKKIILAGLKEREQE--------SAKQEAELLKSLK---HPN--IVAYKDSFMID--GTLIIIMEYC
|.  ...| | ||  .  |   . |   . .. .|.| . .... ..|        . |.| ...| ||   |||  || ..| |. .    . ||||||
YCLNHCLGKGSFG-VKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYC

EEGDIAFHIKRKKN-----KQEYFSERVILNWFLQIAFALIYIHDKKILHRDIKTSNIFVTSN------------GTVKIGDFGISRVLEHT---QDQAQ
. ||    ||..|.     .. ..||  ... | ||. .. ..|...| ||||| .|| .. .            |..||.||| .....     |.. |
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TVV------GTPYYMSPEVCE----SKPYT-QKSDVWALGCVVYELCTLKHAFNSNNLLGLV--------------YKIVKEQVEDIP----EIYSNELK
| |      |||.||.|.. .     |||.  |.|.| |||. ||. . |  |.|.    ..              ..| .....  .     . |.|.|
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

NLVKQMFIKDDALRPNLRQVLASPFL
.| ..|...|   | .  .... |..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 8589.AA Pkinase_Tyr 38-205 28 3.7e-29 99.39 Pfam 34-210 (270) Show / Hide 
Range on Protein: 38-205
Range on HMM: 34-210/270
Sequence Identity: 28% (51 aa)

KIILAGLKERE--QESAKQEAELLKSL-KHPNIVAYKDSFM-IDGT--LIIIMEYCEEGDIAFHIKRKKNKQEYFSERVILNWFLQIAFALIYIHDKKIL
|..  |  ...  .|.  .||...|.| .||||| .    .  ..   ..|.|||.. ||   . ..... .. ..   .|.. .||| .. | ..|.. 
KMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI

HRDIKTSNIFVTSNGTVKIGDFGISRVLEHTQDQAQTVVGT-----PYYMSPEVCESKPYTQKSDVWALGCVVYELCTL
|||. . |. ||.|..|||.||| .| . .  |.  .....        |.||.   . .| |||||. | . .|..|.
HRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase 8589.AA TyrKc 8-264 22 2.7e-23 84.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-264
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

YQELEIIGRGNFG---SATLVKEIATQILFIAKKIILAGLKEREQESAKQEAELLKSL--KHPNIVAYKDSFMID-------GTLIIIMEYCEEGDIAFH
 . ....|.|.||    .|.        .  | | . ..     .|   .||.....|  .|||||.     . .       . | |.|||.. ||   .
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKRKKNKQEYFSERVILNWFLQIAFALIYIHDKKILHRDIKTSNIFVTSNGTVKIGDFGISRVLEHT-------QDQAQTV-VGTP-----YYMSPEVCE
......|   .. .  |.. .|||    |.|.|.. |||. . |. |..|.||||.||| || ...        .   ..   |.        |.||.  
LRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

SKPYTQKSDVWALGCVVYELCTLKHAFNSN------NLLGLVYKIVKEQVEDIPEI--------YSNELKNLVKQMFIKDDALRPNLRQVLASPFL
 . .| |||||. | . .|..|.     ..      .   .. .. .    ..|.          . |. .. ||    | . ||. ...    ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 8589.AA Pkinase_Tyr 8-21 28 8.135911 0.0 Pfam 1-14 (270) Show / Hide 
Range on Protein: 8-21
Range on HMM: 1-14/270
Sequence Identity: 28% (4 aa)

YQELEIIGRGNFGS
 . .. .|.|.||.
ITFGKKLGEGAFGE