Gene 16588 (Tetrahymena)

16588

Species: Tetrahymena
Alias: PreTt16588, TTHERM_00094330, 6.m00662, 3836.m02246, 93, 16588
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
16588.AA Protein None 450 None Fasta, JSON
16588.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
16588.NA RNA None 1353 None Fasta, JSON

Protein domain

Protein domains of 16588.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 16588.AA ULK 18-276 36 1.1e-122 413.92 In-house 1-324 (324) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-324/324
Sequence Identity: 36% (117 aa)

IYQDKMLGNGSYG-QVFEGINKNT---KENVAIKVIPIKKIEAESQNP--QVIFQQIKNEITNMQLIE---GQH--IVKLID----K--KNIYLILEYCN
.. ...|| ||.| .|..|.||.|   .. ||.|.|..||.   ...   |.. |..|||| .|. .    ...  ||||.|    .  .|||.|.||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGNLQSILKHNQG--------SLSESQAVNIIYQITEGYKCLLAKNMAHRDLKPANILFKDGI-------------AKIADFGFSKVVGLN-DDTKLRHS
||.|....| |..         |||..|.....|| .|.|.|  .|  |||.||.||| ..|.             .|||||||.|.|  |  .  ....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IL------GSPQYMSPQLLS----QQEYCPKKADMWSLGMIFYEMLYRKVP---WRADSPQ----DLLFQ-------IQQKPLEFP---AVPQVSLIVKK
..      |.| ||.||.|.    |..|. .|.|.||||.||||||| |.|   | . . .    .|. .       |...|..||   . |..|  .| 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

VISYMLKIEESDRISWEELINEPLF
 |. ||...|.|||||||..| |.|
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 16588.AA ULK 18-276 36 2.7e-121 409.27 In-house 1-329 (329) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-329/329
Sequence Identity: 36% (120 aa)

IYQDKMLGNGSYGQVFEGINKNTK----ENVAIKVIPIKKIEAESQNP--QVIFQQIKNEITNMQLIE----GQH----IVKLID----K--KNIYLILE
.. ...|| ||.|.|..|.||.||    | ||.|.|...|.  ....   |.. |..|||| .|. .     ...    ||||.|    .  .|||.|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNGGNLQSILKHNQG---------SLSESQAVNIIYQITEGYKCLLAKNMAHRDLKPANILFKDGI-------------AKIADFGFSKVVGLN-DDTK
|||||.|....| |..          |||..|.....|| .|.|.|  .|  |||.||.||| ..|.             .|||||||.|.|  . .. .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LRHSIL------GSPQYMSPQLLS----QQEYCPKKADMWSLGMIFYEMLYRKVP---WRADSPQ-----DLLFQ-------IQQKPLEFP---AVPQVS
. .. .      |.| ||.||.|.    |..|. .|.|.||||.||||||| |.|   | . . .     .|. .       |...||.||   . ||.|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

LIVKKVISYMLKIEESDRISWEELINEPLF
  .|  |. ||...|.||||||||.| |.|
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 16588.AA Ciliate-E2c 18-276 31 2e-70 240.28 In-house 1-310 (310) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-310/310
Sequence Identity: 31% (99 aa)

IYQDKMLGNGSYGQVFEG---INKNTKENV-------AIKVIPIKKIEAESQNPQVIFQQIKNEITNMQLIEGQHIVKLID----KKNIYLILEYCNGGN
|  ...|| ||||.|. .     ...  |.       ||| .. | ..    |   |   |..|| .|      ||.| .|    .|.||||.||||||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LQSILKHN-QGSLSESQAVNIIYQITEGYKCLLAK-NMAHRDLKPANILFKDGIAKIADFGFSKVVGLNDDTKLRHS----ILGSPQYMSPQLLSQQEYC
|.. ..|. .  ..| | .    ||  . | |  . |..|||.||.||| ..|. ||||||||| .  .||..   .    . |.|.||.|| |.   | 
LEQYIYHKPK--PNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKIC--QDDNIQNTQGFNTCCGTPMYMAPQILEGKNYY

PKKADMWSLGMIFYEMLYRKVPWR------------------ADSPQDLLFQIQ---------------QKPLEFPAV--PQVSLIVKKVISYMLKIEES
 .|.| ||||   |.||..| ||.                  ... . |   |                .... ||      .|. ||  |  ||  .|.
TEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEE

DRISWEELINEPLF
.||.|.|..| ...
KRIDWDEIFNHECI
Kinase 16588.AA Ciliate-E2 18-276 22 1.3e-67 230.98 In-house 1-365 (365) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

IYQDKMLGNGSYGQVFEGINKNTKENVAIK---------------VIPIKKIEAESQNPQVIFQQIKNEIT-------------NMQLIEGQHIVKLI--
.   |..|.|..|.|... ........|||                | |. ..  ..|   .. |.....              .....   .|.|..  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

----DKKNIYLILEYCNGGNLQSILKHNQ----------GSLSESQAVNIIYQITEGY---------------KCLLAKN-MAHRDLKPANILFKDGIAK
    |..||||..|||.||.|....|.|.          ....| .. .|..||..|.               . |  ||   |||.|| ||||     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGFSKVVGLN-----------DDTKLR-------------------HSILGSPQYMSPQLLSQQEY--------CPKKADMWSLGMIFYEMLYRKVP
|.|||.|| .  .             .  .                   ..|.|.| ||.|. |. ..|          .|.|.||||.|.||||. | |
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

WRADSPQDLLFQIQQK-PLEFP----------------AVPQVSLIVKKVISY----MLKIEESDRIS-WEELINEPLF
.         .|.... ...||                   ..|. .|  |.     ||. ... ||. ||...| | |
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 16588.AA S_TKc 18-276 26 2.5e-65 224.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-231/231
Sequence Identity: 26% (73 aa)

IYQDKMLGNGSYGQVFEGINKNTKENVAIKVIPIKKIEAESQNPQVIFQQIKNEITNMQLIEGQHIVKLIDK---KNIYLILEYCNG--GNLQSILKHNQ
    . .| |..|.|. ...|.|.. ||||.|.               ..|..||  ..     .||||.|    ...|...|||.|  |.| ...|...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRG

GS-----LSESQAVNIIYQITEGYKCLLAKNMAHRDLKPANILFKDGIAKIADFGFSKVVGLNDDTKLRHSILGSPQYMSPQLLSQQEYCPKKADMWSLG
.      ..| .|  ..||| .. . .  ..  ||||||.|||. .   ||.|||.....         ... |.| ||.| .|    | ..|.|.||.|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

MIFYEMLYRKVPWRADSPQDLLFQIQQKPLEFPAVPQVSLIVKKVISYMLKIEESDRISWEELIN-------EPLF
 |.||||... |..    ....|..             |  .|  |. .|. . ..|..  |. .        | |
CILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 16588.AA CAMK 23-276 20 1.2e-64 206.93 In-house 1-425 (425) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-425/425
Sequence Identity: 20% (87 aa)

MLGNGSYGQVFEGINKNTK------------ENVAIKVIPIKK--------------IEAESQNP------QVIFQQIKNEITNMQL-------IEGQHI
 || ||.|.|...|.|||.            . ||||.|. ||              |. . .        ..  .....||  |..       .   .|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLID-----------------------KKNIYLIL---EYCNGG----N-LQSILKHNQ-------------GSLSESQAVNIIYQITEGYKCLLAKNM
.||..                       .|..|...   ||| ||      .. | .| .             | ..|..|  .. || .. . .  .| 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHRDLKPANILFKD------------------GIAKIADFGFSKVVGLNDD---------------------TKLRHSILGSPQYMS-PQLLSQ------
.|||||| |||. |                  .  ||.||||....  ...                     ... .   |.| ||. | .|..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------QEYCPKKADMWSLGMIFYEMLYRKVPWRAD-------------SPQDLLFQIQQKPLEFP--AVPQVSLI--------------------VKK
       ..|...|.||||.| | | ||  . |...|             ....|. .|..   .||   .. .| .                    .| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

VISYMLKIEESDRISWEELINEPLF
 |. ||. . ..|.. |.  | | .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 16588.AA Pkinase 18-276 26 7e-59 206.72 Pfam 1-293 (293) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

IYQDKMLGNGSYGQVFEGINKNTKENVAIKVIPIKKIEAESQNPQVIFQQIKN--EITNMQLIEGQHIVKLID----KKNIYLILEYCNGG----NLQSI
.   . .| ||.|.|.....|.| . ||.|.|. .... .        |.  .  ||  |. .   .||.|.|    |..||...|||.||     | ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSW------KDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LK-HNQGSL--SESQAVNIIYQITEGYKCLLAKNMAHRDLKPANILFK-DGIA----KIADFGFSKVVGLNDDTKLRHSILGSPQYMSPQLLSQQEYCPK
.. ...|..  || .. ...||| .| . . ...  ||||||.|||.. .|      ||.|||..|..  .      ... |.| ||.| ..  ..| ..
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KADMWSLGMIFYEMLYRKVPWRAD------SPQDLLFQIQQKPLEFP--------------------AVPQVSLIVKKVISYMLKIEESDRISWEELINE
|.||||.| |.|||| .. |.. .      ... ....| ..||.|.                      . .|   |..|...|.   ..|...|.. . 
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PLF
| |
PWF
Kinase 16588.AA CAMKL 16-276 28 5.3e-57 180.38 In-house 1-297 (297) Show / Hide 
Range on Protein: 16-276
Range on HMM: 1-297/297
Sequence Identity: 28% (87 aa)

YVIYQDKMLGNGSYGQVFEGIN-KNTKENVAIKVIPIKKIEAESQNPQVIFQQ-----------IKNEITNMQLIE---GQHIVKLIDK----------K
| | .   || ||.|.|  ... ..|.| ||||.| .|||    .| ... .            |. ||  |...     ..|.|| .           |
YRIGK--TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKI----WNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETK

NIYLILEYCNGGN--LQSILK-HNQ--GSLSESQAVNIIYQITEGYKCLLAKNMAHRDLKPANILFK-DG--IAKIADFGFSKVVG---LNDDTKLRHSI
 |||..||| ||.  |.  .. |    |...|..|  .  || .. . .  .. .|||.|| |||.  .|   .||.|||||        ... ||. . 
KIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFC

LGSPQYMSPQLLSQ--QEYCPKKADMWSLGMIFYEMLYRKVPWRADSP-------QDLLFQIQQKPLEFPAVP-QVSLIVKKVISYMLKIEESDRISWEE
 ||| ||.| ...   ..|. .|.|.||.| | | |.. ..|...|.        . .|. .. .  ..| .. .||  ..  |. ||.   ..|.. ..
-GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQ

LINEPLF
. | | .
IMNHPWM
Kinase 16588.AA Ciliate-E2-Unclassified 18-276 25 1.4e-54 187.64 In-house 1-352 (352) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

IYQDKMLGNGSYGQVFEGINKNTKENVAIKVIPIKKIEAESQNPQVIFQQIKNEITNMQLIE-------------------GQHIVKLIDKK----NIYL
    | .|.|..|.|.. ..|..|  .... . .|...  ... .    .|.||.. |. ..                     .|||... .    |||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ILEYCNGGNLQSILKHNQG----------------SLSESQAV-----NIIYQITEGYKCLLAKN-MAHRDLKPANILFKDG----IAKIADFGFSKVVG
..|||.||.|. ..|.. .                 ..| ||.     ....|| .| . |  ||   |||.|| ||||...      ||.|||.||  .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

LNDD-------------TKLRHSILGSPQYM----SPQLLSQQEYCP---KKADMWSLGMIFYEMLYRKVPWRADSPQD----------------LLFQI
 |..              .. ... |.|.||    .| .| .|.|     .|.|.||||.|.||||. . |  . .  .                |. .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

QQKPLEFPAVP------QVSLIVKKVIS----YMLKIEESDRISWEELINEPLF
.||...||  |      ..|  .|  |.     |||   . ||..|...| |.|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 16588.AA STE 19-276 21 3.3e-53 183.08 In-house 1-359 (359) Show / Hide 
Range on Protein: 19-276
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

YQD-KMLGNGSYGQVFEGINK------NTKEN---------VAIKVIPIKKIEA-----ESQNPQ------VIFQQIKNEITNMQLIE--GQHIVKLIDK
... ...|.|..|.|. ..|.       |.|.         .|||...... ..     |. . .       ..|||..||  |.      ..||| .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

-----------KNIYLILEYCNGGNLQSILKHNQGSLS-------------ESQAVNIIYQITEG-YKCLLAKNMAHRDLKPANILFKDGIAKIADFGFS
            ......||..|| | .|.||. | .              |||   |..|| .|  . |  ..  |||.||||||.    .|..|||..
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVC

K-VVGLND------------DTK-LRHSILGSPQYMSPQLLSQQEYCPK------KADMWSLGMIFYEMLYRKVPWRADSPQDLLFQIQQKP--------
. ..  ..            ...  | .. |.| .|.|  ..|.. . .      |.|.||||    ||.  |.||   .|   .|.|...         
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-----LEFPAVPQ--------------------VSLIVKKVISYMLKIEESDRISWEELIN--EPLF
      . |  |.                    .|   |  |.  |... ..| . ..|..   | .
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 16588.AA STE11 18-276 25 6.3e-41 142.29 In-house 1-303 (303) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-303/303
Sequence Identity: 25% (78 aa)

IYQDKMLGNGSYGQVFEGINKNTKENVAIKVIPIKKIEA-------ESQNPQVIFQQIKNEITNMQLIEGQHIVKLID-------KKNIYLILEYCNGGN
    ...| |..|.|. ..|..| | .|.| |.|....        | |  . ..  |. ||  |. .  ..||. ..       ..... ..||| || 
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQS-HKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGS

LQSILKHNQGS--LSESQAVNIIYQITEGYKCLLAKNMAHRDLKPANILF-KDGI-AKIADFGFSKVVG-LNDDTKL-------RHSILGSPQ-------
| |.|.|..|   ..|.   . . || || . | ...  |||.|.||||  .||.  |.|||| .| .   .  |.          |. |.|.       
LSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTP

-YMSPQLLSQQE---YCPKKADMWSLGMIFYEMLYRKVPWRADS--PQDLLFQIQQK-PLEFPAVPQVS------LIVKKVISYMLKIEESDRISWEELI
 .|.|  ..|.    |. .||| |||| . .||.  | ||   .  ..  .| |  .     |    .|         .  ..  .... ..| .  .| 
MWMAPEVIKQEGRDGYG-RKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLL

NEPLF
. | .
QHPFI
Kinase 16588.AA TKL 24-221 19 2.9e-39 136.78 In-house 1-290 (364) Show / Hide 
Range on Protein: 24-221
Range on HMM: 1-290/364
Sequence Identity: 19% (57 aa)

LGNGSYGQVFEGINKNTK--------ENVAIKVIPI---KKIEAESQN----------------PQVIFQQIKNEITNMQLIEGQHIVKLID--------
.| |..|.|. |. ...         . ||.|....   .. .  ||.                .. .......||  |  .  ..||...         
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------KKNIYLILEYCNGGNLQSILKHNQGSLSESQAVNIIYQITEGYKCLLA--------KNMAHRDLKPANILFKDGI---------------A
         ....... ||| ||.| ..|         .| ......|  |   | .        ....|||||..||| ..                 .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIADFGFSKVV---GLNDDTK--------------LRHSILGSPQYMSPQLLSQQEY---------------CPKKADMWSLGMIFYEMLYRKVPWR
||.|||.|...   | . ||.               .... |.|..|.| .| .|..                 .|.|..| |....|.| |..|..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
Kinase 16588.AA Pkinase_Tyr 18-173 29 1.9e-20 69.91 Pfam 1-166 (270) Show / Hide 
Range on Protein: 18-173
Range on HMM: 1-166/270
Sequence Identity: 29% (51 aa)

IYQDKMLGNGSYGQVFEGINK----NTKENVAIKVIPIKKIEAESQNPQVIFQQIKNEITNMQLI-EGQHIVKLI-----DKKN--IYLILEYCNGGNLQ
|  .|.|| |..|.|..|. |    |||  ||.|..  |    ..||   . .   .|.  |  .   ..||.|.     ...   ||...||. .|.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

SILKHN---QGSLSESQAVNIIYQITEGYKCLLAKNMAHRDLKPANILFK-DGIAKIADFGFSKVVGLNDDT
. |. .   ...|. .. ... .|| .|   | .||. ||||   |.| . ....||.||| .. .  |||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDY
Kinase 16588.AA TyrKc 18-276 20 6.2e-14 2.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

IYQDKMLGNGSYGQVFEGINKNTKENVAIKVIPIKKIEAESQNPQVIFQQIKNEITNMQLI--EGQHIVKLI----DK-------KNIYLILEYCNGGNL
|  .|.||.| .|.|..|. |   ..||.|..   .            . . .|.  |  .  . ..||.|.    ..       . .....||. .|.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

QSILKHNQGSLSESQAVNIIYQITEGYKCLLAKNMAHRDLKPANILFKDG-IAKIADFGFSKVVGLN-------DDTK-----LRH--SILGSPQYMSPQ
.. |. ... |. .. ... .|| .|   |  ||  ||||   |.| ... ..||.||| |. ..         |  .      ..    .     |.| 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI---RWMAPE

LLSQQEYCPKKADMWSLGMIFYEML-YRKVPWRA-----DSPQDLLFQIQQK-PLEFPAV------PQVSLIVKKVISYMLKIEESDRISWEELINEPLF
 .   .. . | | || |   .|.. | . |.        |.|... ...|   .. |.       .  .  . ....   . . .|| . .|.    .|
CINYGKFTT-KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF