Gene 15010 (Tetrahymena)

15010

Species: Tetrahymena
Alias: TTHERM_00543620, 3729.m00017, 15010, PreTt15010, 343, 71.m00137
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
15010.AA Protein None 716 None Fasta, JSON
15010.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
15010.NA RNA None 2151 None Fasta, JSON

Protein domain

Protein domains of 15010.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15010.AA ULK 55-312 34 1.4e-125 423.47 In-house 1-324 (324) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-324/324
Sequence Identity: 34% (112 aa)

YIFIKQIGSGAYS-TVHQGKHNQT---YQKVAIKMIPNSKLNETIYQ--------RVVSEIKILTRLN---HPN--IVRIIDFKKTS--QNYYLIFEFCS
|. ....|.|..  .|..|....|    |.||.|||. .|.|.  ..           .||.|.  |.   |||  ||. .|...||   |.|.|.|.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGDLENYIKKH-------YEGKISETLCQQVIFQVREAFKELTKHKIVHRDLKLANILVDEEF------------TIKIADFGFAKHNQDD----DLLKS
 ||||.||||.       .....||  ..|.. |  ..|||| ||.|.|||.|..|||. . .            ..|||||||||| ...    .....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

TL------GTPITMAPEILN----GKQYN-EKCDIWSLGVIIYQMVFGKPP----FMPAKGGGINGLIRE-------IQKEKFDFP---DQIPISEELKN
..      |||..|||.||.    .|.|.  ||||||||.|.|.|..||.|    |.. . . |  ||.        |......||   ....||.|.|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LLRRMLTVDPQKRLNFKELFSNRWI
|.||||..|. .| .. |.|.. |.
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 15010.AA ULK 55-312 35 9.5e-124 417.42 In-house 1-329 (329) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-329/329
Sequence Identity: 35% (117 aa)

YIFIKQIGSGAYSTVHQGKHNQT----YQKVAIKMIPNSKLNETIYQR--------VVSEIKILTRLN--------HPNIVRIIDFKKTS--QNYYLIFE
|. ....|.|.. .|..|....|     .|||.|||. .|.|.  ...        . .||||. .|.        |||||. .|...||   |.|.|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCSNGDLENYIKKH--------YEGKISETLCQQVIFQVREAFKELTKHKIVHRDLKLANILVDEEF------------TIKIADFGFAKHNQDD----D
.|  ||||.||||.        .....||  ..|.. |  ..|||| ||.|.|||.|..|||... .            ..|||||||||| ..|    .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LLKSTL------GTPITMAPEILN----GKQYN-EKCDIWSLGVIIYQMVFGKPP----FMPAKGGGINGLIRE-------IQKEKFDFP---DQIPISE
......      |||..|||.||.    .|.|.  ||||||||.|.|.|..||||    |.. .  .|. ||.        |.|....||   ....||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

ELKNLLRRMLTVDPQKRLNFKELFSNRWI
|.|.|.||||..|. .| .. |||.. |.
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 15010.AA S_TKc 55-312 32 1.3e-92 314.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

YIFIKQIGSGAYSTVHQGKHNQTYQKVAIKMIPNSKLNETIYQRVVSEIKILTRLNHPNIVRIIDFKKTSQNYYLIFEFCSN--GDLENYIKKHYEGK--
| ....||.||...|....|. | ..||||.|.         ... .||.|| . .|||||...|.  . ...|...|.|..  |||  ||||.  ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--ISETLCQQVIFQVREAFKELTKHKIVHRDLKLANILVDEEFTIKIADFGFAKHNQDDDLLKSTLGTPITMAPEILNGKQYNE-KCDIWSLGVIIYQMV
  ..|  .. .. |. .| . . .|.|.||||| .|||.||  .|||.|||.|..       ..  |||  ||||.|   .|.  |||.||.|.|.| |.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

FGKPPFMPAKGGGINGLIREIQKEKFDFPDQIPISEELKNLLRRMLTVDPQKRLNFKELFS-------NRWI
 |.|||       .. ... |             |.|.|...|..|..||.||.   |..          |.
CGYPPFP-----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15010.AA CAMK 60-312 25 2e-90 291.54 In-house 1-425 (425) Show / Hide 
Range on Protein: 60-312
Range on HMM: 1-425/425
Sequence Identity: 25% (108 aa)

QIGSGAYSTVHQGKHNQT------------YQKVAIKMIPNSKLN--------------------------ETIYQRVVSEIKILTR-------LNHPNI
..|.|....|. ..| .|             ||||||.|. .||                           .   ..| .||.|. .       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRIIDFKK------------TSQN--------YYLIF---EFCSNG----DLENYIKKHYE-------------GKISETLCQQVIFQVREAFKELTKHK
......              | ..        .|...   |.||.|    || .||..|               |...|  ..... |. .| . . .|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKLANILVDEE-----------------FTIKIADFGFAKHNQD------------------------DDLLKSTLGTPITMA-PEILNGKQ---
|||||||. |||.|.                  ..|||.|||||.. ..                        ....|   |||  || ||.||||.   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YNEKCDIWSLGVIIYQMVFGKPPFMPAKGGGING----------LIREIQKEKFDFPDQ----IP----------ISEE--------LK
           |..|||.||.||| | |. |.|||   ..  | .          | . |.| |.|||.     |.          ||.|         |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NLLRRMLTVDPQKRLNFKELFSNRWI
.|.|.||.|||.||.. ..  .  |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15010.AA Ciliate-E2 55-312 26 2.9e-90 306.16 In-house 1-365 (365) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-365/365
Sequence Identity: 26% (102 aa)

YIFIKQIGSGAYSTVHQGKHNQTYQKVAIKMIPNSK-------------------LNETIYQRVVSEIKILT----------------RLNHPNIVRIID
|.|||.||.|....| ..|. .. ...|||.|   |                   ...   . . .||.|.                 .||||||.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

FKK--TSQNYYLIFEFCSNGDLENYIKKH----------YEGKISETLCQQVIFQVRE---------------AFKELTKHK-IVHRDLKLANILVDEEF
. .  . .|.||..|.|. |||. |||..          . ....|  ..... |. .               |...| . . |.|||.|. |||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

TIKIADFGFAKHNQDD--------------------------------DLLKSTLGTPITMAPEILNGKQ---------YNEKCDIWSLGVIIYQMVFGK
 |||.|||..| ..||                                .. ....|||  |||||||||.         |..||||||||||.|.|.|||
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFMPAKGGGINGLIREIQKEKFDFP----------------DQIPISEELKNLLRR----MLTVDPQKRLN-FKELFSNRWI
|||           ...|.. |.|||                .   .|.| |.|...    || .||.||.. ..... . |.
PPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 15010.AA Pkinase 55-312 30 9e-89 306.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

YIFIKQIGSGAYSTVHQGKHNQTYQKVAIKMIPNSKLNETIYQRVVS--EIKILTRLNHPNIVRIIDFKKTSQNYYLIFEFCSNG----DLENYIKKHYE
| ....||||....| ...|  | ..||.| |. .. ..   |. .   ||.|. |||||||||..|.  .....|...|.| .|    ||  ||. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKI--SETLCQQVIFQVREAFKELTKHKIVHRDLKLANILVDEEFTI----KIADFGFAKH--NQDDDLLKSTLGTPITMAPEILN-GKQYNEKCDIWSL
|..  ||  |. .. |. .. . . ...|.|||||..|||.|.. .|    ||.|||.||.  .  .  ...  |||  ||||... |. |  |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVIIYQMVFGKPPFMPA----KGGGINGLIREIQKEKFDFPDQIPIS-------------------EELKNLLRRMLTVDPQKRLNFKELFSNRWI
|.|.|.|..|.|||  .    .    . .|..| . ...|. . ..|                   ||.| .....|..||.||.......   |.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 15010.AA AGC 55-312 21 3e-88 227.54 In-house 1-395 (395) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-395/395
Sequence Identity: 21% (87 aa)

YIFIKQIGSGAYSTVHQGKHN------QTYQKVAIKMIPNSK--------LNETIYQR--------VVSEIKILTRLN----------HPNIVR-IIDFK
. |.| || |....|.. ...      .| .  |.|..  ..          | ..          | .| .||...|          ||.||.      
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KTSQN--YYLIFEFCS--------NGDLENYIKKH---YEGKISETLCQQVIFQ-------VREAFKELTK-HKIVHRD-LKLANILVDEEFTIKIADFG
.. ..   |.. |...         |..| .. ..    ||. .|  ..  . .       .  |.  | . ..|.||| ||. ||| ||.  ||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKHNQDD---------------------------------------------------DLLKSTLG--TPITMAPEILNGKQYNEKCDIWS--LGVIIY
..| . .|                                                   |. ..  |  ||  ||||||    |.  ||.||  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

QMVFGKPPFMPAKGG----------GINGLIRE-----IQKEKF------DFPDQIPISEELKNLLRRMLTVDPQKRLN----------FKELFSNRWI
.|..|.|||     .           .  .|..      .|.||      .||..  .|.|.|.|....|..|| |||           ..|. .  | 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 15010.AA CAMKL 55-312 32 2.9e-82 262.33 In-house 1-297 (297) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-297/297
Sequence Identity: 32% (98 aa)

YIFIKQIGSGAYSTVHQGKH-NQTYQKVAIKMIPNSKLN-ETIYQR------------VVSEIKILTRLN---HPNIVRIIDFKKTSQN------YYLIF
|...|..| |....|  ..|   | .|||||.|  .|.. ... ..            .  ||.|. .||   ||||... .   |...      .||. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCSNGD--LENYIKKHYE--GKISETLCQQVIFQVREAFKELTKHKIVHRDLKLANILVDEEF--TIKIADFGFA---K-H-NQDDDLLKSTLGTPITM
| ||.|.  | .||.|| .  |...|  ...   |. .| . . .|.|||||.|. |||.||    .|||.||||.   . . ......||   |.|  |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILNG--KQYN-EKCDIWSLGVIIYQMVFGKPPFMPA-----KGGGINGLIREIQKEKFDFPDQIPISEELKNLLRRMLTVDPQKRLNFKELFSNRWI
||||..|  |.|.  | ||||.||| | ||.|. ||  .     .   |  | ..| .  . .|  . .| ....|.|.||.|.| || . ... . .| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 15010.AA Ciliate-E2-Unclassified 55-312 25 3.4e-80 272.75 In-house 1-352 (352) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

YIFIKQIGSGAYSTVHQGKHNQTYQKVAIKMIPNSKLNETIYQRV----------VSEIK-------------ILTRLNHPNIVRIIDFKKTSQNYYLIF
|..|||||.|....|.. .|....|. |.|..  .. .   ...           . ..|             ||  ..||.||. .. ... || |.. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFCSNGDLENYIKK---------------HYEGKISETLCQ-----QVIFQVREAFKELTKHK-IVHRDLKLANILVDEE---FTIKIADFGFAKHNQDD
|.| .|||..||||               ..  ...|  ..     . . |. .... | . . |.|||.|. |||.|..   . |||.|||..|..|..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------------DLLKSTLGTPITM----APEILNGKQYN----EKCDIWSLGVIIYQMVFGKPPFMPAKGGG-------------INGLIREIQK
                ...... |||..|    |||.| |..|.    .||||||||||.|.|.||..||   .                .  |...|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

EKFDFPDQIP------ISEELKNLLR----RMLTVDPQKRLNFKELFSNRWI
 ...|| . .      .|.| |....    .|| ..| ||..|....   |.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 15010.AA MARK 55-312 39 6.1e-77 251.07 In-house 1-262 (262) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-262/262
Sequence Identity: 39% (104 aa)

YIFIKQIGSGAYSTVHQGKHNQTYQKVAIKMIPNSKLNE-TIYQRVVSEIKILTRLNHPNIVR---IIDFKKTSQN-YYLIFEFCSNGDLENYIKKHYEG
| ..|.|| |.|..|  . |  | .|||||.... |||.    . | .||.|. .|.||||..   .|. . |.|.  ||| | .|.|.| .|||.|  |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIE-QDTEQHQIYLIMEYASGGELYDYIKAHPNG

KISETLCQQVIFQVREAFKELTKHKIVHRDLKLANILVDEEF--TIKIADFGFAKHNQDDDLLKSTLGTPITMAPEILNGKQYN-EKCDIWSLGVIIYQM
...| .. .   |. .| . . .. |||||.|. |||.||.    |||.||||. . . . .|..  |||  |||||...| |.  | |||||||. | |
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

VFGKPPFMPAKGGGINGLIREIQKEKFDFPDQIPISEELKNLLRRMLTVDPQKRLNFKELFSNRWI
| |. ||. ... ... | ..|...|.|.|.   .| |..||..|.|||.| .|   .|. . .|.
VCGYFPFD-GDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 15010.AA Ciliate-E2c 55-312 31 3.7e-71 242.73 In-house 1-310 (310) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-310/310
Sequence Identity: 31% (100 aa)

YIFIKQIGSGAYSTVHQGKHNQ---TYQKV-------AIKMIPNSKL-----NETIYQ-RVVSEIKILTRLNHPNIVRIIDFKKTSQNYYLIFEFCSNGD
.   .  ||| | .|  .. .    . ...       ||||.. . .     ||..   ..  || ..  .|||.|....|.|.|... ||| |.|. |.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LENYIKKH-YEGKISETLCQQVIF---QVREAFKELTKH-KIVHRDLKLANILVDEEFTIKIADFGFAKHNQDDDLLKST-----LGTPITMAPEILNG-
|| ||..  .   ..|   .|...   |   |||.| |  .| |||.| .|||  .  .||||||||.|  |||     .      |||. |||.||.| 
LEQYIYHKPK---PNE---KQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNG-MIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGK

KQYNEKCDIWSLGVIIYQMVFGKPPFM---------------PAKGGGINGLIREIQ---------------KEKFDFPDQ--IPISEELKNLLRRMLTV
..| || |||||||  |.|.. |.|.                | ...   .|. .|                . .. ||..  . ||.|.| |...|| |
NYYTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQV

DPQKRLNFKELFSNRWI
|. ||....|.| .  |
DEEKRIDWDEIFNHECI
Kinase 15010.AA QIK 55-312 34 2.6e-63 216.64 In-house 1-272 (272) Show / Hide 
Range on Protein: 55-312
Range on HMM: 1-272/272
Sequence Identity: 34% (95 aa)

YIFIKQIGSGAYSTVHQGKHNQTYQKVAIKMIPNSKLNETIYQRVVSEIKILTRLNHPNIVRIIDFKKTSQNYYLIFEFCSNGDLENYIKKHYEGK----
|   . || | . .|  ..|  | .||||| |  |.|.|.  |... |..|. .|.||.|..  .   | .  |.. |.||||..  |. ||  |.    
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKH--GRKGVK

----------------ISETLCQQVIFQVREAFKELTKHKIVHRDLKLANILVDEEFTIKIADFGFAKHNQDDDLLKSTLGTPITMAPEILNGKQYN-EK
                ..|   ...  |.  | . . |..|||||||  ||| |..  ||||||||  . . . ||..  |.|   |||.. ||.|.  |
MVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPK

CDIWSLGVIIYQMVFGKPPFMPAKGGGINGLIREIQKEKFDFPDQIPISEELKNLLRRMLTVDPQKRLNFKELFSNRWI
 ||||.||. | .| |. ||    |  .. | . .   ||  |    .|...  | |.||.|||..|.. .     ||.
VDIWSMGVVLYVLVCGALPFD---GKTLQNLRQRVLSGKFRIP--FFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase 15010.AA Pkinase_Tyr 55-241 30 7.1e-36 122.13 Pfam 1-202 (270) Show / Hide 
Range on Protein: 55-241
Range on HMM: 1-202/270
Sequence Identity: 30% (61 aa)

YIFIKQIGSGAYSTVHQGKHN----QTYQKVAIKMIPNSKLNETI--YQRVVSEIKILTRL-NHPNIVRIIDFKK-TSQN--YYLIFEFCSNGDLENYIK
 .|.|..|.||. .|..|. .    .| ..||.||. . .  .     .   .|.||.. | .|||||| .      ..   .|...|.. .||| .| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KH--YEGKISETLCQQVIFQVREAFKELTKHKIVHRDLKLANILVDEEFTIKIADFGFAKHNQDDDLL-KSTLGTPIT---MAPEILNGKQYNEKCDIWS
||   .....     |  .|. ..   |  ....||||   |.||.|....||.||| |.  ..||   ... |...    |||| .| . ...| |.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGV
 ||
FGV
Kinase 15010.AA TyrKc 55-311 22 3.2e-32 114.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 55-311
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

YIFIKQIGSGAYSTVHQGKHNQTYQKVAIKMIPNSKLNETIYQRVVSEIKILTRL--NHPNIVRIIDFKKTS-------QNYYLIFEFCSNGDLENYIKK
  ..|..|.||. .|..|. .   ..||.||. ...      .   .|..|...|  .||||||..    ..       . .....|....||| .|..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HYEGKISETLCQQVIFQVREAFKELTKHKIVHRDLKLANILVDEEFTIKIADFGFAKHNQDD-------DLLKSTL--GTP--IT---MAPEILNGKQYN
| .  ..     .  .|. .    | .....||||   |.||.|..|.||.||| ..   ||       |  ...   |.   .    |||| .| . ..
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKCDIWSLGVIIYQMV-FGKPPF-------MPAKGGGINGLIREIQKEKFDFPDQIP-------ISEELKNLLRRMLTVDPQKRLNFKELFSNRW
.| |.|| || .. .  .|..|        |...      .|. ... .   . . .        ..|. .. ..    || .| .|.|.   ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ-----EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF