Gene 4269 (Tetrahymena)

4269

Species: Tetrahymena
Alias: PreTt04269, TTHERM_00494350, 3711.m00103, 4269, 417, 61.m00256
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: TLK

Sequence

Name Sequence Type Origin Length Description Download
4269.AA Protein None 856 None Fasta, JSON
4269.kin_dom Protein Kinase Domain None 277 None Fasta, JSON
4269.NA RNA None 2571 None Fasta, JSON

Protein domain

Protein domains of 4269.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 4269.AA TLK 577-853 61 2.5e-229 768.17 In-house 1-285 (285) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-285/285
Sequence Identity: 61% (175 aa)

YQLLSLLGKGGFSEVYKAIDLEEFREVAIKIHYIDKSWSNRVKQNYLKHAFREHGIQKELNHPNIVKLYDYIEIDSTSFASVLQFCEGPDLSQHLKIHST
||||.|||||||||||||.||.|||.||.|||...|.|....|.||.|||.||..|.|||.|..|||||||.|||..||..||..|||.||...||.|.|
YQLLHLLGKGGFSEVYKAFDLHEFRYVACKIHQLNKNWKEEKKANYIKHACREYKIHKELDHCRIVKLYDYFEIDNNSFCTVLEYCEGNDLDFYLKQHKT

IIEQDAKYIVKKILECLEYLSSFQSKVIHYDLKPQNIIFHKG----QIKITDFGLSKIIEDNATR----LELTSQGVGTYWYLPPECFENFGCEENEKAP
..|..|..|...|..||.||.......|||||||||||||||    .|||||||||||..|...|    .||||||.|||||||||||....|||.|..|
MPEKEARCIIMQIVCCLKYLNEIKPPIIHYDLKPQNIIFHKGNTCGEIKITDFGLSKIMDDEQYRHDHGMELTSQGAGTYWYLPPECFVVGKCEEFENPP

TISNKVDIWSVGVIFYEMLFGQKPFGNKMTQEQILRQNTILNSKEVKFPKKPLISKEAQSFIIGCLKHNQEERFDVKQALNHPYF
.||.|||.||||||||..|.||||||..|.|.|||.|||||...||.||.||..|.|...||..||...||.|.||.|..||||.
KISCKVDVWSVGVIFYQCLYGQKPFGHNMSQQQILEQNTILKATEVQFPSKPQVSNECKDFIRRCLQYRQEDRWDVQQLWNHPYM
Kinase 4269.AA S_TKc 577-853 30 2.7e-76 260.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-231/231
Sequence Identity: 30% (90 aa)

YQLLSLLGKGGFSEVYKAIDLEEFREVAIKIHYIDKSWSNRVKQNYLKHAFREHGIQKELNHPNIVKLYDYIEIDSTSFASVLQFCEG--PDLSQHLKIH
|..| ..|||.|..|||... .  |.|||||                .|. ||  | |. .|||||||||...   ...  |. .|.|   || ...| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

ST------IIEQDAKYIVKKILECLEYLSSFQSKVIHYDLKPQNIIFHKGQIKITDFGLSKIIEDNATRLELTSQGVGTYWYLPPECFENFGCEENEKAP
 .      . | .|..... |.. |||. |   ..|| ||||.|| . . .|||.||||....          .  .|| ||..|| .            
GRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-HIKICDFGLARQL----------TTFCGTPWYMAPEVL------------

TISN-KVDIWSVGVIFYEMLFGQKPFGNKMTQEQILRQNTILNSKEVKFPKKPLISKEAQSFIIGCLKHNQEERFDVKQALN-------HPYF
  .  |.|.||.|.|.|||| |. ||    ........                 |.|| .|| .||. . |.|  . .||.       ||.|
GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 4269.AA Ciliate-E2 577-853 26 1.6e-64 220.44 In-house 1-365 (365) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-365/365
Sequence Identity: 26% (101 aa)

YQLLSLLGKGGFSEVYKAIDLEEFREVAIKIHYIDKSWSN---------------RVKQNYLKHAFREHGIQKELN----------------HPNIVKLY
| .. ..|.|.|. |||. . .. ...|||| . .|. .                ..|.| ... ..|  | .|.|                ||||.|.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DYIE-IDSTSFASVLQFCEGPDLSQHLKIHSTII-----------EQDAKYIVKKILE---------------CLEYLSSFQSKVIHYDLKPQNIIFHKG
.. . .| ...  |. .|.| || ...|....             |. .||| |.||.               .|||| |  . .|| |.||.||.|   
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF---

QIKITDFGLSKIIEDN-------ATRLELTSQG----------------------VGTYWYLPPECFENFGCEENEKAPTISNKVDIWSVGVIFYEMLFG
 |||.||||||.. |.         . ...  .                      .||. |..|| ... . . ..|    . |.||||.|||.||||||
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

QKPFGNKMTQEQILRQNTILNSKE---------VKFPK-KPLISKEAQSFIIG----CLKHNQEERFD-VKQALNHPYF
. ||     |.||. ..  ....|         .|  | .  .|.|.. .|      .|. ..|.|..  .|.||||.|
KPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKW-KSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 4269.AA Pkinase 577-853 29 3.9e-63 220.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-293/293
Sequence Identity: 29% (94 aa)

YQLLSLLGKGGFSEVYKAIDLEEFREVAIKIHYIDKSWSNRVKQNYLKHAFR--EHGIQKELNHPNIVKLYDYIEIDSTSFASVLQFCEGP----DLSQH
|.... .|.|.|..|||...  . ..||.||   ..      | . .....|  |  | |.|||||||.|||. |  ...   |. .|||     ||. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRH-----EKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY

LK--IHSTI--IEQDAKYIVKKILECLEYLSSFQSKVIHYDLKPQNIIFH-KGQI----KITDFGLSKIIEDNATRLELTSQGVGTYWYLPPECFENFGC
..   | ..   |...| ... ||. |||. |   ..|| ||||.|| .. .|.|    ||.||||.| ..    . . ..  .||.||..||       
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR----

EENEKAPTISNKVDIWSVGVIFYEMLFGQKPFGNK-----MTQEQILRQNTI--LNSKEVKF---------------PKKPLISKEAQSFIIGCLKHNQE
    ... .. |||.||.|.|.||||.|. || ..     ..| |.....    | . . .                .. ...|.|...|| .||. . .
----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPK

ERFDVKQALNHPYF
.|   .|.|.||.|
KRPTAEQILQHPWF
Kinase 4269.AA CAMK 582-853 20 1.5e-54 173.8 In-house 1-425 (425) Show / Hide 
Range on Protein: 582-853
Range on HMM: 1-425/425
Sequence Identity: 20% (87 aa)

LLGKGGFSEVYKAIDL-EEF-----------REVAIKI---------------------HYIDKSWSNRVKQNYLKHAFREHGIQKE-------LNHPNI
 ||.|.|..|...|.                ..|||||                     .   |. ....... .|  .||  | |        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYDYIE------------IDST-SFAS-------VL---QFCEGP----DLSQHLKIH---------------STIIEQDAKYIVKKILECLEYLSSF
.|||...|              |.  | .       |.    .|.|     || .... |                 . |..|..... |.. ..|. | 
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

QSKVIHYDLKPQNIIF-HK-----------------GQIKITDFGLSKIIEDNATRL--------------------ELTSQGVGTYWYLP-PECFENFG
   ..| |||| || . ..                 ..|||.|||........   .                    .. .  .||  | . || ..  |
N--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

CEENEKAPT------ISNKVDIWSVGVIFYEMLFGQKPFGNK----------------MTQEQILRQNTILNSKEVK-----------------FPKKPL
. ... | |      .. |.|.||.||| | || |  ||  .                 . |.|.. .    .....                 | ..  
HCNMQNA-TDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF-HH-F

ISKEAQSFIIGCLKHNQEERFDVKQALNHPYF
.|.|....| ..|. . |.|. ..|.|||| .
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 4269.AA Ciliate-E2-Unclassified 577-853 26 1.6e-54 187.46 In-house 1-352 (352) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-352/352
Sequence Identity: 26% (95 aa)

YQLLSLLGKGGFSEVYKAIDLEEFREV-----AIKIHYIDKSWSNRV--------KQNYLKHAFREH---GIQKE--LNHPNIVKLYDYIEI-DSTSFAS
| ..  .|.|||..|||... ..  ..     ..||. ...   ...          | .|. .       | ..  ||||........ .  |   .  
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VLQFCEGPDLSQHLKIHST-----------------IIEQDAK-----YIVKKILECLEYLSSFQSKVIHYDLKPQNIIFHKG----QIKITDFGLSKII
|...||| ||.|..|. ..                 . || ||     .. . ||..|||| . . ..||.|.||.||.|...    .|||.|||.|| .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

EDN------------ATRLELTSQGVGTYWYL----PPECFENFGCEENEKAPTISNKVDIWSVGVIFYEMLFGQKPFG-------NKMTQEQILR----
..|             .. ..... .||. |.    .||.... . ..         |.||||.|||.||||||. ||.       .......|      
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-----YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYR

--QNTILNSKEVKFPKKPL------ISKEAQSFII----GCLKHNQEERFDVKQALNHPYF
  .  . . |...||| |       .|.||. ||      .|| |...| . .|.||||.|
KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 4269.AA AGC 577-853 21 2.1e-53 135.34 In-house 1-395 (395) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-395/395
Sequence Identity: 21% (91 aa)

YQLLSLLGKGGFSEVYKAIDL------EEFREVAIKIHYIDKS-WSNRVKQNYLKHAFRE------------HGIQKELN----------HPNIVK-LYD
...| ..|||.|..|| . .          .  |.|.  ..|. .  . |.| ..|. .|              | ...|          ||.||| |. 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKV--LKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILH-

YIEIDSTS--FASVLQFCE----------GPDLSQHLK---IHSTIIEQDAKYIVKK-------ILECLEYLSSFQS-K-VIHYD-LKPQNIIFHK-GQI
|   | .      |.....          | .| .||.      .  |. |...          |. .||||    | . .|| | ||| || . . | |
YSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYL---HSHMGIIHRDYLKPENILLDEDGHI

KITDFGLSKIIEDN---------------------------------------------ATRLE---LTSQGVG--TYWYLPPECFENFGCEENEKAPTI
|.|||||.|.. ..                                              || .   .|.  .|  |  |..|| .              
KLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKRDRTWTFCGPCTPEYMAPEIL-------------Y

SNKVDIWS--VGVIFYEMLFGQKPFGNKMTQ-------EQILRQNTILN-----SKEVKFPKK--------PLISKEAQSFIIGCLKHNQEERFD-----
.  .|.||  .|...||||.|. || .. .|        .    . |.|     ...|||| .        . .|.||...| ..|. . |.|       
GKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGND

-----VKQALNHPYF
     ...  |||.|
FGDKGAEEIKNHPWF
Kinase 4269.AA ULK 577-853 29 7.7e-52 178.54 In-house 1-324 (324) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-324/324
Sequence Identity: 29% (98 aa)

YQLLSLLGKGGFS-EVYKAIDLEEF---REVAIKIHYIDKSWSNRVKQN----YLKHAFR-EHGIQKELN---HPN--IVKLYDYIEIDS-TSFASVLQF
|.|   |||| |   |||... .       ||.|.  |||.  |  |..    |..  .. |  |.|.|.   |||  ||||||. | .  . .  .. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKM--IDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEY

CEGPDLSQHLKIH---------STIIEQDAKYIVKKILECLEYLSSFQSKVIHYDLKPQNIIFHKGQ-------------IKITDFGLSKIIEDNATRLE
|.| ||.| .| .          .. || |. . | |.. . .|   . ..|| |.|||||  |.||             .||.|||..|....|     
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKEL--HKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

LTSQGV------GTYWYLPPECFENF--GCEENEKAPTISNKVDIWSVGVIFYEMLFGQKPFGNK-MTQE----QILRQ----NTILNSKEVKFP---KK
.. . |      ||  |  |. ...   ... ...      |.||||.|.||||||.|. || .  ..|.    . ...     .. . . ..||   | 
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDY------KCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKD

PLISKEAQSFIIGCLKHNQEERFDVKQALNHPYF
| ||.| ...| ..|. ....|..  . .||| |
PKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 4269.AA ULK 577-853 28 2.1e-47 163.55 In-house 1-329 (329) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-329/329
Sequence Identity: 28% (98 aa)

YQLLSLLGKGGFSEVYKAIDLEE----FREVAIKIHYIDKSWSNRVKQ----NYLKHAFR-EHGIQKELN--------HPNIVKLYDYIEIDS-TSFASV
|.|   |||| |  |||... .        ||.|.  |||.  |. ..    .|..  .. |  |.|.|.        |||||||||. | .  . .  .
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKM--IDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

LQFCEGPDLSQHLKIH----------STIIEQDAKYIVKKILECLEYLSSFQSKVIHYDLKPQNIIFHKGQ-------------IKITDFGLSKIIEDNA
. .|.| ||.| .| .           .. || |. . | ||. . .|   . ..|| |.|||||  |.||             .||.|||..| .... 
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKEL--HKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

TRLELTSQGV------GTYWYLPPECFENF--GCEENEKAPTISNKVDIWSVGVIFYEMLFGQKPFGNK-MTQE-QILRQN-TI-------LNSKEVKFP
   ...   |      ||  |  |. ...   ... ...      |.||||.|.||||||.|. || .  ..|  ||....  .        ...  .||
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDY------KCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFP

---KKPLISKEAQSFIIGCLKHNQEERFDVKQALNHPYF
   ..| ||.| ...| ..|. ....|..  . .||| |
KDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 4269.AA CAMKL 577-853 27 1.9e-41 129.97 In-house 1-297 (297) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-297/297
Sequence Identity: 27% (86 aa)

YQLLSLLGKGGFSEVYKAID-LEEFREVAIKIHYIDKSWSNRVKQN---------YLKHAFREHGIQKELN---HPNIVKLYDYIEIDST-----SFASV
|...  ||||.|..|  |.. .   ..|||||  ..| | . ....          . . .||  |.| ||   ||||.|||. || ...      .  |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LQFCEGPD--LSQHLKIHST----IIEQDAKYIVKKILECLEYLSSFQSKVIHYDLKPQNIIFH-KG--QIKITDFGLSKIIEDN-ATRLELTSQGVGTY
.  |.| .  | .... |      . | .|. . . |.. ..|. |    ..| |.|| || .  .|  .|||.|||.| .....  .. .. .   |..
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

WYLPPECFENFGCEENEKAPTISNKVDIWSVGVIFYEMLFGQKPFGNK----MTQEQILRQNTILNSKEVKFPKKPLISKEAQSFIIGCLKHNQEERFDV
 | .|| |.        . | .  |||||| ||| | |..|. || .       .. | .   . ..   ..|. . .| .....| . |..| |.|. .
PYMAPEIFQG------NNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTI

KQALNHPYF
.| .||| .
HQIMNHPWM
Kinase 4269.AA STE 577-853 21 2e-39 136.91 In-house 1-359 (359) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

YQLLSLLGKGGFSEVYKAIDLE---------------EFREVAIKIHYIDKSWSNRVK-----------QNYLKHAFREHGIQKELN--HPNIVKLYDYI
..... .|||.| .||||.. .                 . .|||.  .... ..  .           .. ..   .|  | |..|  |||||| |.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EIDS------TSFASVLQFCEGPDLSQHLK-IHSTII-------------EQDAKYIVKKILEC-LEYLSSFQSKVIHYDLKPQNIIFHKGQIKITDFGL
. ..      ..   .. ...|  |.. .|  ...               |.  .||.. ||.  |.|| | .  .|| |.||.|| .    .|..|||.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL----VKLCDFGV

SKIIEDN-------------ATRLELTSQGVGTYWYLPPECFENFGCEENEKAPTISNKVDIWSVGVIFYEMLFGQKPF--GNKMTQEQILRQN------
.....|.             .|. . .   |||  .  ||  .. |.  .   .  . |.||||.|    ||. |. |.  .. |       .|      
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R--DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

----TILNSKEVKFPK-----------------KPLISKEAQSFIIGCLKHNQEERFDVKQALN--HPYF
     |.| .  ..|                  .   |.| . ||  ||. . ..| ...| |.  || .
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 4269.AA CMGC 577-793 20 2e-37 119.89 In-house 1-342 (513) Show / Hide 
Range on Protein: 577-793
Range on HMM: 1-342/513
Sequence Identity: 20% (72 aa)

YQLLSLLGKGGFSEVYKAID--------------LEEFREVAIKIHYID-KSWSNR---VKQNYLKHAFREHGIQKELN-----------------HPNI
|. .. .|.| ...|||..|               |  ..||||.   . . .  .    | .  . |.||  | |.||                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLYDYIEIDS----------------TSFASVLQFCEGPDLSQHLKIHST----------------------------IIEQDAKYIVKKILECLE--Y
|||||..  .                  ..  |  ...  || | .| ...                            ..  . . . . ||..|.  |
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LSSFQSKVIHYDLKPQNIIFHK---------------------GQIKITDFGLSKIIEDNATR------------------LELTSQGVGTYWYLPPECF
. |   ..|| ||||.|| . .                     |..|| ||||.......                     ..  .. | | || .||  
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

ENFGCE---ENEKAPTISNKVDIWSVGVIFYEMLFG-------QKPF
  .|..   ... .   . ..|.|||| ||.||. |        ||.
--LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase 4269.AA TyrKc 577-853 23 2.9e-13 -8.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 577-853
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

YQLLSLLGKGGFSEVYKAIDLEEFREVAIKIHYIDKSWSNRVKQNYLKHAFREHGIQKEL--NHPNIVKLYDYIEIDS------TSFASVLQFCEGPDLS
 .|.  || | | ||||..     ..||.|    |.          ..   ||  | ..|  .|||||.|| ..  ..           |. .... || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

QHLKIHST-IIEQDAKYIVKKILECLEYLSSFQSKVIHYDLKPQNIIFHKGQ-IKITDFGLSKIIEDN--------ATRLELTSQGV--GTYWYLPPECF
..|. |   .  .|  ..   | .  |||.|   ..|| ||   |.  .... .||.|||||. |.|           |   ...|     .  ..|||.
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

ENFGCEENEKAPTISNKVDIWSVGVIFYEML-FGQKPFGN----KMTQEQILRQNTILNSKEVKFPKKPL------ISKEAQSFIIGCLKHNQEERFDVK
         .  . . | |.|| ||  .|.. .||.|  .    .|. ......  . . .  . |. ..       ..|  . .  | ... |.|   .
---------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY--VKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

QALNHPYF
.   | .|
EI--HECF
Kinase 4269.AA CMGC 815-853 18 1.2e-09 26.95 In-house 443-513 (513) Show / Hide 
Range on Protein: 815-853
Range on HMM: 443-513/513
Sequence Identity: 18% (13 aa)

KFPKKPL--------------------------------ISKEAQSFIIGCLKHNQEERFDVKQALNHPYF
.||..|                                 ....|  .. ..|. . ..|  ..|||.||||
LFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF