Gene 19858 (Tetrahymena)

19858

Species: Tetrahymena
Alias: 3830.m00511, 68.m00147, 19858, PreTt19858, 123, TTHERM_00532000
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: TLK

Sequence

Name Sequence Type Origin Length Description Download
19858.AA Protein None 972 None Fasta, JSON
19858.kin_dom Protein Kinase Domain None 271 None Fasta, JSON
19858.NA RNA None 2919 None Fasta, JSON

Protein domain

Protein domains of 19858.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19858.AA TLK 697-967 68 1.3e-230 772.41 In-house 1-285 (285) Show / Hide 
Range on Protein: 697-967
Range on HMM: 1-285/285
Sequence Identity: 68% (195 aa)

YQLLSLLGRGGFSEVYKAYDLHEFKEVACKIHQLNLNWSEPSKANYIKHAVRESKIHSELKHANIVQLYDTVEIDNNSFATILEYCEGPDLYFYLKKHKV
||||.|||.|||||||||.|||||..|||||||||.||.|..||||||||.||.|||.||.|..||.|||..|||||||.|.||||||.||.||||.||.
YQLLHLLGKGGFSEVYKAFDLHEFRYVACKIHQLNKNWKEEKKANYIKHACREYKIHKELDHCRIVKLYDYFEIDNNSFCTVLEYCEGNDLDFYLKQHKT

LPEKEAKILIRQILCALRYMNSLKTRIIHYDLKPQNIIFHKG----ELKISDFGLSKIFDDGQTR----MELTSQGVGTYWYLPPETFE------FENSA
.|||||...|.||.|.|.|.|..|..||||||||||||||||    |.||.|||||||.||.|.|    |||||||.|||||||||.|.      |||..
MPEKEARCIIMQIVCCLKYLNEIKPPIIHYDLKPQNIIFHKGNTCGEIKITDFGLSKIMDDEQYRHDHGMELTSQGAGTYWYLPPECFVVGKCEEFENPP

LISPKVDIWSVGVIFFEMVFGQRPFGNNKSQDQILKENIILKSTSVTFPSKPSVSNECKDFIRNCLTYDQNRRWDIQKAWDSPYM
.||.|||.|||||||.....||.|||.|.||.|||..|.|||.|.|.|||||.||||||||||.||.|.|..|||.|..|..|||
KISCKVDVWSVGVIFYQCLYGQKPFGHNMSQQQILEQNTILKATEVQFPSKPQVSNECKDFIRRCLQYRQEDRWDVQQLWNHPYM
Kinase 19858.AA S_TKc 697-967 31 1.3e-82 281.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 697-967
Range on HMM: 1-231/231
Sequence Identity: 31% (90 aa)

YQLLSLLGRGGFSEVYKAYDLHEFKEVACKIHQLNLNWSEPSKANYIKHAVRESKIHSELKHANIVQLYDTVEIDNNSFATILEYCEG--PDLYFYLKKH
|..| ..|.|.|..|||... .  ..||.||                .|. || .|... .| |||.|||. .   ...  ..|||.|   ||. |.||.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

KV------LPEKEAKILIRQILCALRYMNSLKTRIIHYDLKPQNIIFHKGELKISDFGLSKIFDDGQTRMELTSQGVGTYWYLPPETFEFENSALISP-K
.       .|| .|. ...||.||| |. |.  .||| ||||.|| . . ..||.||||....          .  .|| ||..|| .        .. |
GRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-HIKICDFGLARQL----------TTFCGTPWYMAPEVL------GYGKCK

VDIWSVGVIFFEMVFGQRPFGNNKSQDQILKENIILKSTSVTFPSKPSVSNECKDFIRNCLTYDQNRRWDIQKAWD-------SPYM
.|.||.|.|..||. |. ||     |.| . ..|               | |.|||||.||..| ..|. . .|          |..
CDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19858.AA Pkinase 697-967 31 9.9e-68 236.12 Pfam 1-293 (293) Show / Hide 
Range on Protein: 697-967
Range on HMM: 1-293/293
Sequence Identity: 31% (98 aa)

YQLLSLLGRGGFSEVYKAYDLHEFKEVACKIHQLNLNWSEPSKANYIKHAVR--ESKIHSELKHANIVQLYDTVEIDNNSFATILEYCEGP----DLYFY
|.... .|.|.|..|||...  . |.||.||  .     .  | .  ....|  | .|. .|.| |||.|||..|  ...   ..|||||     ||. |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKK-----RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY

LK--KHKVL--PEKEAKILIRQILCALRYMNSLKTRIIHYDLKPQNIIFH-KGEL----KISDFGLSKIFDDGQTRMELTSQGVGTYWYLPPETFEFENS
..  .|...  .|.|.|  ..|||..| |. |   .||| ||||.|| .. .|..    ||.||||.| ||    . . ..  .||.||..||      .
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR--GG

ALISPKVDIWSVGVIFFEMVFGQRPFGNN----KSQDQILKENIILK-STSVTFPSKPSVS-----------------NECKDFIRNCLTYDQNRRWDIQ
  ..||||.||.|.|..||..|. || .     .  ||. . . |..  ..  .| . |.|                  ||||||..||..| ..|. ..
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

KAWDSPYM
 .  .|..
QILQHPWF
Kinase 19858.AA Ciliate-E2 697-967 24 1.4e-65 224.09 In-house 1-365 (365) Show / Hide 
Range on Protein: 697-967
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

YQLLSLLGRGGFSEVYKAYDLHEFKEVA----------------CKIHQLNLNWSEPSKANYIKHAVRESK-------------IHSELKHANIVQLYDT
| .. ..|.|.|. |||. .  . |..|                .|| . ...  .... ..||   .. .             | ..|.| ||...|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VE-IDNNSFATILEYCEGPDLYFYLKKH-----------KVLPEKEAKILIRQILC---------------ALRYMNSLKTRIIHYDLKPQNIIFHKGEL
 . .|.|..  ..|||.| ||. |.|..           | . |||.| ...|||                ||.|. | .  ||| |.||.||.|    .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF----I

KISDFGLSKIFDD-------GQTRMELTSQG----------------------VGTYWYLPPETFEFEN------SALISPKVDIWSVGVIFFEMVFGQR
||.||||||..||       .| . ...  .                      .||. |..|| .. ..      .   . |.||||.|||..||.||..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFGNNKSQDQILKENIILKSTSVTFP----------------SKPSVSNECKDFIRN----CLTYDQNRRWD-IQKAWDSPYM
||             .. |   . ||                |. ..|.||||.|..    .| .|.. | . .... . |..
PF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19858.AA ULK 697-967 31 2.6e-62 213.35 In-house 1-324 (324) Show / Hide 
Range on Protein: 697-967
Range on HMM: 1-324/324
Sequence Identity: 31% (103 aa)

YQLLSLLGRGGFS-EVYKAYDLHEF---KEVACKIHQLNLNWSEPSKA--NYIKHAVR-ESKIHSELK---HAN--IVQLYDTVEIDN-NSFATILEYCE
|.|   || | |   |||...       . ||||. ...     ....  .|..   . | .|  .||   | |  ||.|||  | .| | .  |.|||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GPDLYFYLKKHKV---------LPEKEAKILIRQILCALRYMNSLKTRIIHYDLKPQNIIFHKGE-------------LKISDFGLSKIFDDGQTRMELT
| ||  |.||.|          |.|.||.. ..||. ....... .  ||| |.|||||  |.|              |||.|||..|..|...    ..
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

SQGV------GTYWYLPPETFEFE--NSALISPKVDIWSVGVIFFEMVFGQRPFGNNKSQDQI-----LKEN-----IILKSTSVTFP---SKPSVSNEC
 . |      ||  |  |. .. .  .    . |.||||.|.||.||..|. || ..  .||.     |..|     |. | . . ||   . | .|.||
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

KDFIRNCLTYDQNRRWDIQKAWDSPYM
||.|| .|.||.. | ...   . | .
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 19858.AA ULK 697-967 31 1.6e-61 210.74 In-house 1-329 (329) Show / Hide 
Range on Protein: 697-967
Range on HMM: 1-329/329
Sequence Identity: 31% (103 aa)

YQLLSLLGRGGFSEVYKAYDLHE----FKEVACKIHQLNLNWSEPSKA--NYIKHAVR-ESKIHSELK--------HANIVQLYDTVEIDN-NSFATILE
|.|   || | |  |||...        . ||||. ...    ..  .  .|..  .. | ||  .||        | |||.|||  | .| | .  |.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEGPDLYFYLKKHKV----------LPEKEAKILIRQILCALRYMNSLKTRIIHYDLKPQNIIFHKGE-------------LKISDFGLSKIFDDGQTR
||.| ||  |.||.|           |.|.||.. ..||| ....... .  ||| |.|||||  |.|              |||.|||..| .|...  
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

MELTSQGV------GTYWYLPPETFEFE--NSALISPKVDIWSVGVIFFEMVFGQRPFGNNKSQDQI---LKENII--------LKSTSVTFP---SKPS
 ...   |      ||  |  |. .. .  .    . |.||||.|.||.||..|. || ..  .||.   ....|          |..   ||   ..| 
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

VSNECKDFIRNCLTYDQNRRWDIQKAWDSPYM
.|.||||.|| .|.||.. | ...   . | .
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 19858.AA CAMK 702-967 21 3.3e-60 192.39 In-house 1-425 (425) Show / Hide 
Range on Protein: 702-967
Range on HMM: 1-425/425
Sequence Identity: 21% (91 aa)

LLGRGGFSEVYKAYDL-HEF-----------KEVACKI-----HQLN----------LNWSEPSK------ANYIKHAVRESKIHSE-------LKHANI
 ||||.|..|.....                ..||.||     .. .          .. |....      ..  |   || .|..        |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDTVE------------IDNN-------SFATIL---EYCEGP----DLYFYLKKH---------------KVLPEKEAKILIRQILCALRYMNSLK
..||.. |              ..        .  ..   |||.|     ||. |...|               . ..|.||. ..|||..|..|. |..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

TRIIHYDLKPQNIIF-HK-----------------GELKISDFGLSKIFDDGQ--------------------TRMELTSQGVGTYWYLP-PETFEF---
  |.| |||| || . ..                 . .||.|||....||.|.                    |  .. .  .||  | . || ..    
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

--------ENSALISPKVDIWSVGVIFFEMVFGQRPFGNNKSQDQI-----------LKENIILKSTSVTFPS------------KPSVSNE--------
        |.   ..||.|.||.||| . |. |  ||   . ....           |.|.|.    .   |               ..|.|        
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

CKDFIRNCLTYDQNRRWDIQKAWDSPYM
|||.||..|..| ..|. |. . . | |
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 19858.AA Ciliate-E2-Unclassified 697-967 24 3.4e-59 202.98 In-house 1-352 (352) Show / Hide 
Range on Protein: 697-967
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

YQLLSLLGRGGFSEVYKAYDLHEFKEV-----ACKIHQLNLNWSEPSKANYIKHAVRESKIH---------------SELKHANIVQLYDTVEIDNNSFA
| ..  .|.|||..|||...  .  ..     ..||.. . .  . .. ...  . .. ..                . ..| .|| .... . ..| . 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN-IY

TILEYCEGPDLYFYLKKHKV-----------------LPEKEAK-----ILIRQILCALRYMNSLKTRIIHYDLKPQNIIFHKG----ELKISDFGLSKI
 ..||||| || .|.|| |                  ..|..||      ...|||..| |. . .  |||.|.||.||.|...    ..||.|||.|| 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

FDD------------GQTRMELTSQGVGTYWYL----PPETFEFENSALIS-PKVDIWSVGVIFFEMVFGQRPF-GNNKSQDQ-------------ILKE
 ..            .... ..... .||. |.    .|| .. .|    .  |.||||.|||..||.||..|| .||. |.|             .|..
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

NIILKSTSVTFPSK----PSVSNECKDFIR----NCLTYDQNRRWDIQKAWDSPYM
||. | ...   ..      .|.|.||||.     .| ...| | .....   |..
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 19858.AA CAMKL 697-967 29 2.5e-50 158.71 In-house 1-297 (297) Show / Hide 
Range on Protein: 697-967
Range on HMM: 1-297/297
Sequence Identity: 29% (91 aa)

YQLLSLLGRGGFSEVYKAYD-LHEFKEVACKIHQLNLNWSEPSKANY-----------IKHAVRESKIHSELK---HANIVQLYDTVEIDNN-----SFA
|...  ||.|.|..|  | . ..  ..|| ||   .  | .| . .            |.   || .|.. |.   | ||..||...| ...      . 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIR---REIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY

TILEYCEGPD--LYFYLKKH----KVLPEKEAKILIRQILCALRYMNSLKTRIIHYDLKPQNIIFH-KG--ELKISDFGLSKIFDDG-QTRMELTSQGVG
 ..|||.| .  |. |..||    . .||.||. . |||..|. |. |..  |.| |.|| || .  .|   .||.|||.| .....  .. .. .   |
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG

TYWYLPPETFEFENSALISPKVDIWSVGVIFFEMVFGQRPFGNNKSQ----DQILKENIILKSTSVTFPSKPSVSNECKDFIRNCLTYDQNRRWDIQKAW
.. | .|| |.  |   . ||||||| ||| . ||.|. || .   .    | | ..  . ...   .|  ..|| .|.|.||  |. . ..|  |.   
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

DSPYM
  | |
NHPWM
Kinase 19858.AA TKL 703-955 18 4.2e-43 149.53 In-house 1-354 (364) Show / Hide 
Range on Protein: 703-955
Range on HMM: 1-354/364
Sequence Identity: 18% (68 aa)

LGRGGFSEVYKA-YDLHE-------FKEVACKIHQL--NLNWSEPSKAN------------------YIKHAVRESKIHSELKHANIVQLYDTVEIDNN-
.|.|||.||||. .  .         |.|| |.     . .... |. |                  . .. ..| ...| |.| ||||..  .   .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------SFATILEYCEGPDLYFYLKKHKVLPEKEAKILIRQILCALRYMNSLK------TRIIHYDLKPQNIIFHK-GE--------------LK
            .. . |||.| .|. ||             ....| ... |. | .        ||| |||..||  .. ..              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ISDFGLSKIFDD--GQTRME--------------LTSQGVGTYWYLPPETFE----FENSA---------LISPKVDIWSVGVIFFEMVFGQRPFGNNKS
|.|||||. ..   ......               |.  .||. ...|| ..    ... .           |.|.|..| |....|.. ..||. ....
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

QDQILK-------ENIILKSTSVTFP----------SKPSVSNECKDFIRNCLTYDQNRR
 ..|.        . ...|.   . |            |..  . |. .  |  .| . |
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase 19858.AA STE 697-967 21 1e-42 148.2 In-house 1-359 (359) Show / Hide 
Range on Protein: 697-967
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

YQLLSLLGRGGFSEVYKAYDLH-----EFKEV--------ACKIHQLNLNWSEPSKAN-------------YIKHAVRESKIHSELK--HANIVQLYDTV
..... .|.|.| .||||.. .     . .||         . | |.||. ..... .              ..   .| ||.....  | |||. |.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EID------NNSFATILEYCEGPDLYFYLK-KHKV-------------LPEKEAKILIRQILCA-LRYMNSLKTRIIHYDLKPQNIIFHKGELKISDFGL
. .      ...   ..||..|  |   .| |...             .||.. .. .|||| . | |  |..  ||| |.||.|| .     |..|||.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL----VKLCDFGV

SKIFDDG-------------QTRMELTSQGVGTYWYLPPETFEFEN---SALISPKVDIWSVGVIFFEMVFGQRPFGN-NKSQDQILKENI---------
.....|              .|. . .   |||  .  ||  . ..   .   . |.||||.|    ||. |. |. . .  .   .. .          
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

--ILKSTSVTFPS-----------------KPSVSNECKDFIRNCLTYDQNRRWDIQKAWD--SPYM
  |.. .. ..|.                 . ..| |.||||..||..| | |.. ..      |  
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 19858.AA CMGC 697-907 22 1.4e-40 130.41 In-house 232-573 (513) Show / Hide 
Range on Protein: 697-907
Range on HMM: 232-573/513
Sequence Identity: 22% (80 aa)

YQLLSLLGRGGFSEVYKAYD-------------LHEFKE-VACKIHQLN-LNWSEP---SKANYIKHAVRESKIHSELK-----------------HANI
|. .. .|.| ...|||..|             .|| .| || |.  ..   . .     | .  . | || ||  .|.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQLYDTVEIDN----------------NSFATILEYCEGPDLYFYLKKHK---------VLPEKE------------AKILI------RQILCALR--YM
|.||| .  .|                |..  . ||..  ||| |.|...          |.| .             | ..      .|||..|   |.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

NSLKTRIIHYDLKPQNIIFHK---------------------GELKISDFGLSKIFDDGQTR------------------MELTSQGVGTYWYLPPETFE
 | . .||| ||||.|| . .                     |.||| ||||...... .                    ..  .. | | || .||   
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI--

FENSALIS--------------PKVDIWSVGVIFFEMVFG-------QRPF
     |..              ...|.|||| ||.||. |        .|.
-----LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase 19858.AA TyrKc 697-962 24 2.2e-14 9.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 697-962
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

YQLLSLLGRGGFSEVYKAYDLHEFKEVACKIHQLNLNWSEPSKANYIKHAVRESKIHSEL--KHANIVQLYDTVEIDN------NSFATILEYCEGPDLY
 .|.  ||.| | ||||.       .|| |  . .           ..   || .| ..|  .| |||.||  .  .            ..||... || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

FYLKKHKV-LPEKEAKILIRQILCALRYMNSLKTRIIHYDLKPQNIIFHKGE-LKISDFGLSKIFDDG--------QTRMELTSQGV--GTYWYLPPETF
 ||.||.  |. |.      || |  .|  |   ..|| ||   |.  ...   ||||||||.  .|.          |.  ...|     .  ..||..
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EFENSALISPKVDIWSVGVIFFEMV-FGQRPFGNNKSQDQILKENIILKSTSVTFPSKPSV---------SNECKDFIRNCLTYDQNRR---WDIQKAW
   |    ..| |.|| ||  .|.  .|| |  .   |  .  . .| .  .   . .|           . |  . .. |  .| . |   ..| . .
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 19858.AA CMGC 930-967 15 3e-06 15.63 In-house 444-513 (513) Show / Hide 
Range on Protein: 930-967
Range on HMM: 444-513/513
Sequence Identity: 15% (11 aa)

FPSKPS--------------------------------VSNECKDFIRNCLTYDQNRRWDIQKAWDSPYM
|| .|                                  . .. |.. ..|.|| ..|. .. | . || 
FPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF