Gene 11253 (Tetrahymena)

11253

Species: Tetrahymena
Alias: 3.m01640, PreTt11253, 11253, TTHERM_00047740, 179, 3824.m03012
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
11253.AA Protein None 571 None Fasta, JSON
11253.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
11253.NA RNA None 1716 None Fasta, JSON

Protein domain

Protein domains of 11253.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11253.AA ULK 8-263 35 3.7e-129 435.39 In-house 1-324 (324) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-324/324
Sequence Identity: 35% (116 aa)

YVLKEVIGSGQYG-KVFKSTHQKT---GQVFAVKVIKLEKFKSVPKLHE------FTNNEIQTLTKLN---NPN--VITFIEMLRTS--NNVYLVYEFCN
|.|....|.|..| ||.| ...||   .|..|.|.| . |..  ... |      . .||||.. ||.   .||  .. ......||  ||.|...|.||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGTLEDIIKKK---------KFLNEKEALVIFQQILNAFKSLFKENILHRDLKPSNILLHDGI-------------IKVADFGFCKTLLSP---QDLTQT
||.||..|||.         |.|.|.||. .|.||.|.|| | |.|| |||.||.|||.|.|.             .|.|||||.|.. ..   |...||
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

MV------GSPIYMAPEILKGN----NYN-IKADIWSMGVVLFEMLFGFCP----YEDKT--IARLIGQ-------IDTKLLQIPK--SINPISSKVEEL
.|      |.|.||||.||.|.    .|. .|.||||.|....|||.| .|    ..|    |..|| .       | .. .|.||  ....||.....|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

LYKMLTVDPAKRIEWNTLLNYPLF
...||..|. .||.|  ..| |.|
IRRMLQYDEKDRISWEEIFNHPWF
Kinase 11253.AA ULK 8-263 35 9.3e-128 430.73 In-house 1-329 (329) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-329/329
Sequence Identity: 35% (116 aa)

YVLKEVIGSGQYGKVFKSTHQKT----GQVFAVKVIKLEKFKSVPKLHE------FTNNEIQTLTKLN--------NPNVITFIEMLRTS--NNVYLVYE
|.|....|.|..|||.| ...||    ....|.|.| ..|..  ... |      . .|||... ||.        .||.. ......||  ||.|...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCNGGTLEDIIKKK----------KFLNEKEALVIFQQILNAFKSLFKENILHRDLKPSNILLHDGI-------------IKVADFGFCKTLLSP---QD
.||||.||..|||.          |.|.|.||. .|.||||.|| | |.|| |||.||.|||.|.|.             .|.|||||.|.. ..   |.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LTQTMV------GSPIYMAPEILKGN----NYN-IKADIWSMGVVLFEMLFGFCP----YEDKT---IARLIGQ-------IDTKLLQIPK--SINPISS
...|.|      |.|.||||.||.|.    .|.  |.||||.|....|||.| .|    ..|     | .|| .       |... ||.||  ....||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

KVEELLYKMLTVDPAKRIEWNTLLNYPLF
....|...||..|. .||.|  |.| |.|
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 11253.AA S_TKc 8-263 32 1.9e-90 307.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

YVLKEVIGSGQYGKVFKSTHQKTGQVFAVKVIKLEKFKSVPKLHEFTNNEIQTLTKLNNPNVITFIEMLRTSNNVYLVYEFCNG--GTLEDIIKKKKF--
| . ..||.| .|||.| .| |||...|.|.||           | . .||| | | . ||....... .. ...|.| |.|.|  |.| |.|||..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LNEKEALVIFQQILNAFKSLFKENILHRDLKPSNILLHDGIIKVADFGFCKTLLSPQDLTQTMVGSPIYMAPEILKGNNYNI-KADIWSMGVVLFE
    ..| .|  ...||..| . . . .|.||||||.|||| .  ||..|||... |        |..|.| |||||.|    |.  |.|.|| |..|.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLFGFCPYEDKTIARLIGQIDTKLLQIPKSINPISSKVEELLYKMLTVDPAKRIEWNTLLN-------YPLF
|| |  |..  ...... .|              |. . ... |.|..||.||.    .|.        | |
MLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11253.AA Ciliate-E2c 8-263 35 3.4e-90 305.95 In-house 1-310 (310) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-310/310
Sequence Identity: 35% (111 aa)

YVLKEVIGSGQYGKVFKS-------THQKT---GQVFAVKVIKLEKF----KSVPKLHEFTNNEIQTLTKLNNPNVITFIEMLRTSNNVYLVYEFCNGGT
.   .  |||.||||.|        . ..    .|.||.| . |  .     .  .  |.  .||. . ..|.|..| |..   |....||. |.|||||
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LEDIIKKKKFLNEKEALVIFQQILNAFKSLFKE-NILHRDLKPSNILLHDGIIKVADFGFCKTLLSPQDL-TQ---TMVGSPIYMAPEILKGNNYNI-KA
||. |..|  .|||. |  | ||..||| | || ||.|||.||.|||.|.|.|| ||||| |      .  ||   | .|.|.||||.||.| ||.  |.
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DIWSMGVVLFEMLFGFCPYE------------------DKTIARLIGQID---------------TKLLQIPKS-INPISSKVEELLYKMLTVDPAKRIE
|||| ||.|..||.   | |                  . | . |.  |.               |. .. |..  . || .| .|. ||| ||..|||.
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

WNTLLNYPLF
|. . | ...
WDEIFNHECI
Kinase 11253.AA Ciliate-E2-Unclassified 8-263 28 6.4e-85 288.44 In-house 1-352 (352) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-352/352
Sequence Identity: 28% (99 aa)

YVLKEVIGSGQYGKVFKSTHQKTGQVFAVKVIK--LEKF-KSVPKLHEFTNNEIQTLTKLN-------------------NPNVITFIEMLRTSNNVYLV
| . ..||.|..|||.|  | |..|..| | .|   ..  |.. . .   .||.... ...                   .|... .... .. .|.|.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

YEFCNGGTLEDIIKKKKF-----------------LNEKEAL-----VIFQQILNAFKSLFKEN-ILHRDLKPSNILLHDG----IIKVADFGFCKTLLS
.|.|.||.|...|||.|.                 . |..|.      .| |||.....| ..| |.|||.||.|||....     ||..|||..| . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

P---------------QDLTQTMVGSPIYM----APEILKGNNYN----IKADIWSMGVVLFEMLFGFCPYEDKTIAR----------------LIGQID
.               |....|..|.|.||    |||.|.|.||.    .|.||||.||.|.||||| .|..|..                   |. .| 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

TKLLQIPKSIN-----PISSKVEELLY----KMLTVDPAKRIEWNTLLNYPLF
 | .|.||. .      .| ......     ||| ..| ||| .. .|| |.|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 11253.AA Ciliate-E2 8-263 27 2.8e-81 276.36 In-house 1-365 (365) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-365/365
Sequence Identity: 27% (105 aa)

YVLKEVIGSGQYGKVFKSTHQKTGQVFA----------------VKVIKLEKFKSVPKLHEFTNNEIQTLT----------------KLNNPNVITFIEM
| . ..||.|..|.|.| .. |... ||                ||. . ..    ..  |....||. .                 .||.||.| ..| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LR--TSNNVYLVYEFCNGGTLEDIIK--KKKF---------LNEKEALVIFQQILN---------------AFKSLFKEN-ILHRDLKPSNILLHDGIIK
    . ||.||| |.|.||.|.|.||  |||.         ..|||.. |..|||.               |...| ..| |.|||.||.|||.    ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

VADFGFCKTLLSP-------------------------------QDLTQTMVGSPIYMAPEILKGNN---------YNIKADIWSMGVVLFEMLFGFCPY
..|||..| .  .                               |....| .|.| |||||||.| .         |. |.||||.||.|.|||||  |.
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

EDKTIARLIGQIDTKLLQIPK------------------SINPISSKVEELLYK----MLTVDPAKRIE-WNTLLNYPLF
           .. .. .  .                  | . .| ..  |. |    || .|| |||  |. .|| | |
-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 11253.AA Pkinase 8-263 29 3.1e-81 280.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

YVLKEVIGSGQYGKVFKSTHQKTGQVFAVKVIKLEKFKS-VPKLHEFTNNEIQTLTKLNNPNVITFIEMLRTSNNVYLVYEFCNGG----TLEDIIK--K
|.....|||| .|.|.| .|..||...|||.||... || ... |  . .||| . .|| ||....... ......|.| |.|.||     | |.|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KKFL--NEKEALVIFQQILNAFKSLFKENILHRDLKPSNILLH-DGII----KVADFGFCKTL-LSPQDLTQTMVGSPIYMAPEILK-GNNYNIKADIWS
.. .   |.|.  .. ||| . . . ...|.||||||.|||.. .| |    |..|||..| . . ..  ..| .|.| |||||... |. |  |.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

MGVVLFEMLFGFCPYEDK----TIARLIGQIDTKLLQIPKSINPIS---------------------SKVEELLYKMLTVDPAKRIEWNTLLNYPLF
.|..|.|||.|  |. ..    . .. .  |. ..  ....  | .                     .   ......|..||.||. .  .|. | |
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 11253.AA CAMK 13-252 22 4.1e-74 238.03 In-house 1-414 (425) Show / Hide 
Range on Protein: 13-252
Range on HMM: 1-414/425
Sequence Identity: 22% (95 aa)

VIGSGQYGKVFKSTHQKTG------------QVFAVKVIKLEKFKS------------------------VPKLHEFTNNEIQTLTK-------LNNPNV
..|.|..|||.. .| .|.            | .|.|.|. .| |.                         ||  ..  .||. . |       |. ||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITFIEMLR------------TSNN--------VYLVY---EFCNGG----TLEDIIKKKKF---------------LNEKEALVIFQQILNAFKSLFKEN
| ..|.              | ..        .|.|    |.| ||     | | |....                ..|.||  .|.||. | . . . |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDLKPSNILL-HD-----------------GIIKVADFGFCKTLLS-----------------------PQDLTQTMVGSPIYMA-PEILKGNN---
| |||||| |||| ..                 . ||..|||| . . .                       . .. .|..|.| ||| ||.|.|.    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YNIKADIWSMGVVLFEMLFGFCPYEDK-------------TIARLIGQIDTKLLQ-IPKSINP------------ISSK--------VE
           |. |.|.||.||.|. || |. |....             .. .|  .| .   . .|. . |            ||          . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ELLYKMLTVDPAKRI
 |. |||.||| ||.
DLIRKMLQVDPEKRM
Kinase 11253.AA CAMKL 8-263 32 3.5e-71 226.35 In-house 1-297 (297) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-297/297
Sequence Identity: 32% (98 aa)

YVLKEVIGSGQYGKVFKSTH-QKTGQVFAVKVIKLEKFKSVPKLHEF-----------TNNEIQTLTKLN---NPNVITFIEMLRTSNN------VYLVY
| . ...| | .|||   || . ||.  |.|.|. .| .  |. .                ||| . .||    ||.| . |.. |...      .||| 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCNGGT--LEDIIKKKKF----LNEKEALVIFQQILNAFKSLFKENILHRDLKPSNILLH-DG--IIKVADFGFCKT---L-LSPQDLTQTMVGSPIYM
| | ||   | | |.|..     . |.||  .|.||. | . . . .| |||.|| ||||  .|   ||..||||.         | ..  |  ||| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILKG--NNYN-IKADIWSMGVVLFEMLFGFCPYEDKTIA---------RLIGQIDTKLLQIPKSINPISSKVEELLYKMLTVDPAKRIEWNTLLNYP
||||..|    |.  |.||||.||.|. |..|  | .| |..         ...  .. .   |....   |  .. |. |||.|.| ||.    ..| |
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHV---S-DCRDLIRKMLQVNPEKRPTIHQIMNHP

LF
 .
WM
Kinase 11253.AA STE 8-263 23 8.8e-67 228.17 In-house 1-359 (359) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-359/359
Sequence Identity: 23% (84 aa)

YVLKEVIGSGQYGKVFKSTHQK---------------TGQVFAVKVIKLEKFK-------------SVPKLHEFTNNEIQTLTKLN--NPNVITFIEMLR
. . |.||.| .|.|.|  . |               ||...|.|...||. .             . .. ..   .||... |.|   ||..... .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TS-------NNVYLVYEFCNGGTLEDIIK-KKKFLN-------------EKEALVIFQQILNA-FKSLFKENILHRDLKPSNILLHDGIIKVADFGFCKT
         ...... |...||.|.|||| |.. ..             |..  .| .||| .  . | . .| |||.||.||||    .| .|||.|. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LLS---------------PQD-LTQTMVGSPIYMAPEILKG------NNYNIKADIWSMGVVLFEMLFGFCPYEDKTIARLIGQIDTKL-----------
| .                ..  ..|.||.| .||||....      . |..|.|||| | .. ||. |  |. | .  | . .| ..            
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--LQIPKSINPIS-------------------SKVEELLYKMLTVDPAKRIEWNTLLN--YPLF
   ..|.  ...|                   ..  . . | |. || ||   . ||.   | .
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 11253.AA RSK 10-263 32 2e-62 213.67 In-house 1-278 (278) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-278/278
Sequence Identity: 32% (90 aa)

LKEV--IGSGQYGKVFKSTHQKTGQVFAVKVIKLEKFKSVPKLHEFTNNEIQTLTKLN-NPNVITFIEMLRTSNNVYLVYEFCNGGTLEDIIKKKKF---
||.   .| | .  . | || .|||..|.||.|  |..   |  . |  |.. |   .  |...|  .  .|   .||. |.|.|| | . ..|.|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LNEKEALVIFQQILNAFKSLFKENILHRDLKPSNILLHD----GIIKVADFGFCKT-LLSPQDLTQTMVGSPIYMAPEILK---GNN-YNIKADIWSMGV
. |.|| ... .|  | . | .  | ||||||.|||..|    | ||. ||||||   ..   .|.| ...  |||||.||   ... ..  .|.|| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VLFEMLFGFCPYED---KTIARLIGQIDTKL--LQIP--KSINPISSKVEELLYKMLTVDPAKRIE-----WNTLLNYPLF
...|||.|. |.     .. . .. .| ..   | .|  ..   .|    .|. |||..||.||.       . ... | |
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQY---LSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 11253.AA NEK 8-199 32 7.4e-57 195.21 In-house 1-217 (286) Show / Hide 
Range on Protein: 8-199
Range on HMM: 1-217/286
Sequence Identity: 32% (71 aa)

YVLKEVIGSGQYGKVFKSTHQKTGQV-----FAVKVIKLEKFKSVPKLH--EFTNNEIQTLTKLNNPNVITFIEMLRT--SNNVYLVYEFCN-GGTLEDI
| . ..||.|..|||.|  ....|..     .. | |.... ..  |        ||.. | .|..||......      .|  . | |.|. ||.|.. 
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQN---NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQK

---IKKKK----FLNEKEALVIFQQILNAFKSLFKE-----NILHRDLKPSNILLH-DGI----IKVADFGFCKTLLSPQDLTQT-MVGSPIYMAPEILK
   |||.|    .. |.. . .|.|.. | | . ..     .|||||.||.|| |  ...    .|. |||  | | . .|. .| .|| | ||.||...
IKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQ

GNNYNIKADIWSMGVVLFEM
.  || |.|||| |.||.||
NKPYNNKSDIWSLGCVLYEM
Kinase 11253.AA Pkinase_Tyr 8-218 25 3.2e-20 69.09 Pfam 1-228 (270) Show / Hide 
Range on Protein: 8-218
Range on HMM: 1-228/270
Sequence Identity: 25% (58 aa)

YVLKEVIGSGQYGKVFKSTHQ----KTGQVFAVKVIKLEKFKSVPK---LHEFTNNEIQTLTKL-NNPNVITFIEMLR-TSNN--VYLVYEFCNGGTLED
 .. ...|.|..|.|.| |      .|..  |||..  |  .. ..   . .| . |......| ..||.. ..      .    .|.| |.. .| | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE--GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

IIKK----KKFLNEKEALVIFQQILNAFKSLFKENILHRDLKPSNILLH-DGIIKVADFGFCKTL-LSPQD-LTQTMVGSPI-YMAPEILKGNNYNIKAD
  .|    |. |. |. | . .|| ..   |   |. ||||   |.|.. ....|..||| ....    .   ...    ||  |||| .. . ...| |
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

IWSMGVVLFEMLF-GFCP-YEDKTIARLIGQI
.|| ||...|..  |  | |.. . .... .|
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase 11253.AA TyrKc 8-263 21 5.8e-18 66.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YVLKEVIGSGQYGKVFKSTHQKTGQVFAVKVIKLEKFKSVPKLHEFTNNEIQTLTKL--NNPNVITFIEMLRTS-------NNVYLVYEFCNGGTLEDII
 .|....|.|..|.|.| |     .  |||..| ..      . .|  .|.. ..||  ..||.. ..   ...         ...| |.. .| | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFM-REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKKK-FLNEKEALVIFQQILNAFKSLFKENILHRDLKPSNILLHDG-IIKVADFGFCKTLLSP------QDLTQT----MVG--SPI-YMAPEILKGNNY
.|..  |. |. | .  || .    | . |. ||||   |.|.... ..|..||| .. . .       .|   .          ||  |||| .. . .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NIKADIWSMGVVLFEML-FGFCPYED-----KTIARLIGQIDTK-LLQIPKSINP-----ISSKVEELLYKMLTVDPAKRIEWNTLLNYPLF
..| |.|| ||...|.. .|  ||..     .. ...| ....   . .|... |      .... ..  .    ||..|   ...  . .|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 11253.AA NEK 233-263 32 0.000225 11.76 In-house 256-286 (286) Show / Hide 
Range on Protein: 233-263
Range on HMM: 256-286/286
Sequence Identity: 32% (10 aa)

SSKVEELLYKMLTVDPAKRIEWNTLLNYPLF
|..  .|. .||..|| .|   | .|. |. 
SQDLQNLISQMLQKDPEQRPSCNQILEMPFI