Gene 19558 (Tetrahymena)

19558

Species: Tetrahymena
Alias: 19558, 3680.m00053, PreTt19558, 665, 59.m00196, TTHERM_00486270
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
19558.AA Protein None 858 None Fasta, JSON
19558.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
19558.NA RNA None 2577 None Fasta, JSON

Protein domain

Protein domains of 19558.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19558.AA ULK 14-270 35 2.3e-113 382.91 In-house 1-321 (324) Show / Hide 
Range on Protein: 14-270
Range on HMM: 1-321/324
Sequence Identity: 35% (114 aa)

FSINYCLGQGEYG-KVFQGVNKIT---NEDVAIKQID---QRMVQQD---QYIKQSLQREIEALKKIK---HPN--VIELKDVYYSD--NYIYIIQEFCQ
...| |||.| .| ||..| ||.|   |..||.|.||   ... ...   ||..|.|..||. .||.|   |||  ...|.|.....  |.||||.|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DGELKHYIQTIQKSNMPF----DEYEKICLEIAYQITQGMQTVHRMDIIHRDLKPQNILVHNKK-------------IKIIDFGFCKSFDN---QAHMIK
.| |..||.. .|...         |...... .|| .|..  | . |||||.||||||.||..             .|| ||||.|..||   .. |..
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SAV------GSPYYMSPQILS----KIPYT-YKTDIWSFGMIFYELVFKKLP---YYANSEA----ELLGY-------IQNQPIQYDQ----LKCGPVSK
..|      |.|.||.||||.    ..||. ||.||||.|.||||... | |   . .|..     .|.         |.|||||..      |. | .|
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

EVLQKSLIINEKDRASWDDLYEI
. ... |...|||| ||......
DLIRRMLQYDEKDRISWEEIFNH
Kinase 19558.AA ULK 14-270 34 3.2e-112 379.11 In-house 1-326 (329) Show / Hide 
Range on Protein: 14-270
Range on HMM: 1-326/329
Sequence Identity: 34% (113 aa)

FSINYCLGQGEYGKVFQGVNKIT----NEDVAIKQID---QRMVQQD---QYIKQSLQREIEALKKIK--------HPNVIELKDVYYSD--NYIYIIQE
...| |||.| .|||..| ||.|    ||.||.|.||   ... ...   ||..|.|..||. .||.|        |||...|.|.....  |.||||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCQDGELKHYIQTIQKSNMPF----DEYEKICLEIAYQITQGMQTVHRMDIIHRDLKPQNILVHNKK-------------IKIIDFGFCKSFDNQ---AH
.|..| |..||.. .|....        |...... .|| .|..  | . |||||.||||||.||..             .|| ||||.|..||    . 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

MIKSAV------GSPYYMSPQILS----KIPYT-YKTDIWSFGMIFYELVFKKLP---YYANSEA-----ELLGY-------IQNQPIQYD----QLKCG
|....|      |.|.||.||||.    ..||. ||.||||.|.||||... | |   . .|..      .|. .       |..||.|..    . .. 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PVSKEVLQKSLIINEKDRASWDDLYEI
| .|. ... |...|||| ||..|...
PECKDLIRRMLQYDEKDRISWEELFNH
Kinase 19558.AA S_TKc 14-275 29 2.5e-68 234.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-275
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

FSINYCLGQGEYGKVFQGVNKITNEDVAIKQIDQRMVQQDQYIKQSLQREIEALKKIKHPNVIELKDVYYSDNYIYIIQEFCQD--GELKHYIQTIQK--
. |   .|.| .|||.....| |.. ||||.|.           ....|||. ||| .|||.. |.||... ...|.. |.|    |.|..||.  ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

SNMPFDEYEKICLEIAYQITQGMQTVHRMDIIHRDLKPQNILVHNKKIKIIDFGFCKSFDNQAHMIKSAVGSPYYMSPQILSKIPYTY-KTDIWSFGMIF
 . ||.| .  .  ..||| ....  |.. ||||||||.|||. .  |||.|||... .       .. .|.|.||.| .|   .|.. | |.||.| |.
LRFPFPE-H--ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YELVFKKLPYYANSEAELLGYIQNQPIQYDQLKCGPVSKEVLQKSLIINEKDRASWDDLYE-----ILNKWH
||..  . |..   .....  |             |  |. ..| |  . ..| .  .. .      .  | 
YEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19558.AA Ciliate-E2 14-267 22 1.2e-64 220.88 In-house 1-359 (365) Show / Hide 
Range on Protein: 14-267
Range on HMM: 1-359/365
Sequence Identity: 22% (85 aa)

FSINYCLGQGEYGKVFQGVNKITNEDVAIKQIDQRM-----------------VQQDQYIKQSLQREIEALKKIK----------------HPNVIELKD
. .. ..||| .|.|... .. .....|||.|| ..                  .. .. .... .||  ...|.                |||.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VYY--SDNYIYIIQEFCQDGELKHYIQ---TIQKSNMP----FDEYEKICLEIAYQITQ---------------GMQTVHRMD-IIHRDLKPQNILVHNK
...  .||.||.. |.|| |.|..||.   . .... .    |.|.|  ...| .||.|               ...  |    |||||.||.|||.   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKE--IKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

KIKIIDFGFCKSFDNQ-------------------------------AHMIKSAVGSPYYMSPQILSKIP---------YTYKTDIWSFGMIFYELVFKK
 |||||||..| .|..                                .|... .|.|.||.|.||.. .         |.|| ||||.|.|.||..|.|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

LPYYANSEAELLGYIQNQ--PIQYDQLKCG--------------PVSKE---VLQK----SLIINEKDRAS-WDDL
.|.          ..|..  .|.... ...               .|.|    ..|     |  ... | . |...
PPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase 19558.AA Pkinase 14-227 31 5.3e-64 223.74 Pfam 1-224 (293) Show / Hide 
Range on Protein: 14-227
Range on HMM: 1-224/293
Sequence Identity: 31% (74 aa)

FSINYCLGQGEYGKVFQGVNKITNEDVAIKQIDQRMVQQDQYIKQSLQ-REIEALKKIKHPNVIELKDVYYSDNYIYIIQEFCQDG----ELKHYIQTIQ
. |  ..|.| .|.|.....| |.. ||.|.|. |  . ..  .. .  .||. .|...|||...|.|.......||...|.|. |    .|..||.|  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

KSNMPF--DEYEKICLEIAYQITQGMQTVHRMDIIHRDLKPQNILVH-NKKI----KIIDFGFCKSF-DNQAHMIKSAVGSPYYMSPQILS-KIPYTYKT
... .|  .| |  |  ..||| .|..  |.| ||||||||.|||.. |  |    ||.|||..| |     .  .. .|.|.||.| ..    .|..| 
WRHGCFYFSEWE--CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSFGMIFYELVFKKLPYYAN----SEAELL
|.||.| |.||......|..      . .. .
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQM
Kinase 19558.AA CAMK 19-232 22 1.6e-61 196.73 In-house 1-361 (425) Show / Hide 
Range on Protein: 19-232
Range on HMM: 1-361/425
Sequence Identity: 22% (81 aa)

CLGQGEYGKVFQGVNKITN------------EDVAIKQIDQRMVQQD------------------------QYIKQSLQREIEALKK-------IKHPNV
 ||.| .|||. ...| |.            . |||| || . .. .                        .. .....|||| .||       ..|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IELKDVYYS-------------------DNYIYIIQ---EFCQDGEL----KHYIQTIQKSNMPF--------DEY-EKICLEIAYQITQGMQTVHRMDI
| | .|| .                   |...|..    |.|. |||      ||.   .    |          . |. .  .  || ....  | ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPQNILVHNK------------------KIKIIDFGFCKSFDN-----------------------QAHMIKSAVGSPYYMS-PQILSK------
.|||||| |||. ..                  .|||||||| . ||                        . .. |  .|.|.||. | .|..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------IPYTYKTDIWSFGMIFYELVFKKLPYYAN-------------SEAELLGYIQN
         .|..|.|.|| | | | ..  ..|.|.              .. ||.  |..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMK
Kinase 19558.AA CAMKL 14-263 29 3e-55 174.7 In-house 1-287 (297) Show / Hide 
Range on Protein: 14-263
Range on HMM: 1-287/297
Sequence Identity: 29% (86 aa)

FSINYCLGQGEYGKVFQGVN-KITNEDVAIKQIDQRMVQQDQYIKQS-----------LQREIEALKKIK---HPNVIELKDVYYSDNY------IYIIQ
. |   ||.| .|||  ... ..|.| |||| || .  . |...|.            ..|||. .|...   |||.| | .|.. ...      ||.. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCQDGE--LKHYIQTIQKSN--MPFDEYEKICLEIAYQITQGMQTVHRMDIIHRDLKPQNILVHNKK---IKIIDFGFCKSFDNQ----AHMIKSAVGS
| |. ||  | .||.   . .  ||    |. .  .  ||  ...  |...|.|||.|| |||. ...   ||||||||.  ....     .. |   ||
EYCSGGEMDLFDYIVKHGHRRGRMP----EHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PYYMSPQILSK--IPYT-YKTDIWSFGMIFYELVFKKLPYY-------ANSEAELLGYIQNQPIQYDQLKCGP-VSKEVLQKSLIINEKDRAS
| ||.| |...   ||  .|.|||| | | | .|. .||          ..   .|  ....   |.   . .   .  ..| |  | ..|..
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPT
Kinase 19558.AA Ciliate-E2-Unclassified 14-238 25 3.4e-55 189.69 In-house 1-306 (352) Show / Hide 
Range on Protein: 14-238
Range on HMM: 1-306/352
Sequence Identity: 25% (77 aa)

FSINYCLGQGEYGKVFQGVNKITNEDVAIKQIDQRMVQQDQYIKQS--LQREIEALKKIK-------------------HPNVIELKDVYYSDNYIYIIQ
. |....||| .|||.. ..| ...  |.|.. . ... ...|...  . .|.......|                   ||... . ..  ....|||. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFCQDGELKHYIQ-------------TIQKSNMPFDEYEKI---CLEIAYQITQGMQTVHRMD-IIHRDLKPQNILVHNK----KIKIIDFGFCKSFDNQ
|.|..|.|. ||.               .|..  |.|.. .    . ...|| || .  |.   |||||.||.|||..|.    .|||||||..|  ...
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------------AHMIKSAVGSPYYM----SPQILSKIPYT----YKTDIWSFGMIFYELVFKKLPYYANSEAE----------------LLGYIQN
                .|... .|.|.||    .| .| .  |     || ||||.|.|.||..| ..|.|.|.. .                |.  |..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

QPIQYD
..||..
KNIQFP
Kinase 19558.AA STE 14-270 20 3.6e-51 176.3 In-house 1-359 (359) Show / Hide 
Range on Protein: 14-270
Range on HMM: 1-359/359
Sequence Identity: 20% (74 aa)

FSINYCLGQGEYGKVFQGVNK------ITNED---------VAIKQID----------QRMVQQDQ------YIKQSLQREIEALKKIK--HPNVIELKD
. .  ..|.| .|.|....|.       |.|          .||||..          |    | .       ..|....||. .|| .  |||...  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQ-EN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG

VYYSD-------NYIYIIQEFCQDGELKHYIQTIQKSNMPFDEY--------EKICLEIAYQITQG-MQTVHRMDIIHRDLKPQNILVHNKKIKIIDFGF
 |. .       ....|. |..  | |   |..  . ..|..          |..   |..|| .| ..  |.. |||||.||.|||.    .|..|||.
CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGV

CKSFDN---------------QAH-MIKSAVGSPYYMSPQILSK------IPYTYKTDIWSFGMIFYELVFKKLPYYANSEAELLGYIQ-----------
|.....                   . .. ||.| .|.| ....       .|..| ||||.|    |..  | |.   .  . . .|.           
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-----NQPIQYDQ------------------LKCGPVSKEVLQKSLIINEKDRASWDDLYE-----I
     ..| .  .                   |. |  |. ..| |... ..|.. ..| .     |
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 19558.AA CAMK-Unique 14-227 21 8.8e-49 159.05 In-house 1-310 (363) Show / Hide 
Range on Protein: 14-227
Range on HMM: 1-310/363
Sequence Identity: 21% (66 aa)

FSINYCLGQGEYGKVFQGVNKITNEDVAIKQIDQRMVQQDQYIKQ----------------SLQREIEALKKIKHPNVIELKDV----YYSDN-------
   .  .|.|..|.|. . .. |    |.| .    .. . .. |                .| ||.. .|. .||| |.| |.    .  ..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------YIYIIQEFCQDGELKHYIQT----------------IQKSNMPFDE--YEKICLEIAYQITQGMQTVHRMDIIHRDLKPQNILVHNK-----
        |.||..|.||.|.|. .||                 ..... .| |  ..   . |  ....     |  ||.|||||. ||.| .      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWD--TCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN

------------KIKIIDFGFCKSFD-NQAH-MIKSAVGSPYYMSP--------------QILSKIPYTYKT----DIWSFGMIFYELVFKKLPYYANSE
            .||..||| |. .. |..  |... .|.|.||.|              ...   .| ..     |||| | | |.. . ..| ....|
HHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECE

A--------ELL
.        |..
DRDYENHDKEIF
Kinase 19558.AA TKL 20-271 17 5.3e-46 159.16 In-house 1-364 (364) Show / Hide 
Range on Protein: 20-271
Range on HMM: 1-364/364
Sequence Identity: 17% (67 aa)

LGQGEYGKVFQGVNKITN--------EDVAIKQIDQRMVQQ--------------------DQYIKQSLQREIEALKK---IKHPNVIELKDVYYSDNY-
.|.| .|.|..|. . ..        .|||.|.. .. ..                     |. ...  ..|.| ..    ..|||.. .. .  . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------IYIIQEFCQDGE-LKHYIQTIQKSNMPFDEYEKICLEIAYQITQGMQTVHRMD--------IIHRDLKPQNILVHNKK----------
            ..|. |.|. |  | ...                 . .|..| .||.  | |.        |||||||..||||...           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

-----IKIIDFGFCKSFDNQAHMIKS-------------------AVGSPYYMSPQILSKI----------------PYTYKTDIWSFGMIFYELVFKKL
     .|| |||.......  .| ..                    .|.|..|.| .| .                 .|. |.|..|||....|..  ..
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

PYYANSEA------------ELLGY-IQNQPIQ---------YDQLKCGPVSKEVLQKSLIINEKDRASWDDLYEIL
||| . .             .. ..  .  ||          ..   | |  |. .|.    . ..| | ... ..|
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 19558.AA Ciliate-E2c 14-271 28 1.4e-45 157.78 In-house 1-310 (310) Show / Hide 
Range on Protein: 14-271
Range on HMM: 1-310/310
Sequence Identity: 28% (90 aa)

FSINYCLGQGEYGKVFQG-----VNKITNE---------DVAIKQIDQRMVQQDQYIKQSLQREIEALKKIKHPNVIELKDVYYSDNYIYIIQEFCQDGE
...|  ||.| ||||. .     .. . |.              ..  .    .  || |. |||. .|. .||..|.  |    |. ||.| |.| .| 
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LKHYIQTIQKSN-MPFDEYEKICLEIAYQITQGMQTVHRM-DIIHRDLKPQNILVHNKKIKIIDFGFCKSFDNQAHMIKS----AVGSPYYMSPQILSK-
|. ||    ...  |    || ||    || ....  |    |.|||.|| ||| ||  ||| |||| | ....   ...     .|.|.||.||||.  
LEQYI----YHKPKP---NEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGK

IPYTYKTDIWSFGMIFYELVFKKLPYY------------------ANSEAELLGYIQ---------------NQPIQYDQL---KCGPVSKEVLQKSLII
  ||.| |||| |   |. ...||| .                  .|. ..|   |                .|.|.  .    .  .  |. ..| |  
NYYTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQV

NEKDRASWDDLY--EIL
 |..| .||..   |..
DEEKRIDWDEIFNHECI
Kinase 19558.AA Pkinase_Tyr 14-163 29 4e-22 75.56 Pfam 1-156 (270) Show / Hide 
Range on Protein: 14-163
Range on HMM: 1-156/270
Sequence Identity: 29% (47 aa)

FSINYCLGQGEYGKVFQGVNK----ITNEDVAIKQIDQRMVQQDQYIKQSLQREIEALKKI-KHPNVIELKDVYY-SDNY--IYIIQEFCQDGELKHYIQ
 ...  ||.|..|.|..|. |     |. .||.| . .   ...  ..... ||.. .|.. .|||.. |  | .  .    |||. |... | |..| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

TI--QKSNMPFDEYEKICLEIAYQITQGMQTVHRMDIIHRDLKPQNILVH-NKKIKIIDFG
.   .| . .     |  |....|| .||.  ... .|||||   |.||. |...|| |||
KHREDKQPLTM----KDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 19558.AA TyrKc 14-271 21 1.4e-17 61.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-271
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FSINYCLGQGEYGKVFQGVNKITNEDVAIKQIDQRMVQQDQYIKQSLQREIEALKKI--KHPNVIELKDVYYSD-------NYIYIIQEFCQDGELKHYI
 . .  || |..|.|..|. |   ..||.| .           .. . ||.. ..|.  .|||.. |  |  ..         ..|. |..  | ||.|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QTIQKSNMPFDEYEKICLEIAYQITQGMQTVHRMDIIHRDLKPQNILVHNKK-IKIIDFGFCKSFDNQ------AHMIKSAV--GSP-----YYMSPQIL
.  ..         |  |....|| .||.  |.. .|||||   |.||.... .|| ||| ..  ..         .....   |.        |.|  .
RKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

SKIPYTYKTDIWSFGMIFYELV-FKKLPYYA-----NSEAELLGYIQNQPIQYDQLK--------CGPVSKEVLQKSLIINEKDRASWDDLYEIL
 .  .| |.|.||||   .|.  . . ||.       | .|.. |...                 | .   .. ..    . .|| .  ...|..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 19558.AA Pkinase_Tyr 195-205 63 1.148587 2.88 Pfam 191-201 (270) Show / Hide 
Range on Protein: 195-205
Range on HMM: 191-201/270
Sequence Identity: 63% (7 aa)

YTYKTDIWSFG
.| |.|.||||
FTTKSDVWSFG