Gene 1439 (Tetrahymena)

1439

Species: Tetrahymena
Alias: PreTt01439, TTHERM_00971680, 3749.m00257, 180.m00059, 1439, 294
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
1439.AA Protein None 1234 None Fasta, JSON
1439.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
1439.NA RNA None 3705 None Fasta, JSON

Protein domain

Protein domains of 1439.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1439.AA ULK 25-283 37 7.50000000001e-125 421.07 In-house 1-324 (324) Show / Hide 
Range on Protein: 25-283
Range on HMM: 1-324/324
Sequence Identity: 37% (123 aa)

ICMKDILGSGSFG-VVYKCTDKQN----EVWAAKQISKNLINGKK-----DYLEKLLRQEVGVQKQMK---SEN--IVRLKEFLISD--NNYYLILDYCN
.|....||.|||| .||| ..|..    ...|.|.|.|. .| ||     .|. .||..|. ..|..|   ..|  ||.|.... ..  ||.|.|..|||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

AGNLKQQIQKEKK---------FSENKAKQIMIQIMSGLKEMYQRSIVHRDIKPENILVAQTPQGF---------VYKLADFGFAKILNN----QDMIKS
 |.|.| |.| ||         .||..|.|...||..|.||.... |.||||||.|||.    ...         |.|.|||||||...|    |.|...
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QV------GTPLYMDPQILL----GKPYD-SKCDIWSVGIIFYELLYGCTP--WPRVTSQY----DLLEK-------IKKIPIRFQ---EQISVSEKAKS
.|      |||||| ||||     .|||. .||||||.|.||||.||| .|  ..  ..||    .|...       ||. ||.|.   ... .|.. |.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIKKMLQIEPTKRISYQELFEDNYF
||..|||.....||| .|.|.   |
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 1439.AA ULK 25-283 37 1.1e-123 417.16 In-house 1-329 (329) Show / Hide 
Range on Protein: 25-283
Range on HMM: 1-329/329
Sequence Identity: 37% (123 aa)

ICMKDILGSGSFGVVYKCTDKQN-----EVWAAKQISKNLINGKK-----DYLEKLLRQEVGVQKQMK----SEN----IVRLKEFLISD--NNYYLILD
.|....||.||||.||| ..|..     |..|.|.|.|. .| |.     .|. .||..|. ..|..|    ..|    ||.|.... ..  ||.|.|..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNAGNLKQQIQKEKK----------FSENKAKQIMIQIMSGLKEMYQRSIVHRDIKPENILVAQTPQGF---------VYKLADFGFAKILN-N---QD
||| |.|.| |.| ||          .||..|.|...||..|.||.... |.||||||.|||.    ...         |.|.||||||| .. .   |.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

MIKSQV------GTPLYMDPQILL----GKPYD-SKCDIWSVGIIFYELLYGCTP--WPRVTSQY-----DLLEK-------IKKIPIRFQ---EQISVS
|....|      |||||| ||||     .|||. .||||||.|.||||.||| .|  ..  ..||     .|...       |||.|..|.   ... .|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

EKAKSLIKKMLQIEPTKRISYQELFEDNYF
.. |.||..|||.....||| .|||.   |
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 1439.AA S_TKc 25-283 30 1.2e-86 295.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-283
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

ICMKDILGSGSFGVVYKCTDKQ-NEVWAAKQISKNLINGKKDYLEKLLRQEVGVQKQMKSENIVRLKEFLISDNNYYLILDYCNA--GNLKQQIQKEKK-
  . ...|.|.||.||||..|  ... | |.|.            . .|.|. . |. . .|||.|...  . ...|....||.   |.|.. |.| .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FSENKAKQIMIQIMSGLKEMYQRSIVHRDIKPENILVAQTPQGFVYKLADFGFAKILNNQDMIKSQVGTPLYMDPQILLGKPYDS-KCDIWSVGI
     |.|  |. .| || ..|. . .. |.|||.||||||. .     . |..|||.|..|      ....||| || | .|   .|.  |||.||.|.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

IFYELLYGCTPWPRVTSQYDLLEKIKKIPIRFQEQISVSEKAKSLIKKMLQIEPTKRISYQELFE-------DNYF
|.||.|.|..|.|    .. ...||.            |. ||..|.|.|| .|.||..  |...       . .|
ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1439.AA CAMK 30-283 21 8.5e-86 276.34 In-house 1-425 (425) Show / Hide 
Range on Protein: 30-283
Range on HMM: 1-425/425
Sequence Identity: 21% (91 aa)

ILGSGSFGVVYKCTDK-QN------------EVWAAKQISKNLINGK-----------------------KDYLEKLLRQEVGVQKQ-------MKSENI
.||.||||.|..|..|  .            . .|.| |.|. . .|                       ... .| .|.|. . |.       .. .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLKEFLIS-------------------DNNYYLIL---DYCNAG----NLKQQIQKE---------------KKFSENKAKQIMIQIMSGLKEMYQRSI
..| |.  .                   |...|...   .||  |     | . |..                ..|.|  |.... || |... . .. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKPENILVAQTPQG--------------FVYKLADFGFAKILNN------------------------QDMIKSQVGTPLYMD-PQILLG------
||||.||||||. .   .              .  |..|||||....                          .. | ..||| ||  | .|.|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KPYDSKCDIWSVGIIFYELLYGCTPWPRVT------------SQYDLLEKIKKIPIR-FQEQIS-------------VSEK--------AKS
        ..|. |||.||.|.| | .| |. |.   .            ..|.|.|||.|   .   ...|             .|.         .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIKKMLQIEPTKRISYQELFEDNYF
||.|||| .|.||.. ..  ..  .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 1439.AA Ciliate-E2 25-283 25 1.1e-82 281.0 In-house 1-365 (365) Show / Hide 
Range on Protein: 25-283
Range on HMM: 1-365/365
Sequence Identity: 25% (96 aa)

ICMKDILGSGSFGVVYKCTDKQNEV------------------------WAAKQISKN--LINGKKDYLEKLLR------QEVGVQKQMKSENIVRLKEF
.    ..|.|.||.||||.....                           | |...||   .  ..... . ..      .|  ...|... ||....|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LI--SDNNYYLILDYCNAGNLKQQIQ------------KEKKFSENKAKQIMIQIMS---------------GLKEMYQRS-IVHRDIKPENILVAQTPQ
 .  .|||.||...||. |.|.. |.            . |.|.|...|.|| || .               .|... ..  |.||||||||||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

GFVYKLADFGFAKILNNQ--------------------------------DMIKSQVGTPLYMDPQILLGKP---------YDSKCDIWSVGIIFYELLY
    |..|||..|.....                                .|.....||| || |.|| ||.         || ||||||.|.|.||.|.
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GCTPWPRVTSQYDLLEKIKKIPIRFQEQ----------------ISVSEKAKSLIKK----MLQIEPTKRIS-YQELFEDNYF
| .|.         ...||. .|.|...                 ..|...| ||||    ||| .| |||. ......  .|
GKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 1439.AA Pkinase 25-283 30 1.3e-77 268.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-283
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

ICMKDILGSGSFGVVYKCTDKQNEV-WAAKQISKNLINGKKDYLEKLLRQEVGVQKQMKSENIVRLKEFLISDNNYYLILDYCNAG----NLKQQIQ--K
.. . ..||||||.||||..| ..  .| |.|.|  .. .||.   .| .|. . | ....|||||...  .....|....||. |     |.  |.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

EKKF--SENKAKQIMIQIMSGLKEMYQRSIVHRDIKPENILVAQTPQGFV---YKLADFGFAKI--LNNQDMIKSQVGTPLYMDPQILL-GKPYDSKCDI
...|  ||. .| .| || .||. .....|.|||.||||||.    .| .    |..|||.||   . |.   .. .||| || | ... |..|..|.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGIIFYELLYGCTPWPRV-----TSQYDLLEKIKKIPIRFQEQISVS-------------------EKAKSLIKKMLQIEPTKRISYQELFEDNYF
||.|.|.||.| | .|.|        .|. ....|.. |..|... . |                   | .|..||..|.  |.||.. ...... .|
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 1439.AA Ciliate-E2a 27-283 34 1.3e-75 222.06 In-house 3-275 (275) Show / Hide 
Range on Protein: 27-283
Range on HMM: 3-275/275
Sequence Identity: 34% (95 aa)

MKDILGSGSFGVVYKCTDKQNEVW-AAKQISKNLINGKKDYLEKLLRQEVGVQKQMKSENIVRLKEFLISDNNYYLILDYCNAGNLKQQIQKEKKFSEN-
 ....|.|.||.||. . ||.    |.| ..|  .. .|.  |.. . |.   .|..  || .| |. ...|||||...||. | |.. |.. |.| |. 
FIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMN-EINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-KAKQIMIQIMS-GLKEMYQRSIVHRDIKPENILVA-QTPQG---FVYKLADFGFAKIL--NNQDMIKSQVGTPLYMD------PQILLGKPYDSKCDIW
 ....|| |. . ||  | || |.|||.||||||     ...   .  |..|||.|.    . .. .....||| |.       ...|..| || |||.|
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

SVGIIFYELLYGCTPWPRVTSQYDLLEKIKKIPIRFQEQI---SVSEKAKSLIKKMLQIEPTKRISYQELFEDNYF
|.|.||| ||.|..| .  | . . |...||  | |. ..    .|  .| |.||||.  | |||. |.. .. .|
SCGVIFYILLCGKPPFKGKTYN-EILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 1439.AA AGC 27-283 21 2e-75 193.63 In-house 1-395 (395) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-395/395
Sequence Identity: 21% (85 aa)

MKDI--LGSGSFGVVYKCTDKQ-------NEVWAAKQISKNL-INGKKD-YLEKL-----------LRQEVGVQKQMK----------SENIVR-LKEFL
 . .  .| |||| || . .|        ... | | ..|   |  ||   .|.            ...|  . ....          . .||. |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ISDNN--YYLILDYCN--------AGN--LKQQIQ---KEKKFSENKAKQIMIQ-------IMSGLKEMYQ-RSIVHRD-IKPENILVAQTPQGFVYKLA
 ....   |....|..         |   | ...|   ||..|.|. |. .. .       | ..|  . . . |.||| .||||||  .   | . ||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED--GHI-KLT

DFGFAKILN---------------------------------------------------NQDMIKSQVG--TPLYMDPQILLGKPYDSKCDIWS--VGI
|||..|...                                                   ..|. .. .|  || || | ||    |.  ||.||  .|.
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC

IFYELLYGCTP----------WPRVTSQYDLLEKIK------KIPIRFQ--------EQISVSEKAKSLIKKMLQIEPTKRIS----------YQELFED
..||.|.|..|            ........ .||.      . ...|         |. ..|. ||.||||.|. .|.||.           ..|. . 
LMYEMLTGYPPFYGDNPQENRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

NYF
 .|
PWF
Kinase 1439.AA CAMK1 23-283 32 4.8e-75 217.57 In-house 1-276 (276) Show / Hide 
Range on Protein: 23-283
Range on HMM: 1-276/276
Sequence Identity: 32% (93 aa)

YTICMKDILGSGSFGVVYKCTDKQ----NEVWAAKQISKNLINGKKDYLEK-------LLRQEVGVQKQM---KSENIVRLKEFLISDNNYYLILDYCNA
| .  ....|.|.|..||.||.|.    .. .| | |.|      |. ..|       .|..|... |.    . .||. ..|.  ||| .||...... 
YEF--GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK------KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTG

GNLKQQIQKEKKFSENKAKQIMIQIMSGLKEMYQRSIVHRDIKPENILVAQTPQGFVYK--LADFGFAKILNNQD-MIKSQVGTPLYMDPQILLG---KP
| |  .| . ....|..|  || || | .. | .. |||||.||||.| .    ..  |  .|||| .||..... . | ..||| |. | .| .   ||
GELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKP

YDSKCDIWSVGIIFYELLYGCTPWPRVTSQYDLLEKIKKIPIRFQEQ--ISVSEK-AKSLIKKMLQIEPTKRISYQELFEDNYF
|| .||.||.|.|.| || |. |    . .  |.||||| ...| .    ..|.. || .||.||  .|.||.....  ..  .
YDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 1439.AA Ciliate-E2-Unclassified 25-283 27 2.7e-65 223.23 In-house 1-352 (352) Show / Hide 
Range on Protein: 25-283
Range on HMM: 1-352/352
Sequence Identity: 27% (97 aa)

ICMKDILGSGSFGVVYKCTD-KQNEVWAAKQISKNLINGKKDYLEK----LLRQEVGVQK----------------QMKSENIVRLKEFLISDNNYYLIL
  .  ..|.|.||.|||| . ||... | |...|. |. .| ...|    .  .|.  .|                ......||.. .   ...| |...
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DYCNAGNLKQQIQKEKK-----------------FSENKAK-----QIMIQIMSGLKEMYQRS-IVHRDIKPENILVAQTPQGFVYKLADFGFAKILNN-
.||. |.|.| |.| ||                 |.|..||     ... || .||. . .   |.||||||||||. .  . .  |..|||..| ... 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------------QDMIKSQVGTPLYM----DPQILLGKPYD----SKCDIWSVGIIFYELLYGCTPWPRVTSQY---------------DLLEKIKK
               |.|.....||| ||     | .| |. ||     ||||||.|.|.||.|.|  | .  ..                  |...||.
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

IPIRFQEQI------SVSEKAKSLIK----KMLQIEPTKRISYQELFEDNYF
 .| |...        .|..|| .|.    |||.  | |||.......  .|
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 1439.AA CAMK-Unique 25-283 24 8.6e-60 195.97 In-house 1-363 (363) Show / Hide 
Range on Protein: 25-283
Range on HMM: 1-363/363
Sequence Identity: 24% (88 aa)

ICMKDILGSGSFGVVYKCTDKQNEV-WAAKQISKNLINGKKDYL---------------EKLLRQEVGVQKQMKSENIVRLKEF----LISDN-------
. |  |.|.|.||.||.|.|. ... || | . |     || ..               .  |. |... |  . .||..| ..       ..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NYYLILDYCNAGNLKQQIQK--------------------EKKFSE--NKAKQIMIQIMSGLKEMYQRSIVHRDIKPENILVAQTPQ-----
        ..|....||..| |.. |||                    . .|||  . . .|| .. | .. | . .|||||.|.|||.|   ..     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------GFVYKLADFGFAKILN-NQDM--IKSQVGTPLYMDP--------------QILLGKPYDSKC----DIWSVGIIFYELLYGCTPWPRVTSQ-
            ||.||| .. .| |.    ... .|||.|| |              ... . .||..|    |||| | | |..| ||.|    ..  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

------YDLLEKIKKIPI-RF---QEQIS--VSEKAKSLIKKMLQIEPTKRISYQELFEDNYF
        ..|.|.|  . .|   .....  .|. ||...|. ....| .|.|  || |  ..
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 1439.AA RSK 27-283 29 7.1e-56 191.94 In-house 1-278 (278) Show / Hide 
Range on Protein: 27-283
Range on HMM: 1-278/278
Sequence Identity: 29% (84 aa)

MKDI--LGSGSFGVVYKCT-DKQNEVWAAKQISKNLINGK-KDYLEKLLRQEVGVQKQMK-SENIVRLKEFLISDNNYYLILDYCNAGNLKQQIQKEKK-
.|.   .| |.. .. |||  ... . | |...|. |  . ||   .  ..|. . .  . . .||.|..    .   |||..||. | |   .||||  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKD--TRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

--FSENKAKQIMIQIMSGLKEMYQRSIVHRDIKPENILVAQ-TPQ-GFVYKLADFGFAKILNNQ--DMIKSQVGTPLYMDPQILL---GKP-YDSKCDIW
  |||. |...| .| . .. . |. |.|||.|||||| .. . . | . || ||||.|.....   . .. ..|  || | .|    ..  .|  ||.|
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHI-KLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWW

SVGIIFYELLYGCTPWPRV---TSQYDLLEKIKKIP--IRFQEQISVSEKAKSLIKKMLQIEPTKRIS-----YQELFEDNYF
| |.. ||.| ||.|  .     .. .....|.|     .. .  ..|. ||.||.|||. .| ||..      .|. .. .|
SLGVLMYEMLTGCPPF-QGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 1439.AA TyrKc 25-290 20 5.3e-16 36.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-290
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

ICMKDILGSGSFGVVYKCTDKQNEVWAAKQISKNLINGKKDYLEKLLRQEVGVQKQM--KSENIVRLKEFLISD-------NNYYLILDYCNAGNLKQQI
| ....||.| ||.|||.| |  .  | | . ..         .. ...|  . ..   . .|||||    ...         ..... |.  |.||. .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QKEKK-FSENKAKQIMIQIMSGLKEMYQRSIVHRDIKPENILVAQTPQGFVYKLADFGFAKILNNQ-------DMIKSQV--GTP--L---YMDPQILLG
.| .. ..  .  ....|| .|     .. ..|||.   |.||.      . | .||| .. . .        |.....   |.   |    | |  .  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

KPYDSKCDIWSVGIIFYELL-YGCTPWPRV----TSQYDLLEKIKKIPIRFQEQI--------SVSEKAKSLIKKMLQIEPTKRISYQELFEDNYFQAPQ
. . .| |.|| |.  .|.. || .|.| .     | ....|..|.   . | .           .|  . ..|.  . .| .| . .|.          
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI---------H

SCL
.|.
ECF
Kinase 1439.AA Pkinase_Tyr 25-181 27 5.3e-09 31.12 Pfam 1-165 (270) Show / Hide 
Range on Protein: 25-181
Range on HMM: 1-165/270
Sequence Identity: 27% (47 aa)

ICMKDILGSGSFGVVYKCTDK-----QNEVWAAKQISKNLINGKKD-YLEKLLRQEVGVQKQM-KSENIVRLKEFLI-SDNN--YYLILDYCNAGNLKQQ
| .   ||.|.||.|||.| |     ..   | | . |.    ... ..|...| |. . ||. . .|||||    .  .    .|... |.  |.|.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IQK----EKKFSENKAKQIMIQIMSGLKEMYQRSIVHRDIKPENILVAQTPQGFVYKLADFGFAKILNNQD
 .|    .....     |. .|| .|.    .. ..|||.   |.||.    ..| | .||| |. . | |
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDD
Kinase 1439.AA Pkinase_Tyr 203-241 26 0.167716 5.71 Pfam 191-231 (270) Show / Hide 
Range on Protein: 203-241
Range on HMM: 191-231/270
Sequence Identity: 26% (11 aa)

YDSKCDIWSVGIIFYELLYGC-TP-WPRVTSQYDLLEKI-KK
. .| |.|| |.  .|..  . .| .| . | ....|.| ..
FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYED