Gene 24363 (Tetrahymena)

24363

Species: Tetrahymena
Alias: 3698.m00131, 24363, 10.m00412, 547, TTHERM_00136380, PreTt24363
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
24363.AA Protein None 762 None Fasta, JSON
24363.kin_dom Protein Kinase Domain None 290 None Fasta, JSON
24363.NA RNA None 2289 None Fasta, JSON

Protein domain

Protein domains of 24363.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24363.AA ULK 15-304 35 1.9e-127 429.67 In-house 1-324 (324) Show / Hide 
Range on Protein: 15-304
Range on HMM: 1-324/324
Sequence Identity: 35% (122 aa)

FNCSDTLGKGSFG-TVYKGRVIAT---NEVVAIKALNRSLLQIQNQ----KFMIDQLKKEINLMQEIK---SEH--IVRIYDLVGTETH--IYIIIEYCG
.. .. ||||||| .||||| . |   |..||.|  ... ......    ..|...||.||..|...|   ...  ||. ||   | .|  |||| ||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DGDLRGLLEKNNY--------NISESQAISILQQILQGFKSLIDQGYVHRDIKPENILINKNT-------------FKIADFGFATKIQD--QNAQVLKE
.|||. ...||..        ..||..||....||..||| | .....||||||.||||....             .|||||||| ....  ...|....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

CV------GSPLYMSPQLLQ----QKPYS-SKSDIWSIGLLYYEILFGKLP---WLCRGIYLYSNYSILQDRIKSETILKKSIFYKFAHKYDNHEIKINY
||      |.||||.||.||    ||||. .|.||||.| ..||.|.|| |   |  .  ||| ... .. . | |              .   .|.|..
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNG-K-E--------------Q---QIYIKN

EVFRFP---FDKPVTDFSKDFIKGCLQFEEYKRFSWDQVFNHELF
. ..||    |... . .||.|...||..| .|.||...|||..|
QPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 24363.AA ULK 15-304 34 2.2e-122 412.9 In-house 1-329 (329) Show / Hide 
Range on Protein: 15-304
Range on HMM: 1-329/329
Sequence Identity: 34% (121 aa)

FNCSDTLGKGSFGTVYKGRVIAT----NEVVAIKALNRSLLQIQNQ----KFMIDQLKKEINLMQEIK----SEH----IVRIYDLVGTETH--IYIIIE
.. .. |||||||.||||| . |    ||.||.| . .. ....|.    ..|...||.|| .|...|    ...    ||. ||   | .|  |||| |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCGDGDLRGLLEKNNY---------NISESQAISILQQILQGFKSLIDQGYVHRDIKPENILINKN-------------TFKIADFGFATKIQDQ--NAQ
|| .|||. ...||..         ..||..||....|||.||| | .....||||||.||||...             ..|||||||| ....   ..|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VLKECV------GSPLYMSPQLLQ----QKPYS-SKSDIWSIGLLYYEILFGKLP---WLCRGIYLYSNYSILQDRIKSETILKKSIFYKFAHKYDNHEI
... ||      |.||||.||.||    ||||. .|.||||.| ..||.|.|| |   |  .  ||. ... .... ....                   
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQ-------------------

KINYEVFRFP---FDKPVTDFSKDFIKGCLQFEEYKRFSWDQVFNHELF
.|. . ..||    |... . .||.|...||..| .|.||...|||..|
QIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 24363.AA S_TKc 15-304 25 1.3e-78 268.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-304
Range on HMM: 1-231/231
Sequence Identity: 25% (78 aa)

FNCSDTLGKGSFGTVYKGRVIATNEVVAIKALNRSLLQIQNQKFMIDQLKKEINLMQEIKSEHIVRIYDLVGTETHIYIIIEYCGD--GDLRGLLEKNNY
.   ...|||.||.|||.| . |...|||| ..             .....||..... . ..||..||   . .|.|.. |||.   |||. ...|...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

N-----ISESQAISILQQILQGFKSLIDQGYVHRDIKPENILINKNTFKIADFGFATKIQDQNAQVLKECVGSPLYMSPQLLQQKPYSS-KSDIWSIGLL
.     ..| .| ....||... . . ..| .|||.||||||... . ||.|||.|...        . ..|.| ||.| .|   .|.  |.|.||.| .
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

YYEILFGKLPWLCRGIYLYSNYSILQDRIKSETILKKSIFYKFAHKYDNHEIKINYEVFRFPFDKPVTDFSKDFIKGCLQFEEYKRFSWDQVFN------
 || | |. |.         ..  . ..|.                                     ..  ||||..|||..  || .  ....      
LYEMLCGYPPFP--------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HELF
 |. |
CHPWF
Kinase 24363.AA Ciliate-E2 15-304 22 3.6e-75 256.05 In-house 1-365 (365) Show / Hide 
Range on Protein: 15-304
Range on HMM: 1-365/365
Sequence Identity: 22% (93 aa)

FNCSDTLGKGSFGTVYKGRVIATNEVVAIKALNRSLLQIQN----------------QKFMIDQLKKEINLMQEIK----------------SEHIVRIY
..    .|.|.||.|||..|. ... .|||  .  .. ...                .| .| |.|.||..|.||.                . .|...|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DLVG--TETHIYIIIEYCGDGDLRGLLEKNN----------YNISESQAISILQQILQ---------------GFKSLIDQG-YVHRDIKPENILINKNT
.     ....||.. |||  |||. ....|.           ...| ... | .||||               ....|  ..  .||||||||||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

FKIADFGFATKIQDQNA------------------------------QVLKECVGSPLYMSPQLLQQKP---------YSSKSDIWSIGLLYYEILFGKL
 ||.|||...|..|.|                               .. . ..|.| ||.|. |. |.         |. |.||||.| . || ||||.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PWLCRGIYLYSNYSILQDRIKSETILKKSIFYKFAHKYDNHEIKINYE-VFRFPFD----------------KPVTDFSKDFIKG----CLQFEEYKRFS
|.                                        .... .  ..||.                 | ...  ||.||     .|| .. ||..
PF----------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT

-WDQVFNHELF
 |.|..||. |
GWEQILNHPWF
Kinase 24363.AA CAMK 20-304 17 2.9e-64 205.69 In-house 1-425 (425) Show / Hide 
Range on Protein: 20-304
Range on HMM: 1-425/425
Sequence Identity: 17% (82 aa)

TLGKGSFGTVYKGRVIATN------------EVVAIKALNRSLLQIQN----------------------QKFMIDQLKKEINLMQE-------IKSEHI
|||.||||.|.... . |.            . |||| .... |. ..                      . .. .....||..|.        .. ..|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRIYD-------------------LVGT-ETHIYIII---EYCGDG----DLRGLLEKNNYN--------------ISESQAISILQQILQGFKSLIDQG
...|.                    . | ..|.|..    |||  |    ||   . .. ..              ..|..|  . .||... . . ...
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

YVHRDIKPENILINKN------------------TFKIADFGFATKIQDQN----------------------AQVLKECVGSPLYMS-PQLLQQ-----
 ||||.||||||...|                  . ||.|||||.|... .                       | .|...|.| ||. | .|..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KPYSSKSDIWSIGLLYYEILFGKLPWLC----------RGIYLYSNYSILQDRIKSETILKKSIFYKFAHKYDNHEIKINYEVFRFPFDKP
         ..|. |.|.||.| . |  | |..|.            .                               ... .|.. .    .. |. |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEW------------------------------IGMNDYELFEKIMKGKYDFPPP

VTDF------------------------SKDFIKGCLQFEEYKRFSWDQVFNHELF
  .                          ||.|...|| .  ||.. .|. ||. .
YFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 24363.AA Ciliate-E2c 15-217 38 3e-63 216.42 In-house 1-219 (310) Show / Hide 
Range on Protein: 15-217
Range on HMM: 1-219/310
Sequence Identity: 38% (84 aa)

FNCSDTLGKGSFGTVYKG-------RVIAT---NEVVAIKALNRSLL--QIQNQKFMIDQLKKEINLMQEIKSEHIVRIYDLVGTETHIYIIIEYCGDGD
..    ||.||.|.|||.        .|.    | . ||| .  ...   . |.|     ...|||.| . .. ||...|| . |. |||.| ||| .|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LRGLLEKN-NYNISESQAISILQQILQGFKSLIDQ-GYVHRDIKPENILINKNTFKIADFGFATKIQDQNAQ---VLKECVGSPLYMSPQLLQQ-KPYSS
|  ..... .  ..| | .    ||...|| |... .  |||||||||||.. . |||||||. ..||.| |       |.|.|.||.|| |   . | .
LEQYIYHKPK--PNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTE

KSDIWSIGLLYYEILFGKLPW
|||||| | . |. |. ||||
KSDIWSLGVTLYYMLCYKLPW
Kinase 24363.AA Pkinase 15-217 32 4.2e-62 217.42 Pfam 1-212 (293) Show / Hide 
Range on Protein: 15-217
Range on HMM: 1-212/293
Sequence Identity: 32% (70 aa)

FNCSDTLGKGSFGTVYKGRVIATNEVVAIKALNRSLLQIQNQKFMIDQLKKEINLMQEIKSEHIVRIYDLVGTETHIYIIIEYCGDG----DLRGLLE-K
. .  ..|.||||.|||.. . |...||.| ....   .  .| ... .  || .|.......|||.|| . ...|||.. |||. |    ||  ... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

NNYNI--SESQAISILQQILQGFKSLIDQGYVHRDIKPENILIN-KNTF----KIADFGFATKIQDQNAQVLKECVGSPLYMSPQLLQ-QKPYSSKSDIW
.. ..  || ...... |||.| . . ..| .|||.|||||||. ...     ||.|||.| ...  | . ..  .|.| ||.| ... ...|..|.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SIGLLYYEILFGKLPW
|.|.. || |.|..|.
SCGCILYEMLCGRPPF
Kinase 24363.AA CAMKL 15-217 32 4.1e-61 193.72 In-house 1-236 (297) Show / Hide 
Range on Protein: 15-217
Range on HMM: 1-236/297
Sequence Identity: 32% (77 aa)

FNCSDTLGKGSFGTVYKGRV-IATNEVVAIKALNRSLLQ-IQNQKFMIDQ--------LKKEINLMQEIK---SEHIVRIYDLVGTETH------IYIII
..  .||||||||.|  ..  . |.| |||| .... .. ... | .           ...||..|. ..    ..|...|. . |..|      ||.. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCGDGD--LRGLLEKN-NYN--ISESQAISILQQILQGFKSLIDQGYVHRDIKPENILINKNT---FKIADFGFATKIQ---DQNAQVLKECVGSPLYM
|||. |.  |   ..|. . .  ..|..|  . .||. . . . ..| |||||||||||. .|     ||.||||.....   ... | ||.. ||| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPQLLQQ--KPYS-SKSDIWSIGLLYYEILFGKLPW
.| ..|   |||   | ||||.| . | ...|.||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPF
Kinase 24363.AA Ciliate-E2-Unclassified 15-304 24 1.1e-57 197.99 In-house 1-352 (352) Show / Hide 
Range on Protein: 15-304
Range on HMM: 1-352/352
Sequence Identity: 24% (91 aa)

FNCSDTLGKGSFGTVYKGRVIATNEVV-----AIKALNRSLLQIQNQKFMIDQLKKEIN----------------LMQEIKSEHIVRIYDLVGTETHIYI
..   ..|.|.||.||| . . ..  .     ..|. ... .||.|..  | . .||.|                ... .....||. ..   .. .|||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IIEYCGDGDLRGLLE-------------KNNYN---ISESQAI-----SILQQILQGFKSLIDQG-YVHRDIKPENILINKN----TFKIADFGFATKIQ
. ||| .|||.  ..             .|...   ..| ||.      .. |||||...|. ..  .||||||||||...|      ||.|||.. |.|
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

DQNA--------------QVLKECVGSPLYM----SPQLLQQKPYS----SKSDIWSIGLLYYEILFGKLPWLCRGIYL---YSNYSILQ--DRIKSETI
..|               | .. ..|.| ||    .| .||.. |.     |.|||| | . ||.|||..|  ..  .    ...  | .  .|   . .
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQN

LKKSIFYKFAHKYDNHEIKINYEVFRFPFDKPVTDFSKDFIK----GCLQFEEYKRFSWDQVFNHELF
 |. ..... ..  .             ..| . .  ||||.     .|.    || ...|..|| .|
IKQKNIQFPKFPWQQ-------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 24363.AA STE 15-217 27 1.7e-55 190.7 In-house 1-268 (359) Show / Hide 
Range on Protein: 15-217
Range on HMM: 1-268/359
Sequence Identity: 27% (74 aa)

FNCSDTLGKGSFGTVYKGRVI------ATNEV---------VAIKALNRSLLQIQNQK------------FMIDQLKKEINLMQEIK--SEHIVRIYDLV
. . . .|||.||||||.. .       |.||         .||| .| .  .  . .              ..|..|||..|.. .  ...||. |.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

GTE-------THIYIIIEYCGDGDLRGLLE-KNNYNIS------------ESQAISILQQILQGFKSLID-QGYVHRDIKPENILINKNTFKIADFGFAT
  |       ....|. ||.. | |. ... |   . .            ||| . |..|||.|. ...  ....|||||| |||.     |..|||...
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

KIQD---------------QNAQVLKECVGSPLYMSPQLLQQ------KPYSSKSDIWSIGLLYYEILFGKLPW
...|                ..|  . .||.| .|.|  .||      |.|. |.||||.|..  | . || ||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase 24363.AA MARK 15-217 33 4e-51 165.45 In-house 1-206 (262) Show / Hide 
Range on Protein: 15-217
Range on HMM: 1-206/262
Sequence Identity: 33% (72 aa)

FNCSDTLGKGSFGTVYKGRVIATNEVVAIKALNRSLLQI-QNQKFMIDQLKKEINLMQEIKSEHIVRIYDLVG--TETH-IYIIIEYCGDGDLRGLLEKN
.    |.|.||...|.... . |.. |||| ...  |.  |. |     .. ||..|. .. ..|.. .. .   ||.| ||.| ||.. |.|.. ... 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKN----VMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAH

-NYNISESQAISILQQILQGFKSLIDQGYVHRDIKPENILINKNT---FKIADFGFATKIQDQNAQVLKECVGSPLYMSPQLLQQKPYS-SKSDIWSIGL
 |  ..|. |  | .||. . . . ... |||||||||||| .|.    ||.||||...|  .. | |... |.| ||.|.....|||   | |||| | 
PNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI--PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV

LYYEILFGKLPW
. | .. |..|.
VLYFMVCGYFPF
Kinase 24363.AA STE20 15-216 28 3.7e-48 166.3 In-house 1-226 (288) Show / Hide 
Range on Protein: 15-216
Range on HMM: 1-226/288
Sequence Identity: 28% (66 aa)

FNCSDTLGKGSFGTVYKGRVIATNEV----VAIKALNRSLLQIQNQK---FMIDQLKKEINLMQEIKSEHIVRIYDLVGTE----THIYIIIEYCGDGDL
... . .|.||.|.|||.. . |.|.    |||| .|     . ...    ... ..|||. |.. |...||. |.    .    ....|..|||| | |
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMN-----LEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSL

RGLLEKNN--------YNISESQAISILQQILQGFKSLIDQGYVHRDIKPENILINKN-TFKIADFGFATKIQD----QNAQVLKECVGSPLYMSPQLLQ
. ......        . ..|.|   |....||| . |  ....|||||  |||....   |.||||.. ....     ...  .  ||.| .|.| ..|
TDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQ

Q-----KPYSSKSDIWSIGLLYYEILFGKLP
.     |.| .|.|||| |    | . |. |
CMEGPDKGYDYKCDIWSLGITAIEMAEGEPP
Kinase 24363.AA Pkinase_Tyr 15-211 28 2.7e-22 76.15 Pfam 1-208 (270) Show / Hide 
Range on Protein: 15-211
Range on HMM: 1-208/270
Sequence Identity: 28% (61 aa)

FNCSDTLGKGSFGTVYKGRVI----ATNEVVAIKALNRSLLQIQNQKFMIDQLKKEINLMQEI-KSEHIVRIYDLVG-TETH--IYIIIEYCGDGDLRGL
     .||.|.||.||||.       |.  ||.| |. .  . ||   ... . .|...| .. . ..||| |  .   . .  |||. ||.  |||.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LEKN---NYNISESQAISILQQILQGFKSLIDQGYVHRDIKPENILIN-KNTFKIADFGFATKI-QDQNA-QVLKECVGSPLYMSPQLLQQKPYSSKSDI
| |.   . ... .. ... .|| .|   | .....|||.   |.|.. .|. ||.||| |  |  | .  .. ...      |.|  .. . ...|||.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSIGLLYYEIL
|| | | .||.
WSFGVLMWEIF
Kinase 24363.AA TyrKc 15-304 21 2.5e-17 57.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-304
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

FNCSDTLGKGSFGTVYKGRVIATNEVVAIKALNRSLLQIQNQKFMIDQLKKEINLMQEI--KSEHIVRIYDLVGTE-------THIYIIIEYCGDGDLRG
    ..|| | ||.||||. .   . ||.| |. .          .  . .|...| ..  . ..|||.|  . ..         ..|. ||.  |||. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LLEKNNYNISESQAISILQQILQGFKSLIDQGYVHRDIKPENILINKNT-FKIADFGFATKIQDQ-------NAQVLKE--CVG--SPL-YMSPQLLQQK
 | |.  ... .. .|.  || .|   | .....|||.   |.|...|   ||.||| . .| |           . ||  .     |.  |.|  .. .
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYSSKSDIWSIGLLYYEIL-FGKLPWL------CRGIYLYSNYSILQDRIKSETILKKSIFYKFAHKYDNHEIKINYEVFRFPFDKPVTDFSKDFIKGCL
 ...|||.|| | . .||. .|. |.       .  . .. .      . . . ..   .                       |    .|   . .| | 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS----------------------F-VCCPDEMYQIMKQCW

QFEEYKRFSWDQVFNHELF
...  .| .  ..  ||.|
HEDPEDRPTFSEI--HECF
Kinase 24363.AA Ciliate-E2c 278-304 48 1.2e-10 33.67 In-house 284-310 (310) Show / Hide 
Range on Protein: 278-304
Range on HMM: 284-310/310
Sequence Identity: 48% (13 aa)

KDFIKGCLQFEEYKRFSWDQVFNHELF
|..|.  ||..| ||..||..||||..
KQLIHKMLQVDEEKRIDWDEIFNHECI
Kinase 24363.AA Pkinase 278-304 44 7e-06 21.8 Pfam 267-293 (293) Show / Hide 
Range on Protein: 278-304
Range on HMM: 267-293/293
Sequence Identity: 44% (12 aa)

KDFIKGCLQFEEYKRFSWDQVFNHELF
|||||.||..  .|| ...|...|. |
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 24363.AA STE 278-304 37 0.003838 7.09 In-house 331-359 (359) Show / Hide 
Range on Protein: 278-304
Range on HMM: 331-359/359
Sequence Identity: 37% (11 aa)

KDFIKGCLQFEEYKRFSWDQVFN--HELF
||||. ||| .  || . .|  .  |. .
KDFINKCLQKDPNKRPTASQLLKSEHPFI
Efhand 24363.AA efhand 513-541 44 1.1e-05 25.26 Pfam 1-29 (29) Show / Hide 
Range on Protein: 513-541
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

NLKDLFDRFDLDQDGKLTGDEFFILLKKL
 ||..|. || |.||... .||  ..|||
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 24363.AA EFh 513-541 37 0.000103 22.9 SMART 1-29 (29) Show / Hide 
Range on Protein: 513-541
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

NLKDLFDRFDLDQDGKLTGDEFFILLKKL
 .|..|. || | ||... .||  ..|.|
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 24363.AA EFh 549-577 31 0.366659 0.01 SMART 1-29 (29) Show / Hide 
Range on Protein: 549-577
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

QAKHLFSILDKQENGYMLFDQFESMFNEW
. | .|...||  .||  |. |  |. . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 24363.AA efhand 549-576 32 1.787475 6.15 Pfam 1-28 (29) Show / Hide 
Range on Protein: 549-576
Range on HMM: 1-28/29
Sequence Identity: 32% (9 aa)

QAKHLFSILDKQENGYMLFDQFESMFNE
..| .|...||  .||  |. | .|. .
ELKEMFKEFDKDGDGYIDFEEFCEMMKK
Efhand 24363.AA efhand 603-631 34 0.00044 19.36 Pfam 1-29 (29) Show / Hide 
Range on Protein: 603-631
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

DLENIFKNFDKGQNGNLSLQEFEELILLI
.|...|| ||| ..| ....|| |..  .
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 24363.AA EFh 603-631 24 0.003654 16.15 SMART 1-29 (29) Show / Hide 
Range on Protein: 603-631
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

DLENIFKNFDKGQNGNLSLQEFEELILLI
... .|. |||  .| ....|| ...  .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 24363.AA EFh 639-667 37 7.5e-09 36.65 SMART 1-29 (29) Show / Hide 
Range on Protein: 639-667
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

EIKQIFDKFDLNKDQQISFNEFSNVMTRK
|.|..|..|| ..| .|.|.||  .|...
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 24363.AA efhand 639-667 37 3.7e-08 34.27 Pfam 1-29 (29) Show / Hide 
Range on Protein: 639-667
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

EIKQIFDKFDLNKDQQISFNEFSNVMTRK
|.|..|..|| ..| .|.|.|| ..|...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 24363.AA efhand 735-758 33 0.000566 18.96 Pfam 1-24 (29) Show / Hide 
Range on Protein: 735-758
Range on HMM: 1-24/29
Sequence Identity: 33% (8 aa)

GIHLLFRYMDIDNDGEISYTEFKT
 .  .|. .| |.||.|.. ||..
ELKEMFKEFDKDGDGYIDFEEFCE
EFh 24363.AA EFh 735-760 41 0.048288 7.11 SMART 1-29 (29) Show / Hide 
Range on Protein: 735-760
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

GIHLLFRYMDIDNDGEISYTEFK---TSL
 .  .|| .| |.||.|.. |||   .||
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL