Gene 18315 (Tetrahymena)

18315

Species: Tetrahymena
Alias: TTHERM_00756520, 18315, 123.m00134, 306, 3742.m00064, PreTt18315
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
18315.AA Protein None 1583 None Fasta, JSON
18315.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
18315.NA RNA None 4752 None Fasta, JSON

Protein domain

Protein domains of 18315.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18315.AA ULK 4-256 30 4.1e-88 299.04 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-329/329
Sequence Identity: 30% (102 aa)

YHIYEDIAKGKYSIIYKARKKKT----IDYFAVKSME--KCKRKK-----------LMNEVKIFNLLD--------HVNILKYYNWYETK--NHLWAIFE
|.. . . || .   ||.|.|||      ..|.| ..  |...|.           |.||.||   |.        | || |.| |.||.  |... |.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YSSGGNLLSLIEQDKK----------LTEPQIKIFAKDLIQGLLYLHSKGIIYCDLKPSNILLNEY------------GTLKYCDFGLARQ-IVD-----
|  ||.| ..|...||          |.|.....| |....|. .||...|| .|.||.|||...             |.|| .|||.|..   |     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-LIQTD-EDVKEGSKK---GTPYYMAPELFQDDG----VYSYQSDLWSLGCILYELSNGKPPFVSKSFQDLVWLIINKE--------------PEVVEG-
 .  .  |       |   |||.||||...|. |     |.| .|.||||||.||.  |||||..  |.|....||.|.              |   .  
MMMTCVNE-------KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKD

-----FSSDFHSFVFGLLQKNPLKRLNWSEIINHPFL
     .|......  ..||... .| .| |..|||..
GNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 18315.AA S_TKc 4-256 33 1.3e-85 291.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

YHIYEDIAKGKYSIIYKARKKKTIDYFAVKSMEKCKRKKLMNEVKIFNLLDHVNILKYYNWYETKNHLWAIFEYSSG--GNLLSLIEQDKK------LTE
|.| . | || ..  ||.|.|||  ..|.| .     .....|..|    .| || |.| .... .||. ..|| .|  |.|...|.. ..      ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

PQIKIFAKDLIQGLLYLHSKGIIYCDLKPSNILLNEYGTLKYCDFGLARQIVDLIQTDEDVKEGSKKGTPYYMAPELFQDDGVYSY-QSDLWSLGCILYE
 ... ... ....| |.||.|||..||||.||||.|  ..| ||||||||.             .  |||.|||||..     |..  .| ||.||||||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LSNGKPPFVSKSFQDLVWLIINKEPEVVEGFSSDFHSFVFGLLQKNPLKRLNWSEIIN-------HPFL
.  |.|||     | .  .|           |... .|. ..|||.| ||.   |. .       ||..
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18315.AA ULK 4-256 30 1.2e-84 287.55 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-324/324
Sequence Identity: 30% (101 aa)

YHIYEDIAKGKYS-IIYKARKKKT---IDYFAVKSMEKCKRKK-------------LMNEVKIFNLLD---HVN--ILKYYNWYETK--NHLWAIFEYSS
| . . . || .    ||.|.|||     |.|.| ..|.| .|             |.||..|   |.   |.|  | |.| |.||.  |... |.||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGNLLSLIEQDKK---------LTEPQIKIFAKDLIQGLLYLHSKGIIYCDLKPSNILLNEY------------GTLKYCDFGLARQI-------VDLIQ
||.| ..|...||         |.|.....| |....|. .||...|| .|.||.|||...             |.|| .|||.|...        .. .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

TD-EDVKEGSKK---GTPYYMAPELFQDDG----VYSYQSDLWSLGCILYELSNGKPPFVSKSFQDLVW--------------LIINKEPEVV-----EG
.  |       |   |||.||||...|. |     |.| .|.||||||.||.  ||.||.|  |.|...              .| |.  .         
CVNE-------KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPK

FSSDFHSFVFGLLQKNPLKRLNWSEIINHPFL
.|......  ..||... .| .| ||.|||..
ISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 18315.AA AGC 4-256 22 4e-83 213.97 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-395/395
Sequence Identity: 22% (88 aa)

YHIYEDIAKGKYSIIYKARKK------KTIDYFAVKSMEKCK---------RKKLMNE------------VKIFNLLD----------HVNILK-YYNWY
....  | || ..  | .|||       | .|.|.| ..| .          .. |.|             .|. ...          | .| |  .  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKNH--LWAIFEYSS---------GG-NLLSLIE---QDKKLTEPQIKIFAKD-------LIQGLLYLHS-KGIIYCD-LKPSNILLNEYGTLKYCDFG
..|.|  |  . || .         ||  |.. .    . ....|......|         .. .| |||| .|||. | ||| ||||.| | .| .|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LARQIVD-----------------------------------LIQTD----------EDVKEGSKKG--TPYYMAPELFQDDGVYSYQSDLWS--LGCIL
|. ....                                   . ..           ....  .  |  || ||||| .     |... | ||  |||..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YELSNGKPPFVSKS----------FQDLVWLII------NKEPEVV----------EGFSSDFHSFVFGLLQKNPLKRLN----------WSEIINHPFL
||.  |.||| ...            ..  .|.      |....            . ||..  ... .||.|.| |||            .|| |||. 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 18315.AA Pkinase 4-256 30 4.6e-76 263.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

YHIYEDIAKGKYSIIYKARKKKTIDYFAVKSMEKCKRKKLMN-------EVKIFNLLDHVNILKYYNWYETKNHLWAIFEYSSGG----NLLSLIE--QD
||| . | .| ..  ||...|.| . .||| ..|...|. ..       |..| . |.| ||...| |.|.|.|.. ..||  ||     | ..|.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KKL--TEPQIKIFAKDLIQGLLYLHSKGIIYCDLKPSNILLNEYGTL----KYCDFGLARQIVDLIQTDEDVKEGSKKGTPYYMAPELFQDDGVYSYQSD
...  .| ..| ... ...|| |.||.|||..||||.|||... |..    | ||||||.|.     .  ..   .  |||.|||||. ...  |.. .|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

LWSLGCILYELSNGKPPFVSK----SFQDLVWLIINKEPEVVEGFS------------------------SDFHSFVFGLLQKNPLKRLNWSEIINHPFL
 ||.||||||. .|.||| ..    .  |  ..| .. .  ..  .                        ... .|. ..|.|.| ||... .| .||..
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 18315.AA CAMK 9-256 18 8.9e-67 213.95 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-256
Range on HMM: 1-425/425
Sequence Identity: 18% (80 aa)

DIAKGKYSIIYKARKKKTI------------DYFAVKSMEKC-------------------------------KRKKLMNEVKIFNL-------LDHVNI
 . .| ... .... |.|               .|.| ..|                                .||....|..| ..       ||| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKYYNWYE------------TKNH--------LWAIF---EYSSGG----NLLSLIEQD---------------KKLTEPQIKIFAKDLIQGLLYLHSKG
.| | .||            | ..        .. ..   || |||     |.. | .                ...|| . . . . ..... |.||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIYCDLKPSNILLNEY-----------------GTLKYCDFGLARQIVDLI------------------QTDEDVKEGSKKGTPYYMA-PELFQD-----
|. .|||| ||||..                  ...| .|||.|... .                    ...|. |     |||.||| ||...      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------DGVYSYQSDLWSLGCILYELSNGKPPFVSK-------------SFQDLVWLIINKEPE-VVEGFSS-----------------------DFH
           |....| ||.|.||| .  |.||| ..             . ..|   |.. . .   . ||                        .  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SFVFGLLQKNPLKRLNWSEIINHPFL
... ..||..| ||.. ... |||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 18315.AA STE 4-256 25 1.7e-66 227.23 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-359/359
Sequence Identity: 25% (94 aa)

YHIYEDIAKGKYSIIYKARKKK---------------TIDYFAVKSME--------------------KCKRKKLMNEVKIFNLLD--HVNILKYYNWYE
. . | | || .   |||...|               | ...|.| |.                    . .......|.|| . ..  | || |||  |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TK-------NHLWAIFEYSSGGNLLSLIE---QDKK-LT----------EPQIKIFAKDLIQG-LLYLHSKGIIYCDLKPSNILLNEYGTLKYCDFGLAR
 .       ..|| . || .|| | ..|.     .| |.          |.||.........| | ||||..||  |.||.||||      | ||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QIVDLIQ-----------TDEDVKEGSKKGTPYYMAPELFQD-----DGVYSYQSDLWSLGCILYELSNGKPPFVSKSFQDLVWLII-------------
|..| .             . . |  .  ||| .||||  |      |. |....| ||||| . |. .||||.   .     ..|.             
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NKEPEVVE-------------------GFSSDFHSFVFGLLQKNPLKRLNWSEIIN--HPFL
   .. |   .                    .|..|. |.   |||.| || . |. ..  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 18315.AA Ciliate-E2 4-256 23 3.8e-65 222.56 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

YHIYEDIAKGKYSIIYKARKKKT-----------------------IDYFAVKSMEKCKRKKLMNEVKIFN----------------LLDHVNILKYYNW
| . . | .| ....||....|.                       | ..|.|.|.| . . ...| .|..                .|.| ||.|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--TKNHLWAIFEYSSGGNLLSLIE------------QDKKLTEPQIKIFAKDLIQ---------------GLLYLHSKG-IIYCDLKPSNILLNEYGT
..  ..|..  ..|| .||.|...|.            . |..|| .|| . | ..|               .| |||||. ||. |.||.|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKYCDFGLARQIVD------------LIQTDEDVKEGSKK---------------GTPYYMAPELFQDDGV--------YSYQSDLWSLGCILYELSNGK
.| .||||.... |            ...     ....                 |||.||||| ..  .         |.|..|.||||.||||.  ||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFVSKSFQDLVWLIINKEPEVV--------------------EGFSSDFHSFVFG----LLQKNPLKRLN-WSEIINHPFL
|||          ....|. ..                     .  | .   .       .|||.| ||.. |..|.|||..
PPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 18315.AA Fused 4-256 36 8.8e-56 189.96 In-house 1-251 (251) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-251/251
Sequence Identity: 36% (95 aa)

YHIYEDIAKGKYSIIYKARKKKTIDYFAVKSMEKCKR-----KKLMNEVKIFNLLDHVNILKYYNWYETKNHLWAIFEYSSGGNLLSLIEQDKKLTEPQI
||. | . .| .  .||||.|      |.|   |  |     | |  |. |   . | .|    . .||.  . .. .|   ..|    | | |. | |.
YHVSEMVGQGSFGCVYKARRKYDSKVVAIKFIPKRGRSDKELKNLRRECEIMRRMHHPHIIHMIDSFETDKEVVVVTDYAE-MELHQYLEYDGKMPEEQV

KIFAKDLIQGLLYLHSKGIIYCDLKPSNILLNEYGTLKYCDFGLARQ--IVDLIQTDEDVKEGSKKGTPYYMAPELFQDDGVYSYQSDLWSLGCILYELS
.  |  |.  | ||||  |   |.|| ||||   .  | ||||.||   |  .. |       | |||| ||||||      |    |.|||||||||| 
RRIACHLVSALYYLHSHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHVLT-------SIKGTPLYMAPELVEEQP-YDHHADMWSLGCILYELM

NGKPPFVSKSFQDLVWLIINKEPEVVEGFSSDFHSFVFGLLQKNPLKRLNWSEIINHPFL
 |.|||   |   || .|.  .       .| . .|  ||| | | .|. | .   ||| 
VGQPPFCANSIFHLVSMIKHDDVKWPSTITSCCRNFLQGLLTKDPRHRISWPQLLCHPFV
Kinase 18315.AA STE20 4-256 32 1.6e-55 190.73 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-288/288
Sequence Identity: 32% (95 aa)

YHIYEDIAKGKYSIIYKARKKKTIDY----FAVKSMEK-------CKRKKLMNEVKIFNLLDHVNILKYYNWYETK----NHLWAIFEYSSGGNLLSLIE
| ..| | .| |  .|||..|.| .|     |.| |.        .... ...|. | . ..| || |||. |  .    ..|| . || .|| |. ...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---QDKK------LTEPQIKIFAKDLIQGLLYLHSKGIIYCDLKPSNILLNEYGTLKYCDFGLARQIVDLIQTDEDV---KEGSKKGTPYYMAPELFQD-
    ..|      ..|.||    ... ||| ||||..||  |.|  ||||.| |  | .|||.. |. ..  . . .   |  .  ||||.||||. |  
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEVIQCM

---DGVYSYQSDLWSLGCILYELSNGKPPFVS-KSFQDLVWLI--INKEPEVVE----GFSSDFHSFVFGLLQKNPLKRLNWSEIINHPFL
   |. | | .| ||||  . |. .|.||.     .. .   .   |. |.  .     .|..|| ||   |||.| ||   |.  .|||.
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 18315.AA Ciliate-E2-Unclassified 4-256 24 5e-55 189.13 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

YHIYEDIAKGKYSIIYKARKKKTIDYF-----AVKSMEKCKRKKL-----------MNEVK-------------IFNLLDHVNILKYYNWYETKNHLWAI
|.| . | .| ....||...||.  ..     . |.... .....           ||. |             |.  ..| .|.|.. . ..|...  .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

FEYSSGGNLLSLIEQDKK-----------------LTEPQIK-----IFAKDLIQGLLYLHSKG-IIYCDLKPSNILLNEYG---TLKYCDFGLARQIVD
 ||  ||.|.  |.. ||                 .|| |.|      ... ..||| |||.|. ||. |.||.|||... |    .| .|||..... .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

LIQTDEDV----------KEGSKK-GTPYYM----APELFQDDGVYS---YQSDLWSLGCILYELSNGKPPFVSKSFQD----------------LVWLI
 .. | .           .. . . |||.||    |||..|  . .    |..| ||||.||||.  |..|| ...  .                |   |
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

INKEPEVVE--------GFSSDFHSFVF----GLLQKNPLKRLNWSEIINHPFL
..|.... .        . |     |.      .|.||| ||.....|.|||..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 18315.AA RSK 6-256 25 1.5e-51 177.56 In-house 1-278 (278) Show / Hide 
Range on Protein: 6-256
Range on HMM: 1-278/278
Sequence Identity: 25% (71 aa)

IYED--IAKGKYSIIYKARKKKTIDYFAVKSMEKCKRKKL-------MNEVKIFNLLD-HVNILKYYNWYETKNHLWAIFEYSSGGNLLSLIEQDKK---
. ..  ...||...  | . ..|  ..|.|  .| |...        | |..|  .   | .| ...  ..|. .|. | || .|| |.  ... |    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LTEPQIKIFAKDLIQGLLYLHSKGIIYCDLKPSNILLNE---YGTLKYCDFGLARQIVDLIQTDEDVKEGSKKGTPYYMAPELFQ---DDGVYSYQSDLW
..|   .. .  ..  . .||..|||. ||||.|||...    |..| .|||...|       |.  .  .  .|  |||||.      .| .. . |.|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF----RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWW

SLGCILYELSNGKPPFVS---KSFQDLVWLIINKE--PEVV--EGFSSDFHSFVFGLLQKNPLKRLN-----WSEIINHPFL
|||...||.  |.||| .   .. ...   | ...  ..    .  | .. ... ..|...| |||.      .|| .||..
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 18315.AA Pkinase_Tyr 31-214 28 2.1e-17 59.56 Pfam 32-228 (270) Show / Hide 
Range on Protein: 31-214
Range on HMM: 32-228/270
Sequence Identity: 28% (57 aa)

AVKSMEKCKRKK------LMNEVKIFNLL-DHVNILKYYNWYE-TKNH--LWAIFEYSSGGNLLSLIEQ----DKKLTEPQIKIFAKDLIQGLLYLHSKG
|||..     ..      .|.|.||   | .| ||...|      . .  .. ..||  .|.||.   .    ...|| ...  .. .  .|. ||.||.
AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN

IIYCDLKPSNILLNEYGTLKYCDFGLARQIVDLIQTDED-VKEGSKKGTPYYMAPELFQDDGVYSYQSDLWSLGCILYELSN-GKPP-FVSKSFQDLVWL
.|  ||   |.|..| .. | ||||||| |     .|.  .| |. |     |||| ...   .. .|| || |  ..|.   |. | .   | .... .
CIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEY

I
|
I
Kinase 18315.AA TyrKc 4-256 23 4.8e-17 52.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YHIYEDIAKGKYSIIYKARKKKTIDYFAVKSMEKCKRKKLMNEVKIFNLL--DHVNILKYYNWYETK-------NHLWAIFEYSSGGNLLSLIEQDKK-L
 .  . .  | . ..||.. |      |||.. ...|. .|.| .|   |  .| ||.. |    ..         |. ..|| ..|.|.. .   .. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

TEPQIKIFAKDLIQGLLYLHSKGIIYCDLKPSNILLNEYGTLKYCDFGLARQIVDL----IQTDEDVKEG--SKK--GTPYYMAPELFQDDGVYSYQSDL
. ..   |. .  .|  |||||..|  ||   |.|..| .| | .||||.| | |       .|  .| .  ..|       |||| . ..|... .|| 
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDV

WSLGCILYEL-SNGKPPFVS-----KSFQDLVWLIINK-EPEVVEG--------FSSDFHSFVFGLLQKNPLKRLNWSEIINHPFL
|| |  ..|. ..|..|        .| |... .. .   ..  .          ... ..      . .| .| . |||  | ..
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF