Gene 20769 (Tetrahymena)

20769

Species: Tetrahymena
Alias: 20769, PreTt20769, 3700.m00163, 525, 12.m00443, TTHERM_00151080
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
20769.AA Protein None 640 None Fasta, JSON
20769.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
20769.NA RNA None 1923 None Fasta, JSON

Protein domain

Protein domains of 20769.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20769.AA ULK 43-297 38 2.3e-125 422.77 In-house 1-324 (324) Show / Hide 
Range on Protein: 43-297
Range on HMM: 1-324/324
Sequence Identity: 38% (124 aa)

YNLRHCLGEGAYG-KVYEGVEKNT---QQTVAIKKLD---IRQFQND---NYLRNSIISEIEILKRFN---HKN--IVKFIDLITTQ--RSLYIITEFCK
|.|.||||.|..| |||.|  |.|   .| ||.|. |   .....|.   .|. .....||.|.| ..   |.|  |||..|   |.    .|||.|.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DKDLRFLIQNK----------RLTENQALHVLRDIVEGFKELVKHNVIHRDLKPANILINDQ-------------VFKIADFGFAKYVDY--SSAQLLRS
. ||. .|...          ||.|..|......|..|||||.|||.||||.||.||||..              |.||||||||| ||.   ..|.. .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

CV------GSPLYMAPQILA----RKAYG-LKSDIWSIGVIFHEMVYQDVP---WKARDER----ELLNN-------IMRQPFKLR---KNVKLQTISEE
||      |.|||||||||     .| |.  |.||||.|.||.||.|  .|   | ..|.     .|.||       |  ||.. .   |..|.   ...
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

ILRRTLVIEEKDRISWDELFKMFDQ
..|| |...|||||||.|.|...  
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 20769.AA ULK 43-297 36 8.99999999999e-123 414.18 In-house 1-329 (329) Show / Hide 
Range on Protein: 43-297
Range on HMM: 1-329/329
Sequence Identity: 36% (122 aa)

YNLRHCLGEGAYGKVYEGVEKNT----QQTVAIKKLDIRQFQNDNYLRN------SIISEIEILKRFN----HKN----IVKFIDLITTQ--RSLYIITE
|.|.||||.|..||||.|  |.|    .. ||.|..|. .....|....      ....||.|.|. .    |||    |||..|   |.    .|||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCKDKDLRFLIQNK-----------RLTENQALHVLRDIVEGFKELVKHNVIHRDLKPANILINDQ-------------VFKIADFGFAKYVDYS--SAQ
.| . ||. .|...           ||.|..|......|..|||||.|||.||||.||.||||..              |.||||||||| ||..  ..|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LLRSCV------GSPLYMAPQILA----RKAYG-LKSDIWSIGVIFHEMVYQDVP---WKARDER-----ELLNN-------IMRQPFKLR---KNVKLQ
.. .||      |.|||||||||     .| |.  |.||||.|.||.||.|  .|   | ..|.      .|.||       |  ||.. .   ..... 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

TISEEILRRTLVIEEKDRISWDELFKMFDQ
  .....|| |...|||||||.|||...  
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 20769.AA S_TKc 43-295 28 2.4e-74 254.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 43-295
Range on HMM: 1-231/231
Sequence Identity: 28% (77 aa)

YNLRHCLGEGAYGKVYEGVEKNTQQTVAIKKLDIRQFQNDNYLRNSIISEIEILKRFNHKNIVKFIDLITTQRSLYIITEFCKD--KDLRFLIQNKR---
| .   .|.||.|||| ...|.|.. ||||...           ..|..||.|||. .|.||||..| . .  .||...|.|     ||. .|....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LTENQALHVLRDIVEGFKELVKHNVIHRDLKPANILINDQVFKIADFGFAKYVDYSSAQLLRSCVGSPLYMAPQILARKAYGL-KSDIWSIGVIFH
    ..| .| .... |... . . .|..|||||||.|||... . ||.|||.|. .        ....|.| |||| .|    ||  |.|.||.|.|. 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMVYQDVPWKARDERELLNNIMRQPFKLRKNVKLQTISEEILRRTLVIEEKDRISWDELFK---------MF
||..   |.   .. .....|.            .   . ..|. |. . ..|..  |...          |
EMLCGYPPFP--QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20769.AA Ciliate-E2c 43-292 30 9.5e-73 248.0 In-house 1-305 (310) Show / Hide 
Range on Protein: 43-292
Range on HMM: 1-305/310
Sequence Identity: 30% (94 aa)

YNLRHCLGEGAYGKVYEG---VEKNTQQTV-------AIKKLDIRQF----QNDNYLRNSIISEIEILKRFNHKNIVKFIDLITTQRSLYIITEFCKDKD
..    || | ||||| .    ...... .       ||| .    .     |.    .||| ||...|  ||..|.||.| . |   .|.|.|.| . .
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LRFLIQNK-RLTENQALHVLRDIVEGFKELVKH-NVIHRDLKPANILINDQVFKIADFGFAKYVDYSSAQ---LLRSCVGSPLYMAPQILARKAYGL-KS
|  .| .| ...| | |     |. .||.| |  |..|||.||.||||.. . |||||||.| ..    |       |.|.|.||||||| .| | . ||
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DIWSIGVIFHEMVYQDVPWK----------------ARDE--RELLNNIM---------------RQPFKLRKN--VKLQTISEEILRRTLVIEEKDRIS
|||| ||   .|..   ||.                  ..   .|  .|                .|...  .|  ....    ..... |. .|..||.
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

WDELF
|||.|
WDEIF
Kinase 20769.AA Pkinase 43-295 26 6.8e-72 249.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 43-295
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

YNLRHCLGEGAYGKVYEGVEKNTQQTVAIKKLDIRQFQNDNYLRNSII-SEIEILKRFNHKNIVKFIDLITTQRSLYIITEFCKDK----DLRFLIQ---
| .  ..|.|..|.||....|.|...||.|... |  .... ... .  |||.|.||.||.|||...|  .. ...|...|.|       ||  .|.   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NKRL--TENQALHVLRDIVEGFKELVKHNVIHRDLKPANILIN-DQVF----KIADFGFAKYVDYSSAQLLRSCVGSPLYMAPQILA-RKAYGLKSDIWS
....  .|... .... |..| . . ....|||||||.||||. . .     ||.|||.|| .|| . . . . .|.| |||| ..  .. || |.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGVIFHEMVYQDVPWKAR------DERELLNNIMRQPFKLRKNVKLQ-------------------TISEEILRRTLVIEEKDRISWDELFKM--F
.|.|..||.    |.. .      |.......||. |..     .                         ..... |    |.|........   |
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 20769.AA Ciliate-E2 43-293 20 1.1e-71 244.53 In-house 1-361 (365) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-361/365
Sequence Identity: 20% (75 aa)

YNLRHCLGEGAYGKVYEGVEKNTQQ--------------------TVAIKKLDIRQFQNDNYLRN--SIISEIE----------ILKRFNHKNIVKFIDL
|..  ..|.|..|.||..  ...|.                    .. |. . | . .. ... .  .|. ||.          ||.. ||.||.|... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IT--TQRSLYIITEFCKDKDLRFLIQNK------------RLTENQALHVLRDIVE---------------GFKELVKHN-VIHRDLKPANILINDQVFK
    .. ..|...|.|. .||. .|.|.            ..||...... . |..               ....| . | .||||.|| |||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGFAKYVDYS------------------------------SAQLLRSCVGSPLYMAPQILARKA---------YGLKSDIWSIGVIFHEMVYQDVPW
|.|||..|..| .                              . .. ....|.| ||||.|| .|          |. |.||||.|||..||..   |.
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

KARDERELLNNIMRQPFKLRKNV-------------KLQTISEE---ILRR----TLVIEEKDRIS-WDELFK
        ...|. ........              . . .|.|   ....     |. ... ||. |.....
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 20769.AA CAMK 48-287 20 4.7e-69 221.43 In-house 1-415 (425) Show / Hide 
Range on Protein: 48-287
Range on HMM: 1-415/425
Sequence Identity: 20% (85 aa)

CLGEGAYGKVYEGVEKNTQ------------QTVAIKKLDIRQFQNDN------------------------YLRNSIISEIEILKR-------FNHKNI
 ||.|..|||.....|||.            | |||| .| .. ....                        . | .. .||||.|.        .|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFIDLIT------------TQRS--------LYIIT---EFCKDK----D-LRFLIQN---------------KRLTENQALHVLRDIVEGFKELVKHN
.|... .             | .         .|...   |.|       | . .....               .|.|| .| .. | |... . . .||
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDLKPANILINDQ------------------VFKIADFGFAKYVDYSS----------------------AQLLRSCVGSPLYMA-PQILAR-----
..|||||| |||..|                     ||.|||||...| ..                       |... ..|.| ||| | .| .     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KAYGLKSDIWSIGVIFHEMVYQDVPWKAR-------------DERELLNNIMRQPFK-LRKNVKLQT----------ISEE----------
         . || |.|.||.|||   |.    |. .              ...||. .||.  .    . ..  .          ||.|          
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

-ILRRTLVIEEKDRIS
  .|. |. . ..|..
DLIRKMLQVDPEKRMT
Kinase 20769.AA CAMKL 43-287 28 8e-66 208.99 In-house 1-287 (297) Show / Hide 
Range on Protein: 43-287
Range on HMM: 1-287/297
Sequence Identity: 28% (82 aa)

YNLRHCLGEGAYGKVYEGVE-KNTQQTVAIKKLDIRQFQNDNYLRNS-----------IISEIEILKRFN---HKNIVKFIDLITTQRS------LYIIT
|..   ||.|..|||  ..  ..|.. |||| .|..  .|| . ..            |  ||.|.|..|   |.||.|. . |.|..       .|...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCKDKD--LRFLIQNK-----RLTENQALHVLRDIVEGFKELVKHNVIHRDLKPANILIN-DQ--VFKIADFGFAKYVD-Y--SSAQLLRSCVGSPLYM
| |   .  |   |...     |..|..| .  | ||.. . . .|...|||.|| |||.  ..  . ||.||||. . . .   . |.|. . ||| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APQILAR--K-AYGLKSDIWSIGVIFHEMVYQDVPWKAR--------DERELLNNIMRQPFKLRKNVKLQTISEEILRRTLVIEEKDRIS
|| |...  |  .| | ||||.|||   ||.  .|...         .  .|.. ||.. .. .. ...    . ..|. |.   ..|..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPT
Kinase 20769.AA Ciliate-E2-Unclassified 43-293 21 8.1e-64 218.33 In-house 1-348 (352) Show / Hide 
Range on Protein: 43-293
Range on HMM: 1-348/352
Sequence Identity: 21% (76 aa)

YNLRHCLGEGAYGKVYEGVEKNTQQTVAIKKLDIRQFQNDNYLRNS--------IISEIE-------------ILKRFNHKNIVKFIDLITTQRSLYIIT
|.. ...|.|..||||. ..|...|  |.| .   | ..... .|.        .. ...             ||. ..| .|||...  ...  .||..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFCKDKDLRFLIQN------------------KRLTENQAL-----HVLRDIVEGFKELVKHN-VIHRDLKPANILINDQ----VFKIADFGFAKYVDYS
|.|...||.. |..                  |..||.||.     . .. |..|.. | . | .||||.|| |||....      ||.|||..|. ...
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------SAQLLRSCVGSPLYM----APQILARKAYGLK----SDIWSIGVIFHEMVYQDVPWKARDERE----------------LLNNIMR
              . |.. ...|.| ||    || .| .. |. .    .|||| |||..||...  | ..... .                |..||. 
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

QPFKLRK--N----VKLQTISEEILR----RTLVIEEKDRISWDELFK
.... .|  .     ...   .....    . |.   . ||.......
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 20769.AA Ciliate-E2b 49-295 27 8e-57 171.25 In-house 7-272 (272) Show / Hide 
Range on Protein: 49-295
Range on HMM: 7-272/272
Sequence Identity: 27% (73 aa)

LGEGAYGKVYEGVE-KNTQQTVAIKKLDIRQFQNDNYLRNSIISEIEILKRFNHKNIVKFIDLITTQRSLYIITEFCKDKDLRFLIQNKR---LTENQAL
|| |..| || . . |||.|  |.|   . |    | .  ....|...|.. || .|.|||.   . ...| . |||.  .|  .| .     | .....
LGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQN-MEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQ

HVLRDIVEGFKELVKHNVIHRDLKPANILIND-QVFKIADFGFAKYVDYSSAQLLR--SCVGSPLYMAPQILA-----RKAYGLKSDIWSIGVIFHEMVY
     |. ....| . |.|.||.|| ||..      |..|.| ||. . .. |. |  . .| | ||||.|.       | |. |.||||.|..  |.  
FYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMC

QDVPW--KARDERELLNNIMRQ-----PFKLRKNVKL-QTISEEILRRTLVIEEKDRISWDELFKMF
  |||  ...|  |.   |. .      .   |...   .. .  | .. .. .  ..|| .... |
GYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 20769.AA STE 43-241 26 2.4e-55 190.16 In-house 1-268 (359) Show / Hide 
Range on Protein: 43-241
Range on HMM: 1-268/359
Sequence Identity: 26% (71 aa)

YNLRHCLGEGAYGKVYEGVEKN---------------TQQTVAIKKLDIRQFQN-------------DNYLRNSIISEIEILKRFN--HKNIVKFIDLIT
. .  ..|.||.|.|| .. ..               |.. .|||...... .|             ..  ...|. ||.|.|..|  |.||||...   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TQR-------SLYIITEFCKDKDLRFLIQNK---------------RLTENQALHVLRDIVEG-FKELVKHNVIHRDLKPANILINDQVFKIADFGFAKY
          .|.|. |..    |. .|..|               |. |.|  ...|.|..|  . | .|..||||.||||||.     |..|||... 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VDYSSA---------------QLLRSCVGSPLYMAPQILAR------KAYGLKSDIWSIGVIFHEMVYQDVPW
.. |.|               |   ..||.| .||| .. .      | |. |.||||.|    ||.   .||
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase 20769.AA STE20 43-235 29 1.5e-46 161.01 In-house 1-221 (288) Show / Hide 
Range on Protein: 43-235
Range on HMM: 1-221/288
Sequence Identity: 29% (67 aa)

YNLRHCLGEGAYGKVYEGVEKNTQQT----VAIKKLDIRQF---QNDNYLRNSIISEIEILKRFNHKNIVKFIDLITTQ----RSLYIITEFCKD---KD
|.| ...|.|.||||| . .| |..     |||||.....    |     ...|. || |.|...|.||||...          .|.|. |.|      |
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ---DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTD

LRF--LIQNK-----RLTENQALHVLRDIVEGFKELVKHNVIHRDLKPANILINDQ-VFKIADFGFAKYVDY----SSAQLLRSCVGSPLYMAPQILAR-
.    .. .|     ...| |   ..|....| . | ....||||.| .|||....   |.||||..  ..     . ..   . ||.| .||| .... 
IMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

----KAYGLKSDIWSIGVIFHEMV
    | |. |.|||| |    ||.
EGPDKGYDYKCDIWSLGITAIEMA
Kinase 20769.AA Pkinase_Tyr 43-226 31 2.8e-28 96.42 Pfam 1-199 (270) Show / Hide 
Range on Protein: 43-226
Range on HMM: 1-199/270
Sequence Identity: 31% (63 aa)

YNLRHCLGEGAYGKVYEGVEK----NTQQTVAIKKL--DIRQFQNDNYLRNSIISEIEILKRF-NHKNIVKFIDLIT-TQRS--LYIITEFCKDKDLRFL
  . . |||||.|.||.|. |    ||...||.|.|  .  . ||   .| . ..|..|.| . .|.|||...  .|  ...  .||..|...  ||.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IQNK-----RLTENQALHVLRDIVEGFKELVKHNVIHRDLKPANILIN-DQVFKIADFGFAKYV---DYSSAQLLRSCVGSPLYMAPQILARKAYGLKSD
 ...     .||  . |.  ..| .|   |  .| |||||   |.|.. . | ||.||| |...   ||   .   ..      |||  .. . .  |||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

IWS
.||
VWS
Kinase 20769.AA TyrKc 43-295 24 3.3e-17 55.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-295
Range on HMM: 1-280/280
Sequence Identity: 24% (70 aa)

YNLRHCLGEGAYGKVYEGVEKNTQQTVAIKKLDIRQFQNDNYLRNSIISEIEILKRF--NHKNIVKFIDLITTQ-------RSLYIITEFCKDKDLRFLI
  | . |||||.|.||.|. |   ..||.|.|           |  ...|..|....  .|.|||...  .|.|         |.|..|...  ||.  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QNKR--LTENQALHVLRDIVEGFKELVKHNVIHRDLKPANILINDQV-FKIADFGFAKYVDYS-----SAQLLRS----CVG--SPL-YMAPQILARKAY
...|  |.  . |.   .| .|   | ..|.|||||   |.|....   ||.||| .....       | .  |.    .     |.  |||  .  . .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GLKSDIWSIGVIFHEMV-YQDVPWKA-----RDERELLNNIMRQPFKLRKNV--------KLQTISEEILRRTLVIEEKDRISWDELFKMF
  |||.|| ||   |.  | . |.        . .|.......     .             . . . | ..    . .|| .  |. . |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF