Gene 21870 (Tetrahymena)

21870

Species: Tetrahymena
Alias: PreTt21870, 117.m00122, 21870, 1066, TTHERM_00726040
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
21870.AA Protein None 1503 None Fasta, JSON
21870.kin_dom Protein Kinase Domain None 361 None Fasta, JSON
21870.NA RNA None 4512 None Fasta, JSON

Protein domain

Protein domains of 21870.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD 21870.AA RWD 63-179 18 5e-14 53.85 SMART 1-128 (128) Show / Hide 
Range on Protein: 63-179
Range on HMM: 1-128/128
Sequence Identity: 18% (24 aa)

VEIEKLRSIYMENMIGLPPEHGY---YRSFQINLFPQQL------KLKYQDENASDQAEFYLFLIFNIPREYPDQMPKVSVKSFK-GFAKQDE--QLLQE
 |.| | |||..... .  .. .    . .||.. |.        .    ..   ....  . | |. |. |||  |........ .......  | ||.
MELEALESIYPDDFECIDEDRHHWVINCCIQIHIHPHEDEMQITNY-D-NFYE-GEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLSDEQKYYQELQK

KLFDYALKN--SGKEMLFDLILQSRDYVESA
.| ... .|  .| .|.|...   ... .. 
HLQEIWEENWCRGMCMIFEWVQWVQEFLSEH
RWD 21870.AA RWD 56-176 21 1.7e-12 48.46 Pfam 1-119 (119) Show / Hide 
Range on Protein: 56-176
Range on HMM: 1-119/119
Sequence Identity: 21% (28 aa)

QLNEALNVEIEKLRSIYMENM----IGLPPEHGYYRSFQINLFPQQLKLKYQDENASDQAEFYLFLIFNIPREYP-DQMPKVS-VKSFKGFA---KQDEQ
  .|... |.| |.|||...     . .  .    ..|.| .            ..... .  | |.|  | .|| |. |..| ... ..     ... |
MCQEEQEDELEALESIYPDDFEDLRGTICWTEISPWHFTIKI-----------DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDYQIQ

LLQEKLFDYALKNS-GKEMLFDLILQSRDYV
 |..|| .|.  |  | .|.|..|   ....
QLCKKLQEYWEENCHGMVMIFEWIEWLQENL
Kinase 21870.AA GCN2 552-912 33 4.4e-184 617.85 In-house 1-511 (511) Show / Hide 
Range on Protein: 552-912
Range on HMM: 1-511/511
Sequence Identity: 33% (172 aa)

FEEIQVLGQGAFGQVVK-VRNKLDGRYYAIKKIKIR-KGQNIEK---LMREVTLLSRLHHRHVLRYYQAWLE----------------------------
||||..||.|.|||||| |||..|||||||||..|. |......    ||||.||.||||.|| ||||||.|                            
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

---------ESNQSEE----EESMGSQMSDQDDD----------------------------NG-----ELSDDRYRYR---------------------
         ..|||||    ||||...||.....                            .|     .|.||.|.|.                     
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWDIESNN

------SNNFSSRYQDNNSS-----------YYDLSSLRN----SQDSSVREQSGKNQENQKYPVTNFKLM---------ILFIQLEYCP-STLSHQIKE
      ..|.....|.||.|           |||...|.|    .|......|..|...||.......|.|         .|.||.|||. .||...|..
VRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDN

LKFQQDTVQIWQYFRQILEGLNYIHSQNTIHRDLKPENIFIDCLGDIKIGDFGLAKS-------------QKQNVFSKYQYVIEKEENELFNQLVNKQYL
.....|....|.|||||||||||||||..||||||| |||.|| |..||||||||..             |.|...|......|......|||...... 
HGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQ

TEKELEAIDQTLNVGTYFYRPPAS-QSMHEERADIYAL-GIIFFEMWFY-FQSKYQRFKVLTILRNNNLFPDQFE---QFHPK-QAKLIAWMLNFSSQKC
.....|....| .|||.||..|.. .|......|.|.| ||||||||.. |.....|...|..|| .. ||..|.   ..|.| |...|.|.||. .||.
WDQQDEQVHHTGKVGTPFYMCPEQQKSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-SCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKR

QKVMEIMQSDLI
.......|....
PSAQQLLQHEFL
Kinase 21870.AA PEK 552-912 23 4e-146 491.76 In-house 1-655 (655) Show / Hide 
Range on Protein: 552-912
Range on HMM: 1-655/655
Sequence Identity: 23% (155 aa)

FEEIQVLGQGAF-GQVVKVRNKLDGRYYAIKKIKIRKGQ-----------------NIEKLMREVTLLSRLHHRHVLRYYQAWLE---------------
|||||.||.|.| |||.||.|||||.|||||.||. . |                  .|| .|||..|.||.|... ||..||.|               
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

-----------------------------------------------------ESNQSEE----EESMGSQMSDQDDDNG--------------------
                                                     |||....    ||||....|...|..                     
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

---------------------------------------ELSDDRYRYR---------------------------SNNFSSRYQDNNSS----------
                                       ..|...|...                           |.......|....|          
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

--------YYDLSSLRN---SQDSSVREQSGKNQENQKYPVTNFKLM---------ILFIQLEYCP-STLSHQIKELK----------------------
        ..| ....|   ....| .........|...  ..|| |         .|.|| |||. .||.. |.. .                      
KKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIM

---------------------FQQDTVQIWQYFRQILEGLNYIHSQNTIHRDLKPENIFIDCLGD-----IKIGDFGLAKS------------QKQNVFS
                      ..|..|.|..||||||||||||||  ||||||| |||.|| |.     .||||||||..            | |. .|
NQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQ-QD-QS

KYQYVIEKEENELFNQLVNKQYLTEKEL---------------EAIDQTLNVGTYFYRPPASQS-------MHEERADIYALGIIFFEMWFY-FQSKYQR
...||........... .|... .....               |....| .|||..|..| ..|       .. ...|.|.|||||||||.. |.. . |
YWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMER

FKVLTILRN-NNLFPDQFE----QF-HPKQAKLIAWMLNFSSQKCQKVMEIMQSDLI
.|.||.||. .. ||..|.    .  .||||..| |||. . |..  ...|.|....
VKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase 21870.AA CMGC 552-789 17 2e-42 136.66 In-house 1-286 (513) Show / Hide 
Range on Protein: 552-789
Range on HMM: 1-286/513
Sequence Identity: 17% (60 aa)

FEEIQVLGQGAFGQVVKVRNKLDG--------------RYYAIKKIKIRKGQNIEKL------------MREVTLLSRL-----------------HHRH
.| |...|.|..|.|.| |.|. .              ...|||||| ..   ....             ||. .| .|                 || .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VLRYYQAWLEESNQSEEEESMGSQMSDQDDDNGELSDDRYRYRSNNFSSRYQDNNSSYYDLSSLRNSQDSSVREQSGKNQENQKYPVTNFKLMILFIQLE
... |     . ....|.|. ..                                                               .  ...  |..  |
IVKLYDIFYHKNSDGNEYEDKHI---------------------------------------------------------------I-SQHFNHLYLVFE

YCPSTLSHQIKELKF-----QQDTVQIWQ---------------YF------RQILEGLN--YIHSQN--TIHRDLKPENIFID----------------
|.. .| . ||. .|     ..      .               ..      .|||.||.  |.||..   |||||||||| |.                
YMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDW

----CLGDIKIGDFGLAKSQKQN---------------------VFSKYQYV
      | .||.|||||..  ..                     .   ..||
NPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYV
Kinase 21870.AA STE 552-777 17 1.2e-40 141.3 In-house 1-196 (359) Show / Hide 
Range on Protein: 552-777
Range on HMM: 1-196/359
Sequence Identity: 17% (49 aa)

FEEIQVLGQGAFGQVVKVRNKL---------------DGRYYAIKKIKIRKG-----------------QNIEKLMREVTLLSRLH--HRHVLRYYQAWL
.| |...|.||||.|.| .|.                 |...|||......                  ........|. ......  | .. .|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EESNQSEEEESMGSQMSDQDDDNGELSDDRYRYRSNNFSSRYQDNNSSYYDLSSLRNSQDSSVREQSGKNQENQKYPVTNFKLM--ILFIQLEYCP-STL
 |..                                                                             .     |.| .||..  .|
KEGHN----------------------------------------------------------------------------HKNDDELWICMEYMDGGSL

SHQIK---ELKFQQD----------TVQIWQYFRQILEG-LNYIHSQNTIHRDLKPENIFIDCLGDIKIGDFGLAKS
.  ||   . .....            ||  . ||||.| |.|.||.. ||||.|| ||..     .|. |||....
DDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQ
Kinase 21870.AA CAMKL 552-775 18 3.5e-40 125.82 In-house 1-176 (297) Show / Hide 
Range on Protein: 552-775
Range on HMM: 1-176/297
Sequence Identity: 18% (48 aa)

FEEIQVLGQGAFGQVVKVRN-KLDGRYYAIKKIKIRKGQNIEKLM---------------REVTLLSRLH---HRHVLRYYQAWLEESNQSEEEESMGSQ
.. ...||.|.||.|   .. .. |. .||| |...| .|... .               ||. ....|.   | .. . |. .  ...           
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEH-----------

MSDQDDDNGELSDDRYRYRSNNFSSRYQDNNSSYYDLSSLRNSQDSSVREQSGKNQENQKYPVTNFKLMI-----LFIQLEYCPST---LSHQIKELKF-
                                                                           ... .|||..    | . |.. .  
---------------------------------------------------------------------DIETKKIYLVMEYCSGGEMDLFDYIVKHGHR

--QQDTVQIWQYFRQILEGLNYIHSQNTIHRDLKPENIFIDCLGD--IKIGDFGLA
    .  .  .|||||....||.||.. .|||.||||| .|. |.  ||| |||..
RGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase 21870.AA S_TKc 552-912 18 1.3e-34 122.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 552-912
Range on HMM: 1-231/231
Sequence Identity: 18% (70 aa)

FEEIQVLGQGAFGQVVKVRNKLDGRYYAIKKIKIRKGQNIEKLMREVTLLSRLHHRHVLRYYQAWLEESNQSEEEESMGSQMSDQDDDNGELSDDRYRYR
.| ....|.||||.| |.|.| .||..|||.||                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

SNNFSSRYQDNNSSYYDLSSLRNSQDSSVREQSGKNQENQKYPVTNFKLMI---LFIQLEYCPS---TLSHQIKELKFQ-----QDTVQIWQYFRQILEG
                         ..  || .   . . .. |. .  .    |.. .|||.    .| . ||. . .      .  ... |..||...
-------------------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCA

LNYIHSQNTIHRDLKPENIFIDCLGDIKIGDFGLAKSQKQNVFSKYQYVIEKEENELFNQLVNKQYLTEKELEAIDQTLNVGTYFYRPPASQSMHEE-RA
|.|.||.. ||||||||||..|    |||.|||||.                                         |  .|| .|..|     .   ..
LEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------------------TTFCGTPWYMAPEVL-GYGKCKC

DIYALGIIFFEMWF---YFQSKYQRFKVLTILRNNNLFPDQFEQFHPKQAK-LIAWMLNFSSQ---KCQKVME----IMQSDLI
|....|.|..||      |.   | .... ...             ...|| .|  .|..  .    . ....    |..   .
DWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21870.AA WEE 552-620 39 1.3e-24 79.54 In-house 1-78 (297) Show / Hide 
Range on Protein: 552-620
Range on HMM: 1-78/297
Sequence Identity: 39% (31 aa)

FEEIQVLGQGAFGQVVKVRNKLDGRYYAIKKIK--IRKGQNIEKLMREVTLLSRLH-------HRHVLRYYQAWLEES
|.|.|..|.| ||.|.|.|...||. |||||.|  .|. .. .   |||  .. |        | |..|||.|| | .
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDD
Kinase 21870.AA HRI 552-622 47 2.6e-24 82.21 In-house 1-73 (613) Show / Hide 
Range on Protein: 552-622
Range on HMM: 1-73/613
Sequence Identity: 47% (35 aa)

FEEIQVLGQGAFGQVVKVRNKLDGRYYAIKKIKI--RKGQNIEKLMREVTLLSRLHHRHVLRYYQAWLEESNQ
||.  ..|.| .|.| |||.|||. .||||||||  |.   . |..|||  |  | |  . || |||.|.  |
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEHVHQ
Kinase 21870.AA PEK 552-619 42 2.2e-23 73.93 In-house 1-77 (758) Show / Hide 
Range on Protein: 552-619
Range on HMM: 1-77/758
Sequence Identity: 42% (33 aa)

FEEIQVLGQGAFGQVVKVRNKLDGRYYAIKKIKIRK---------GQNIEKLMREVTLLSRLHHRHVLRYYQAWLEE
||.||.||.| || | .. ||.|. .||||.|                .|| ||||  |  | |.  .||. ||||.
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLET
Kinase 21870.AA STE-Unique 553-626 32 6.8e-23 77.73 In-house 1-83 (616) Show / Hide 
Range on Protein: 553-626
Range on HMM: 1-83/616
Sequence Identity: 32% (27 aa)

EEIQVLGQGAFGQVVKVRNKLDGRYYAIKKIKIRKGQ--N----IEKLMREVTLLSRLHHRHVLRYYQAWLEE---SNQSEEE
...| .|.|.|| |.. .|| |....|||.|....    |    .... .|......|||  . .||..||..   | || ||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGGCDSFQSLEE
Kinase 21870.AA WEE 702-781 27 7.4e-23 73.56 In-house 79-185 (297) Show / Hide 
Range on Protein: 702-781
Range on HMM: 79-185/297
Sequence Identity: 27% (30 aa)

ILFIQLEYCPS-------TLSHQIKELKFQQDTVQIWQYFRQILEGLNYIHSQ-NTIHRDLKPENIFIDCLG--------------------DIKIGDFG
...|| ||| .        ... ... . ...  .|||....|..||..|||. . .| |.|||||||   .                     .||||||
HMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPE-WMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFG

LAKSQKQN
...... |
HVTDMNSN
Kinase 21870.AA NEK 552-623 35 2.9e-22 75.48 In-house 101-180 (286) Show / Hide 
Range on Protein: 552-623
Range on HMM: 101-180/286
Sequence Identity: 35% (28 aa)

FEEIQVLGQGAFGQVVKVRNKLDGRY-----YAIKKIKIRKG--QNIEKLM-REVTLLSRLHHRHVLRYYQAWLEESNQS
.|.|...|||.||.| ||| | ||.      |..|||.. .   .. ....  || .|..|.| .. .|| ...|| |..
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNC
Kinase 21870.AA NEK 703-781 33 1.3e-21 73.18 In-house 81-176 (286) Show / Hide 
Range on Protein: 703-781
Range on HMM: 81-176/286
Sequence Identity: 33% (33 aa)

LFIQLEYCPS--TLSHQ---IKELK-----FQQDTVQIWQYFRQILEGLNYIHSQ-----NTIHRDLKPENIFIDCLGD----IKIGDFGLAKSQKQN
|.|  |||    .|. .   ||. |     |. .  ||| .| |.. .|.|.|..     . .|||.|| |||..  .     .||||||..| ....
LCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEE--QIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHT
Kinase 21870.AA Pkinase 733-776 64 8.2e-20 71.14 Pfam 113-160 (293) Show / Hide 
Range on Protein: 733-776
Range on HMM: 113-160/293
Sequence Identity: 64% (31 aa)

YFRQILEGLNYIHSQNTIHRDLKPENIFIDCLGDI----KIGDFGLAK
|..|||.||.|.||.. ||||||||||.||  |.|    ||.||||||
YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase 21870.AA STE-Unique 729-777 50 2.3e-18 61.4 In-house 404-459 (616) Show / Hide 
Range on Protein: 729-777
Range on HMM: 404-459/616
Sequence Identity: 50% (28 aa)

QIWQYFRQILEGLNYIHSQN--TIHRDLKPENIFIDCLG-----DIKIGDFGLAKS
..  | .||||||.|.|||    ||||||| |||..  |      .||.|||.|..
EVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATC
Kinase 21870.AA PEK 734-776 41 2.7e-16 49.74 In-house 448-514 (758) Show / Hide 
Range on Protein: 734-776
Range on HMM: 448-514/758
Sequence Identity: 41% (28 aa)

FRQILEGLNYIHSQNTIHRDLKPENIFIDCLGD------------------------IKIGDFGLAK
| ||.||.|||||   ||||||| |||    ..                        ||||||||..
FHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLVT
Kinase 21870.AA Pkinase 552-621 26 5.3e-16 57.65 Pfam 1-74 (293) Show / Hide 
Range on Protein: 552-621
Range on HMM: 1-74/293
Sequence Identity: 26% (20 aa)

FEEIQVLGQGAFGQVVKVRNKLDGRYYAIKKIKIRKGQNIEKLMR-----EVTLLSRLHHRHVLRYYQAWLEESN
.. ....|.|.||.| | ..| .|. .|.|.|| | ... .|...     |. .. ||.| ...|.| .. ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDH
Kinase 21870.AA HRI 730-775 50 1.3e-15 50.85 In-house 435-484 (613) Show / Hide 
Range on Protein: 730-775
Range on HMM: 435-484/613
Sequence Identity: 50% (25 aa)

IWQYFRQILEGLNYIHSQNTIHRDLKPENIFIDCLGD----IKIGDFGLA
| . | ||.||..|||    .|||.|| |||     .    .||||||||
IQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLA
Kinase 21870.AA PEK 840-893 36 8.2e-14 41.32 In-house 686-739 (758) Show / Hide 
Range on Protein: 840-893
Range on HMM: 686-739/758
Sequence Identity: 36% (20 aa)

DIYALGIIFFEMWFY-FQSKYQRFKVLTILRNNNLFPDQFEQFHPKQAKLIAWML
|||.||.||||. .. |     | .....|||   .|  | | .|.....| .|.
DIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQ-WPKWFTQKYPQEYEFIQQMM
Kinase 21870.AA TyrKc 552-848 13 1.6e-10 -52.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 552-848
Range on HMM: 1-280/280
Sequence Identity: 13% (52 aa)

FEEIQVLGQGAFGQVVKVRNKLDGRYYAIKKIKIRKGQNIEKLMREVTLLSRL--HHRHVLRYYQAWLEE-------SNQSE-----EEESMGSQMSDQD
 . ...|| ||||.|.| . |   .  |.|..|  .   .| .|||  ....|  || ...| | . ...                 .  .  .   .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

DDNGELSDDRYRYRSNNFSSRYQDNNSSYYDLSSLRNSQDSSVREQSGKNQENQKYPVTNFKLMILFIQLEYCPSTLSHQIKELKFQQDTVQIWQYFRQI
..                                                                                       . .  ..  ||
PK-------------------------------------------------------------------------------------LCMKDLLSFCWQI

LEGLNYIHSQNTIHRDLKPENIFIDCLGDIKIGDFGLAKSQKQN----VFSKYQYV----IEK-------------EEN----------------ELFNQ
 .| .|.||.| |||||   |. ..  . .||.||||..  .      . ..|  .     .|              ..                |.|  
ACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFT-

LVNKQYLTE----KELEAIDQTLNVGTYFYRPPA---------SQSMH-----------EERADIYALGIIF
.  . |  .    .. . . . .  | .  .||          .. |.           |.|    ..  .|
YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 21870.AA Pkinase_Tyr 552-613 27 3.5e-09 31.73 Pfam 1-70 (270) Show / Hide 
Range on Protein: 552-613
Range on HMM: 1-70/270
Sequence Identity: 27% (21 aa)

FEEIQVLGQGAFGQVVKVRNKLDGRYY----------AIKKIKIRKGQN---IEKLMREVTLLSRL-HHRHVLRYY
 . ...||.||||.|.|      |...          |.|..|    .    .|..|||. ... | || ...|.|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase 21870.AA HRI 840-912 28 6e-06 16.09 In-house 542-613 (613) Show / Hide 
Range on Protein: 840-912
Range on HMM: 542-613/613
Sequence Identity: 28% (21 aa)

DIYALGIIFFEMWFYFQSKYQRFKVLTILRNNNLFPDQFEQFHPKQAKLIAWMLNFSSQKCQKVMEIMQSDLI
| | .|.| ||..  |     | .||| .|   . |.      | ||| |  .    . .    . ..||.| 
DMYSMGVILFELFQPFGTEMERAEVLTGVRTGQI-PESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase 21870.AA Pkinase_Tyr 739-776 44 0.000265 15.2 Pfam 122-159 (270) Show / Hide 
Range on Protein: 739-776
Range on HMM: 122-159/270
Sequence Identity: 44% (17 aa)

EGLNYIHSQNTIHRDLKPENIFIDCLGDIKIGDFGLAK
.|..| .|.| |||||   |. ... . .||.|||||.
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 21870.AA STE-Unique 835-889 17 0.000554 9.38 In-house 530-593 (616) Show / Hide 
Range on Protein: 835-889
Range on HMM: 530-593/616
Sequence Identity: 17% (11 aa)

HEERADIYALGIIFFEMWFYFQSKYQRFKV--LTILRNNNLFPDQ-------FEQFHPKQAKLI
.  ..||. ||...|.| . ..   ||.    .  ..... ..         .... | |. .|
YDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFI
Kinase 21870.AA Pkinase 821-851 26 0.027653 9.16 Pfam 172-205 (293) Show / Hide 
Range on Protein: 821-851
Range on HMM: 172-205/293
Sequence Identity: 26% (9 aa)

VGTYFYRPP---ASQSMHEERADIYALGIIFFEM
.||..|..|    .....  ..|....|.|..||
CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 21870.AA STE 837-851 40 0.279025 0.43 In-house 247-261 (359) Show / Hide 
Range on Protein: 837-851
Range on HMM: 247-261/359
Sequence Identity: 40% (6 aa)

ERADIYALGIIFFEM
...||. ||.   ||
TKCDIWSLGCTIIEM