Gene 25339 (Tetrahymena)
25339
Group:
Other
Family:
Other-Unique
Sequence
Protein domains of 25339.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | 25339.AA | S_TKc | 27-285 | 24 | 6.2e-40 | 139.91 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 27-285 Range on HMM: 1-231/231 Sequence Identity: 24% (66 aa) YKIIKQIGKGYYGVVYKALHIKDNTIVAIKGMVFNSQNERQKLMNEFQCLKSIDHPNVIKVLEYIAYPDNSCGFYSMEFCQS---DLAEVLEKHRKQKTW |.|...|||| .|.|||. |.|.. ||||| . .....| |.||. .|||..| .... .. . ||.| || ....|...... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LNQEDIYFIANQILQGLKAIHQKNIIHFNISCENVLLGQDGQYKIGDFGECKRLNQGENSSKTHGECSRKYGSPEQLHKLLQVKDIQHYTQ-SSDIYS .. .. |.. ||...|. .|...||| . ||.|| . . ||.||| ...| |. .. | .|| | .|. ..|..| FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------GYGKCKCDWWS LGIVYYYLTNRTL--DYEHVPIFKKVEFHSFLNPEYSQFNTLISQMIQFRQEDRVKLHSVEN------TLSYL .|.. | . . . .. .|||. ... .|... |. |.| . . .. CGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 25339.AA | Ciliate-A1 | 27-285 | 24 | 5.4e-38 | 126.92 | In-house | 1-301 (301) | Show / Hide |
Range on Protein: 27-285 Range on HMM: 1-301/301 Sequence Identity: 24% (76 aa) YKIIKQIGKGYYGVVYKALHIKDNT-IVAIKGMVFNSQNERQKLMNEFQCLKSIDHPNVIKVLEYIAYPDN--SCGFYSMEFCQSDLAEVLEKHRKQKTW | |.|| .||| .| | . ...| . . ..|.. .| | |.||||. . . | .| | | ||.|| . | .|. . YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGN---LFNYCYQNDY LNQEDIYFIANQILQGLKAIHQKNIIHFNISCENVLLGQDGQYKIGDFGECKRLNQGE-----------------NSSKTHGECSRKYGSPEQ--LHK-L . |.|| | || .|. .|| .||.| . .|.|.. | ..|| |.| | | | . . . .. | |||| .| MKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRD LQVKDIQHYTQSSDIYSLGIVYYYLTN-----------RTLDYEHVPI------------FKKVEFHSFLNPEYSQFNTLISQMIQFRQEDRVKLHSVEN . .. | | ||.||||.. . |.. . . || | .. .|.. . . || .|.| . |..| . QMFIENKIYKQ-SDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCID TLSYL | . CLYIF |
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| Kinase | 25339.AA | CMGC | 27-200 | 19 | 2.4e-37 | 119.63 | In-house | 1-297 (513) | Show / Hide |
Range on Protein: 27-200 Range on HMM: 1-297/513 Sequence Identity: 19% (57 aa) YKIIKQIGKGYYGVVYKALH--------------IKDNTIVAIKGMVFNSQNERQKL------------MNEFQCLKSI-----------------DHPN |.|||.||.| ||||||. . ...| ||||| . . .|.|.. | ..|| . .|.| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VIKVLEYIAYPDNS---------------CGFYSMEFCQSDLAEVLEKHR------KQKTWLNQE-----------DIYFIA------NQILQGLK--AI ..| .... .... . . .|... ||........ ... . .| .. |||.||| . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HQKN--IIHFNISCENVLLGQDGQY--------------------KIGDFGECKRLNQG--------------------ENSSKTHGECSRKYGSPEQL |... ||| . ||.|. ..... ||.||| .. ... .| || ..| | .|| | HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL |
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| Kinase | 25339.AA | Pkinase | 27-233 | 26 | 6.7e-35 | 124.48 | Pfam | 1-210 (293) | Show / Hide |
Range on Protein: 27-233 Range on HMM: 1-210/293 Sequence Identity: 26% (59 aa) YKIIKQIGKGYYGVVYKALHIKDNTIVAIKGMVFNSQNERQKLMN-----EFQCLKSIDHPNVIKVLEYIAYPDNSCGFYSMEFCQSDLAEVLEKH---- |.|...||.| .|.|||. |.... |||.| . . .. .|... | | .|...|||... ... ..|. . ||.|. .| |.. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK-IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLY-VMDLFDYIS RKQKTWL--NQEDIYFIANQILQGLKAIHQKNIIHFNISCENVLLGQDGQY----KIGDFGECKRLNQGENSSKTHGECSRKYGSPEQLHKLLQVKDIQH ....... ... |.. |||.||. .|...||| . ||.|. ..|. ||.||| .| .. || |. ... | .|| . . |. TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR------GGQY YTQSSDIYSLGIVYYYLTNRTL |....|..|.|.. |.. .. . YGPKVDMWSCGCILYEMLCGRP |
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| Kinase | 25339.AA | Ciliate-E2 | 27-272 | 21 | 8.2e-34 | 113.44 | In-house | 1-352 (365) | Show / Hide |
Range on Protein: 27-272
Range on HMM: 1-352/365
Sequence Identity: 21% (77 aa)
YKIIKQIGKGYYGVVYKALHIKDNT-----------------------IVAIKGMVFNSQNERQK---LM----------NEFQCLKSIDHPNVIKVLEY
||.||.||.| .|.|||. ..|.. |.|.| | | .. . .| || . |....|||.|| |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
IAYPDNSCGFYSMEFCQS-DLAEVLEKHRKQKT-------WLNQEDIYFIANQILQ---------------GLKAIHQKN-IIHFNISCENVLLGQDGQY
|... .. ||.|| || . .....|... .. . | .| |||| .|. .|.|| ||| .| ||.|.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I
KIGDFGECKRLNQG----------ENSSKTHGECSRKYG----------------SPEQLHK-LLQVKDI------QHYTQSSDIYSLGIVYYYLTNRTL
|| ||| .|.... .. ... || .| .|. . |. |.. ..|. ..||.|||.. |.. .
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP
DYEHVPIFKKVEFHSFLNPEYSQFN-----------------------TLISQ----MIQFRQEDR
. . . . ...... ||.. |.| .| |
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKR
|
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| Kinase | 25339.AA | Ciliate-E3 | 27-229 | 32 | 4.9e-31 | 94.19 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 27-229 Range on HMM: 1-202/202 Sequence Identity: 32% (70 aa) YKIIKQIGKGYYGVVYKALHIKDNTIVAIKGMVFNSQNE------RQKLMNEFQCLKSIDHPNVIKVLEYIAYPDNSCGFYSMEFCQS-DLAEVLEKHRK | . ...|.| .|.||||. |..|||| . |. ||. .||| ..| . || |. . . .| | .|.| || . . . | YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQNK QKTWLNQEDIYFIANQILQGLKAIHQKNIIHFNISCENVLLGQDG---QYKIGDFGECKRLNQGE--NSSKTHGECSRKYGSPEQLHKLLQVKDIQHYTQ . |. || |. ||.||. |||.||||| | .| |... ||.|||| | | . .. . | .. | .|||. . | T-----QNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQG-WTPFYAAPEQNDQ-------QQISK SSDIYSLGIVYYYLT ||.||.| | | ESDYYSVGAVFCQLC |
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| Kinase | 25339.AA | ULK | 27-228 | 25 | 7.7e-31 | 104.93 | In-house | 1-249 (329) | Show / Hide |
Range on Protein: 27-228 Range on HMM: 1-249/329 Sequence Identity: 25% (65 aa) YKIIKQIGKGYYGVVYKALHIKD----NTIVAIKGMV---FNSQNERQK-------LMNEFQCLKSID--------HPNVIKVLEYIAYPDNSCGFYSME | .....||| .|.|||. ..|. | .||.| . .| .| | |.|| . .| .. |||..| ... ... . . || YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME FCQS-DLAEVLEKHRK------QKTWLNQEDIYFIANQILQGLKAIHQKNIIHFNISCENVLLGQD------------GQYKIGDFGECKRLNQG--ENS .|. || . ..|..| | |... . . |||.|.|..|..|||| | .|.|. . |..||.||| .| .. . |. YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ SKTHGE------CSRKYGSPEQLHKLLQVK--DIQHYTQSSDIYSLGIVYYYL . .. | .|. .|| . ...|. .||.|||...|.. MMMTCVNEKRLCGTPLYMAPQ----ILQGQGEQKPYYDYKCDIWSLGCIFYEM |
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| Kinase | 25339.AA | Ciliate-E1 | 33-219 | 25 | 2e-30 | 96.39 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 33-219 Range on HMM: 1-202/202 Sequence Identity: 25% (53 aa) IGKGYYGVVYKALHIKDN-TIVAIKGMVFN---SQNERQKLMNEFQ-CLKSID-HPNVIKVLEYIAYPDNSCGFYSMEFCQSDLAEVLE---------KH ||.| ...|.|| ...| ||.| . .||. |.. .| . .| . . ..|....|| .| .|.|. | . |. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC RKQKTWLNQEDIYFIANQILQGLKAIHQKNIIHFNISCENVLLGQDGQYKIGDFGECKRLNQGENSSKTHGECSRKYGSPEQLH--KLLQVKDIQHYTQS .... ..... . |. |...|| ..||.||||..| .|.| ..|.|.. ||| .| |. .|... .| .|||. . . .. | ... QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYK SDIY |||| SDIY |
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| Kinase | 25339.AA | ULK | 27-272 | 22 | 2.2e-30 | 105.06 | In-house | 1-312 (324) | Show / Hide |
Range on Protein: 27-272
Range on HMM: 1-312/324
Sequence Identity: 22% (70 aa)
YKIIKQIGKGYYG-VVYKALHIKD---NTIVAIKGMV---FNSQNER-------QKLMNEFQCLKSID---HPN--VIKVLEYIAYPDNSCGFYSMEFCQ
| .....||| .| .|||. ..|. | .||.| . .| .. . |.|.|| | .| .. ||| ..| ... ... . ||.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN
S-DLAEVLEKHRK-----QKTWLNQEDIYFIANQILQGLKAIHQKNIIHFNISCENVLLGQD------------GQYKIGDFGECKRLNQG-ENSSKT--
|| . ..|..| | |... . . ||..|.|..|..|||| | .| |. . |..||.||| .| .. . .. ..
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT
---HGE---CSRKYGSPEQLHKLLQVK--DIQHYTQSSDIYSLGIVYYYLTNRTLD---YEHVPIF-------------------KKVEFHS--FLNPEY
. .. | .|. .|| . ...|. .||.|||...|.. . . . ....| . ..
CVNE-KRIKGTPLYMAPQ----ILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS
SQFNTLISQMIQFRQEDR
... ||..|.|. ..||
PECKDLIRRMLQYDEKDR
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| Kinase | 25339.AA | Ciliate-E2-Unclassified | 27-228 | 25 | 3.1e-30 | 102.07 | In-house | 1-263 (352) | Show / Hide |
Range on Protein: 27-228 Range on HMM: 1-263/352 Sequence Identity: 25% (69 aa) YKIIKQIGKGYYGVVYKALHIKDNTIV-----AIKGMVFNSQNERQKLMNEFQCLKSID--------------------HPNVIKVLEYIAYPDNSCGFY ||||||||.| .|.|||. |.|.. . ..| ....... ..| .. ...| . ||. ..| .. . | . . YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI SMEFC-QSDLAEVLEK------------HRKQKTW-LNQEDIY-----FIANQILQGLKAIHQKN-IIHFNISCENVLLGQDG---QYKIGDFGECKRLN ||.| . || . ..| |..... . . . |.. ||||||. .|.|| ||| .| .||.|. ..| . || ||| .|... VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ QGEN-------------SSKTHGEC-SRKYG----SPEQLHKLLQVKDIQHYTQS----SDIYSLGIVYYYL | .| . ... | . | .|| | . |.| .| .||.|||.. |.. QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQG-------QNYDHSKAYKCDIWSLGVILYEM |
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| Kinase | 25339.AA | NEK | 27-172 | 29 | 1e-27 | 94.93 | In-house | 1-168 (286) | Show / Hide |
Range on Protein: 27-172 Range on HMM: 1-168/286 Sequence Identity: 29% (49 aa) YKIIKQIGKGYYGVVYKALHIKDNTI-----VAIKGMVFN--SQNERQKLM-NEFQCLKSIDHPNVIKVLEYIAYPDNSCGFYSMEFCQS--DLAEV--- |.|||.||.| .|.|||. ...|. . ...| . .. |. |.|... || . ||...|||..| . . .|.| . ||.| ||.. YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS LEKHRKQKTWLNQEDIYFIANQILQGLKAIHQK-----NIIHFNISCENVLLGQDGQ----YKIGDFG ..|...... . | | . |.. .|| .|.. .|.| | . |. | .. |||||| IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFG |
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| Kinase | 25339.AA | Ciliate-E5 | 29-172 | 38 | 2.1e-27 | 86.11 | In-house | 2-148 (271) | Show / Hide |
Range on Protein: 29-172 Range on HMM: 2-148/271 Sequence Identity: 38% (57 aa) IIKQI-GKGYYGVVYKALHIKDNTIVAIKGMVFNSQNERQKLMNEFQCLKSIDHPNVIKVLEYIAYP--DNSCGFYSMEFCQSDLAEVLEKHRKQKTWLN | .|| ||| |.| |. . .||| | ...| .. .||. ||.. |..||| ... | ... | || | || . | | . |..|.. IENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKWQK QEDIYFIANQILQGLKAIHQKNIIHFNISCENVLLGQDGQYKIGDFG .||| | | .||..|||||||| | |.||| | | |.| HQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMG |
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| Kinase | 25339.AA | TyrKc | 27-282 | 19 | 1.2e-13 | -2.23 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 27-282 Range on HMM: 1-280/280 Sequence Identity: 19% (59 aa) YKIIKQIGKGYYGVVYKALHIKDNTIVAIKGMVFNSQNERQKLMNEFQCLKSI--DHPNVIKVLEYIAYP-------DNSCGFYSMEFCQS-DLAEVLEK . .|..| | .|.|||. . . ||.| . .. |. .|.| . .... .|||... . .. . . . ||.. || . | | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV--MEYMPHGDLKDYLRK HRKQKTWLNQEDIYFIANQILQGLKAIHQKNIIHFNISCENVLLGQDGQYKIGDFGECKRLNQG-----ENSSKTHGE--CSR-----KYGSPEQLHKLL ||.. |. .| .. || .| .|.||.|| . . |.|.| ... ||.||| .. . . . . ... | ... . .|| . HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---- QVKDIQHYTQSSD----------IYSLGIVYYY------LTNRTLDYEHVPIFKKVEFHSFLNPEY-----------SQFNTLISQMIQFRQEDRVKLHS . .| || |...| |. ..|. . .|.| . . |.. .. ...| .. ||| ---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV-IEYVKQGYRMPQ-----PPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSE VENTL . . IHECF |
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| Kinase | 25339.AA | Pkinase_Tyr | 27-86 | 26 | 5.6e-12 | 41.2 | Pfam | 1-68 (270) | Show / Hide |
Range on Protein: 27-86 Range on HMM: 1-68/270 Sequence Identity: 26% (18 aa) YKIIKQIGKGYYGVVYKALHI----KDNTIVAIKGMV--FNSQNE--RQKLMNEFQCLKSI-DHPNVIK ...|..|.| .|.|||. .... ||.| |. .. . |...|.| . .|.. .|||... ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK-MLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVR |
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| Kinase | 25339.AA | Ciliate-E5 | 191-229 | 30 | 1.3e-07 | 20.58 | In-house | 217-271 (271) | Show / Hide |
Range on Protein: 191-229 Range on HMM: 217-271/271 Sequence Identity: 30% (17 aa) SRKYGSPEQLHKLLQVKD-----------------IQHYTQSSDIYSLGIVYYYLT .. | |||| .. . .. . | .||||||||| || TQCYSSPEQ-YQCYHNQMFYILIRNLPDIKYIQSFKKKITKQSDIYSLGIVFLELT |
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| Kinase | 25339.AA | Pkinase_Tyr | 144-224 | 25 | 0.089729 | 6.63 | Pfam | 128-203 (270) | Show / Hide |
Range on Protein: 144-224 Range on HMM: 128-203/270 Sequence Identity: 25% (21 aa) HQKNIIHFNISCENVLLGQDGQYKIGDFGECKRL-NQGEN-SSKTHGECSRKYGSPEQLHKLLQVKDIQHYTQSSDIYSLGIV ..||.|| . . |.|.. ... ||.||| .. . | .. ....| . | .|| .. .| ||..| |.. ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-------FTTKSDVWSFGVL |
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