Gene 13600 (Tetrahymena)
13600
Group:
Other
Family:
Other-Unique
Sequence
Protein domains of 13600.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13600.AA | Other-Unique | 226-438 | 10 | 3.2e-23 | 75.94 | In-house | 1-249 (249) | Show / Hide |
Range on Protein: 226-438 Range on HMM: 1-249/249 Sequence Identity: 10% (28 aa) FFEDDKNIYTVTEQYEGNLKSFLMKNYTQNDLIPEEVIL-----------------------------------DMIFQIYLPINYLFDNKLKIIQSLKL .....|. |... ... |.|. .... |....| . .. .|||.|. | . ........|.... IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKREQIYHYQIIHCIFYWTMNHCHLCFCYEHCPNMIFYIMYPWY--HHHCECQCQCEHW TTILIDSKKKLKIPIFSYSTFNLNPKSMPIQSMKYLAPEII----------SSNYKIEPSQYQSSWTLGVLLLDILLKGYENGPFDLQNFEQNYTSKVQK . ........ ..... . ...||... |. ....... . ...||.... . . . . . ....... ||........ .. MNCCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYHFG DIITNKILTFNIEKYMAQNSSIFSNYSPQFIEFIKLLLSPQVTGRIKLNQIKNHQFFQ .. ..... ..|..|... .....||. | .|.......... . .|...|.. |. CYHFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY |
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| S_TKc | 13600.AA | S_TKc | 100-437 | 15 | 4e-09 | -43.18 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 100-437
Range on HMM: 1-231/231
Sequence Identity: 15% (55 aa)
VNRGQTMEKGNY-KIFFSYNIQATISNIYYCQEFNKEHSKKEKEQNYFTSSQIHSNSPRLNQGLQTAHNWRQVQEYLKFIPKVMRITPKLFQNQPIEGLF
... || . | . ... |. . . .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----------------------------------------------------------------
RSEYLKNVFNNECCRYQ-HLRMFVRYFDFFEDDKNIYTVTEQYEG---NLKSFLMKNYTQN--DLIPEEVILDMIFQIYLPINYLFDNKLKIIQS-LKLT
. . .| . | |...|.|.| ...| |.| .| .|.... |. .. .|| .. .. || . ..|. ...|| ||
------EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYC--HSHGIIHRDLKPE
TILIDSKKKLKIPIFSYSTFNLNPKSMPIQSMKYLAPEIISSNYKIEPSQYQS-S---WTLGVLLLDILLKGYENGPFDLQNFEQNYTSKVQKDIITNKI
||.|. .|| | ... . . . |.|||.. .| . | .|..| | || ||. | . . .||
NILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCILYEMLC-GYP--PFP------------QMQMMFKKI
LTFNIEKYMAQNSSIFSNYSPQFIEFIKLLLSPQVTGRIKLNQIKN-------HQFF
. ||....||. .| . |. .. . |..|
G------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 13600.AA | Ciliate-E2-Unclassified | 221-437 | 22 | 3.9e-08 | 24.34 | In-house | 84-352 (352) | Show / Hide |
Range on Protein: 221-437 Range on HMM: 84-352/352 Sequence Identity: 22% (63 aa) VRYFDFFEDDKNIYTVTEQYEGNLKSFLMKNYTQ--------------NDLIPEEVIL-----DMIFQIYLPINYLFDNKLKIIQ-SLKLTTILIDSKK- |..|. |.|..||| |.|. ||. .. .|.. . . ..|. .. ... || . ..|| .. .|| .|. ||.|... VKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGK --KLKIPIFSYSTFNLNP--------------KSMPIQSM----KYL----APEIISS-NYKIEPSQYQS-SWTLGVLLLDILLKGYENGPFDLQNFEQN ..|| |. | .. .. |.. .... |. |||.. . || . . |.. |.|||.| .| || ||. .| ||. NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILY-EMLFGY--YPFYDNNCEQH YTSKVQ------KDIITNKILTFNIEKYMAQN---SSIFSNYSPQFIE-FIKLLLSPQVTGRIKLNQIKNHQFF .... | . .. ..|. ||.. . . . . |. ||. ... .| . || ..||.||..| QQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 13600.AA | Ciliate-E2 | 364-437 | 17 | 7.1e-07 | 19.62 | In-house | 295-365 (365) | Show / Hide |
Range on Protein: 364-437 Range on HMM: 295-365/365 Sequence Identity: 17% (15 aa) PFDLQNFEQNYTSKVQKDIITNKILTFNIEKYMAQNSS-------IFSNYSPQFIEFIKL----LLSPQVTGRIK-LNQIKNHQFF || ..| .. . |. ... . .. . |.. . .|| .| . || .||.||..| PF--------------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 13600.AA | AGC | 404-437 | 27 | 3e-06 | 10.48 | In-house | 352-395 (395) | Show / Hide |
Range on Protein: 404-437 Range on HMM: 352-395/395 Sequence Identity: 27% (12 aa) SNYSPQFIEFIKLLLSPQVTGRIK----------LNQIKNHQFF .. ||. .|| || . . |. ..|||| .| RWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | 13600.AA | CAMK | 405-437 | 21 | 7e-06 | 14.1 | In-house | 393-425 (425) | Show / Hide |
Range on Protein: 405-437 Range on HMM: 393-425/425 Sequence Identity: 21% (7 aa) NYSPQFIEFIKLLLSPQVTGRIKLNQIKNHQFF . |.. . .|. .| . . |... |..||... FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 13600.AA | CAMKK | 383-437 | 33 | 2e-05 | 12.66 | In-house | 341-396 (396) | Show / Hide |
Range on Protein: 383-437 Range on HMM: 341-396/396 Sequence Identity: 33% (19 aa) ITNKILTFNIEKYMAQNSSIF-SNYSPQFIEFIKLLLSPQVTGRIKLNQIKNHQFF | |. ..| . | | | || .. |.... || .| .| ||.. |||.|... IKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV |
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| Kinase | 13600.AA | DMPK | 407-437 | 26 | 2e-05 | 8.5 | In-house | 238-270 (270) | Show / Hide |
Range on Protein: 407-437 Range on HMM: 238-270/270 Sequence Identity: 26% (9 aa) SPQFIEFIKLLLSPQVTGRIK---LNQIKNHQFF |... .|. ||... . |.. . ..|.| || SEEAKDLICQLLCDREE-RLGRNGYEDFKCHPFF |
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| Kinase | 13600.AA | CAMKL | 364-437 | 17 | 3.5e-05 | 12.31 | In-house | 235-297 (297) | Show / Hide |
Range on Protein: 364-437 Range on HMM: 235-297/297 Sequence Identity: 17% (13 aa) PFDLQNFEQNYTSKVQKDIITNKILTFNIEKYMAQNSSIFSNYSPQFIEFIKLLLSPQVTGRIKLNQIKNHQFF ||| .. . . .|. . ..... . |.. | . . .|. .| . . |... ||.|| .. PFDDDTYN-K-------QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 13600.AA | PLK1 | 221-332 | 27 | 6e-05 | 11.92 | In-house | 62-172 (253) | Show / Hide |
Range on Protein: 221-332
Range on HMM: 62-172/253
Sequence Identity: 27% (32 aa)
VRYFDFFEDDKNIYTVTEQYEGNLKSFLMKNYTQNDLIPEEVILDMIFQIYLPINYLFDNKLKIIQSLKLTTILIDSKKKLKIPIFSYSTFNLNP---KS
|....||||..|.| | | . . || . | | . || . . || .||. | ||| . .. . ..|| | |. . |
VKFHHFFEDKQNVYIVLELCR---RRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKI-IHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKK
MPIQSMKYLAPEIIS
|.|||...
TLCGTPNYIAPEVLN
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| Kinase | 13600.AA | CAMK-Unique | 407-437 | 19 | 0.000142 | 10.79 | In-house | 333-363 (363) | Show / Hide |
Range on Protein: 407-437 Range on HMM: 333-363/363 Sequence Identity: 19% (6 aa) SPQFIEFIKLLLSPQVTGRIKLNQIKNHQFF |.... |.| .. . |....... ||.. SQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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| Kinase | 13600.AA | Ciliate-E2 | 221-270 | 25 | 0.005912 | 5.96 | In-house | 95-154 (365) | Show / Hide |
Range on Protein: 221-270 Range on HMM: 95-154/365 Sequence Identity: 25% (15 aa) VRYFDFFE--DDKNIYTVTEQYEG-NLKSFLMKNYTQNDLIPE-------EVILDMIFQI ......|. ||.||| |.| ..| .|.... .|... . ..| . |.... || IKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQI |
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| Kinase | 13600.AA | CAMK-Unique | 224-251 | 20 | 0.013887 | 4.12 | In-house | 82-129 (363) | Show / Hide |
Range on Protein: 224-251 Range on HMM: 82-129/363 Sequence Identity: 20% (10 aa) FDF----FEDDK---------------NIYTVTEQYEGN-LKSFLMKN .|. |.|.| ..|.|.| .|. |.. ..|. YDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKW |
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| Kinase | 13600.AA | PLK1 | 401-437 | 32 | 0.130877 | 0.76 | In-house | 217-253 (253) | Show / Hide |
Range on Protein: 401-437 Range on HMM: 217-253/253 Sequence Identity: 32% (12 aa) SIFSNYSPQFIEFIKLLLSPQVTGRIKLNQIKNHQFF .| |. |. ..|. .| |. | | . .|. | .|| RIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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