Gene 18701 (Tetrahymena)

18701

Species: Tetrahymena
Alias: 18701, TTHERM_00468000, PreTt18701, 3710.m00105, 421, 55.m00256
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
18701.AA Protein None 682 None Fasta, JSON
18701.kin_dom Protein Kinase Domain None 263 None Fasta, JSON
18701.NA RNA None 2049 None Fasta, JSON

Protein domain

Protein domains of 18701.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18701.AA ULK 14-276 40 2.7e-140 472.37 In-house 1-324 (324) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-324/324
Sequence Identity: 40% (131 aa)

FNLNQRIGSGSYA-NVYKGEDRET---GKAVAIKMIDRKKISQE------DYLMNGLLQEIQIMKKLD---SNY--IVKLIDVLETK--NNYYIVQEFCD
..||...|.||..  ||||.. .|   ...||.||||.||...       .|... | .||||||||.   ...  ||||.|..||.  ||.||..|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

QGDFRNYLKQKGY---------LPEQEAKQVLVDILNGFLELLKHGIIHRDLKPENILIQTKNPQTGER-------IFKLADFGFSRTVDN--FRRELLT
.||...|.|....         |.||||.|.. .|.||| || ||.|||||.||.||||  ..|.| ..       ..|.|||||...|||  .   ...
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SLV------GTPLYMSPQILM----FKKYT-SKSDIWSIGLIMYEMLYGKTP---WNAISQY----QLVEM-------INKQPINWK---SENIISEEAI
..|      ||||||.||||.     |.|. .|.||||.| |.|||||||.|   | . .||    .|...       |..|||...   ....||.| .
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

NFMYKCLQLEEEKRIQWDEIYAHPLF
.. ...|| .|..|| |.||..||.|
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 18701.AA ULK 14-276 39 6.6e-138 464.45 In-house 1-329 (329) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-329/329
Sequence Identity: 39% (130 aa)

FNLNQRIGSGSYANVYKGEDRET----GKAVAIKMIDRKKISQED------YLMNGLLQEIQIMKKLD----SNY----IVKLIDVLETK--NNYYIVQE
..||...|.||.. ||||.. .|    ...||.||||..|..|.       |... | .||.|||||.    ...    ||||.|..||.  ||.||..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCDQGDFRNYLKQKGY----------LPEQEAKQVLVDILNGFLELLKHGIIHRDLKPENILIQTKNPQTGER-------IFKLADFGFSRTVDNF--RR
.|..||...|.|....          |.||||.|.. .||||| || ||.|||||.||.||||  ..|.| ..       ..|.|||||...|||.    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSKKVHPNGVLKIADFGFAKHVDNDNMEQ

ELLTSLV------GTPLYMSPQILM----FKKYT-SKSDIWSIGLIMYEMLYGKTP---WNAISQY-----QLVEM-------INKQPINWK---SENII
..... |      ||||||.||||.     |.|. .|.||||.| |.|||||||.|   | . .||     .|..        |.|||....   ....|
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

SEEAINFMYKCLQLEEEKRIQWDEIYAHPLF
|.| ... ...|| .|..|| |.|...||.|
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 18701.AA S_TKc 14-276 34 3.8e-89 303.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-231/231
Sequence Identity: 34% (97 aa)

FNLNQRIGSGSYANVYKGEDRETGKAVAIKMIDRKKISQEDYLMNGLLQEIQIMKKLDSNYIVKLIDVLETKNNYYIVQEFCDQ--GDFRNYLKQKGY--
. . . ||.|... |||. ...||. ||||.|.           . ...||||.|| .  .||||.|| .. ...|.| |.||.  || . |.|..|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPEQEAKQVLVDILNGFLELLKHGIIHRDLKPENILIQTKNPQTGERIFKLADFGFSRTVDNFRRELLTSLVGTPLYMSPQILMFKKYTS-KSDIW
    .|| .|. ..  |...   . .||||||||||||||. .          |..|||..| .        |...||| ||.| .|   .|.  |.|.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWW

SIGLIMYEMLYGKTPWNAISQYQLVEMINKQPINWKSENIISEEAINFMYKCLQLEEEKRIQWDEIYA-------HPLF
|.| |.||||.|..|.      |. .|..|           |.||..|. |||| . |||.   |. .       || |
SCGCILYEMLCGYPPFP-----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18701.AA Pkinase 14-276 32 1.1e-83 289.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

FNLNQRIGSGSYANVYKGEDRETGKAVAIKMIDRKKISQEDYLMNGLL-QEIQIMKKLDSNYIVKLIDVLETKNNYYIVQEFCDQG----DFRNYLK--Q
. . ..|||||.. |||. .. ||| ||.| |...... .. ... .. .||||||.|.. .||.|.|. |.|...|.|.|.|. |    |   |..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEK-SWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KGYL--PEQEAKQVLVDILNGFLELLKHGIIHRDLKPENILIQTKNPQTGERIFKLADFGFSRTVDNFRRELLTSLVGTPLYMSPQILM-FKKYTSKSDI
.| .  .|.|.| ..  || |   . ..||||||||||||||  .|..... ..|..|||... .|. . . .|...||| ||.| ...  ..|..|.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSIGLIMYEMLYGKTPWNAI------SQYQLVEMINKQPINWKSENIIS-------------------EEAINFMYKCLQLEEEKRIQWDEIYAHPLF
||.|.|.|||| |..|.         .|.|....| . |. . ... .|                   ||.. |...||..  .||. ...|  || |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 18701.AA Ciliate-E2 14-276 25 7.7e-83 281.52 In-house 1-365 (365) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-365/365
Sequence Identity: 25% (100 aa)

FNLNQRIGSGSYANVYKGEDRETGKAVAIKMIDRKK---------------------------ISQEDYLMN-------GLLQEIQIMKKLDSNYIVKLI
..... ||.|... |||.......| .|||.|| .|                           |.||...|.        . .| .|...|....|.|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMY

DVLE--TKNNYYIVQEFCDQGDFRNYLKQK-----------GYLPEQEAKQVLVDILN---------------GFLELLKHG-IIHRDLKPENILIQTKN
.. .  ..||.|.| |.|..|| . |.|..           .|. |.|.|..   ||.               .. .| . . |||||.||||||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

PQTGERIFKLADFGFSRTVDNFRR------------------------------ELLTSLVGTPLYMSPQILMFKK---------YTSKSDIWSIGLIMY
        |..|||.|. .|...                               ..  ...||| ||.|.||. ||         |. |.||||.| |.|
-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

EMLYGKTPWNAISQYQLVEMINKQPIN----------------WKSENIISEEAINFMYK----CLQLEEEKRIQ-WDEIYAHPLF
|||.||.|.         . | ...|.                ||| . .|.|..... |    .|| ..||||. |..|  || |
EMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 18701.AA CAMK 19-276 22 6.5e-81 260.33 In-house 1-425 (425) Show / Hide 
Range on Protein: 19-276
Range on HMM: 1-425/425
Sequence Identity: 22% (94 aa)

RIGSGSYANVYKGEDRETG------------KAVAIKMIDRKKISQ------------------------EDYLMNGLLQEIQIMKK-------LDSNYI
 .|.||.. |.......|.            . ||||.||.||..                         ... .  ...||.||||       ||   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLIDVLE------------TKNN--------YYIVQ---EFCDQG----DFRNYLKQK---------------GYLPEQEAKQVLVDILNGFLELLKHG
.||..| |            | ..        .|.|    |.|. |    |  .|....               |...|.||...   |. .   . .|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKPENILIQTKNPQTGE-----------RIFKLADFGFSRTVDN--------------FRRE---------LLTSLVGTPLYMS-PQILMFKK--
|.||||||||||....|. .                |..||||.. .|               . ..         ...  .||| ||. | .|  |.  
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEM-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------YTSKSDIWSIGLIMYEMLYGKTPWNAI-------------SQYQLVEMINKQPINWKSENI--------------ISEE--------A
            |. |.|.||.| |.| || |. |...              ..|.| |.| |   .. .. .              ||.|        .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

INFMYKCLQLEEEKRIQWDEIYAHPLF
...  |.|| . |||.  ... .|| .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 18701.AA AGC 14-276 21 1.6e-78 201.77 In-house 1-395 (395) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-395/395
Sequence Identity: 21% (87 aa)

FNLNQRIGSGSYANVYKGEDR------ETGKAVAIKMIDRKK-IS-----QEDYLMNG--------LLQEIQIMKKLD----------SNYIVK-LIDVL
|..   || ||.  ||  ...       |||  |.|... |. |      .... |.         . .| .|..|..          . .||| |    
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKNN--YYIVQEFCD--------QGDFRNYLKQKG-----YLPEQEAKQVLVD-------ILNGFLELLK-HGIIHRD-LKPENILIQTKNPQTGERIF
..|..   |.| |..          |..  .| ..|     ...|..|.  .         |. ..  | . .|||||| |||||||.  .         
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED------GHI

KLADFGFSRTVDNFR-------------------------------------------------RELLTSLVG--TPLYMSPQILMFKKYTSKSDIWS--
||.|||..  . | .                                                 |.. ....|  || ||.| ||    |.   |.||  
KLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFG

IGLIMYEMLYGKTPWNAIS----------QYQLVEMIN------KQPINWKSE--------NIISEEAINFMYKCLQLEEEKRIQ----------WDEIY
 | .|||||.|..| .. .          .... . |       .... . .           .|.|| ... |.|. . |||.            .|| 
LGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIK

AHPLF
.|| |
NHPWF
Kinase 18701.AA CAMKL 14-276 29 1.1e-70 224.77 In-house 1-297 (297) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-297/297
Sequence Identity: 29% (91 aa)

FNLNQRIGSGSYANVYKGED-RETGKAVAIKMIDRKKISQEDYLMNG-----------LLQEIQIMKKLD---SNYIVKLIDVLETKNN------YYIVQ
... . .| ||.. |  ... | ||. ||||.||.|||. ... ..            . .||||||.|.      |.|| .|.||...      .|.| 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCDQGD--FRNYLKQKGY----LPEQEAKQVLVDILNGFLELLKHGIIHRDLKPENILIQTKNPQTGERIFKLADFGFSRTVDNF---RRELLTSLVGT
| |. |.    .|....|.    .|| ||..    |. .   . .|||.|||.||||||.  .. .      |..|||||   ..    . ..|.   |.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN----NIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PLYMSPQILMF--KKYT-SKSDIWSIGLIMYEMLYGKTPWNAI--------SQYQLVEMINKQPINWKSENIISEEAINFMYKCLQLEEEKRIQWDEIYA
| ||.| |.    |.|   | ||||.| |.| |..|. |...          .  | ..|...  ..   . .| .....  | ||   |||.  ..|  
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN

HPLF
|| .
HPWM
Kinase 18701.AA Ciliate-E2-Unclassified 14-276 24 1.2e-70 241.05 In-house 1-352 (352) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

FNLNQRIGSGSYANVYKGEDRETGKAVAIKMIDRKKISQEDYLMNG--------LLQEIQ-------------IMKKLDSNYIVKLIDVLETKNNYYIVQ
..... ||.|... ||| ........ |.|..  ..|    . ||          .....             |.. ... .|||.... ..|.| ||| 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFCDQGDFRNYLKQK-----------------GYLPEQEAK-----QVLVDILNGF-LELLKHGIIHRDLKPENILIQTKNPQTGERIFKLADFGFSRTV
|.|..|| ..|.|..                   ..||.||     . .  ||.|.     |..|||||.||||||.. ..        |..|||.|.  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---NYYIKIIDFGISKKY

DNF--------------RRELLTSLVGTPLYM----SPQILMFKKYT----SKSDIWSIGLIMYEMLYGKTPWNAISQYQ----------------LVEM
...              ....... .||| ||    .| .|. ..|      |.|||| | |.||||.|. | .. ...|                | . 
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

INKQPINWKSEN------IISEEAINFMY----KCLQLEEEKRIQWDEIYAHPLF
|....|. ....      ..|.||..|      |.|.   .|||....|  ||.|
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 18701.AA Ciliate-E2c 14-276 30 1.6e-64 220.7 In-house 1-310 (310) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-310/310
Sequence Identity: 30% (98 aa)

FNLNQRIGSGSYANVYKG---EDRETGKAV-------AIKMIDRKKI----SQEDYLMNGLLQEIQIMKKLDSNYIVKLIDVLETKNNYYIVQEFCDQGD
.. |   |||||..|||.   ||  . ...       ||||.  | .      |    . . .||..||.... .|.| .|   |... |.. |.| .|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

FRNYLKQKGYLPEQEAKQVLVDILNGFLELLKH-GIIHRDLKPENILIQTKNPQTGERIFKLADFGFSRTVDNFRRELLT---SLVGTPLYMSPQILMF-
   |.. | .. |..       |...| .| |  .|.|||.|||||||        . . |.||||||. ....     .     .|||.||.||||   
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIH-------NGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGK

KKYTSKSDIWSIGLIMYEMLYGKTPWN------------------AISQYQLVEMIN---------------KQPINWKSE--NIISEEAINFMYKCLQL
..||.|||||| |   |.||. | ||                   . .. .|.. |                .|.|.   .  . ||.|   .  | || 
NYYTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQV

EEEKRIQWDEIYAHPLF
.|||||.||||  |...
DEEKRIDWDEIFNHECI
Kinase 18701.AA STE 14-276 22 6.1e-63 215.42 In-house 1-359 (359) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-359/359
Sequence Identity: 22% (84 aa)

FNLNQRIGSGSYANVYKGEDRE---------------TGKAVAIKMIDRKKISQEDYL--------------MNGLLQEIQIMKKLD--SNYIVKLIDVL
. . ..||.|..  |||. ...               ||. .||| .. .. ...|                |. .|.||.||||..  . .||| ..  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

ETK-------NNYYIVQEFCDQGDFRNYLKQK--------------GYLPEQEAKQVLVDILNGFLELLK-HGIIHRDLKPENILIQTKNPQTGERIFKL
. .       .. .|. |..| | ..  .|.|              ...||.. . ....|| |.|..|  |.|||||.|| |||.            ||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------VKL

ADFGFSRTVDN---------------FRRELLTSLVGTPLYMSPQILM------FKKYTSKSDIWSIGLIMYEMLYGKTPW---NAISQYQLVEMIN---
.|||..  ...                . .  ...|||| .|.| ...       |.|. |.||||.|. . ||. || ||   .  . . .  . .   
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

----------KQPINWKS-----------------ENIISEEAINFMYKCLQLEEEKRIQWDEIYA--HPLF
          ..|   ..                     |.| ..|. |||| . .||   ..     || .
QQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 18701.AA CAMK-Unique 14-276 22 1.4e-58 191.92 In-house 1-363 (363) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-363/363
Sequence Identity: 22% (81 aa)

FNLNQRIGSGSYANVYKGEDRETGKAVAIKMIDRKKISQEDYLM----------------NGLLQEIQIMKKLDSNYIVKLIDV----LETKN-------
  ... ||.|..  ||.. ||||||  |.||.  .. . . ..                 . |  |.||.|..| . |.|| |.     ....       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NYYIVQEFCDQGDFRNYLKQ--------------------KGYLPE--QEAKQVLVDILNGFLELLKHGIIHRDLKPENILIQTKNPQ----
        ..|||.|.|. ||   .. .                    .|.. |   .. ..   .|     . . .|.|||||.|||....  .     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

------TGERIFKLADFGFSRTVDNFRRE-LLTSLVGTPLYMSP--------------QILMFKKYTSKS----DIWSIGLIMYEMLYGKTPWNAISQY-
            ||.||| .. ... . . .. . .|||.||.|              ..... .| ...    ||||.| |||.|| |..| .. .   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------QLVEMINKQPI---NWKSENI---ISEEAINFMYKCLQLEEEKRIQWDEIYAHPLF
        . | | |  .    || ...   ||.||..|  .|....  .|.   |.. |. .
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 18701.AA Pkinase_Tyr 14-234 27 6.1e-29 98.63 Pfam 1-231 (270) Show / Hide 
Range on Protein: 14-234
Range on HMM: 1-231/270
Sequence Identity: 27% (66 aa)

FNLNQRIGSGSYANVYKGEDR----ETGKAVAIKMIDRKKISQEDYLMNGLLQEIQIMKKL-DSNYIVKLIDVLE-TKNN--YYIVQEFCDQGDFRNYLK
  ... .|.|.. .||||. .    .|.  ||.||. . . ..|. ..  ...|..|||.| .   ||.|. |    .    .||| |..  || ..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

Q----KGYLPEQEAKQVLVDILNGFLELLKHGIIHRDLKPENILIQTKNPQTGERIFKLADFGFSRTVDNFRRELL-TSLVGTPL---YMSPQILMFKKY
.    |. |. ..  |  ..| .|   |  ...|||||   |.|.        ... | .||| .|..  .  .   ..  |..|    |.|  ....|.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE------NNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKF

TSKSDIWSIGLIMYEMLY-GKTP-WNAISQYQLVEMI-NK
|.|||.|| |  |.|..  |..| .  .| ....|.|  .
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase 18701.AA TyrKc 14-276 24 1.5e-27 98.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-276
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

FNLNQRIGSGSYANVYKGEDRETGKAVAIKMIDRKKISQEDYLMNGLLQEIQIMKKL--DSNYIVKLIDVLETK-------NNYYIVQEFCDQGDFRNYL
  |.. .|.| .  ||||. .     ||.||.   .       .  ...|..||.||  .   ||.|. |  ..         ..|| |... || ..||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KQKGY-LPEQEAKQVLVDILNGFLELLKHGIIHRDLKPENILIQTKNPQTGERIFKLADFGFSRTVDNF-----RRELLTSLV--GTP--L---YMSPQI
. ..  |. ..  .  ..| .|   | ....|||||   |.|.  ..      . | .||| || ...      . .  ..    |.   |    |.|  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LMFKKYTSKSDIWSIGLIMYEML-YGKTPWNA-----ISQYQLVEMINKQPINWKSEN-------IISEEAINFMYKCLQLEEEKRIQWDEIYAHPLF
....|.|.|||.|| |  |.|.. ||..|.       .| ....| . .     . .|       . ..|  . | .| . . |.|    ||  | .|
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Efhand 18701.AA efhand 311-339 34 9.2e-05 21.85 Pfam 1-29 (29) Show / Hide 
Range on Protein: 311-339
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

DLMQLFKYFDLTNDSKLTIKEFEQLMKQI
.| ..|| ||  .| .....|| ..||..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 18701.AA EFh 311-339 27 0.003491 16.31 SMART 1-29 (29) Show / Hide 
Range on Protein: 311-339
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

DLMQLFKYFDLTNDSKLTIKEFEQLMKQI
.....|. ||  .| ... .|| ..|| .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 18701.AA efhand 347-375 41 2.1e-07 31.54 Pfam 1-29 (29) Show / Hide 
Range on Protein: 347-375
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

EIEYIFNKFDSDGDNKIDFTEFQKWLEHN
|.. .|..|| ||| .||| ||...... 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 18701.AA EFh 347-375 41 0.000175 22.14 SMART 1-29 (29) Show / Hide 
Range on Protein: 347-375
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

EIEYIFNKFDSDGDNKIDFTEFQKWLEHN
|.. .|..|| ||| .||| ||.. .   
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 18701.AA EFh 525-553 34 0.172058 2.66 SMART 1-29 (29) Show / Hide 
Range on Protein: 525-553
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

NNKELFNRYDKSQQDAIQLSEFTRMIKKI
  ||.|. .||     | . || .|.|..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 18701.AA efhand 527-553 40 0.373224 8.64 Pfam 3-29 (29) Show / Hide 
Range on Protein: 527-553
Range on HMM: 3-29/29
Sequence Identity: 40% (11 aa)

KELFNRYDKSQQDAIQLSEFTRMIKKI
||.|. .|| .   | . || .|.||.
KEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 18701.AA efhand 561-589 31 0.000219 20.47 Pfam 1-29 (29) Show / Hide 
Range on Protein: 561-589
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

EIAIAFQKFDYDNSGKITFKKFDTTLANI
|.  .|..|| |..|.|.|. | . ....
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 18701.AA EFh 561-589 31 0.002492 17.49 SMART 1-29 (29) Show / Hide 
Range on Protein: 561-589
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

EIAIAFQKFDYDNSGKITFKKFDTTLANI
|.  .|..|| |..|.|.|. | . ....
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL