Gene 15675 (Tetrahymena)

15675

Species: Tetrahymena
Alias: 15675, PreTt15675, 27.m00335, 585, 3692.m00138, TTHERM_00295650
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
15675.AA Protein None 757 None Fasta, JSON
15675.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
15675.NA RNA None 2274 None Fasta, JSON

Protein domain

Protein domains of 15675.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15675.AA ULK 29-292 35 5.3e-124 418.27 In-house 1-324 (324) Show / Hide 
Range on Protein: 29-292
Range on HMM: 1-324/324
Sequence Identity: 35% (115 aa)

IFQERMLGEGQYG-KVYEAA-EQNN-QSKRYAVKVIP--SQIFQQSMSN----SQMLQKEIDVLKKLR---HEN--LVCLHEISQSP--NNLYLFLDYCN
.   ..||.|..| |||..  ...| | . .|.|.|.  ... ......     |.|..|| ..|||    |.|   |.|.......  ||.|....|||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLSKYIDNKPQ-------KRLTESEALEFFKQFVNGYQHLYQSKIIHRDIKPENLMLHNGK-------------IKLGDFGFGRFVEGN-MNQQHRMS
||||..|| ..         |||.|.||..||||..||...|.. .||||||||.|...|||.             .|..||||...|. | |.|| ...
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IK------CTPIYASPQLLL----KEIYS-SKCDVWGAGCLLYKMLYGEYPFIGKDMKTL--IQDIQNK-------VRGKEFKFK---DDVVVSEDVKNL
..      .||.| .||.|     .. |. .|||.|  ||..| ||||.||| .  ...   ||. .|.       .. . ..|.   .|...|...|.|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

IRRMFRYDENDRISWEDVFTHPAL
||||. |||.||||||..| || .
IRRMLQYDEKDRISWEEIFNHPWF
Kinase 15675.AA ULK 29-292 33 4.4e-121 408.56 In-house 1-329 (329) Show / Hide 
Range on Protein: 29-292
Range on HMM: 1-329/329
Sequence Identity: 33% (112 aa)

IFQERMLGEGQYGKVYEAAEQNNQ---SKRYAVKVIPSQ--IFQQSMSN----SQMLQKEIDVLKKLR--------HENLVCLHEISQSP--NNLYLFLD
.   ..||.|..||||..  ....    . .|.|.|..|  . .. ...     |.|..||...|||         |.| |.|.......  ||.|....
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNGGDLSKYIDNKPQ--------KRLTESEALEFFKQFVNGYQHLYQSKIIHRDIKPENLMLHNGK-------------IKLGDFGFGRFVEGN-MNQQ
|||||||..|| ..          |||.|.||..||||..||...|.. .||||||||.| ..|||.             .|..||||...|. . |.||
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

HRMSIK------CTPIYASPQLLL----KEIYS-SKCDVWGAGCLLYKMLYGEYPFIGKDMKTLI-----QDIQN------KVRGKEFKFK---DDVVVS
  |. .      .||.| .||.|     .. |. .|||.|  ||..| ||||..|| .    ...     . |.|      ... . ..|.   .|...|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

EDVKNLIRRMFRYDENDRISWEDVFTHPAL
...|.|||||. |||.||||||..| || .
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 15675.AA S_TKc 29-292 28 4.9e-78 266.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-292
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

IFQERMLGEGQYGKVYEAAEQNNQSKRYAVKVIPSQIFQQSMSNSQMLQKEIDVLKKLRHENLVCLHEISQSPNNLYLFLDYCNG--GDLSKYIDNKPQK
    | .|.| .|||| . . .   ...|.|.|.           .....||..||| .|.|.| |... |. ..||....||.|  ||| .||.... .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

R----LTESEALEFFKQFVNGYQHLYQSKIIHRDIKPENLMLHNGKIKLGDFGFGRFVEGNMNQQHRMSIKCTPIYASPQLLLKEIYSS-KCDVWGAGCL
.    ..| .|  ...| ... ... . .|||||.||||..| .  ||..|||. |..         ...  || | .| .|    |.  |||.|  ||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYKMLYGEYPFIGKDMKTLIQDIQNKVRGKEFKFKDDVVVSEDVKNLIRRMFRYDENDRISWEDVFT-------HPAL
|| ||.|. ||   .|..... |                 |...|..||.....| ..|..  ....       || .
LYEMLCGYPPFP--QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15675.AA CAMK 34-292 21 4.6e-74 237.86 In-house 1-425 (425) Show / Hide 
Range on Protein: 34-292
Range on HMM: 1-425/425
Sequence Identity: 21% (91 aa)

MLGEGQYGKVYEAAEQNNQS-----------KRYAVKVIPSQ---------------IFQQ---------SMSNSQMLQKEIDVLKK-------LRHENL
 ||.|..|||... . |..            ...|.|.|. .               |. .         . .. .....||...||       |.|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VCLHEISQSPNN-------------------LYLFL---DYCNGG----DLSKYIDNKPQ-------------KRLTESEALEFFKQFVNGYQHLYQSKI
. |.|. ..|..                   .|...   .|| ||    ||  ||  ...             .|.||.||  .|.| . . ... . .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENLML-HN-----------------GKIKLGDFGFGR-FVEGNMNQ-------------------QHRMSIKC-TPIYAS-PQLLLKEI----
.|||.||||..| .|                 ..||. |||| . | .|. |                     . |.  | || |.. | .|...     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YSSKCDVWGAGCLLYKMLYGEYPFIGKDMKTLI---------QDIQNKVRGKEFKFKDDVV----------------------VSEDVKN
          |. |||.| .|..|| || |..|| |.. .  .         ...  |..  .. | .. .                      ||...|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRRMFRYDENDRISWEDVFTHPAL
|||.| ..| ..|.. |..  || .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15675.AA Ciliate-E2 27-292 23 2.2e-70 240.15 In-house 1-365 (365) Show / Hide 
Range on Protein: 27-292
Range on HMM: 1-365/365
Sequence Identity: 23% (91 aa)

YIIFQERMLGEGQYGKVYEA---AEQN-------------------NQSKRYAVKVIPSQIFQQSMSNSQMLQ---------KEIDVLKKLRHENLVCLH
|..   ...|.|..|.||..    .|.                   ...| ||.|..  .  .| ..  ....         .|  .|..| | |.. ..
YKFI--KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

EISQ--SPNNLYLFLDYCNGGDLSKYIDNKPQKR---------LTESEALEFFKQFVNGY---------------QHLYQSK-IIHRDIKPENLMLHNGK
|  |  . ||.|| ..||.|||| .|| |...||         .|| |.....|| ..|.               ..| . . ||||||||||...    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

IKLGDFGFGRFV-EGNMNQQHRMSIK-----------------------------CTPIYASPQLLL---------KEIYSSKCDVWGAGCLLYKMLYGE
||. |||. ... . | |..| ...                              .|| | .|. |          .. |. |||.| .|..|| ||.|.
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPFIGKDMKTLIQDIQNKVRGKEFKFK----------------DDVVVSEDVKNLIRR----MFRYDENDRIS-WEDVFTHPAL
.||            |..   ....|                 .   .|...|.||..    |. .|.. ||. ||... || .
PPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 15675.AA Ciliate-E2c 29-292 28 2.8e-70 239.77 In-house 1-310 (310) Show / Hide 
Range on Protein: 29-292
Range on HMM: 1-310/310
Sequence Identity: 28% (90 aa)

IFQERMLGEGQYGKVYEA---AEQNNQSKR------YAVKVIPSQIF---QQSMSNSQ-MLQKEIDVLKKLRHENLVCLHEISQSPNNLYLFLDYCNGGD
|  . .|| |.||||| |    ...|....      .|.| .. ...   . . ..    . .||. .|.. | . .   .  |  ...||.. |||||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LSKYIDNKPQKRLTESEALEFFKQFVNGYQHLYQS-KIIHRDIKPENLMLHNGKIKLGDFGFGRFV-EGNMN-QQHRMSIKCTPIYASPQLLLK-EIYSS
| .|| .||  ...| . |  |.| ... ..|..  .|.||||||||  .||| ||. |||| ... ..| .  |    .  ||.| .|| |     | .
LEQYIYHKP--KPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTE

KCDVWGAGCLLYKMLYGEYPFI-----------------GKD-MKTLIQDIQN-----------KVRGKEFKFKDD--VVVSEDVKNLIRRMFRYDENDR
| |.| .|..|| ||. ..|.                    . || |.| | .               ....| ..  . .|..|| ||..|  .||..|
KSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKR

ISWEDVFTHPAL
|.|...| |. .
IDWDEIFNHECI
Kinase 15675.AA CAMKL 35-292 27 1.9e-66 210.99 In-house 7-297 (297) Show / Hide 
Range on Protein: 35-292
Range on HMM: 7-297/297
Sequence Identity: 27% (81 aa)

LGEGQYGKVYEAAEQNNQSKRYAVKVIP--SQIFQQSMSNSQM---------LQKEIDVLKKLR---HENLVCLHEISQSPNN------LYLFLDYCNGG
||.| .|||  |  . .. ...|.|.|        . |..            ...||  .|.|.   |.| . |.|. . |..      .||.. || ||
LGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGG

D--LSKYIDNKPQKR--LTESEALEFFKQFVNGYQHLYQSKIIHRDIKPENLMLH-NG--KIKLGDFGFGRFVEGN-MNQQHRMSIKC-TPIYASPQLLL
.  |  ||.... .|  ..|.||  .|.| | . ... . .|.||||||||..|  ||  .||. ||||. . . .  .  . ... | .| |..| ...
EMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQ

K--EIYS-SKCDVWGAGCLLYKMLYGEYPFIGKDMK----TLIQDIQNKVRGKEFKFKDDVVVSEDVKNLIRRMFRYDENDRISWEDVFTHPAL
.  . |   | |.| .| .|| |..|..|| . ...    . |    .|...  ...   . || |...|||.|   . ..|.. ...  || .
GNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 15675.AA Pkinase 29-292 26 4.8e-66 230.51 Pfam 1-293 (293) Show / Hide 
Range on Protein: 29-292
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

IFQERMLGEGQYGKVYEAAEQNNQSKRYAVKVIPSQIFQQSMSNSQMLQK--EIDVLKKLRHENLVCLHEISQSPNNLYLFLDYCNGG----DLSKYIDN
.  .| .|.| .|.||.. .....  ..|||.|. .   ....  | . .  || ..|.|.|.| | |... ......|. ..||.||    ||. ||  
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KPQKRL--TESEALEFFKQFVNGYQHLYQSKIIHRDIKPENLMLH-NGKI----KLGDFGFGRFVEGNMNQQHRMSIKCTPIYASPQLLL-KEIYSSKCD
. ....  .| |.  ...| . | ..... .|||||.||||.... || |    |..|||. .... . |..  ... .|| |..| ...  . |..|.|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWGAGCLLYKMLYGEYPFIGK------DMKTLIQDIQN-KVRGKEFKF---------------KDDVVVSEDVKNLIRRMFRYDENDRISWEDVFTHPAL
.|..||.|| || |. || |.      |.. .|. |   ...  ...                .  . .||. | .|......| ..|...|... || .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 15675.AA Ciliate-E2-Unclassified 27-292 24 1.7e-63 217.28 In-house 1-352 (352) Show / Hide 
Range on Protein: 27-292
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

YIIFQERMLGEGQYGKVYEAAEQNN----------QSKRYAVKVIPSQIFQQSMSNSQMLQK----------EID-VLKKLRHENLVCLHEISQSPNNLY
|.| .   .|.|..||||.. . ..          ... |..| | ... . ...  .| .|          . .  |. . |...| .... |. .|.|
YKIIKQ--IGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LFLDYCNGGDLSKYIDNKPQ---------------KRLTESEAL-----EFFKQFVNGYQHLYQSK-IIHRDIKPENLMLHNG----KIKLGDFGFGRFV
. ..||.||||..|| ....               |..|| .|.      .|.| ..| ..| ... ||||||||||....|.    .||. |||. .. 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

EGN------------MNQQHRM-SIKCTPIYA----SPQLLLKEIYS----SKCDVWGAGCLLYKMLYGEYPFIGKDMKT----------------LIQD
. |            ...|..| .. .||.|     .| .| .. |.     |||.|. |..|| ||.|.||| ... .                 |.|.
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

I-QNKVRGKEFKFK-DDVVVSEDVKNLIR----RMFRYDENDRISWEDVFTHPAL
| |...  ..|... ..  .|. .|..|.    .|. .. | ||..|... || .
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 15675.AA MARK 35-292 30 2.1e-54 176.32 In-house 7-262 (262) Show / Hide 
Range on Protein: 35-292
Range on HMM: 7-262/262
Sequence Identity: 30% (83 aa)

LGEGQYGKVYEAAEQNNQSKRYAVKVIP-SQIFQ-QSMSNSQMLQKEIDVLKKLRHENLVCLHEISQ--SPNN-LYLFLDYCNGGDLSKYIDNKPQKRLT
.|.| |.||. |  .. . ...|.|...  ...  |.|   .... ||...||| |.| ..|... .   ... .|| ..|. ||.|  || ..|  ||.
IGHGSYAKVKLACHKHTG-RKVAIKIYEKFKLNDPQWM---KNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLH

ESEALEFFKQFVNGYQHLYQSKIIHRDIKPENLML-HNG--KIKLGDFGFGRFV-EGNMNQQHRMSIKC-TPIYASPQLLLKEIYS-SKCDVWGAGCLLY
|.||  .|.| | . . . .  |.||||||||... .||  .||. ||||.. . .|..      .. | || |..|...||. |   | |.|  | .||
EEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK-----LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLY

KMLYGEYPFIGKDMKTLIQDIQNKVRGKEFKFKDDVVVSEDVKNLIRRMFRYDENDRISWEDVFTHPAL
 |. | .|| |...   . ... |..  .... .   || . .|||.|..  . ..|.. |..  || .
FMVCGYFPFDGDTQD--YKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 15675.AA Ciliate-E2a 30-292 27 2.2e-50 146.54 In-house 2-275 (275) Show / Hide 
Range on Protein: 30-292
Range on HMM: 2-275/275
Sequence Identity: 27% (77 aa)

FQERMLGEGQYGKVYEAAEQNNQSKRYAVKVIPSQIFQQSMSNSQMLQKEIDVLKKLRHENLVCLHEISQSPNNLYLFLDYCNGGDLSKYIDNKPQKRLT
. ....|.|..|.||  |.. .. |..|.|..    ..|.  ... ...||. ...|.| |.  |.|. .. ||.|| ..||.||.| ..| .. .    
KFIKKIGKGNFGSVY-LAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

ESEALEFFKQFV-NGYQHLYQSKIIHRDIKPENLMLH----NG----KIKLGDFGFGRFVEGNMNQQHRMSIKC-TPIYAS------PQLLLKEIYSSKC
. |. .. .|.   | ... | .|.|||.||||...     |.    .||. |||...|. ..  .. .|  || || |        .. |... |. ||
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD--EKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKC

DVWGAGCLLYKMLYGEYPFIGKDMKTLIQDIQNKVRGKEFKFKDDV---VVSEDVKNLIRRMFRYDENDRISWEDVFTHPAL
|.| .|. .| .|.|. || ||. .    .|  ...  .. | . .    .| . |.|...|  .| . ||. ..   ||  
DMWSCGVIFYILLCGKPPFKGKTYN----EILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 15675.AA STE 30-292 20 8.2e-46 158.52 In-house 1-359 (359) Show / Hide 
Range on Protein: 30-292
Range on HMM: 1-359/359
Sequence Identity: 20% (74 aa)

FQE-RMLGEGQYGKVYEAAEQ--------------NNQSKRYAVKVIPSQIFQQSMSN--------------SQMLQKEIDVLKKLR--HENLVCLHEIS
..  ...|.| .|.|| |.                ... ...|.|... .  ...  .               | ..|||...||..  |.| |  .   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

Q-------SPNNLYLFLDYCNGGDLSKYIDN--KPQKRLT----------ESEALEFFKQFVNG-YQHLYQSKIIHRDIKPENLMLHNGKIKLGDFGFGR
        . ..|.... |..|| |.. |..  ...|.|.          ||.   . .| . |  ..| . .|||||||| | .|    .|| |||.  
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

FVEGNMN--------------QQHRMSIKCTPIYASPQLLLKEI------YSSKCDVWGAGCLLYKMLYGEYPFIG-KDMKTLIQDIQNK--VR------
 .. .|               ||.| ..  || . .|  ....       |. |||.|  ||..  |. |..|.   ..|. . . ..|.  ..      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GKEFKFKDDVV-----------------VSEDVKNLIRRMFRYDENDRISWEDVFT--HPAL
   |.  ...|..                  .|.. |. |.. ...| |.| . ..     || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 15675.AA TyrKc 29-292 19 1.4e-16 45.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 29-292
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

IFQERMLGEGQYGKVYEAAEQNNQSKRYAVKVIPSQIFQQSMSNSQMLQKEIDVLKKL--RHENLVCLHEISQSP-------NNLYLFLDYCNGGDLSKY
|  ...||||..|.||..          |||.. .          ... .|. ...||  .|.|.|.|. .  ..         |.. . |. .||| .|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

I-DNKPQKRLTESEALEFFKQFVNGYQHLYQSKIIHRDIKPENLMLHNGK-IKLGDFGFGRFVEGN--------MNQ-----QHR--MSIKCTPIYASPQ
. ...|.  |. .. |.|  |  .| ..| . ..||||.   | ...... .| .|||  |...          .       . .  . |. ... .   
LRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

LLLKEIYSSKCDVWGAGCLLYKML-YGEYPFIG-----KDMKTLIQDIQNK-VRGKEFK-----FKDDVVVSEDVKNLIRRMFRYDENDRISWEDVFTHP
   . ....| |||  | ... .. ||. |  |     .. . .|.....   . .        |   |  .... .....  ..| .|| . ...  | 
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE

AL
 .
CF
Kinase 15675.AA Pkinase_Tyr 28-175 27 1.3e-15 53.46 Pfam 1-156 (270) Show / Hide 
Range on Protein: 28-175
Range on HMM: 1-156/270
Sequence Identity: 27% (45 aa)

IIFQERMLGEGQYGKVYEAAEQ---NNQSKRYAVKVIPSQIFQQSMSN---SQMLQKEIDVLKKL-RHENLVCLHEISQ---SPNNLYLFLDYCNGGDLS
|.|  ..||||..|.||..       |.    |||...    ...|.    .... .|. ..|.| .|.|.|.|. .      ||..|. . |. .||| 
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYIDNK--PQKRLTESEALEFFKQFVNGYQHLYQSKIIHRDIKPENLMLH-NGKIKLGDFG
.|  ..  ....|| .. |..  |  .| ..| . ..||||.   | ... |...| .|||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG