Gene 12278 (Tetrahymena)

12278

Species: Tetrahymena
Alias: 892, TTHERM_00856510, 151.m00091, 151.m00090, 12278, PreTt12278
External Links: Tetrahymena Genome Database (TGD) ,
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
12278.AA Protein None 355 None Fasta, JSON
12278.kin_dom Protein Kinase Domain None 264 None Fasta, JSON
12278.NA RNA None 1068 None Fasta, JSON

Protein domain

Protein domains of 12278.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12278.AA STE7-Unclassified 69-332 40 3e-154 518.73 In-house 1-301 (301) Show / Hide 
Range on Protein: 69-332
Range on HMM: 1-301/301
Sequence Identity: 40% (127 aa)

FETISELGRGASGRVFKVKHKE------TGKFYAKKEIR-INDDEMFQKQLIWEIKTLFSCN-SPHIVQYYCAFYTECM---LHLILEYMDMGTLD---T
.|....||.|..| | |..||       .|| .|.|.|. ...|..|.||...|.|||..|. .|.||.||.|.|.|||   .|...||||.|.||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

ILKKT--------KQVSEPILIYTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGICGKVNGTMDQKNTFVGTTIYMSPERLNGD-----
|.||.        ....||.|....||.|.|..|||....|||||.|||||||||.|..||.|.|.||... |.|...|.||...||||||..|.     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

SYTMKTDIWSVGLLLIEFSEGKHPI-------QASNN-------FFEVLNNIIDFKIPPLKN-----INSPEFTNFIEICLKSDQNERADITQLLVNTTS
||..|.||||.||...|...||.|.       |...|       |.|.|..|..|..|.|..     |.|.||..||..|.|....||.||.|||.    
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLN----

FSSFNEHPFL
     |||..
-----EHPWI
Kinase 12278.AA STE7 69-332 40 4.5e-139 468.33 In-house 1-288 (288) Show / Hide 
Range on Protein: 69-332
Range on HMM: 1-288/288
Sequence Identity: 40% (120 aa)

FETISELGRGASGRVFKVKHKETGKFYAKKEIRINDDE-MFQKQLIWEIKTLFSCN-SPHIVQYYCAFYTECM--LHLILEYMDMGTLD---TILKKT--
.|.|.|||.|..| | |. ||..|| .| |.|| .... ..|||...|...|..|| .|.|||.|.|||||..   ....||||.|.||    ..||.  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----KQVSEPILIYTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGICGKVNGTMDQKNTFVGTTIYMSPERLNG--DSYTMKTDIWSVG
    ....|.|| . ....|||.||||...|||||| ||.||||||.|..|..| ||||. . .||...||||. .||.|||..|  ..|....|.||.|
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LLL-IEFSEGKHPI-----------QASNN------FFEVLNNIIDF-KIPPLKNINSPEFTNFIEICLKSDQNERADITQLLVNTTSFSSFNEHPFL
. . ||...|..|.           |..|.      .||.|..|... ..| |. . ||||..|.. ||..|.|||....||..         ||||.
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP-KFSPEFQDFVNKCLQKDPNERPKYHQLMK---------EHPFI
Kinase 12278.AA STE 69-332 28 3.8e-98 332.37 In-house 1-359 (359) Show / Hide 
Range on Protein: 69-332
Range on HMM: 1-359/359
Sequence Identity: 28% (106 aa)

FETISELGRGASGRVFKVKHKE---------------TGKFYAKKEIRINDDE----------------MFQKQLIWEIKTLFSCN--SPHIVQYYCAFY
.| |...|.||.| |.| ....               ||...| |........                . ..|.. |||..  ||  .|.||.||....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TEC-------MLHLILEYMDMGTLDTILK---KTKQ-----------VSEPILIYTTYQIIKG-IHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGIC
 |.        |....|||| |.|| |.|   ....           ..|....| ..||.||  .|||.   |||||.||.|||.     .|..| |.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GKVNG---------------TMD-QKNTFVGTTIYMSPERLNG------DSYTMKTDIWSVGLLLIEFSEGKHPIQASNNF---------------FEVL
|...                ||. . ||||||  .|.||....      . |. | ||||.|...||  .||.|    ...               ||.|
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

NNIIDFKIPPLKN-------------------INSPEFTNFIEICLKSDQNERADITQLLVNTTSFSSFNEHPFL
 .|.....|||..                     |||| .||. ||. | |.|.. .||| .        ||||.
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKS--------EHPFI
Kinase 12278.AA S_TKc 69-332 30 1.5e-72 248.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 69-332
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

FETISELGRGASGRVFKVKHKETGKFYAKKEIRINDDEMFQKQLIWEIKTLFSCNSPHIVQYYCAFYTECMLHLILEYMDM--GTLDTILKKTKQ-----
.| . ..|.|| |.|.|..||.||. .| |.|.        .... ||. | . . |.||..| .|..   |....||.|   |.| ...|| .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VSEPILIYTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGICGKVNGTMDQKNTFVGTTIYMSPERLNGDSYTM-KTDIWSVGLLLIEF
  .|    . .|||.... |.|.  .|||||||| |||...  .|||.| |.. ..       .||.||  ||.|| |   .|.  | |.||.| .|.|.
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

SEGKHPIQASNNFFEVLNNIIDFKIPPLKNINSPEFTNFIEICLKSDQNERADITQLLVNTTSFSSFNEHPFL
  |. | .   . ......|            |||. .||. ||. | ..|  . ..|    . .  . ||..
LCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQ---DEWDIKCHPWF
Kinase 12278.AA MEK1 69-271 45 2.4e-69 236.12 In-house 1-201 (297) Show / Hide 
Range on Protein: 69-271
Range on HMM: 1-201/297
Sequence Identity: 45% (93 aa)

FETISELGRGASGRVFKVKHKETGKFYAKKEIRINDDEMFQKQLIWEIKTLFSCNSPHIVQYYCAFYTECMLHLILEYMDMGTLDTILKKTKQVSEPILI
||.|.||| |  | |.|..|..||   |.| |..      ..|.| |.. |  ||||.|| .| ||| .  . . .|||| | || .||| . . | || 
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

YTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGICGKVNGTMDQKNTFVGTTIYMSPERLNGDSYTMKTDIWSVGLLLIEFSEGKHPIQA
  .  ...|. ||. . ||.||| || ||||||.||||. | |. |..   |   | ||||  ||||||| |  ||.. ||||.|| |.|.  |. || .
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIPP

SNN
 ..
PDQ
Kinase 12278.AA Pkinase 69-317 28 1.9e-66 231.88 Pfam 1-288 (293) Show / Hide 
Range on Protein: 69-317
Range on HMM: 1-288/293
Sequence Identity: 28% (82 aa)

FETISELGRGASGRVFKVKHKETGKFYAKKEIRINDDEM-FQKQLIW--EIKTLFSCNSPHIVQYYCAFYTECMLHLILEYMDMG----TLDTILK--KT
..... .|.|..|.|.| .|| ||| .| |.|.  .... .......  ||. . ..|.|.||..|..|...  .....||...|     | ....  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KQV--SEPILIYTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEI----KISDLGICGKV-NGTMDQKNTFVGTTIYMSPERLN-GDSYTMKTDIWS
. .  ||  ..   |||..|. |.|.  .|||||||| |||....|.|    ||.| |.. .. .      .||.||  ||.|| .. |  |. | |.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGLLLIEFSEGKHPIQAS---------NNFFEVLNNIIDFKIPPLKNIN----------------SPEFTNFIEICLKSDQNERADITQLL
.|..|.|.  |. | . .           .....  ...| .| . .|                 |.|.  ||. ||. | ..|  ..|.|
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL
Kinase 12278.AA STE20 69-332 30 3.8e-64 219.44 In-house 1-288 (288) Show / Hide 
Range on Protein: 69-332
Range on HMM: 1-288/288
Sequence Identity: 30% (91 aa)

FETISELGRGASGRVFKVKHKETGKF----YAKKEIRINDDE---MFQKQLIWEIKTLFSCNSPHIVQYYCAFYTE----CMLHLILEYMDMGTLDTILK
.| . ..|.|..| |.|. ||.||.     .| | . .....     .. .. ||  .  |..|.||.||.... .      | .. ||.. |.|  |.|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---KTKQ------VSEPILIYTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGICGKVNG----TMD-QKNTFVGTTIYMSPERLNG---
   |...       .|.   | .... .| .|||.  .|||||.| .|||....||.|..| | |....     ||. ..||||||  .|.|| ...   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS-NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--DSYTMKTDIWSVGLLLIEFSEGKHPIQASN-NFFEVLNNII--DFKIPPLKN----INSPEFTNFIEICLKSDQNERADITQLLVNTTSFSSFNEHPF
    |. |.||||.|  .||  ||. |   .. . . ..  |.  . . |.||.      |||| .|.. ||  | ..|.  .|||          .|||
PDKGYDYKCDIWSLGITAIEMAEGEPPY--FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLL----------KHPF

L
.
I
Kinase 12278.AA TKL 75-320 18 3.1e-54 186.48 In-house 1-364 (364) Show / Hide 
Range on Protein: 75-320
Range on HMM: 1-364/364
Sequence Identity: 18% (68 aa)

LGRGASGRVFKVKHKE--------TGKFYAKKEIRIND--------------------------DEMFQKQLIWEIKTLFSCNSPHIVQYYC-AFYTECM
.|.|..| |.| |..         |||  | | .....                           . |..... ||. . ... |.|||..  ... .| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LHLILEYMDMGT-LDTILKKTKQVSEPILIYT-TYQIIKGIHYLHKDLK-------IIHRDLKPGNILVNSEGE--------------
            |... ||.. |. |....        . ..    ..| .|..||| .         |||||||. ||||.. ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

IKISDLGICGKVNGTMD-------------------QKNTFVGTTIYMSPERLNGD----------------SYTMKTDIWSVGLLLIEFSEGKHPIQAS
.||.|.|..  ......                   ...| .||. .|.|| |.|.                .|. |.|..| |..| |   ...| .  
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

NNFFEV---------LNNIIDFKIPPLKNINS------------PEFTNFIEICLKSDQNERADITQLLVNT
... ..           .. ... ||...| .            |.. . .. | ..| ..|   ...|   
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 12278.AA NEK 69-317 30 1.4e-53 184.34 In-house 1-281 (286) Show / Hide 
Range on Protein: 69-317
Range on HMM: 1-281/286
Sequence Identity: 30% (87 aa)

FETISELGRGASGRVFKVKHKETGKF-----YAKKEIRIND-DEMFQKQLI-WEIKTLFSCNSPHIVQYYCAFYTEC--MLHLILEYMD-MGTLDTI---
.| | ..|.|. |.|.||..|..||      |. |.| ..  .|  .....  |.. | . ..|.|| || .|. |   .|. . || .  |.|.     
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LKKTK----QVSEPILIYTTYQIIKGIHYLHKDL----KIIHRDLKPGNILVNSEGE----IKISDLGICGKVNGTMDQKNT-FVGTTIYMSPERLNGDS
.|| |      .| .     .|......|.|.      ||.|||.|| ||  ....     .|| |.||    | |.|  .| .|||  ||||| ... .
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YTMKTDIWSVGLLLIEFSEG--KHPIQAS-NNFFEVLNNIIDF-KIPPLKNI--NSPEFTNFIEICLKSDQNERADITQLL
|. | ||||.| .| |      ||| .|.  |. .  ..|.   . ||.      |..  |.|. .|. |  .| ...|.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQIL
Kinase 12278.AA SLK 69-322 34 6e-51 170.05 In-house 1-259 (259) Show / Hide 
Range on Protein: 69-322
Range on HMM: 1-259/259
Sequence Identity: 34% (91 aa)

FETISELGRGASGRVFKVKHKETGKFYAKKEIRINDDEMFQKQLIWEIKTLFSCNSPHIVQYYCAFYTECMLHLILEYMDMGTLDTI-LKKTKQVSEPIL
.| | ||| || |.| | .|||...| | | | |.|.|  .  .. ||  | .|. |.||. | |.| .  | ...|. | | .|.| .   . . |. .
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMV-EIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQI

IYTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGICGKVNGTMDQKNTFVGTTIYMSP-----ERLNGDSYTMKTDIWSVGLLLIEFSEG
 |  .... ....||.. |.|||||| ||||.  .|.... | |.  |   ||... ||.||  .| |     | .  . | .|.||||.|. |||. ..
QYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQM

KHPIQASNNFFEVLNNIIDFKIPPLKNIN--SPEFTNFIEICLKSDQNERADITQLLVNTTS
  | .   |   ||  |     | |..    | || .|...||. | . |    ||.     
E-PPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase 12278.AA Ciliate-E2-Unclassified 69-317 25 4.2e-49 168.46 In-house 1-347 (352) Show / Hide 
Range on Protein: 69-317
Range on HMM: 1-347/352
Sequence Identity: 25% (88 aa)

FETISELGRGASGRVFKVKHKETGKF-----------YAKKEIRINDDEMFQKQLIWEIK--------------TLFSCNSPHIVQYYCAFYTECMLHLI
.. |  .|.|. | |.|..||.....           |..| |. .| |. ........|               | ....|.|| .. .| ..  . ..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYMDMGTLDTILKKTKQ-----------------VSEPILI-----YTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEG---EIKISDLGICG----
.||.. |.|  ..|| |.                 ..|   .     . ..||..|. |||. ..|||||.|| |||....|   .|||.|.||.     
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------KVNGTMDQKN-TFVGTTIYM----SPERLNGDSYT----MKTDIWSVGLLLIEFSEGKHPIQASN---------------NFFEVLNNII
          | . . .|.  ||.|| .||    .|| | |  |      | ||||.| .| |.  |..| .. |                ......||.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

D--FKIPPLKN-----INSPEFTNFIE----ICLKSDQNERADITQLL
.  ...|. ..     . |||  .||.     .|| ..|.| .. |.|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase 12278.AA PAKA 69-262 29 3.5e-44 152.92 In-house 1-199 (260) Show / Hide 
Range on Protein: 69-262
Range on HMM: 1-199/260
Sequence Identity: 29% (59 aa)

FETISELGRGASGRVFKVKHKETGKF--YAKKEIRINDDEMFQKQLIWEIKTLFSCNSPHIVQYYCAFYTECMLHLILEYMDMGTLDTILKKTKQ-----
.......| |||| |.... ..|..    | | ...... . .. .| ||... .|. . ||.|. ..  .  | ...|||. | |  ..... .     
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKEL-IINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNY

VSEPILIYTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGICGKVNGTMDQKNTFVGTTIYMSPERLNGDSYTMKTDIWSVGLLLIEFSE
 .| .  |   ....|....|.  ..||||.|  |||....|..|| | | |   .    ..|| |||  .|.|| ...  |  | |||| | ..||  |
MDEGQIAYVCRECLQGLEFIHS-KHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIE

G
|
G
Kinase 12278.AA TyrKc 69-323 22 1.6e-15 28.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 69-323
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FETISELGRGASGRVFKVKHKETGKFYAKKEIRINDDEMFQKQLIWEIKTLFSC--NSPHIVQYYCAFYTE-------CMLHLILEYMDMGTLDTILKKT
 . . .||.|| |.|.| . |      | | .. .     .. .. |.. . .   . |.||. | .  ..         | ...|||. | |.  |.|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KQ-VSEPILIYTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGICGKVNGT--------MDQK----NT-FVGTTIYMSPERLNGDSYTM
.  .. . |..  .|| .|  ||| . ..|||||   |.||.... .|||| | . ..           .  |    .. ..     |.|| .|   .| 
RPKLCMKDLLSFCWQIACGMEYLH-SKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KTDIWSVGLLLIE-FSEGKHPIQAS----NNFFEVLNNIIDFKIPPLKNI--------NSPEFTNFIEICLKSDQNERADITQLLVNTTSF
|.|.|| | .. | |. |. |         . .||.... . . .|             ..|  . .. | . | ..|   ...      |
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
Kinase 12278.AA Pkinase_Tyr 69-213 27 1.6e-09 32.84 Pfam 1-158 (270) Show / Hide 
Range on Protein: 69-213
Range on HMM: 1-158/270
Sequence Identity: 27% (43 aa)

FETISELGRGASGRVFKVKHK----ETGKFYAKKEIRINDDEM--FQKQLIWEIKTLFSC-NSPHIVQYYCAFY-TECM--LHLILEYMDMGTLDTILKK
 . . .||.|| |.|.| . |    .|.   | | .. . ..   ... .. |.|.. .  . |.||..| . .  .    . ...|||  | |.. |.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TKQVSEPILIYTTYQIIKGIHYLHKDLKIIHRDLKPGNILVNSEGEIKISDLGIC
     .... . |.   .|| ||  ||. . ..|||||   |.||.... .||.| | .
HREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 12278.AA MEK1 273-322 39 3.6e-08 23.48 In-house 247-297 (297) Show / Hide 
Range on Protein: 273-322
Range on HMM: 247-297/297
Sequence Identity: 39% (20 aa)

FEVLNNIIDFKIPPL-KNINSPEFTNFIEICLKSDQNERADITQLLVNTTS
||.|. |.. . | | . . | || .|...||.   .||||. ||.|.|  
FEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase 12278.AA PAKA 284-332 33 2e-06 19.03 In-house 220-260 (260) Show / Hide 
Range on Protein: 284-332
Range on HMM: 220-260/260
Sequence Identity: 33% (17 aa)

IPPLKNIN--SPEFTNFIEICLKSDQNERADITQLLVNTTSFSSFNEHPFL
.|..|. .  |.|| .| . ||. |  .||. ..||          .||||
KPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELL----------HHPFL
Kinase 12278.AA Pkinase_Tyr 233-258 46 2.361158 1.82 Pfam 181-206 (270) Show / Hide 
Range on Protein: 233-258
Range on HMM: 181-206/270
Sequence Identity: 46% (12 aa)

MSPERLNGDSYTMKTDIWSVGLLLIE
|.|| .|   .| |.|.|| | |. |
MAPECINYGKFTTKSDVWSFGVLMWE