Gene 15836 (Tetrahymena)

15836

Species: Tetrahymena
Alias: PreTt15836, 3727.m00052, TTHERM_00647300, 346, 15836, 93.m00132
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
15836.AA Protein None 590 None Fasta, JSON
15836.kin_dom Protein Kinase Domain None 250 None Fasta, JSON
15836.NA RNA None 1773 None Fasta, JSON

Protein domain

Protein domains of 15836.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15836.AA ULK 24-276 36 2.9e-121 409.17 In-house 1-324 (324) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-324/324
Sequence Identity: 36% (118 aa)

YSMNE-LGGGSFG-KVYKAYKKDT---KEVVAIKQIPKEGLNANPKLQQ------LYNSEVSLLKILS---SEN--IIKYIDNFNTTDC--CYIVTEYCN
|..|. || |||| ||||...|.|   ...||.|.|.| ..| ....|.      | ..|....|.|    ..|  |.|..| |.|...  .||..||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

QGDLGTLLVKH---------KRFPEQRVISYFKQLLNGFKDLHKHQVIHRDIKPENILINQKT-------------LKIADLGFAKSITGT------TQT
.||| ... |.         ||..|| .|..|||..||||.||||..|||||||.||||. ..             ||||| ||||..         .||
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

CL------GTYTTMAPEVLE----QKPYG-LEADVFSLGVMLYKLLYGVYP----YRSDT----GNLRY----VIKERIRQIKYDV--SDGIISDVMQDL
|.      ||  .|||..|.    ||||.  ..|..|||...| .||| ||    ....       ..      |... ..|...   .| .||. ..||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

LKRMICYDRRDRITWDQIYQHPIL
..||..||..|||.|..|..||..
IRRMLQYDEKDRISWEEIFNHPWF
Kinase 15836.AA ULK 24-276 35 5.5e-120 404.92 In-house 1-329 (329) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-329/329
Sequence Identity: 35% (118 aa)

YSMNE-LGGGSFGKVYKAYKKDTK----EVVAIKQIPKEGLNANPKLQQ------LYNSEVSLLKILS----SEN----IIKYIDNFNTT--DCCYIVTE
|..|. || ||||||||...|.||    |.||.|.|.|. .| ....|.      | ..|. ..| |     ..|    |.|..| |.|.  ...||..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNQGDLGTLLVKH----------KRFPEQRVISYFKQLLNGFKDLHKHQVIHRDIKPENILINQK-------------TLKIADLGFAKSITGT-----
|||.||| ... |.          ||..|| .|..|||.|||||.||||..|||||||.||||. .             .||||| ||||...       
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-TQTCL------GTYTTMAPEVLE----QKPYG-LEADVFSLGVMLYKLLYGVYP---YRSDTGNLRYVIKERI-----------RQIKYDV--SDGIIS
 ..||.      ||  .|||..|.    ||||.  ..|..|||...| .||| .|   .   . .|....|..            ......   .| .||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DVMQDLLKRMICYDRRDRITWDQIYQHPIL
. ..||..||..||..|||.|.....||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
S_TKc 15836.AA S_TKc 23-276 31 1.5e-84 288.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-231/231
Sequence Identity: 31% (84 aa)

SYSMNELGGGSFGKVYKAYKKDTKEVVAIKQIPKEGLNANPKLQQLYNSEVSLLKILSSENIIKYIDNFNTTDCCYIVTEYCNQ--GDLGTLLVKHKR--
   ....| |.||||||...|.|...||||.|.           .   .|...||    .||.|..| | . |. |.|.|||..  ||| ....|..|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FPEQRVISYFKQLLNGFKDLHKHQVIHRDIKPENILINQKTLKIADLGFAKSITGTTQTCLGTYTTMAPEVLEQKPYGL-EADVFSLGVMLYKLLY
    ||| .. .|..|.... . .|.|..||||.||||||... ..||.| |.|. .     |. ||   ||||||   .||  ..|. |.|..|| .|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GVYPYRSDTGNLRYVIKERIRQIKYDVSDGIISDVMQDLLKRMICYDRRDRITWDQIYQ-------HPIL
|  |..       ... ..|.           |. . |..... ..| ..|.|  .. |       || .
GYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15836.AA CAMK 28-276 22 1.5e-77 249.31 In-house 1-425 (425) Show / Hide 
Range on Protein: 28-276
Range on HMM: 1-425/425
Sequence Identity: 22% (96 aa)

ELGGGSFGKVYKAYKKDTK------------EVVAIKQIPKEGLNA------------------------NPKLQQLYNSEVSLLKILS-------SENI
.|| ||||||.... | |.            . |||| |.|. |                          .|| ..   .|....| |.        .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKYID---------------NFNT-----TDCCYIVT---EYCNQGDL--------------------GTLLVKHKRFPEQRVISYFKQLLNGFKDLHKH
|| ..               . ..     ....|.|.   |||  |.|                    . .. ...||.|. .  ||.|.. . . .|.|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

QVIHRDIKPENILINQK------------------TLKIADLGFAKSITG--------------------------TTQTCLGTYTTMA-PEVLEQ----
 ..|||.||||||....                  ..||.| |||. ...                            .|. ||   || ||||..    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------KPYGLEADVFSLGVMLYKLLYGVYPYRSDTGN----------LRYVIKERIRQIKYDVS---------------DGIISDV--------M
          ..|| ..|. |.||.|| .| | .|...|..|            | ..|.|.. |||                 .. |||          
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QDLLKRMICYDRRDRITWDQIYQHPIL
.||...| ..|  .|.| .|. .|| .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15836.AA Ciliate-E2 24-276 23 2.8e-75 256.41 In-house 1-365 (365) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

YSMNE-LGGGSFGKVYKAYK-----------------------KDTKEVVAIKQIPKEGLNANPKLQQLYN---------SEVSLLKILSSENIIKYIDN
|  .. .| |.||.|||. .                       |...  .|.|.. | ....  . .....          | ..|..|.. ||||... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FN--TTDCCYIVTEYCNQGDLGTLLVKH-----------KRFPEQRVISYFKQLLN---------------GFKDLHKHQ-VIHRDIKPENILINQKTLK
|   .....|.|.|||..|||  .. ..           |.| |. .. ..||.|.               ... ||.   .|||||||||||.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADLGFAKSITG----------------------------------TTQTCLGTYTTMAPEVLEQKP---------YGLEADVFSLGVMLYKLLYGVYPY
|.|.|..| ..                                   ...|..||.  ||||.|. |.         |. ..|..||||.|| .|.| .|.
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

RSDTGNLRYVIKERIRQIKYDVSD--------------------GIISDVMQDLLKR----MICYDRRDRIT-WDQIYQHPIL
              ..|||    |                      .|. ..||.|.    |...|   ||| |.|| .||..
--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 15836.AA Pkinase 29-276 30 3.5e-73 254.23 Pfam 7-293 (293) Show / Hide 
Range on Protein: 29-276
Range on HMM: 7-293/293
Sequence Identity: 30% (89 aa)

LGGGSFGKVYKAYKKDTKEVVAIKQIPKEGLNANPKLQQLYN-SEVSLLKILSSENIIKYIDNFNTTDCCYIVTEYCNQG----DLGTLLV--KHKRF--
.| ||||.|||...|.| ..||.|.|.|.  .   |.|.. . ||....| |...||....| | . | .|.|.|||. |    || ...   .|..|  
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

PEQRVISYFKQLLNGFKDLHKHQVIHRDIKPENILIN-QKTL----KIADLGFA----KSITGTTQTCLGTYTTMAPEVLE-QKPYGLEADVFSLGVMLY
.|. ...|..|.| | . .|.. .||||.|||||||. . ..    ||.| |.|        . ..|  ||.  |||||.  ...|| ..|..|.|..||
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILY

KLLYGVYPYRSD----TGNLRYVIKERIRQIKYDVSDGIIS--------------------DVMQDLLKRMICYDRRDRITWDQIYQHPIL
 .| |  |....    . .  ... .||.. ... .    .                    . ..|..|...|.|  .|.|..|| ||| .
EMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 15836.AA Ciliate-E2-Unclassified 24-276 25 1.3e-72 247.55 In-house 1-352 (352) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-352/352
Sequence Identity: 25% (88 aa)

YSMNE-LGGGSFGKVYKAYKKDTKEVVAIKQIPKEGLNA----NPK---------LQQLYNSEVS--------LLKILSSENIIKYIDNFNTTDCCYIVT
| ... .| |.||||||...|..|.. |.|.. |   ..    . |         .... .. ..        .|. . ...|.|... |......|||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCNQGDLGTLLVKH-----------------KRFPEQRVI-----SYFKQLLNGFKDLHKHQ-VIHRDIKPENILINQK----TLKIADLGFAKSITGT
|||..|||   . |                  |.|.|| ..      ||.|.|.|.. ||. . .|||||||||||....     .||.|.|..| .   
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------------TQTCLGTYTTM----APEVLEQKPYGLE----ADVFSLGVMLYKLLYGVYPYRSDTGNLRY--------------VIKERIR
                  ..|. ||. .|    |||||... |. .    .|..|||| || .|.| ||. . . .  .              .... . 
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

Q-IKYDVSD-----GIISDVMQDLLK----RMICYDRRDRITWDQIYQHPIL
. |... ..      ..|.  .|...    .|. ..   |||..|| .||..
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 15836.AA AGC 24-276 20 4.4e-68 174.17 In-house 1-395 (395) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-395/395
Sequence Identity: 20% (81 aa)

YSMN-ELGGGSFGKVYKAYKK------DTKEVVAIKQIPKEG-LNANPKLQQLYN-SE------------VSLLKILS----------SENIIK-YIDNF
. .   .| ||||||| . ||      ||... |.| . |.     . | .. .. .|               |. ..          . .|.|     |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

NTTDC--CYIVTEYCN--------QGDLGTLLVKHK-----RFPEQRVISYFKQ-------LLNGFKDLHK-HQVIHRD-IKPENILINQ-KTLKIADLG
 . |    |.| ||..         |.. ..| ...     ||.|.|.  |. .       .. ..  ||. . .|||| .||||||...   .|..| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKSITG-----------------------------------------------------TTQTCLG--TYTTMAPEVLEQKPYGLEADVFS--LGVMLY
..| . .                                                     .|.|  |  |   ||||.|    || ..|  |  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

KLLYGVYPYRSDTGN-------LRYVIKERIR--------QIKYDVSD-------GIISDVMQDLLKRMICYDRRDRIT----------WDQIYQHPIL
 .|.|  |...|. .        .. . ..|.        ..|..  .         .|.  .||.|...| |...|..           ..| .||  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 15836.AA CAMKL 24-276 31 3.3e-65 207.0 In-house 1-297 (297) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-297/297
Sequence Identity: 31% (93 aa)

YSMNE-LGGGSFGKVYKAYK-KDTKEVVAIKQIPKEGLNANPKLQQLYNS-----------EVSLLKILS---SENIIKYIDNFNTTDC------CYIVT
| . . || ||||||  |   . |.| |||| | |.... .|. ..               |....| |.    .||||  . . | ..      .|.|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCNQGD--LGTLLVKH----KRFPEQRVISYFKQLLNGFKDLHKHQVIHRDIKPENILINQKT---LKIADLGFAKSIT------GT-TQTCLGTYTTM
|||  |.  |   .|||    .|.||     ||.|.. . . .|.| ..||||||||||. ..    .||.| ||.  ..      |    |. |..  |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLEQ--KPYG-LEADVFSLGVMLYKLLYGVYPYRSDTG------NLRYVIKERIRQIKYDVSDGIISDVMQDLLKRMICYDRRDRITWDQIYQHPIL
|||...   |||   ..|. |.||.|| ...| .| . ||       |  |  .. ... .|.     .|   .||...|   .  .|.| .|| .|| .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 15836.AA STE 24-276 22 2.7e-62 213.29 In-house 1-359 (359) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

YSM-NELGGGSFGKVYKAYKK------DTKEV---------VAIKQIPKEG-------------LNANPKLQQLYNSEVSLLKILS--SENIIKYIDNFN
.    ..| |.||.||||...      .|.||         .||||...|               | |.. .| .  |....| ..  ..||.||.. . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TT-------DCCYIVTEYCNQGDLGTLLV-KH-------------KRFPEQRVISYFKQLLNG-FKDLHKHQVIHRDIKPENILINQKTLKIADLGFAKS
         | ..|. ||.. | |  ..  |.             .||||. .. . .|.| |  . ||.|..||||||| |||.     |..| |....
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

ITG-------------------TTQTCLGTYTTMAPEVLEQ------KPYGLEADVFSLGVMLYKLLYGVYPYRSDTGN------------------LRY
.|                     ..|. ||   |||||..|      |.|.  .|. ||| ..  .. | .|.   .                    | .
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-C

VIKERIRQIKYDVSDG--------------IISDVMQDLLKRMICYDRRDRITWDQIYQ--HPIL
.... . ... ..|..                |. ..| ...   .| ..| | .|  .  || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 15836.AA Ciliate-E2c 24-276 29 1e-54 188.09 In-house 1-310 (310) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-310/310
Sequence Identity: 29% (91 aa)

YSMNE-LGGGSFGKVYKAYKKD---TKEVV-------AIKQIPKEGL--NANPKLQQL--YNSEVSLLKILSSENIIKYIDNFNTTDCCYIVTEYCNQGD
.. |. || ||.|||||||.     .   .       ||| ..   .  ...    ..     |. ..| . . .|||..| . |.   |...||||.|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LGTLLVKHK-RFPEQRVISYFKQLLNGFKDLHKH-QVIHRDIKPENILINQKTLKIADLGFAKSITGTTQT-------CLGTYTTMAPEVLEQKPYGL-E
| . ...|| .  |.... ||.|....|| |||   ..|||||||||||.  ..|||| ||.| ..  . .       | ||   |||..|| | | .  
L-EQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEK

ADVFSLGVMLYKLLYGVYPYR---------------SDTGNLRYVIKERIR---------------QIKYDVSDG---IISDVMQDLLKRMICYDRRDRI
.|. ||||.||  |.  .| .               .  .|.   .|. |.               . .   ..     ||   ..|...|. .|  .||
SDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRI

TWDQIYQHPIL
 ||.|  |...
DWDEIFNHECI
Kinase 15836.AA RSK 26-276 29 5.9e-51 175.6 In-house 1-278 (278) Show / Hide 
Range on Protein: 26-276
Range on HMM: 1-278/278
Sequence Identity: 29% (83 aa)

MNELGGGSFGKVYKAYKK---DTKEVVAIKQIPKEGLNANPKLQQLYNSEVSLLKILS-SENIIKYIDNFNTTDCCYIVTEYCNQGDLGTLLVKHKR---
. .|| |..|||.   |.   ||. . | |.. |  . .. | .     |.. |.    . .|... . | | .  |...|||. |.|.| | |.|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPEQRVISYFKQLLNGFKDLHKHQVIHRDIKPENILINQ----KTLKIADLGFAKS--IT--GTTQTCLGTYTTMAPEVLE---QKP-YGLEADVFSLGV
| | ..  |. ..    . ||....||||.|||||| ..     ..|. | ||.|   .   . |.|  .|   ||||.|    |.  ..  .|..||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

MLYKLLYGVYPYRS--DTGNLRYVIKERIRQIKYDVSDG---IISDVMQDLLKRMICYDRRDRIT-----WDQIYQHPIL
 .| .| |  |...  |  | | .| .||.. |.... .    .|. ..||...| . |  .|..      ..| ||| .
LMYEMLTGCPPFQGPND--NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 15836.AA Pkinase_Tyr 28-209 28 9.7e-16 53.93 Pfam 6-205 (270) Show / Hide 
Range on Protein: 28-209
Range on HMM: 6-205/270
Sequence Identity: 28% (58 aa)

ELGGGSFGKVYKAYKK----DTKEVVAIKQIPKEGLNANPK---LQQLYNSEVSLLKIL-SSENIIKYIDNFN-TTDC--CYIVTEYCNQGDLGTLLVKH
.|| |.||.|||.. |    .||  ||.| . ||  .| ..   .. . . |....| | . .||....       .    |||.||.  ||| . | ||
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE--GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

----KRFPEQRVISYFKQLLNGFKDLHKHQVIHRDIKPENILIN-QKTLKIADLGFAKSI--TGTT-QTCLGTYTT---MAPEVLEQKPYGLEADVFSLG
    .... .. ...  |  .|   |. .. ||||.   |.|.. ... ||.| | |. |  ...  ..  |.      ||||..  . .  . || | |
REDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG

VMLY
| ..
VLMW
Kinase 15836.AA TyrKc 26-276 23 5.2e-15 20.05 SMART 4-280 (280) Show / Hide 
Range on Protein: 26-276
Range on HMM: 4-280/280
Sequence Identity: 23% (67 aa)

MNELGGGSFGKVYKAYKKDTKEVVAIKQIPKEGLNANPKLQQLYNSEVSLLKIL--SSENIIKYIDNFNTT-------DCCYIVTEYCNQGDLGTLLVKH
  .|| | ||.|||.  |   . ||.| . ..        ..   .| .... |  . .||.. .    .        .  .||.||.  |||   | ||
GKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KR-FPEQRVISYFKQLLNGFKDLHKHQVIHRDIKPENILINQKT-LKIADLGFAKSITGT--------TQTC----LGT----YTTMAPEVLEQKPYGLE
.. .. .  .|.  |  .|   ||....||||.   |.|.. .   ||.| | .. |.          . .      |     .  ||||..  . .  .
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

ADVFSLGVMLYKLL-YGVYPYRS------DTGNLRYVIKERIRQIKYDV-----SDGIISDVMQDLLKRMICYDRRDRITWDQIYQHPIL
 ||.| ||... .. ||  ||        .   ..  .|.. |  . .      .  . .| | .. |.   .|  || |  .|  | ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF