Gene 19707 (Tetrahymena)

19707

Species: Tetrahymena
Alias: 91.m00122, PreTt19707, TTHERM_00637040, 19707, 20
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
19707.AA Protein None 819 None Fasta, JSON
19707.kin_dom Protein Kinase Domain None 248 None Fasta, JSON
19707.NA RNA None 2460 None Fasta, JSON

Protein domain

Protein domains of 19707.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19707.AA ULK 8-259 37 1.2e-125 423.77 In-house 1-320 (324) Show / Hide 
Range on Protein: 8-259
Range on HMM: 1-320/324
Sequence Identity: 37% (120 aa)

YVLNEVIGSGQYG-KVYKAKNMNN---DQVVAIKVVKMDKFREIPKLHE------FTMNEIRTLAKID---NPN--CVKFQEMLKTS--NNMYLIYEYCN
|.||...|.|..| ||||..|...   .|.||.|.. ..|....... |      . .|||... |..   .||  .||. ....||  || |.|.||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGTLEQAIHRK---------KFLSEGETIKIFAQLLNAFKAMIKENILHRDLKPSNILFHNN-------------VIKIADFGFCKSLMNP---QDMTST
||.||| |...         |.||| |.|..| |..|.||.. |.|| |||.||.||| ||.             |.|||||||.|...|.   |.|. |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

MV------GSPIYMAPEVLK----GMPYN-TKADVWSMGVVFFECLFGYCP----YEDQS--IAKLITQ-------IDNTELQIPR--YINQISKKAEDL
.|      |.|.||||..|.    ..||.  |.|.||.|..|.|.|.|..|    ..||   |.||| .       | |. .|.|   ....||.. .||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

IRAMLVVDFRKRVDWPQLFA
|| ||..| ..| .|...|.
IRRMLQYDEKDRISWEEIFN
Kinase 19707.AA ULK 8-259 37 4.2e-124 418.6 In-house 1-325 (329) Show / Hide 
Range on Protein: 8-259
Range on HMM: 1-325/329
Sequence Identity: 37% (122 aa)

YVLNEVIGSGQYGKVYKAKNMNN----DQVVAIKVVKMDKFREIPKLHE------FTMNEIRTLAKID--------NPNCVKFQEMLKTS--NNMYLIYE
|.||...|.|..|||||..|...    ...||.|..  .|....... |      . .|||... |..        .||.||. ....||  || |.|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNGGTLEQAIHRK----------KFLSEGETIKIFAQLLNAFKAMIKENILHRDLKPSNILFHNN-------------VIKIADFGFCKSLMNP---QD
|||||.||| |...          |.||| |.|..| |.||.||.. |.|| |||.||.||| ||.             |.|||||||.|...|.   |.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

MTSTMV------GSPIYMAPEVLK----GMPYN-TKADVWSMGVVFFECLFGYCP----YEDQS---IAKLITQ-------IDNTELQIPR--YINQISK
|. |.|      |.|.||||..|.    ..||.  |.|.||.|..|.|.|.|..|    ..||    | ||| .       |... ||.|   ...|||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

KAEDLIRAMLVVDFRKRVDWPQLFA
. .|||| ||..| ..| .|..||.
ECKDLIRRMLQYDEKDRISWEELFN
Kinase 19707.AA S_TKc 8-269 30 2.9e-84 287.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-269
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

YVLNEVIGSGQYGKVYKAKNMNNDQVVAIKVVKMDKFREIPKLHEFTMNEIRTLAKIDNPNCVKFQEMLKTSNNMYLIYEYCNG--GTLEQAIHRKKF--
| . ..||.| .|||||... . ...||||..|           | ...||. | | . || ||. ..  . ...|.. |||.|  |.| . |....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LSEGETIKIFAQLLNAFKAMIKENILHRDLKPSNILFHNNVIKIADFGFCKSLMNPQDMTSTMVGSPIYMAPEVLKGMPYNT-KADVWSMGVVFFE
    ..| .. ....|...| . . . .|.||||||.|||. . .|||.|||... |       .|..|.| |||||||   .|.. |.|.|| |....|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

CLFGYCPYEDQSIAKLITQIDNTELQIPRYINQISKKAEDLIRAMLVVDFRKRVDWPQLFA-LTEEKFHIQI
.| || |..   ..... .|              |. | |.|| .|..| .||    ....   . | |  .
MLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19707.AA Ciliate-E2-Unclassified 8-258 26 2e-81 276.83 In-house 1-347 (352) Show / Hide 
Range on Protein: 8-258
Range on HMM: 1-347/352
Sequence Identity: 26% (94 aa)

YVLNEVIGSGQYGKVYKAKNMNNDQVV----AIKVVKMDKFREIPKLHEFTMNEIRTLAK-------------------IDNPNCVKFQEMLKTSNNMYL
| ....||.|..|||||... ...  .     .|.....| . | . .   |||. .. .                   ...|. ||. .. .. .|.|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IYEYCNGGTLEQAIHRKKF-----------------LSEGETI-----KIFAQLLNAFKAMIKEN-ILHRDLKPSNILFHNN----VIKIADFGFCKSL-
..|||.||.|.| |  .|.                 ..| ...     ..|||.|.... ....| |.|||.||.||||.||     |||.|||..| . 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------MNPQDMTSTMVGSPIYM----APEVLKGMPYN----TKADVWSMGVVFFECLFGYCPYEDQSIAK----------------LITQI
              ...|.|..|..|.|.||    |||||.|  |.     |.|.||.||...|.||||.|..|..  .                |. .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

DNTELQIPRYIN-----QISKKAEDLIR----AMLVVDFRKRVDWPQLF
 . ..|.| . .     ..|..|.|.|.     ||...  || ...|..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase 19707.AA Ciliate-E2 8-258 25 1.4e-80 274.0 In-house 1-360 (365) Show / Hide 
Range on Protein: 8-258
Range on HMM: 1-360/365
Sequence Identity: 25% (94 aa)

YVLNEVIGSGQYGKVYKAKNMNNDQVVAIKVVKMDK-----------------FREIPKLHEFTMNEIRTL----------------AKIDNPNCVKFQE
| ....||.|..|.|||.|. .... .|||. . .|                  . ...  |....||. .                 ....|| .|. |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

MLK--TSNNMYLIYEYCNGGTLEQ--AIHRKKF---------LSEGETIKIFAQLLN---------------AFKAMIKEN-ILHRDLKPSNILFHNNVI
  .  . ||.||. |||.||.|..   ...||.         ..| | ..|..|.|.               |.. . ..| |.|||.||.||||    |
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KIADFGFCKSLMNP-------------------------------QDMTSTMVGSPIYMAPEVLKGMP---------YNTKADVWSMGVVFFECLFGYCP
||.|||..| . ..                               |.|. | .|.| |||||.|.| .         |..|.|.||.||...|.|||. |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

YEDQSIAKLITQIDNTELQIPRY---------------INQISKKAEDLIRA----MLVVDFRKRVD-WPQLF
.        . || . ....| .                ...|... |||.     ||..|  || . | |..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase 19707.AA AGC 8-251 22 6e-77 197.64 In-house 1-373 (395) Show / Hide 
Range on Protein: 8-251
Range on HMM: 1-373/395
Sequence Identity: 22% (83 aa)

YVLNEVIGSGQYGKVYKAKNM------NNDQVVAIKVVKMDK-FREIPK-LHEFTMNE------------IRTLAKID----------NPNCVK-FQEML
. .  ||| | .|||| ..         .... |.||.| ..   .. |   | ||.|             . |.|..          .|. ||      
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KTSNN--MYLIYEYCN---------GG-TLEQAIH---RKKFLSEGETIKIFAQ-------LLNAFKAMIK-ENILHRD-LKPSNILFHN-NVIKIADFG
.. ..   |.. ||..         ||  | . ..   ... ..| ..  ..|.       .. |.  . .  .| ||| ||| |||. .   ||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FCKSLMNPQ--------------------------------------------------DMTSTMVG--SPIYMAPEVLKGMPYNTKADVWS--MGVVFF
.|| .|| .                                                  |.|.|..|  .| |||||.|    |.  .| ||  .|....
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ECLFGYCPYEDQS----------IAKLITQID------NTELQIPRYI-------NQISKKAEDLIRAMLVVDFRKR
| |.|| |. ...           ...  .|       | ....|..         ..|. | |||. .|..| .||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKR
Kinase 19707.AA CAMK 13-251 22 6.4e-77 247.21 In-house 1-413 (425) Show / Hide 
Range on Protein: 13-251
Range on HMM: 1-413/425
Sequence Identity: 22% (95 aa)

VIGSGQYGKVYKAKNMNND------------QVVAIKVVKMDKFRE------------------------IPKLHEFTMNEIRTLAK-------IDNPNC
..|.|..|||..... |.             | ||||... .| ..                         ||  .. ..||. . |       .| || 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFQEMLK------------TSNN--------MYLIY---EYCNGG----TLEQAIHRKKF---------------LSEGETIKIFAQLLNAFKAMIKEN
.|. |.              | ..        ||..    ||| ||     | . | ...                ..| |. ..| |.. | . . . |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDLKPSNILF-HN-----------------NVIKIADFGFCKSLMN-----------------------PQDMTSTMVGSPIYMA-PEVLKG-----
| |||||| |||. .|                 | |||.|||| . ..                        . .. .|..|.| ||| ||||.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------MPYNTKADVWSMGVVFFECLFGYCPYEDQ-------------SIAKLITQIDNTELQ-IPRYINQ------------ISKK--------AE
          .|. |.|.||.||. . .| || |...              .. .|  .| . . . .| |.              ||.         . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLIRAMLVVDFRKR
|||| ||.||  ||
DLIRKMLQVDPEKR
Kinase 19707.AA Ciliate-E2c 8-258 33 1.6e-76 260.52 In-house 1-305 (310) Show / Hide 
Range on Protein: 8-258
Range on HMM: 1-305/310
Sequence Identity: 33% (102 aa)

YVLNEVIGSGQYGKVYKAKNMN-----------------NDQVVAIKVVKMDKFREIPKLHEFTMNEIRTLAKIDNPNCVKFQEMLKTSNNMYLIYEYCN
.  |.  |||.|||||||..                   . .  ..| ..|.....|    |. ..||  . . ..|. .|| .  .|... ||| ||||
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDI---KESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCN

GGTLEQAIHRKKFLSEGETIKIFAQLLNAFKAMIKE-NILHRDLKPSNILFHNNVIKIADFGFCKSLMNPQDM-TS---TMVGSPIYMAPEVLKGMPYNT
|||||| |  |  ..|.. .  | |...|||  .|| ||.|||.||.||| || .|||||||| |  ..  .  |.   | .|.|.||||..|.|  |.|
GGTLEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYT

-KADVWSMGVVFFECLFGYCPYE------------------DQSIAKLITQID---------------NTELQIPRY-INQISKKAEDLIRAMLVVDFRK
 |.|.|| ||. .. |.   | |                  . . ..|.  |.               ..... |    . ||..  .||. ||.||  |
EKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEK

RVDWPQLF
| || ..|
RIDWDEIF
Kinase 19707.AA CAMKL 8-251 29 5.3e-70 222.55 In-house 1-285 (297) Show / Hide 
Range on Protein: 8-251
Range on HMM: 1-285/297
Sequence Identity: 29% (86 aa)

YVLNEVIGSGQYGKVYKAKN-MNNDQVVAIKVVKMDKFREIPKLHEF-----------TMNEIRTLAKID---NPNCVKFQEMLKTSNN------MYLIY
| . ...| | .|||  |.. ... . ||||... .| ...|. .                ||. . ...    || .|. |.. |...      .||. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCNGGT--LEQAIHRKKF----LSEGETIKIFAQLLNAFKAMIKENILHRDLKPSNILFH-NN--VIKIADFGFCKSLMN----PQDMTSTMVGSPIYM
||| ||   | . | ...     ..|.|. ..| |.. | . . . .| |||.|| |||.  |.  .|||.||||.   ..    | .. .|  ||| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLKG--MPYN-TKADVWSMGVVFFECLFGYCPYEDQSIA----KLITQIDNTELQIPRYIN---QISKKAEDLIRAMLVVDFRKR
|||...|   ||.  |.|.||.||. .  ..|| | .|....    . |    . . .   |..   ..|  ..|||| ||.|.  ||
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKR
Kinase 19707.AA Pkinase 8-258 28 6.5e-68 236.74 Pfam 1-288 (293) Show / Hide 
Range on Protein: 8-258
Range on HMM: 1-288/293
Sequence Identity: 28% (83 aa)

YVLNEVIGSGQYGKVYKAKNMNNDQVVAIKVVKMDKFRE-IPKLHEFTMNEIRTLAKIDNPNCVKFQEMLKTSNNMYLIYEYCNGG----TLEQAIH--R
|.. ..|||| .|.|||... .. ..||.|..| .. ..  .. |  . .||. ..... || |.. ..  .....|.. |||.||     |   |.  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KKFL--SEGETIKIFAQLLNAFKAMIKENILHRDLKPSNILFH-NNVI----KIADFGFCKSL-MNPQDMTSTMVGSPIYMAPEVLK-GMPYNTKADVWS
.. .  || | .... |.| . . . ...|.||||||.|||.. |..|    ||.|||..| .   ..  ..| .|.| ||||||.. | .| .|.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

MGVVFFECLFGYCPYEDQ------SIAKLITQIDNTELQIPRY-INQIS-----------------KKAEDLIRAMLVVDFRKRVDWPQLF
.|....| |.|. |. ..      .  ..| .|  ..|  ...  . ||                 . . |.|. .| .|  ||  ..|..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL
Kinase 19707.AA NEK 8-198 33 2e-56 193.78 In-house 1-216 (286) Show / Hide 
Range on Protein: 8-198
Range on HMM: 1-216/286
Sequence Identity: 33% (74 aa)

YVLNEVIGSGQYGKVYKAKNMNNDQV-----VAIKVVKMDK--FREIPKL-HEFTMNEIRTLAKIDNPNCVKFQEMLKT--SNNMYLIYEYCN-GGTLEQ
| . ..||.|..|||||..  .. ..     ...| ..|..   .|  ..      ||.| |.....|| ||. .      .| .. . |||. ||.|.|
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQN----NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQ

A---IHRKK----FLSEGETIKIFAQLLNAFKAMIKE-----NILHRDLKPSNILFHNN-----VIKIADFGFCKSLMNPQDMTST-MVGSPIYMAPEVL
    | ..|    ...| .  ..|.|.. | | | ..     .|||||.||.||   .|     ..|| |||  | |.. .|| .| .|| | ||.|||.
KIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVC

KGMPYNTKADVWSMGVVFFE
.. ||| |.|.|| |.| .|
QNKPYNNKSDIWSLGCVLYE
Kinase 19707.AA STE 8-251 21 2.8e-56 193.27 In-house 1-345 (359) Show / Hide 
Range on Protein: 8-251
Range on HMM: 1-345/359
Sequence Identity: 21% (76 aa)

YVLNEVIGSGQYGKVYKAKNM------NNDQV---------VAIKVVKMDKFR-------------EIPKLHEFTMNEIRTLAKID--NPNCVKFQEMLK
. . |.||.| .|.||||.|.       ...|         .|||...... .               .. ..  ..||... | .   || ||.  .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TS-------NNMYLIYEYCNGGTLEQAIHRK--------------KFLSEGETIKIFAQLLNAFKAMIK-ENILHRDLKPSNILFHNNVIKIADFGFCKS
         .. ... ||..||.|.. |..|              ....| . ..|  |.| .. . .   .| |||.||.|||.    .|..|||.|..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LMN---------------PQD-MTSTMVGSPIYMAPEVLKGM------PYNTKADVWSMGVVFFECLFGYCPYEDQSIAKLITQIDNTE-----------
| .                .. .. |.||.| .|||||....      .|.||.|.|| | .  | . |  |. | .  . . .| .             
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--LQIPRYIN-------------------QISKKAEDLIRAMLVVDFRKR
   ..|.  .                   . |..  | |.  |. | .||
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKR
Kinase 19707.AA TyrKc 8-265 22 9.8e-17 47.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-265
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

YVLNEVIGSGQYGKVYKAKNMNNDQVVAIKVVKMDKFREIPKLHEFTMNEIRTLAKI--DNPNCVKFQEMLKTS-------NNMYLIYEYCNGGTLEQAI
 .|....|.|..|.|||..     . ||.|..| |.      . .| |.|.| . |.  ..|| |..     ..         .... ||. .| | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

HRKK-FLSEGETIKIFAQLLNAFKAMIKENILHRDLKPSNILFHNNV-IKIADFGFCKSLMNP------QDMTST----MVG--SPI-YMAPEVLKGMPY
....  |.  . ...  |  .      . |. ||||   |.| ..|  .||.||| .. . .       .|. ..          ||  ||||...   .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NTKADVWSMGVVFFECL-FGYCPYED-----QSIAKLITQIDNT-ELQIPRYIN-----QISKKAEDLIRAMLVVDFRKRVDWPQLFALTEEKF
.|| |||| ||. .| . .|  ||..      | . .| ....   . .| ..        ...  ....     |  .|    ..     |.|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase 19707.AA Pkinase_Tyr 8-94 22 3.4e-10 35.16 Pfam 1-94 (270) Show / Hide 
Range on Protein: 8-94
Range on HMM: 1-94/270
Sequence Identity: 22% (22 aa)

YVLNEVIGSGQYGKVYKAKNM----NNDQVVAIKVVKMDKFRE-IPKLHEFTMNEIRTLAKI-DNPNCVKFQEMLK-TSNN--MYLIYEYCNGGTL
 ......|.|..|.|||..      |... ||.|..| .   |   .. .|   |.... .. ..|| |..       .    .|.. ||. .| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 19707.AA Pkinase_Tyr 139-220 31 6.9e-07 23.96 Pfam 144-231 (270) Show / Hide 
Range on Protein: 139-220
Range on HMM: 144-231/270
Sequence Identity: 31% (28 aa)

LFHNNVIKIADFGFCKSLMNPQDMT-STMVGSPI---YMAPEVLKGMPYNTKADVWSMGVVFFECLF-GYCP-YEDQSIAKLITQI-DN
. .|||.||.||| .. .  . |    .  |...    ||||... . ..|| |||| ||. .| .  |  | |.. | . .. .| ..
VTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED