Gene 28079 (Tetrahymena)

28079

Species: Tetrahymena
Alias: 3794.m00171, PreTt28079, 272, TTHERM_01107300, 28079, 237.m00036
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
28079.AA Protein None 526 None Fasta, JSON
28079.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
28079.NA RNA None 1581 None Fasta, JSON

Protein domain

Protein domains of 28079.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28079.AA ULK 11-270 34 1.2e-116 393.79 In-house 1-324 (324) Show / Hide 
Range on Protein: 11-270
Range on HMM: 1-324/324
Sequence Identity: 34% (111 aa)

YQLIQRLDEGAIG-QVFKAQNIQT---KEYVAVKQVNIKLFSKSEHLYT------LFEQEIENLKKTK---SVN--TIKYIDHFNDD--NNKYIVVEYVD
|.|...| .|. | .|.|. |..|   ..|||.|....| ..|......      |...||...|| |   ..|  ..|..| |...  || ||..|| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GFTLKKKLEQLQL-----EGKTFSENTTISYFIQLLKGIKDLHKNNIIHRDLKLENIMISK------------EGIIKIIDFGSSRELKEG----FSANT
| .|.. ... .      |.|..||. .|..|.|.. | |.|||.||||||.|..||.|..            .|..|| ||| .. . ..    .   |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LV------GTPYNMAPEVWF----QQDYG-SECDIYSLGVILYQMLFGEYPFFTK-NITQLWGIIKE-------------GNIDFNKGK--IKISQDMQN
.|      |||. |||...     |..|. ..|||.|||.|.|.||.|.||||.  | ..|. |.|.              .|.|.|..  .|||.....
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIRRMLKYEQDQRISWQEIYNNIIF
||||||.|....||||.||.|. .|
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 28079.AA ULK 11-270 32 8.70000000001e-113 381.0 In-house 1-329 (329) Show / Hide 
Range on Protein: 11-270
Range on HMM: 1-329/329
Sequence Identity: 32% (106 aa)

YQLIQRLDEGAIGQVFKAQNIQTK----EYVAVKQVNIKLFSKSEHLYT------LFEQEIENLKKTK----SVN----TIKYIDHFNDD--NNKYIVVE
|.|...| .|. |.|.|. |..||    |.||.|.. .. .........      |...||...|| |    . |    ..|..| |...  || ||..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YVDGFTLKKKLEQLQL------EGKTFSENTTISYFIQLLKGIKDLHKNNIIHRDLKLENIMISKE------------GIIKIIDFGSSRELKEG----F
| .| .|.. ... .       |.|..||. .|..|.|.| | |.|||.||||||.|..||.|..             |..|| ||| .. . ..    .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

SANTLV------GTPYNMAPEVWF----QQDYG-SECDIYSLGVILYQMLFGEYPFFTK-NITQLWGIIKE-------------GNIDFNK--GKIKISQ
 . | |      |||. |||...     |..|. ..|||.|||.|.|.||.|..||..  | ..|..|.|.              ...|.|   ...||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

DMQNLIRRMLKYEQDQRISWQEIYNNIIF
....||||||.|....||||.|..|. .|
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 28079.AA Ciliate-E2-Unclassified 11-270 28 2.2e-80 273.39 In-house 1-352 (352) Show / Hide 
Range on Protein: 11-270
Range on HMM: 1-352/352
Sequence Identity: 28% (100 aa)

YQLIQRLDEGAIGQVFKAQNIQTKEYV------AVKQVNIKLFSKSEHLYTLFEQEIENLKK-----------------TKSVNTIKYIDHFNDDNNKYI
| .|. . .|. |.|.|.|....| ..       ..|.. ..  ....   ..|....| ||                  .. . .|....|.|..| ||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VVEYVDGFTLKKKLE-------------QLQLEGKTFSENTTI-----SYFIQLLKGIKDLHKNN-IIHRDLKLENIMISKEG---IIKIIDFGSSRELK
| ||..| .|.. ..             . ....| |.|. ..      || |.|.|.. ||..| |||||.|.|||.....|    |||||||.|....
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

E-----GFS-----------ANTLVGTPYNM----APEVWFQQDYG----SECDIYSLGVILYQMLFGEYPFFTKNITQ----------------LWGII
.     ...           ..| .|||. |    ||||  .| |.     .|||.|||||||.||||.|||. .| .|                |  .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KEGNIDFNKGKI-----KISQDMQNLIR----RMLKYEQDQRISWQEIYNNIIF
|..||.|.| .      ..|.  ...|.    .|||. ...||....| |  .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 28079.AA S_TKc 11-270 30 1.4e-79 271.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-270
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

YQLIQRLDEGAIGQVFKAQNIQTKEYVAVKQVNIKLFSKSEHLYTLFEQEIENLKKTKSVNTIKYIDHFNDDNNKYIVVEYVDG--FTLKKKLEQLQLEG
|.... . .|| |.|.|.... |...||.|...             ...||. ||| .  | .|..|.| | .. |.| ||.||   .|.. ... . .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--KTFSENTTISYFIQLLKGIKDLHKNNIIHRDLKLENIMISKEGIIKIIDFGSSRELKEGFSANTLVGTPYNMAPEVWFQQDYGS-ECDIYSLGVILYQ
  . |.| .. .|. |...... .|...||||||| |||....   |||.|||..|.|      .|..|||. |||||     ||  .||..|.|.||| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLFGEYPFFTKNITQLWGIIKEGNIDFNKGKIKISQDMQNLIRRMLKYEQDQRISWQEIYN-------NIIF
|| |. ||   .. ... .|.             |... ..||..|... ..|..  |. .          |
MLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28079.AA Ciliate-E2 11-270 25 1.3e-75 257.51 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-270
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

YQLIQRLDEGAIGQVFKAQNIQTKE------------------YVAVKQVNIKLFSKSEHLYTLFEQEIE--------------NLKKTKSVNTIKYIDH
| .|. . .|. |.|.|........                  .|..|....| ..|..  ... |. |               .|.. .. | ||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FN--DDNNKYIVVEYVDGFTLKKKLEQL---------QLEGKTFSENTTISYFIQLLK---------------GIKDLHKNN-IIHRDLKLENIMISKEG
|   |||| |.| ||..| .|.. ...          . . | |.|.  . .. |.|.               ... ||..| |||||.|.|||..    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

IIKIIDFGSSRELKEG--------------------------------FSANTLVGTPYNMAPEVWF---------QQDYGSECDIYSLGVILYQMLFGE
 ||||||| |.....                                 . .||..|||. ||||.           |..|. .|||.|||||||.||||.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPFFTKNITQLWGIIKEGNIDFNKGK---------------IKISQDMQNLIRR----MLKYEQDQRIS-WQEIYNNIIF
.||          .||...|||.. .                |.||....||..    ||......||. |..| |. .|
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 28079.AA AGC 11-270 19 2.4e-69 177.51 In-house 1-395 (395) Show / Hide 
Range on Protein: 11-270
Range on HMM: 1-395/395
Sequence Identity: 19% (78 aa)

YQLIQRLDEGAIGQVFKAQNI------QTKEYVAVKQVN----IKLFS--KSEHLYTL--------FEQEIENLKKTK----------SVNTIK-YIDHF
....  . .|. |.|. ..        .|..| |.| ..    |..    . || .|         . .| . |.| .          . . .|     |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

NDDNN--KYIVVE----YVD------G-FTLKKKLEQLQLEGK---TFSENTTISYFIQ-------LLKGIKDLHK-NNIIHRD-LKLENIMISKEGIIK
 |...   |.| |    ||       |  ..  . ..     .   .|.|...  |. .       .. ..  ||. ..||||| ||.|||.. ..| ||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGR-----RKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIK

IIDFGSSRELK---------------------------------------------------EGFSANTLVG--TPYNMAPEVWFQQDYGSECDIYS--L
. |||.. |..                                                   ... ..|..|  ||  ||||.     || .||..|  |
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGL

GVILYQMLFGEYPFFTKNIT----------QLWGIIK------EGNIDFN-------KGKIKISQDMQNLIRRMLKYEQDQRIS----------WQEIYN
|...|.||.|  ||. .|            ..   |.      . .. |.       ..  ..|.. ..||...|. . ..|.            .|| |
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

NIIF
   |
HPWF
Kinase 28079.AA Pkinase 11-268 27 1.9e-66 231.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YQLIQRLDEGAIGQVFKAQNIQTKEYVAVKQVNIKLFSKSEHLYTLFE-QEIENLKKTKSVNTIKYIDHFNDDNNKYIVVEYVDGF----TLKKKLEQLQ
|...... .|. |.|.|.... | . ||||... .   ||. ..|..  .||. .|. .. | ....| | |... |.| ||..|      |.  ..   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

LEGKTF--SENTTISYFIQLLKGIKDLHKNNIIHRDLKLENIMISKEGII----KIIDFGSSRE--LKEGFSANTLVGTPYNMAPEVWF-QQDYGSECDI
 ....|  ||.. ..|. |.|.|.. .|...|||||||.|||.|...| |    ||.|||...   .  .  ..|..|||. |||||   .|.||...|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSLGVILYQMLFGEYPFFTK------NITQLWGIIKEGNIDFNKGKI------------------KISQDMQNLIRRMLKYEQDQRISWQEIYNN--I
.|.|.|||.||.|. ||  .      .  |.   |... ..|.  .                   ..|.... .|...|..   .|.....| .   .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 28079.AA CAMK 16-266 21 2.3e-62 199.48 In-house 1-421 (425) Show / Hide 
Range on Protein: 16-266
Range on HMM: 1-421/425
Sequence Identity: 21% (89 aa)

RLDEGAIGQVFKAQNIQTK------------EYVAVKQVNIKLFSK------------------------SEHLYTLFEQEIENLKK-------TKSVNT
 | .|. |.|.......|.            . ||.| .. |  ..                        ...    ...||| .||        .  | 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKYIDHFND-------------------DNNKYIVV---EYVDGF----TLKKKLEQLQLEG-----------KTFSENTTISYFIQLLKGIKDLHKNNI
|| .... |                   |.. |.|    ||..|      |  .. .   .|           . |.|  .  || |.. ... .|..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLENIMISKE-----------------GIIKIIDFGSSRELKE------------------------GFSANTLVGTPYNMA-PEVWFQQD----
.|||||.|||....                  . ||||||| ......                        |   .| .|||. || |||  ..     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YGSECDIYSLGVILYQMLFGEYPFFTK-------------NITQLWGIIKEGNIDFNKGKIK---------------------ISQDMQN
          || .||. |.||||| || |..||  .             |. .|.  |..|. ||   ...                     .||. ..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRRMLKYEQDQRISWQEIYN
|||.||... ..|.. ... |
LIRKMLQVDPEKRMTIEQCLN
Kinase 28079.AA STE 11-260 22 5.6e-57 195.62 In-house 1-347 (359) Show / Hide 
Range on Protein: 11-260
Range on HMM: 1-347/359
Sequence Identity: 22% (78 aa)

YQLIQRLDEGAIGQVFKAQNI------QTKEY---------VAVKQVNIKLFS-------------KSEHLYTLFEQEIENLKKTK--SVNTIKYIDHFN
...|... .|| |.|.|| |.      .|.|          .|.||.|..  .             | .     ...||. .|| .  . | .||.... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DD-------NNKYIVVEYVDGFTLKKKLEQLQLEGKTFS----------ENTTISYFIQLLKG-IKDLHKNNIIHRDLKLENIMISKEGIIKIIDFGSSR
..       .. .|. ||.|| .| . ...    ||...          |.  . .  |.|||  . ||...|||||.|  ||..     .|..||| . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ELKE-----------------GFSANTLVGTPYNMAPEVWFQ------QDYGSECDIYSLGVILYQMLFGEYPFFT-KNITQLWGIIKE-----------
 | .                 .   ||.||||  |||||  |      ..|.  |||.|||  .  |. |..|... ..   .. |...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GNIDFNKG----------------KIKISQDMQNLIRRMLKYEQDQRIS
    .   .                   . | |..... |.. |... ..| .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT
Kinase 28079.AA Ciliate-E2a 11-270 31 4.3e-54 157.63 In-house 1-275 (275) Show / Hide 
Range on Protein: 11-270
Range on HMM: 1-275/275
Sequence Identity: 31% (88 aa)

YQLIQRLDEGAIGQVFKAQNIQTKEYVAVKQVNIKLFSKSEHLYTLFEQEIENLKKTKSVNTIKYIDHFNDDNNKYIVVEYVDGFTLKKKLEQLQLEGKT
| .|  . .|. |.|..|| .||..  |.| ..   .. ..  .  |..||  ... .  | || .. . |.|| |.| ||..| .|..|. | .   . 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCK---RF

FSE-NTTISYFIQLL-KGIKDLHKNNIIHRDLKLENIMIS---KEG----IIKIIDFGSSREL--KEGFSANTLVGTPYNMA------PEVWFQQDYGSE
|.| .   ..  ||| .|.  .|..||.|||||.|||..    |..     ||||||| ..    .|.    . .|||. .|      .|| ....|.  
FEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTK

CDIYSLGVILYQMLFGEYPFFTKNITQLWGIIKEGNIDFNKGK--IKISQDMQNLIRRMLKYEQDQRISWQEIYNNIIF
||. |.|||.| .|.|. ||  |. ..    .|. .||||      |.|.. ..|...||..   .||. |...|.  |
CDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 28079.AA NEK 11-270 30 9.5e-51 174.91 In-house 1-286 (286) Show / Hide 
Range on Protein: 11-270
Range on HMM: 1-286/286
Sequence Identity: 30% (89 aa)

YQLIQRLDEGAIGQVFKAQNIQTKEY-----VAVKQVNIKLFSKSEHLYTLFEQEIENLKKTKSVNTIKYIDHFNDDN--NKYIVVEYVD-GFTLKKK--
|..|. . .|. |.|.|.. ....       .. |..|..  |  |   ..  .|.  ||. |. | .||.|.| ...    .|| || . | .| .|  
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQ-NNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-LEQLQLEGKTFSENTTISYFIQLLKGIKDLHKN-----NIIHRDLKLENIMISKEGI----IKIIDFGSSRELKEGFS-ANT-LVGTPYNMAPEVWFQQ
 ... . .|| |.|..   .|||.....| .|..     .|.|||.|  ||...|...    .|| ||| |..|. . . |.| .||||| |.|||. ..
SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

DYGSECDIYSLGVILYQMLFG--EYPFFTK--NITQLWGIIKEGNIDFNKGKIK--ISQDMQNLIRRMLKYEQDQRISWQEIYNNIIF
 |.. .|| |||..||.|     . ||  .  |. .|   |..| .....   .   |||.||||..||. . .|| | ..| .. . 
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG-PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 28079.AA CAMK-Unique 11-270 22 2.8e-50 164.08 In-house 1-363 (363) Show / Hide 
Range on Protein: 11-270
Range on HMM: 1-363/363
Sequence Identity: 22% (82 aa)

YQLIQRLDEGAIGQVFKAQNIQTKEYVAVKQVNIKLFS-KSEHL---------------YTLFEQEIENLKKTKSVNTIKYIDH----FNDDN-------
| ... . .|. | |...... |.   |.| |. .  . |. ..                  .. |.. .|. .  | ||  |     | |..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NKYIVVEYVDGFTLKKKLEQL-----------------QLEGKTFSE--NTTISYFIQLLKGIKDLHKNNIIHRDLKLENIMISKEGI----
        . ||| ||..| .|.... ..                 ...|. |||  . |.... .||  .. .|...|.||||||||||......    
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGH-FSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

------------IKIIDFGSSRELKEGFSAN---TLVGTPYNMAP--------------EVWFQQDYGSEC----DIYSLGVILYQMLFGEYPFFTKNIT
            ||..||| .... .  .     | .|||. |||              ||  .|.|.. |    || |||||.| ||.|. ||   .. 
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED

--------QLWGIIKEGNI-DFNKGKIKI----SQDMQNLIRRMLKYEQDQRISWQEIYNNIIF
         .   |. |.. .| . .  .    ||   ... . .....|.|.|  |.. .. .
RDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 28079.AA TyrKc 11-268 20 1.2e-14 14.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-268
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YQLIQRLDEGAIGQVFKAQNIQTKEYVAVKQVNIKLFSKSEHLYTLFEQEIENLKKT--KSVNTIKYIDHFNDD-------NNKYIVVEYVDGFTLKKKL
 .|.. | ||| |.|.|.. .   . |||| ..             | .|.. ..|   .  | .. .    ..          .||.||...  ||. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

EQLQLEGKTFSENTTISYFIQLLKGIKDLHKNNIIHRDLKLENIMISKEGIIKIIDFGSSRELKEG----FSANTLVGT---PYN-------MAPEVWFQ
   . .   ..  . .|. .|  .|   ||..|.|||||   |.........|| ||| ||.....     |  . . .     .       ||||... 
RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

QDYGSECDIYSLGVILYQML-FGEYPFFT-----KNITQLWGIIKEGNIDFNKGKIK------ISQDMQNLIRRMLKYEQDQRISWQEIYNNI
  . .. |..| || .. .. .|. |        .. ...   .|.|.       .        ...| .....  ... ..| . .||.  .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 28079.AA Pkinase_Tyr 11-159 25 4.1e-05 17.96 Pfam 1-156 (270) Show / Hide 
Range on Protein: 11-159
Range on HMM: 1-156/270
Sequence Identity: 25% (40 aa)

YQLIQRLDEGAIGQVFKAQNI----QTKEYVAVKQVNIKLFSKSEHL--YTLFEQEIENLKKT-KSVNTIKYIDHFN-DDNN--KYIVVEYVDGFTLKKK
 .... | ||| |.|.|.       .||  |||| ..    . ...      | .|.. .|.  .  | ....     ..     |||.||. .  |.. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LEQLQLEGKTFSENTTISYFIQLLKGIKDLHKNNIIHRDLKLENIMISKEGIIKIIDFG
| .   ... ..  . ... .|  ||   |. .|.|||||   |.........|| |||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 28079.AA Pkinase_Tyr 180-204 32 2.856215 1.54 Pfam 181-205 (270) Show / Hide 
Range on Protein: 180-204
Range on HMM: 181-205/270
Sequence Identity: 32% (8 aa)

MAPEVWFQQDYGSECDIYSLGVILY
||||...   . .. |..| || ..
MAPECINYGKFTTKSDVWSFGVLMW