Gene 11434 (Tetrahymena)

11434

Species: Tetrahymena
Alias: TTHERM_00052540, 3824.m03189, PreTt11434, 3.m01819, 173, 11434
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
11434.AA Protein None 864 None Fasta, JSON
11434.kin_dom Protein Kinase Domain None 394 None Fasta, JSON
11434.NA RNA None 2595 None Fasta, JSON

Protein domain

Protein domains of 11434.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11434.AA GCN2 458-850 31 1.6e-192 645.84 In-house 1-511 (511) Show / Hide 
Range on Protein: 458-850
Range on HMM: 1-511/511
Sequence Identity: 31% (160 aa)

FRVIDELGRGGFGRVYK-VQSMVEEKIYAIKKIAVPYDGFSNPKEHKYFREVKSIMSLNHINIVRYHTSWWENCDDEMVNQVNEFLQTNNNLYSDDNSPS
|..|..||.||||.|.| |..|.....|||||..........|..||..||||....|.|...|||...|.|.||..||...|....||||..|||.|..
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

VSEAYQKNKSDYNRSYALSKQTNQTQSYVLSYNNDN----------------------------------------------------------------
.|..|...||.........|......|.....||.|                                                                
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWDIESNN

-----LSCIEWEQSENENQNPNISNNDGI------------------KKKLDDSQTINEYREQNKSHKTFNFTKEPSQLLTLYIQLEYCSGKTLRNYLDE
     ....||||....||.......|..                  |||.............||.|......|.|.....||||.|||.|||||.|.|.
VRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDN

QTHGLDSKEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILFENKIA-KIADFGLSI-------------------------QQELGLINANQELPSQK-N
.....|..|....|.|.|||.||.|....||||||||||.. .    ||.||||..                         |.|...........||. .
HGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQ

IDGQDISVAHTGNVGTPFYMPPEQQDKSGKYNEKIDVYSL-GIILLEIIHK-MDTYHEKLEIVKKLKGSQELPKNLQK----TQKYACELIIQMTSLKPQ
.|.||..|.|||.|||||||.||||  ...||.|.|.||| |||..|.... ..|..|...|.|.|. |.|.|....|    ..|.....|.......||
WDQQDEQVHHTGKVGTPFYMCPEQQ--KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-SCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQ

NRPSIEQILQGKTY
.|||..|.||....
KRPSAQQLLQHEFL
Kinase 11434.AA PEK 458-850 21 4.2e-163 548.16 In-house 1-655 (655) Show / Hide 
Range on Protein: 458-850
Range on HMM: 1-655/655
Sequence Identity: 21% (144 aa)

FRVIDELGRGGF-GRVYKVQSMVEEKIYAIKKIAVPYDG-------------FSNPKEHKYFREVKSIMSLNHINIVRYHTSWWENCDDEMVNQVNEFLQ
| .|..||.||| |.|||||... .. ||||.|.... .             .......|..||||. ..|||.||||||..|.|........|..|..|
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

TNN----------------------------------------------------------NLYSDDNSPSVSEAYQKN---------------------
...                                                          | |......|.|| ....                     
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

-------------------------------------KSDYNRSYALSKQTNQTQSYVLSYNNDNLSCIEWEQSENENQNPNISNNDGIKKKLD------
                                     .|....|.. |..|....|...|..|.. .|..|||.|...|......||. .|..|      
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

------------------------DSQTINEYREQNKSHKTFNFTKEP----SQLLTLYIQLEYCSGKTLRNYLDEQT----------------------
                        .|....|..|.|.......|....    .| ..|||| |||..||||...|...                      
KKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIM

---------------------HGLDSKEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILF---EN---KIAKIADFGLSIQQELG---------------
                     ...|......||.|.|||.||.| ...||||||||||..   ..   .. ||.||||....|..               
NQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYW

---LINANQELPSQKNIDGQDIS--------------------VAHTGNVGTPFYMPPEQQDKS----GKYNEKIDVYSLGIILLEIIHKMDTYH-EKLE
   .....|..  ..... ....                    ..|||.|||..||.|||....    ..||.|.|.||||||..| .... |.. |. .
KYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVK

IVKKLKG------SQELPKNLQKTQKYACELIIQMTSLKPQNRPSIEQILQGKTY
. ..|.       ..  ||............| .|.|..||.|||..|||| ...
TLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase 11434.AA S_TKc 458-851 16 1.2e-45 158.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 458-851
Range on HMM: 1-231/231
Sequence Identity: 16% (69 aa)

FRVIDELGRGGFGRVYKVQSMVEEKIYAIKKIAVPYDGFSNPKEHKYFREVKSIMSLNHINIVRYHTSWWENCDDEMVNQVNEFLQTNNNLYSDDNSPSV
.......|.|.||.|||..     .|.|||.|                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

SEAYQKNKSDYNRSYALSKQTNQTQSYVLSYNNDNLSCIEWEQSENENQNPNISNNDGIKKKLDDSQTINEYREQNKSHKTFNFTKEPSQLLTLYIQLEY
                                                           .. .   |   .        | . .  .      ||. .||
-----------------------------------------------------------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEY

CSG--KTLRNYLDEQTHG-----LDSKEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILFENKIAKIADFGLSIQQELGLINANQELPSQKNIDGQDISV
|.|   .|. |.... ..     ..  .|  .. |......|.|...||||||||.|||. .   ||.||||. |                         
CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------------------------

AHTGNVGTPFYMPPEQQDKSGKYNE-KIDVYSLGIILLEIIHKMDTYHEKLEIVKKLKGSQELPKNLQKTQKYACELIIQMTSLKPQNRPSIEQILQ-G-
  |  .|||.||.||      .|.  |.|..|.|.|| | .     ..  .. . |. |            . |...| ..    |..||.. ..|| . 
--TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

----KTYM
      ..
DIKCHPWF
Kinase 11434.AA STE 458-846 16 6.8e-43 148.82 In-house 1-353 (359) Show / Hide 
Range on Protein: 458-846
Range on HMM: 1-353/359
Sequence Identity: 16% (78 aa)

FRVIDELGRGGFGRVYKVQSMV---------------EEKIYAIKKIAVPYDGFSNPK--------------EHKYFREVKSIMSLN--HINIVRYHTSW
.. |...|.|.|| |||   .                  .|.|||.. .  .  .. .              . .. .|.|  . .|  | |||.|. . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

WENCDDEMVNQVNEFLQTNNNLYSDDNSPSVSEAYQKNKSDYNRSYALSKQTNQTQSYVLSYNNDNLSCIEWEQSENENQNPNISNNDGIKKKLDDSQTI
  ....                                                                                              
FKEGHN----------------------------------------------------------------------------------------------

NEYREQNKSHKTFNFTKEPSQLLTLYIQLEYCSGKTLRNYLDE--QTHGLDS-----------KEAFQIFSQMLEG-VNYLHKNQIIHRDLKPSNILFEN
                   ..  .|.| .||..| .|.  ...   . . ..           ..   |  | |.|  .|||...|||||.||.|||.  
------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

KIAKIADFGLSIQQELGLINANQELPSQKNIDGQDISVAHTGN-----------VGTPFYMPPEQQDK-----SGKYNEKIDVYSLGIILLEIIHKMDTY
  .|..|||.. | .  . |  |   .  .||          .           |||| .| ||  ..     ...|..| |..|||. ..| .     .
--VKLCDFGVCGQLTDSMANI-Q-S-NN-IID----------CIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW

---HEK---LEIVKKL-------------KGSQELPKNLQ----------------KTQKYACELIIQMTSLKPQNRPSIEQILQ
   |     ..| ..              ...  || .|.                |  .  .. | .     |..||. .| |.
HDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
Kinase 11434.AA Ciliate-E2 650-850 24 8.2e-39 130.85 In-house 108-365 (365) Show / Hide 
Range on Protein: 650-850
Range on HMM: 108-365/365
Sequence Identity: 24% (66 aa)

TLYIQLEYCSGKTLRNYLDEQTH----------GLDSKEAFQIFSQMLE---------------GVNYLHKNQ-IIHRDLKPSNILFENKIAKIADFGLS
..|. .|||.|..|. |. .. .           .. ||. .|. | |.               ...|||..  |||||.||.||||     ||.|||||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLS

IQQELGLINANQELPSQK--NIDGQDISVAHTGN------------VGTPFYMPPEQQDKSGK--------YNEKIDVYSLGIILLEIIHKMDTYHEKLE
 ..    .|  . .. .|     ..|.|.  . .            .||| ||.||   . .         |..|.|..|||.|| | . .   .   ..
KKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---QQ

IVKKLKGSQELPK-------------NLQKTQKYACELIIQ----MTSLKPQNRPS-IEQILQGKTY
. |. | .   |.             . .|  . .  || .    |   .|..|.. .||||. .  
QIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 11434.AA CAMKL 650-786 29 3.7e-36 112.77 In-house 89-226 (297) Show / Hide 
Range on Protein: 650-786
Range on HMM: 89-226/297
Sequence Identity: 29% (47 aa)

T------LYIQLEYCSGKT--LRNYLDEQTH---GLDSKEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILFE-NK--IAKIADFGLSIQQE-LGLINAN
.      .|. .|||||    | .|.... |    .. .|| ..| |....|||.|.. |.|||.|| |||.  |.   .||.|||.|....        
HDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC------

QELPSQKNIDGQDISVAHTGN-----VGTPFYMPPEQQDK-SGKYN-EKIDVYSLGIIL
               .  .|.      |.| ||.||   .   .|.  |.|. |.|.||
---------------IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVIL
Kinase 11434.AA STE-Unique 628-850 22 3.1e-35 122.37 In-house 327-616 (616) Show / Hide 
Range on Protein: 628-850
Range on HMM: 327-616/616
Sequence Identity: 22% (65 aa)

EYREQNKSHKTFNFT-------------------KEPSQLLTLYIQLEYCSGKTLRNYLDEQTHG--------LDSKEAFQIFSQMLEGVNYLHKNQ--I
|| |      || |                    | |    ...|..|||...||.  ....  .        .   |.. .  | ||| .|||  .  |
EYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKEQNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPI

IHRDLKPSNILFENKI------AKIADFGLSIQQELG-------LINANQELPSQKN------------IDGQDISVAHTGNVGTPFYMPPEQQDKS---
|||||||.||.. ..       .||.|||....  ..       . | |    .  |             |  .  .  ....|||.|| ||   .    
IHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQI

-GKYNEKIDVYSLGIILLEIIHKMDTYHEKLEIVK----KLKGSQELP-----KNLQKTQKYACELIIQMTSLKPQNRPSIEQILQGKTY
   |. | |..|||.......   ...|.   .       ... ...|         |.|.   ..|.   ...|  |||..| |.  . 
NNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase 11434.AA CAMK 651-786 23 1e-34 108.8 In-house 132-324 (425) Show / Hide 
Range on Protein: 651-786
Range on HMM: 132-324/425
Sequence Identity: 23% (46 aa)

LYIQL---EYCSGK----TLRNYLDEQTHG--------------LDSKEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILFENK----------------
.|. .   |||||      | .|. |....              .. .|| ..| |....|.|.|.. |.|||||| |||. ..                
MYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWN

--IAKIADFGLSIQQELGLINANQELPSQKNIDGQDISVA----------HTGNVGTPFYMP-PEQQDK-------------SGKYNEKIDVYSLGIIL
    ||.|||....    ..  ....  ... .|. .              .  .||| ||. ||   .                |..|.|. |.|.||
NNNIKIIDFGFANK----FDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 11434.AA Pkinase 651-846 25 1.2e-34 123.54 Pfam 75-289 (293) Show / Hide 
Range on Protein: 651-846
Range on HMM: 75-289/293
Sequence Identity: 25% (59 aa)

LYIQLEYCSGK----TLRNYLD-EQTHGL--DSKEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILFE-NKIA----KIADFGLSIQQELGLINANQELP
.|. .||| |      |  |.  ..  ..  . .|.  .. |.|.|..|.|.. ||||||||.|||.  |       ||.||||. | .           
IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------

SQKNIDGQDISVAHTGNVGTPFYMPPEQQDKSGKYNEKIDVYSLGIILLEIIHK-----MD----TYHEKLEIVKKLKGSQELPKNLQKTQ---------
          ..  |. .|||.||.||   .. .|  |.|..|.|.|| | . .      .    . |........ .| .      ..           
-------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW

----------KYACELIIQMTSLKPQNRPSIEQILQ
          . ....|  .  ..|. ||..|||||
HFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ
Kinase 11434.AA TKL 656-846 22 1.1e-32 114.92 In-house 118-362 (364) Show / Hide 
Range on Protein: 656-846
Range on HMM: 118-362/364
Sequence Identity: 22% (60 aa)

EYCSGKTLRNYLDEQTHGLDSKEAFQIFSQMLEGVNYLHKNQ--------IIHRDLKPSNILFENKI---------------AKIADFGLSI-QQELGLI
|||.| .|..||            ...  ..  |.|||| ..        |||||||..|||  ..                .||.|||||   .. |  
EYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM

NANQ-------ELPSQKNIDGQDISVAHTGN------VGTPFYMPPEQ---------------QDKSGKYNEKIDVYSLGIILLEIIHKMDTYH-EKLEI
|...       |             .. ...      .||| .|.||                ..|...|.||.|||| ||.| ||.     |. .. . 
NDTMTTMMESAE-------------HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMP

VK---------KLKGSQELPKNLQ-------------KTQKYACELIIQMTSLKPQNRPSIEQILQ
..         .. ..  |.  .               . .  ..|. .  . .|..||| ..||.
MIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK
Kinase 11434.AA HRI 677-850 32 8.2e-25 84.0 In-house 433-613 (613) Show / Hide 
Range on Protein: 677-850
Range on HMM: 433-613/613
Sequence Identity: 32% (60 aa)

KEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILFENKIA-----KIADFGLSIQQELGL------INANQELPSQKNIDGQDISVAHTGNVGTPFYMPPE
|.. .|| |..||..| |   |.|||.|| ||    .       || ||||  .  |            |.     | ..   .  ||  |||  |  ||
KVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACEDILQEPKTPMRFRRDQDF-DWTNRNPC-VTQTHTSRVGTCTYASPE

QQDKSGKYNEKIDVYSLGIILLEIIHKMDTYHEKLEIVKKLKGSQELPKNLQKTQKYACELIIQMTSLKPQNRPSIEQILQGKTY
| | | .|  | | ||.|.||.|      |  |. |..  ..  | .|  |.|        |  .|      |||  |.||   .
QLDGS-QYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQ-IPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase 11434.AA PEK 752-850 32 6.2e-23 72.38 In-house 645-758 (758) Show / Hide 
Range on Protein: 752-850
Range on HMM: 645-758/758
Sequence Identity: 32% (37 aa)

HTGNVGTPFYMPPEQQDKS---------------GKYNEKIDVYSLGIILLEIIHK-MDTYHEKLEIVKKLKGSQELPKNLQKTQKYACELIIQMTSLKP
||..|||. || |||                   . ||.| | ||||.|. | ||    |  |.  . ..|. .. .|| ...    . |.| ||.|. |
HTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLR-NGQWPKWFTQKYPQEYEFIQQMMSMNP

QNRPSIEQILQGKTY
 .||.  ||.     
DERPTADQISMHDFF
Kinase 11434.AA PEK 458-528 38 2e-22 70.64 In-house 1-76 (758) Show / Hide 
Range on Protein: 458-528
Range on HMM: 1-76/758
Sequence Identity: 38% (29 aa)

FRVIDELGRGGFGRVYKVQSMVEEKIYAIKKIAVPYDGFSNPKEHKYFR-----EVKSIMSLNHINIVRYHTSWWE
| .|. ||.|||| |..... | .  ||||.|..|      |   . .|     ||.   .|.|.|||||. .| |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE
Kinase 11434.AA HRI 458-528 43 2e-20 68.2 In-house 1-69 (613) Show / Hide 
Range on Protein: 458-528
Range on HMM: 1-69/613
Sequence Identity: 43% (31 aa)

FRVIDELGRGGFGRVYKVQSMVEEKIYAIKKIAVPYDGFSNPKEHKYFREVKSIMSLNHINIVRYHTSWWE
|   . .|.||.||||||.     . |||||| .   .       |  ||||    |.| ||||||..| |
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKI--KKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase 11434.AA PEK 631-722 27 1.4e-16 50.76 In-house 394-512 (758) Show / Hide 
Range on Protein: 631-722
Range on HMM: 394-512/758
Sequence Identity: 27% (33 aa)

EQNKSHKTFNFTKEPSQLLTLYIQLEYCSGKTLRNYLDE--QTHGLDSKEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILF--ENK-------------
..|    ...  .  ..  ..||| ..| ..||.  .     .   .  .   .| | .|||||.|   .|||||||||| |  . .             
NNNNNNNKNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSS

----------IAKIADFGL
          | || ||||
FEENSDGGHQIIKIGDFGL
Kinase 11434.AA TyrKc 458-851 14 7.5e-12 -31.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 458-851
Range on HMM: 1-280/280
Sequence Identity: 14% (64 aa)

FRVIDELGRGGFGRVYKVQSMVEEKIYAIKKIAVPYDGFSNPKEHKYFREVKSIMSL--NHINIVRYHTSWWENC------DDEMVNQ-------VNEFL
 . ...||.| ||.||| .        |.|..           .    || .  ..|  .| |||| .    .        .  |.          ...|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QTNNNLYSDDNSPSVSEAYQKNKSDYNRSYALSKQTNQTQSYVLSYNNDNLSCIEWEQSENENQNPNISNNDGIKKKLDDSQTINEYREQNKSHKTFNFT
. . .                                                                                               
RKHRPK----------------------------------------------------------------------------------------------

KEPSQLLTLYIQLEYCSGKTLRNYLDEQTHGLDSKEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNIL-FENKIAKIADFGLSIQQELG-LINANQELPSQ
                               |  |.  ..  |  .| .|||....|||||   |.|  ||...||.|||||   . .            
-------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--------

KNIDGQDISVAH--TGN-VGTPFYMPPEQQDKSGKYNEKIDVYSLGIILLEIIHKMDTYHEK--------LEIVKKLKGSQELPKNLQ--------KTQK
    .. ....    |. .     |.||   . ||...| ||.| |. . ||    .. ..          |.....|    .|.            ...
--ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDE

YACELIIQMTSLKPQNRPSIEQILQGKTYM
    .. |    .| .||. ..|   . ..
MYQ-IMKQCWHEDPEDRPTFSEI---HECF
Kinase 11434.AA Pkinase 458-523 31 1.3e-10 38.56 Pfam 1-66 (293) Show / Hide 
Range on Protein: 458-523
Range on HMM: 1-66/293
Sequence Identity: 31% (21 aa)

FRVIDELGRGGFGRVYKVQSMVEEKIYAIKKIAVPYDGFSNPKEHKYFREVKSIMSLNHINIVRYH
....  .|.|.||.||| .   ..||.|.|.| .. .  . ...|   .|..   .||| ||||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLY
Kinase 11434.AA Ciliate-E2 458-523 20 3.6e-10 31.11 In-house 1-98 (365) Show / Hide 
Range on Protein: 458-523
Range on HMM: 1-98/365
Sequence Identity: 20% (20 aa)

FRVIDELGRGGFGRVYKVQSMVEEKIYAIKKIAVPY----------DGFS------NPKEHKYFREVKSIM-----------------SLNHINIVRYH
. .|  .|.|.|| |||..   . | .|||.|   .          ...       .... ...  ...||                 .||| ||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY
Kinase 11434.AA STE-Unique 459-531 29 1.7e-09 29.31 In-house 1-76 (616) Show / Hide 
Range on Protein: 459-531
Range on HMM: 1-76/616
Sequence Identity: 29% (23 aa)

RVIDELGRGGFGRVYKVQSMVEEKIYAIKKIAVPYDGFS----NPKEHKYFREVKSIMSLNHINIVRYHTSWWEN-CD
. .. .|||.|| |.. | ..  . .|||.| .  ..|.     |   .  .|. .  .|.| |||.|  .| .. ||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHL--KQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGGCD
Kinase 11434.AA TKL 464-522 23 1.7e-08 26.73 In-house 1-90 (364) Show / Hide 
Range on Protein: 464-522
Range on HMM: 1-90/364
Sequence Identity: 23% (21 aa)

LGRGGFGRVYKVQSMVEE--------KIYAIKKIAVPYDGFSNPKE--------------------HKYFREVKSIMSLN---HINIVRY
.|.|||| ||| . . .         |  |.||. . .| ... ..                    .  |.|.. ||...   | |||..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQF
Kinase 11434.AA CAMK 463-521 17 1.6e-07 19.54 In-house 1-102 (425) Show / Hide 
Range on Protein: 463-521
Range on HMM: 1-102/425
Sequence Identity: 17% (18 aa)

ELGRGGFGRVYKVQSMVEE------------KIYAIKKIAVP---------------YDGF---------SNPKEHKYFREVKSIMS-------LNHINI
.||||.|| |....                 . .||| |                   |           .  .... .||..  ..       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VR
..
IK
Kinase 11434.AA Pkinase_Tyr 655-723 35 3.1e-07 25.13 Pfam 86-158 (270) Show / Hide 
Range on Protein: 655-723
Range on HMM: 86-158/270
Sequence Identity: 35% (26 aa)

LEYCSGKTLRNYLDEQ---THGLDSKEAFQIFSQMLEGVNYLHKNQIIHRDLKPSNILFE-NKIAKIADFGLS
.||. .  |..|| ..    . |. |.  |.  |  .| .||. ...|||||   |.| . |...||.||||.
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 11434.AA CAMKL 458-521 23 7e-06 14.69 In-house 1-79 (297) Show / Hide 
Range on Protein: 458-521
Range on HMM: 1-79/297
Sequence Identity: 23% (19 aa)

FRVIDELGRGGFGRVYKVQS-MVEEKIYAIKKIA--VPY-DGFSNPK---------EHKYFREVKSIMSLN---HINIVR
.|....||.|.|| |   .  .  .. .||| |       | ... .         . . .||..  ..||   | ||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIK
Kinase 11434.AA CAMK 823-850 32 0.02321 2.61 In-house 398-425 (425) Show / Hide 
Range on Protein: 823-850
Range on HMM: 398-425/425
Sequence Identity: 32% (9 aa)

ACELIIQMTSLKPQNRPSIEQILQGKTY
.  || .|    |..|..|||.|. . .
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 11434.AA Pkinase_Tyr 458-474 47 0.27927 4.96 Pfam 1-17 (270) Show / Hide 
Range on Protein: 458-474
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

FRVIDELGRGGFGRVYK
 . . .||.| ||.|||
ITFGKKLGEGAFGEVYK