Gene 15837 (Tetrahymena)

15837

Species: Tetrahymena
Alias: 3727.m00053, 345, PreTt15837, TTHERM_00647310, 15837, 93.m00133
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
15837.AA Protein None 614 None Fasta, JSON
15837.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
15837.NA RNA None 1845 None Fasta, JSON

Protein domain

Protein domains of 15837.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15837.AA ULK 13-268 35 1.6e-123 416.7 In-house 1-324 (324) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-324/324
Sequence Identity: 35% (114 aa)

YSIIEKIGEGCFG-RVYKGINLQQ---KEYVAIKQVPYQKFRETAKVRE------LFNSEVKILKAVK---NEN--VVGYVDYFECLEA--AFLVLEYCD
|......|.| ||  ||||.| ..   ..|||.|... .|...  . .|      |...|..|.|  |   ..|  .| . |.||.      ....|||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

SGDLEQYLKKRRT---------IPEPEAIEFFKQILNGFKGLHEVPAVHRDLKVANILIHNKN------------ILKIADLGFGKIIKDN----QLGVT
 ||||||.||...         ..|.|||.|||||.|||| ||.   .|||.| .||||||..            .||||| ||.|.. .|    |.  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VL------GTSLTMAPEVLE----NKKYG-LEVDVYSLGVIFYQMLFGVFP---YVGRSDP----DLLKN-------IKSLPLNLQP--NSIRISENMKD
 .      || |.|||..|.    .|.|.  ..|..|||.|||.||.|  |   .  ...     .|..|       ||  |.. ..  ... ||...||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LLRRMICYQREKRIKWHEVYKHPIF
|.|||..|....|| |.|...||.|
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 15837.AA ULK 13-268 36 1.1e-121 410.62 In-house 1-329 (329) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-329/329
Sequence Identity: 36% (119 aa)

YSIIEKIGEGCFGRVYKGINLQQK----EYVAIKQVPYQKFRETAKVRE------LFNSEVKILKAVK--------NENVVGYVDYFECLEA--AFLVLE
|......|.| ||.||||.| ..|    |.||.|... ||...  . .|      |...|.||.|  |        ..|.| . |.||.      ....|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCDSGDLEQYLKKRRT----------IPEPEAIEFFKQILNGFKGLHEVPAVHRDLKVANILIHNKN------------ILKIADLGFGKIIKDN----Q
||. ||||||.||...          ..|.|||.|||||||||| ||.   .|||.| .||||||..            .||||| ||.| . ..    |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LGVTVL------GTSLTMAPEVLE----NKKYG-LEVDVYSLGVIFYQMLFGVFPYVGRSDPDLL-----KN----------IKSLPLNLQP--NSIRIS
. .| .      || |.|||..|.    .|.|.  ..|..|||.|||.||.|  |...    |.      |.          ||. ||. ..  |.. ||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

ENMKDLLRRMICYQREKRIKWHEVYKHPIF
...|||.|||..|....|| |.|...||.|
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 15837.AA S_TKc 13-268 31 2.9e-76 260.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-231/231
Sequence Identity: 31% (87 aa)

YSIIEKIGEGCFGRVYKGINLQQKEYVAIKQVPYQKFRETAKVRELFNSEVKILKAVKNENVVGYVDYFECLEAAFLVLEYCDS--GDLEQYLKKRRT--
| |..|||.| ||.|||...   ...||||...           | . .|..|||  . .|.| . |.|.  .  ..|.||||   ||| .|.|||..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IPEPEAIEFFKQILNGFKGLHEVPAVHRDLKVANILIHNKNILKIADLGFGKIIKDNQLGVTVLGTSLTMAPEVLENKKYGL-EVDVYSLGVIFYQ
    .|| .|  ...||... . .|.   .||||| .|||. .   .||.| |. ...       |. ||   ||||||   .||  ..|..|.|.|.| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLFGVFPYVGRSDPDLLKNIKSLPLNLQPNSIRISENMKDLLRRMICYQREKRIKWHEVYK-------HPIF
|| |  |.    .  ..|.|.             |. .||..|.. ..  |||.   |. .       || |
MLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15837.AA Ciliate-E2-Unclassified 13-268 26 3.6e-74 252.72 In-house 1-352 (352) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-352/352
Sequence Identity: 26% (93 aa)

YSIIEKIGEGCFGRVYKGINLQQKEYV------AIKQVPYQKFRETAKVRELFN----SEVK-------------ILKAVKNENVVGYVDYFECLEAAFL
| ||..||.|.|| ||| .. .|| ..        .|.  ||  .. . .....     . |             ||.  .....| ....|.  .  ..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VLEYCDSGDLEQYLKKRRT-----------------IPEPEAI-----EFFKQILNGFKGLHEV-PAVHRDLKVANILIHNKN---ILKIADLGFGKIIK
|.|||. |||.||.||| .                 ..| .|.      .|.|||.|.. ||.    .|||.|  |||..|..    .||.|.|. | ..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

DN----------------QLGVTVLGTSLTM----APEVLENKKYGLE----VDVYSLGVIFYQMLFGVFPYVGRSDPD----------------LLKNI
.|                |.  |. ||  .|    |||||....|. .    .|..|||||.|.|||| .|. .... .                |..||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KSLPLNLQPNSI-----RISENMKDLLR----RMICYQREKRIKWHEVYKHPIF
|  ... .. .      ..|.. ||...    .|. .. .||| . .. .||.|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 15837.AA Ciliate-E2 13-268 23 5e-73 248.93 In-house 1-365 (365) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-365/365
Sequence Identity: 23% (87 aa)

YSIIEKIGEGCFGRVYKGINLQQKE-----------------------YVAIKQVPYQKFRETAKVRELFN---------SEVKILKAVKNENVVGYVDY
| .|.|||.|.|| |||. . ....                       ..|.|..  .. ... ..  ...          | .||. ... |.. ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--CLEAAFLVLEYCDSGDLEQYLKKRRTIP-----------EPEAIEFFKQILN---------------GFKGLHEVP-AVHRDLKVANILIHNKNIL
|.    .  .||.|||. |||..|.|....             | |.....||||.               ... ||.    .|||.|  |||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADLGFGKIIKDN--------------------------------QLGVTVLGTSLTMAPEVLENKK---------YGLEVDVYSLGVIFYQMLFGVFP
||.|.|. |...|.                                ..  |..||   ||||.|..||         |. ..|..|||||.|.|||| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

YVGRSDPDLLKNIKSLPLNLQPN---------------SIRISENMKDLLRR----MICYQREKRIK-WHEVYKHPIF
.        ...||  .......                  .|...|||...    |.... ||||  | .. .||.|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 15837.AA Pkinase 13-268 30 2.1e-66 231.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

YSIIEKIGEGCFGRVYKGINLQQKEYVAIKQVPYQKFRETAKVRELFNSEVKILKAVKNENVVGYVDYFECLEAAFLVLEYCDSG----DLEQYLK--KR
| |..|||.| ||.|||...    . ||.|...... ..  ... .  ||..|.| .. .|.| . |.||      .|.|||. |    ||  |..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RTI--PEPEAIEFFKQILNGFKGLHEVPAVHRDLKVANILIHNKNIL----KIADLGFGKI--IKDNQLGVTVLGTSLTMAPEVLE-NKKYGLEVDVYSL
...  .| |.. ...||| | . .|.   .||||| .||||.|.. .    ||.| |. |   .  |.   |. ||.  |||||.  ...|| .||..|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVIFYQMLFGVFPYVGR------SDPDLLKNIKSLPLNLQ-PNSIRIS-----------------ENMKDLLRRMICYQREKRIKWHEVYKHPIF
|.|.|.||.| .|. |.      ..  ....|.. ||  . |....||                 |..||......|.  .||. .... .|| |
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 15837.AA CAMK 18-268 20 1.6e-63 203.29 In-house 1-425 (425) Show / Hide 
Range on Protein: 18-268
Range on HMM: 1-425/425
Sequence Identity: 20% (87 aa)

KIGEGCFGRVYKGINLQQK------------EYVAIKQVPYQKFRE------------------------TAKVRELFNSEVKILKA-------VKNENV
..|.| || |...|. . .            . |||| .. .| ..                        ..| |. . .|..|.|        .. .|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGYVDYFECLEA-------------------AFLVL---EYCDSG----DLEQYLKKR---------------RTIPEPEAIEFFKQILNGFKGLHEVPA
.   ...|  .                     ..|.   |||. |    || .|....               . ..| ||  .|.||. . . .|.   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKVANILIHNK-----------------NILKIADLGFGKIIKDNQLGV------------------------TVLGTSLTMA-PEVLENKK----
||||||  |||. ..                 | .||.| || .......                           |. ||   || ||||. |.    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YGLEVDVYSLGVIFYQMLFGVFPYVGR-------------SDPDLLKNIKSLPLNLQPNSIR-------------ISEN--------MKD
          || ..|. |.||| | || | .|. |              .|..|...|..   .  |  .              ||..         ||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLRRMICYQREKRIKWHEVYKHPIF
|.|.| ..  |||.. ... .|| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15837.AA CAMKL 13-268 27 6.8e-57 180.03 In-house 1-297 (297) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-297/297
Sequence Identity: 27% (81 aa)

YSIIEKIGEGCFGRVYKGIN-LQQKEYVAIKQVPYQKFRETAKVRELFNS-----------EVKILKAVK---NENVVGYVDYFECLEA------AFLVL
| |.. .|.| || |  ... . ..| |||| .  .| ..  ...  .             |..|.| ..    .|..   . .|  |        .||.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCDSGD--LEQYLKKR----RTIPEPEAIEFFKQILNGFKGLHEVPAVHRDLKVANILIHNKN--ILKIADLGFGKIIKD-----NQLGVTVLGTSLTM
|||..|.  | .|..|.    . .||.||  .|.||. . . .|.   ||||.|  |||. ...   .||.| ||. ....     .|.  |  |.   |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLEN--K-KYGLEVDVYSLGVIFYQMLFGVFPYVGRS-------DPDLLKNIKSLPLNLQPNSIRISENMKDLLRRMICYQREKRIKWHEVYKHPIF
|||...   |  .| .||. |.||| | |..| .|  . .       .  .|....       |  ...|   .||.|.|     |||.. |.. .|| .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 15837.AA AGC 13-268 18 7.9e-57 144.41 In-house 1-395 (395) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-395/395
Sequence Identity: 18% (74 aa)

YSIIEKIGEGCFGRVYKGINL------QQKEYVAIKQVPYQK-FRETA--KVREL-----------FNSEVKILKAVK----------NENVVG-YVDYF
. ..  ||.| ||.||           . ..| |.| .  ..   ..   .|.             . .| .||. ..          . ..|      |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ECLEA--AFLVLEY---------CDSG-DLEQYLK---KRRTIPEPEAIEFFKQ-------ILNGFKGLHE-VPAVHRD-LKVANILIHNKNILKIADLG
.  .    ..|.||         |  | .| ..|.   |... .|..|  .. .       |. ..  ||.    .||| ||  |||. ..  .|..| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FGKIIK---------------------------------------------------DNQLGVTVLG--TSLTMAPEVLENKKYGLEVDVYS--LGVIFY
. |...                                                   ....  |  |  |   ||||.|    || ..| .|  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

QMLFGVFPYVGRSDP----------DLLKNIK------SLPLNLQPNS-------IRISENMKDLLRRMICYQREKRIK----------WHEVYKHPIF
.||.|  |. | ..           .. ..|.      . .. . ..          .|.. |||.....|  .|||.             |. .|| |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 15837.AA Ciliate-E2a 13-268 29 3.4e-52 151.93 In-house 1-275 (275) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-275/275
Sequence Identity: 29% (82 aa)

YSIIEKIGEGCFGRVYKGINLQQKEYVAIKQVPYQKFRETAKVRELFNSEVKILKAVKNENVVGYVDYFECLEAAFLVLEYCDSGDLEQYLKKRRTIPEP
|..| |||.|.||.||.   .|...  |.| .   |.... | .| |  |..|.. ... |.    ...|     .||.|||..|.|....|.  .. | 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--EAIEFFKQIL-NGFKGLHEVPAVHRDLKVANILIH--NKN-----ILKIADLGFGKII--KDNQLGVTVLGTSLTMA------PEVLENKKYGLEVDV
  |. .. .|.|  |.  .|    .|||||  |||.   .||      .||.| |... |  ....   .  ||   .|      .|||..|.|.  .|.
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

YSLGVIFYQMLFGVFPYVGRSDPDLLKNIKSLPLNLQPNS--IRISENMKDLLRRMICYQREKRIKWHEVYKHPIF
 |.||||| .|.|  |. |..  . |...|   .... .     .| . |||...|  .. .|||.  . ..|| |
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 15837.AA STE 13-268 21 4.8e-45 155.96 In-house 1-359 (359) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

YSIIEKIGEGCFGRVYKGINLQ---------------QKEYVAIKQVPYQKFR-----------ETA--KVRELFNSEVKILKAVK--NENVVGYVDYFE
. .|||||.| || |||..|                 ..|..||||..... .           |.   . .. .  |.||.|  .   .|.| | ....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

CL-------EAAFLVLEYCDSGDLEQYLK---KR-----------RTIPEPEAIEFFKQILNG-FKGLHEVPAVHRDLKVANILIHNKNILKIADLGFGK
         .  ....||.| | |.. .|   ..            ..||.. . . .||| |  . ||.   .|||.| ||||.      |..| |. .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

IIKD---------------NQLGV--TVLGTSLTMAPEVLEN------KKYGLEVDVYSLGVIFYQMLFGVFPYVGRSDPDLLKNIK-------------
.. |               .. .   |. ||   |||||...      |.|.  .|..|||     |. |  |.   ...  . .|              
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---SLPLNLQPN----------------SIRISENMKDLLRRMICYQREKRIKWHEVYK--HPIF
     |  |...                . . |...|| ...   .  .|| . ..  |  || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 15837.AA Ciliate-E2c 13-268 27 8.5e-45 154.95 In-house 1-310 (310) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-310/310
Sequence Identity: 27% (87 aa)

YSIIEKIGEGCFGRVYKG---------INL-QQKEYVAIKQVPYQKF----RETAKVRELFNSEVKILKAVKNENVVGYVDYFECLEAAFLVLEYCDSGD
... .  | | .| |||.         ||  |.    |||  . . .        .. |    |. ..|  .. ... ..| .      .|..|||  |.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LEQYLKKRRTIPEPEAIEFFKQILNGFKGLHEV-PAVHRDLKVANILIHNKNILKIADLGFGKIIKDNQLGVTV-----LGTSLTMAPEVLENKKYGL-E
||||....  . | . .  |.||...|| ||.     |||.| .||||||  ..|||| || ||. |     |       ||.. |||..|| |.| .  
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHN-GMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEK

VDVYSLGVIFYQMLFGVFPYV------------------GRSDPDLLKNIKS-------------LPLNLQ-PNS--IRISENMKDLLRRMICYQREKRI
 |. ||||  |.||.  .|                    . ..  | ..|.                 |.. |..  . ||.  |.|...|. .  ||||
SDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRI

KWHEVYKHPIF
 | |.  |...
DWDEIFNHECI
Kinase 15837.AA Pkinase_Tyr 13-199 28 6.9e-24 81.52 Pfam 1-202 (270) Show / Hide 
Range on Protein: 13-199
Range on HMM: 1-202/270
Sequence Identity: 28% (60 aa)

YSIIEKIGEGCFGRVYKGINL----QQKEYVAIKQVPYQKFRETAKV---RELFNSEVKILKAV-KNENVVGYVDYFECLEAA---FLVLEYCDSGDLEQ
 ....|.|||.||.||||.      ..|  ||.| ..      . .    || | .|.||.|   ...|.| ..    . .     ..|.||.  |||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YLKK----RRTIPEPEAIEFFKQILNGFKGLHEVPAVHRDLKVANILIHNKNILKIADLGFGKII-KDNQLGVTVLGTSLT----MAPEVLENKKYGLEV
||.|    .. .. .. ...  || .|   |.. . .||||   |.|....|. ||.| |  . | .| .  ... | .      ||||.. ..|.  . 
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKS

DVYSLGV
||.| ||
DVWSFGV
Kinase 15837.AA TyrKc 13-268 25 1.1e-18 69.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

YSIIEKIGEGCFGRVYKGINLQQKEYVAIKQVPYQKFRETAKVRELFNSEVKILKAV--KNENVVGYVDYFECL---------EAAFLVLEYCDSGDLEQ
 . ..|.|||.||.||||.     . ||.| .   .       || | .| .|.. .  ...|.|  . .  |.         |  ..|.||.. ||| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGV--CTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLKKRRT-IPEPEAIEFFKQILNGFKGLHEVPAVHRDLKVANILIHNKNILKIADLGFGKIIKDN-------QLGVT---VLGTS-LT---MAPEVLENK
||.|.|  .. .. ..|  || .|   ||. . .||||   |.|...... ||.| |  . |.|        .  ..     | . |    ||||..  .
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KYGLEVDVYSLGVIFYQML-FGVFPYVG-----RSDPDLLKNIKSLPLNLQPNS------IRISENMKDLLRRMICYQREKRIKWHEVYKHPIF
|.  . ||.| ||  . .. .|  || |      |. ......|.     || .       . .. | .. ..   .. |.|    |.  | .|
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF