Gene 1349 (Tetrahymena)

1349

Species: Tetrahymena
Alias: 1349, PreTt01349, 133.m00074, TTHERM_00790590, 905
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
1349.AA Protein None 303 None Fasta, JSON
1349.kin_dom Protein Kinase Domain None 268 None Fasta, JSON
1349.NA RNA None 912 None Fasta, JSON

Protein domain

Protein domains of 1349.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1349.AA ULK 25-289 41 6.6e-131 441.19 In-house 1-318 (324) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-318/324
Sequence Identity: 41% (133 aa)

YMKNHVLGKGNFA-ETYLATRVEDE--NQILACKMIAKQQIMEKLRRAPDPEGRKKYIIDALKNEVQLWKELD---HPN--IVKFIDFSETP--NNIYFF
| .||.|||| |.   | .. ....  ||. ||||| |... .|  ...   |  .|... ||||.|..|.|.   |||  |||..|..||.  ||||..
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE---G--QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYII

LEYCNGGDLDKLIK---------RQGRLSEVETIHYFKEIVDGCDFLYKKAIIHRDLKPENILIHNG-------------AAKIADFGFAKVIDYDNREK
.||||||||...||         ...|||| |.|..|| |. |. .|.|. |||||.||.|||||||              .|||||||||..|..| |.
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

AATQTYV------GTPYYMAPQIIN----GEEYS-IKCDIWSLGVMLYQALYGMVPFSDK-TSLE----SLAQK-------IKQAEIKFP---PSIPVCN
  .||.|      |||.||||||..    ...|. .||||||||...|. ||| .||.   ....    .| ..       ||.  |.||   ..... .
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISP

EIKELIQKMLTADEDKRISIAEV
|.|.||..||. ||..|||. |.
ECKDLIRRMLQYDEKDRISWEEI
Kinase 1349.AA ULK 25-289 39 1.8e-128 433.08 In-house 1-323 (329) Show / Hide 
Range on Protein: 25-289
Range on HMM: 1-323/329
Sequence Identity: 39% (130 aa)

YMKNHVLGKGNFAETYLATRVEDE---NQILACKMIAKQQIMEKLRRAPDPEGRKKYIIDALKNEVQLWKELD--------HPNIVKFIDFSETP--NNI
| .||.|||| |.  | .. ....   |.. ||||| ||.. .|.  ..   |  .|... ||||....|.|.        ||||||..|..||.  |||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQE---G--QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNI

YFFLEYCNGGDLDKLIKRQGR----------LSEVETIHYFKEIVDGCDFLYKKAIIHRDLKPENILIHNG-------------AAKIADFGFAKVIDYD
|...||||||||...||....          ||| |.|..|| |. |. .|.|. |||||.||.|||||||              .|||||||||..|.|
YIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDND

NREKAATQTYV------GTPYYMAPQIIN----GEEYS-IKCDIWSLGVMLYQALYGMVPFSDK-TSLE-----SLAQK-------IKQAEIKFP---PS
| |.. ..|.|      |||.||||||..    ...|.  ||||||||...|. ||| .||.   ...      .| ..       ||.  ..||   ..
NMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

IPVCNEIKELIQKMLTADEDKRISIAEV
... .|.|.||..||. ||..|||. |.
PQISPECKDLIRRMLQYDEKDRISWEEL
Kinase 1349.AA Ciliate-E2c 25-297 33 6.8e-87 294.99 In-house 1-310 (310) Show / Hide 
Range on Protein: 25-297
Range on HMM: 1-310/310
Sequence Identity: 33% (105 aa)

YMKNHVLGKGNFAETYLATRVEDENQILAC-KMIAKQQIMEKLRRAPDPEGRKKYIID-ALKNEVQLWKELDHPNIVKFIDFSETPNNIYFFLEYCNGGD
. .|  ||.|...  |.| ..||.. . .  .|     |.. .    |    .  .|  ....|... |...||.|.||.|.  | ..||...||||||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LDKLIKRQGRLSEVETIHYFKEIVDGCDFLYKK-AIIHRDLKPENILIHNGAAKIADFGFAKVIDYDNRE-KAATQTYVGTPYYMAPQIING-EEYSIKC
| ..|.   ...| . . ||. |. .   |.|.  |.|||.||||||||||  |||||||.| .. ||   .    |..|||.|||||| .|  .|  | 
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DIWSLGVMLYQALYGMVPFS-----------------DKTSLESLAQKIK---------------QAEIKFPPS--IPVCNEIKELIQKMLTADEDKRIS
|||||||.||. |.   |.                    .... | | |.               ...|.||..  . .  |.|.||.|||  || |||.
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

IAEVKTIMDELY
  |.  . .|. 
WDEI--FNHECI
Kinase 1349.AA S_TKc 25-297 29 3.2e-86 293.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-297
Range on HMM: 1-231/231
Sequence Identity: 29% (85 aa)

YMKNHVLGKGNFAETYLATRVEDENQILACKMIAKQQIMEKLRRAPDPEGRKKYIIDALKNEVQLWKELDHPNIVKFIDFSETPNNIYFFLEYCNG--GD
| .  ..||| |.. |... ..  ..| |.|.|                       . ...|.|. |. .||||||..|. .. ...|...|||.|  ||
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD

LDKLIKRQGR------LSEVETIHYFKEIVDGCDFLYKKAIIHRDLKPENILIHNGAAKIADFGFAKVIDYDNREKAATQTYVGTPYYMAPQIINGEEYS
| ..||..||      ..| .. .|...|... ... .. ||||||||||||. .   ||.|||.|...           |..|||.|||| ..    |.
LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYG

I-KCDIWSLGVMLYQALYGMVPFSDKTSLESLAQKIKQAEIKFPPSIPVCNEIKELIQKMLTADEDKRISIAEVKT-----IMDELY
  |||.||.|..||  |.|  ||.    .. . .||.              | |..|.|.|. | .||... |. .      ...  
KCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1349.AA AGC 25-290 22 3.4e-86 222.11 In-house 1-390 (395) Show / Hide 
Range on Protein: 25-290
Range on HMM: 1-390/395
Sequence Identity: 22% (93 aa)

YMKNHVLGKGNFAETYLATRVE-----DENQILACKMIAKQQ--------IMEKLRRA-------PDPEGRKKYIIDALKNEVQLWKELD----------
.    |.||| | . ||. ...     | ... |.|.. |.          .|.  ..                    ...| .  ....          
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGY------------VWEERNILEKCNHTHNHPIKSH

HPNIVK-FIDFSETPNN--IYFFLEYCN--------GGDLDKLIKRQG-----RLSEVETIHYFKE-------IVDGCDFLYK-KAIIHRD-LKPENILI
||.|||      .....  .|| .||..        ||... ..  ||     |..| .. .|. |       || . ..| . . ||||| |||||||.
HPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILL

HN-GAAKIADFGFAKVIDYDN----------------------------------------------REK--AATQTYVG--TPYYMAPQIINGEEYSIK
 . |  |..|||..|..  |.                                              | |  . |.| .|  || |||| |.    |.  
DEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKA

CDIWS--LGVMLYQALYGMVPFSDKT---------SLESLAQKIK------QAEIKFPPS--------IPVCNEIKELIQKMLTADEDKRIS--------
||.||  ||...|. |.|  ||....         . . . |||.      . ..|||.           . .| | ||.|.|. | .||.         
CDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGD

--IAEVK
  . |.|
KGAEEIK
Kinase 1349.AA CAMK 30-290 24 1.8e-82 265.43 In-house 1-420 (425) Show / Hide 
Range on Protein: 30-290
Range on HMM: 1-420/425
Sequence Identity: 24% (102 aa)

VLGKGNFAETYLATRVEDEN-----------QILACKMIAKQQI-------------MEKLRRAPDPEGRKKYIIDALKNEVQLWKE-------LDHPNI
.||.|.|.. .|... .. .           |  |.|.| |...             ..| .   . . |. .  . ...|... |        ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFIDFSE------------TPNN--------IYFFL---EYCNGG----D-LDKLIKR--------------QGRLSEVETIHYFKEIVDGCDFLYKKA
.|.... |            | ..        .|...   ||| ||    | .|.....               ||..| |. .||. |... ... .. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKPENILI-HN-----------------GAAKIADFGFAKVID----------YDNREKAATQ------------TYVGTPYYMA-PQIING---
|.||||||||||. .|                 .  ||.|||||...|          |...|    .            |..|||.||| | ..||   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------EEYSIKCDIWSLGVMLYQALYGMVPFSDKT------------SLESLAQKIKQAEIKFPPSI----------------------PVCNE
           . |. |||.||.||.||  | |  || ...            ... | .||....  |||.                        |  |
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

IKELIQKMLTADEDKRISIAEVK
 | ||.|||. | .||..|....
CKDLIRKMLQVDPEKRMTIEQCL
Kinase 1349.AA Pkinase 25-293 30 2.1e-81 281.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YMKNHVLGKGNFAETYLATRVEDENQILACKMIAKQQIMEKL----RRAPDPEGRKKYIIDALKNEVQLWKELDHPNIVKFIDFSETPNNIYFFLEYCNG
| .  ..|.|.|.. |..... ..  | |.| | |. . ..     ||.               .|.|. |.|.|||||...|. |....||. .|||.|
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL---------------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEG

G----DLDKLIK--RQGRL--SEVETIHYFKEIVDGCDFLYKKAIIHRDLKPENILIH-NGAA----KIADFGFAKVIDYDNREKAATQTYVGTPYYMAP
|    ||  .|.  |.|..  || | ..|...|. | ...... |||||||||||||. ||      ||.|||.||..|  .  .  ..|..|||.||||
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAP

QIIN-GEEYSIKCDIWSLGVMLYQALYGMVPFSDK-----TSLESLAQKIKQAEIKFPPSIPVC-------------------NEIKELIQKMLTADEDK
 .|. |..|. |.|.||.|..||. | |  ||...      .   . ..|......|. . . .                    | |..| ..|. |  |
EVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RISIAEVKTI--M
|.......    .
RPTAEQILQHPWF
Kinase 1349.AA Ciliate-E2 25-290 27 5.1e-79 268.84 In-house 1-360 (365) Show / Hide 
Range on Protein: 25-290
Range on HMM: 1-360/365
Sequence Identity: 27% (105 aa)

YMKNHVLGKGNFAETYLATRVEDENQI----LACKMIAKQQIMEKLRRAPDPEGRK------KYI----IDALKNEVQLWK----------------ELD
| .. ..|.|||.  |.... .. .|.       ... ..| |.        |. |      |..    | ..|.| ....                .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQ--------EKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN

HPNIVKFIDFSE--TPNNIYFFLEYCNGGDLDKLIKRQ-----------GRLSEVETIHYFKEIVD---------------GCDFLYKKA-IIHRDLKPE
||||.|.... .  . ||||. .|||.|||| ..|| .           ....| | ....|.|..               .  .| .|  |||||.|||
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE

NILIHNGAAKIADFGFAKVIDYDNREKA----------------------------ATQTYVGTPYYMAPQIINGEE---------YSIKCDIWSLGVML
|||.     ||.|||..| .| || ..                              ..|..|||.||||.|.||..         |. |||||||||.|
NILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

YQALYGMVPFSDKTSLESLAQKIKQAEIKFP----------------PSIPVCNEIKELIQK----MLTADEDKRIS-IAEVK
|. |.|  ||          |.||| .|.||                    . .| | ||.|    ||  |..|||. . ...
YEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase 1349.AA CAMKL 24-290 33 3.2e-68 216.78 In-house 1-292 (297) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-292/297
Sequence Identity: 33% (99 aa)

YYMKNHVLGKGNFAETYLATRVEDENQILACKMIA--KQQIMEKLRRAPDPEGRKKYIIDA-LKNEVQLWKELD---HPNIVKFIDFSETPNN------I
| .   .||||.|..  ||| .   ..  | |.|   | .  .. .. . .  .|.   |  .. |.|. | |.   ||||.|. .  |||..      |
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCG--QKH-ESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKI

YFFLEYCNGGD--LDKLIKRQ----GRLSEVETIHYFKEIVDGCDFLYKKAIIHRDLKPENILIH-NG--AAKIADFGFAKVID-Y-DNREKAATQTYVG
| ..||| ||.  |   |...    ||..| |. .||. ||.. ... .. |.|||.||||||.  ||   .||.||||.  .. . .....  . |  |
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLK-TFCG

TPYYMAPQIING--EEYS-IKCDIWSLGVMLYQALYGMVPFSDKT-------SLESLAQKIKQAEIKFPPSIPVCNEIKELIQKMLTADEDKRISIAEVK
.| |||| |..|  ..|   | ||||.||.||  ..| .|| | |           |  ||..   ..|. . |  . . ||.|||. . .||..| ...
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM
Kinase 1349.AA Ciliate-E2-Unclassified 25-290 28 1e-67 231.26 In-house 1-347 (352) Show / Hide 
Range on Protein: 25-290
Range on HMM: 1-347/352
Sequence Identity: 28% (102 aa)

YMKNHVLGKGNFAETYLATRVEDENQILACKMIAKQQIME-KLRRAPDPEGRKKYIIDALKN-----------EVQ-LWKELDHPNIVKFIDFSETPNNI
| .....|.|.|.. |.. . ..  |. | |.. |.||   |. .  | |  .. ......|           . | . . ..||.|||...  .. .||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-E--IMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI

YFFLEYCNGGDLDKLIKRQ-----------------GRLSEVETI-----HYFKEIVDGCDFLYKKA-IIHRDLKPENILIHNG----AAKIADFGFAKV
|. .|||.|||| . || .                  ...| ...     .||..|..| ..| .|  |||||.||||||..|.      ||.|||..| 
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

IDYDNREKAA-------------TQTYVGTPYYM----APQIINGEEYS----IKCDIWSLGVMLYQALYGMVPFSDKTSLE---------------SLA
....| ..               ..| .|||.||    || .. |..|.    .||||||||| ||. |.|  ||.|... .                | 
YQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLY

QKIKQAEIKFPPSIP------VCNEIKELIQ----KMLTADEDKRISIAEVK
|.||| .|.||.. .      . .| |..|.    |||  . .|||.. ...
QNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase 1349.AA CAMK-Unique 25-290 25 7.1e-64 209.68 In-house 1-358 (363) Show / Hide 
Range on Protein: 25-290
Range on HMM: 1-358/363
Sequence Identity: 25% (93 aa)

YMKNHVLGKGNFAETYLATRVEDENQILACKMIAKQQIMEKLRRAPDPEGRKKYII----------------DALKNEVQLWKELDHPNIVKFIDF----
| .. ..|.||| . | ..  | .  . ||||. ||             |.||...                  ||.|.|.|| .|||||.|. |.    
YKMHRIIGHGNFGHVYECMDRE-TGKKWACKMVKKQT-----------HGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPI

SETPN---------------NIYFFLEYCNGGDLDKLIKR--------------------QGRLSE--VETIHYFKEIVDGCDFLYKKAIIHRDLKPENI
 ....               ..| ..|||.|||| ..| .                    ||..||   .|. .. ...    .. .. |.|||||.|||
FCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENI

LIHNGAA-----------------KIADFGFAKVIDYDNREKAA-TQTYVGTPYYMAP--------------QIINGEEYSIKC----DIWSLGVMLYQA
.. .                    |..||| ..  .|.. .. .  ||..|||.||||              ..||.  |. .|    |||||||..|  
MVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCC--HYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYM

LYGMVPFSDKTSLE-------SLAQKIKQAEI-KFPP---SIP--VCNEIKELIQKMLTADEDKRISIAEVK
| |  ||   ..         .. ..|..... .|.    ..|  . .| | .... .| | |.|.|..| .
LCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELL
Kinase 1349.AA PLK-Unclassified 25-297 36 1e-60 208.05 In-house 1-264 (264) Show / Hide 
Range on Protein: 25-297
Range on HMM: 1-264/264
Sequence Identity: 36% (103 aa)

YMKNHVLGKGNFAETYLATRVEDENQILACKMIAKQQIMEKLRRAPDPEGRKKYIIDALKNEVQLWKELDHPNIVKFIDFSETPNNIYFFLEYCNGGDLD
| . | |||| ||  |... .|  ..|.| | |.|. .  .  ||     |.|     |..| .. | |.|.|||||... |   |.|  ||||..|.| 
YHRGHFLGKGGFAKCYQVKNIET-KKIYAAKIIPKSSLTKN--RA-----RQK-----LISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLM

KLIKRQ-------GRLSEVETIHYFKEIVDGCDFLYKKAIIHRDLKPENILI-HNGAAKIADFGFAKVIDYDNREKAATQTYVGTPYYMAPQIINGEE--
 .|||         ||.| |.  |   || .   | .. |||||||. ||..  |   ||.||| | .. .|  .|   .|  ||| | || | .| .  
EYIKRRNFQLFEKKRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKK---KTICGTPNYIAPEILDGKHQG

YSIKCDIWSLGVMLYQALYGMVPFSDKTSLESLAQKIKQAEIKFPPSIPVCNEIKELIQKMLTADEDKRISIAEVKTIMDELY
.|.. |.||.|..||  | |  ||  | . ..  .|||. . .||  ...  . | |||. |. . |.| .| . .  |.  |
HSYEVDCWSFGCILYTLLIGKPPFETK-DVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIM--MHPFY
Kinase 1349.AA TyrKc 25-293 21 3.9e-21 77.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YMKNHVLGKGNFAETYLATRVEDENQILACKMIAKQQIMEKLRRAPDPEGRKKYIIDALKNEVQLWKEL--DHPNIVKFIDFSETP-------NNIYFFL
  ....|| |.| | |..|      .  | ||. .                    . .. .| .. ..|  .|||||...    ..         ..  .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVM

EYCNGGDLDKLIKRQGR-LSEVETIHYFKEIVDGCDFLYKKAIIHRDLKPENILIHNGA-AKIADFGFAKVIDYD-NREKAATQTYV-----GTP-----
||. .|||.. ... .. |.  . ...   | .|...| .| .|||||   |.|....  .||.||| .. |. | ..  .....|.     |.      
EYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPI

YYMAPQIINGEEYSIKCDIWSLGVMLYQAL-YGMVPFSD----KTSLESLAQKIKQAEIKFPPSIP-------VCNEIKELIQKMLTADEDKRISIAEVK
  |||  ||  ....| |.|| ||...  . ||. | ..    . | . . ...|| .   .|  .          |. .....   .| ..| . .|..
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

TIM
 ..
ECF
Kinase 1349.AA Pkinase_Tyr 25-293 24 4.6e-21 71.96 Pfam 1-270 (270) Show / Hide 
Range on Protein: 25-293
Range on HMM: 1-270/270
Sequence Identity: 24% (71 aa)

YMKNHVLGKGNFAETYLATRV---EDENQILACKMIAKQQIMEK-LRRAPDPEGRKKYIIDALKNEVQLWKEL-DHPNIVKFIDFSE-TPNN--IYFFLE
  ....||.|.| | |..|     .....  | ||. |.. |.. .            ..... .|... |.| .|||||...           ||  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN------------CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVME

YCNGGDLDKLIKR----QGRLSEVETIHYFKEIVDGCDFLYKKAIIHRDLKPENILIH-NGAAKIADFGFAKVIDYDNRE-KAATQTYVGTPYYMAPQII
|. .|||..  ..    ...|.  . ...  .| .|...|  | .|||||   |.|.. |. .||.||| |. |  |    .... .       |||  |
YMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECI

NGEEYSIKCDIWSLGVMLYQALY-GMVP-FSDKTSLESLAQKI-KQAEIKFPPSIPV--CNEIKELIQKMLTADEDKRISIAEVKTIM
|  ....| |.|| || ..  .  |. | . .  | | . ..| ..        .|   . || .|...   .| ..| . .|.  ..
NYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYED---GYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL