Gene 2836 (Tetrahymena)

2836

Species: Tetrahymena
Alias: 2836, 233.m00046, 793, PreTt02836, TTHERM_01100450
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
2836.AA Protein None 688 None Fasta, JSON
2836.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
2836.NA RNA None 2067 None Fasta, JSON

Protein domain

Protein domains of 2836.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2836.AA ULK 58-316 32 2.1e-110 373.11 In-house 1-324 (324) Show / Hide 
Range on Protein: 58-316
Range on HMM: 1-324/324
Sequence Identity: 32% (107 aa)

LEDTDIVGEGSFG-KVVRAYDIKNQ--NEDLVAKIIP--LDDQQKYE--------SMQMELKVLCKLP--QHVN--LVNYKKIKMSSQ-NKQYFIMDYCN
 .  .. |.|||| || .....|..  |..  .|.|.     ..|.|        . . | ... ||   .|.|   | .......|. |  |.||.|||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGTLTQYLK---------NQKKISENEILEFLQQFCRGYRVLYKEGIIHRDIKPDNILIHNRI-------------FKIADFGLAKIVD---TLQVQNIS
||.| ||.|         ..|..||.|...|..|.| |.. |.|..||||||||.|||||| .             .||||||.||.||     | .. .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

TR------GTPLYIAPELVK----KEKAS-SKVDMWSLGVILFRMLFKGQYPFLDPLIKYDVPTALKH----------IQQKKLIIP---SNPQRSPEII
.       ||||| ||....    ... . .|.|.||||.|.. ||.   ..| .   ...     |.          |..... .|   ..|..|||..
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

DLVKRMLEKDESKRISWEELFSHNLI
|| .|||..||..||||||.|.| ..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 2836.AA ULK 58-316 33 4.1e-109 368.79 In-house 1-329 (329) Show / Hide 
Range on Protein: 58-316
Range on HMM: 1-329/329
Sequence Identity: 33% (110 aa)

LEDTDIVGEGSFGKVVRAYDIKNQ---NEDLVAKIIPLD--DQQKYE--------SMQMELKVLCKLP-------QHVNLVNYKKIKMSSQ-NKQYFIMD
 .  .. |.|||||| .....|..   ||. ..|.|...  .|...|        . . | |.. ||        .| | | .......|. |  |.||.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNGGTLTQYLK----------NQKKISENEILEFLQQFCRGYRVLYKEGIIHRDIKPDNILIHNRI-------------FKIADFGLAKIVDT---LQV
|||||.| ||.|          ..|..||.|...|..|.. |.. |.|..||||||||.|||||| .             .||||||.|| ||     | 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

QNISTR------GTPLYIAPELVK----KEKAS-SKVDMWSLGVILFRMLFKGQYPFLDPLIKYDVPTALKH----------IQQKKLIIP---SNPQRS
.. ..       ||||| ||....    ... . .|.|.||||.|.. ||.   ...     ...     |           |....| .|   ..||.|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PEIIDLVKRMLEKDESKRISWEELFSHNLI
||..|| .|||..||..||||||||.| ..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 2836.AA S_TKc 58-316 29 5.9e-72 246.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 58-316
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

LEDTDIVGEGSFGKVVRAYDIKNQNEDLVAKIIPLDDQQKYESMQMELKVLCKLPQHVNLVNYKKIKMSSQNKQYFIMDYCNG--GTLTQYLKNQKK---
 |  ...|.|.|||| .....|  ..    |||.       |... |...| |  .| |.|... .  .  .. |..|.||.|  |.| .|.|....   
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ISENEILEFLQQFCRGYRVLYKEGIIHRDIKPDNILIHNRIFKIADFGLAKIVDTLQVQNISTRGTPLYIAPELVKKEKASS-KVDMWSLGVILFRM
   ..| ..  ...| |..   . . ||||||.||.|||. .   ||.|||||...        .  ||| |.|||..   . .  |.|.||.|.||. |
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LFKGQYPFLDPLIKYDVPTALKHIQQKKLIIPSNPQRSPEIIDLVKRMLEKDESKRISWEELFS-------HNLI
|  |. ||       .. . .|.|             ||| .|.....|.|| .||..  |..        |  .
LC-GYPPFP------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2836.AA Ciliate-E2 58-316 25 6.3e-69 235.3 In-house 1-365 (365) Show / Hide 
Range on Protein: 58-316
Range on HMM: 1-365/365
Sequence Identity: 25% (96 aa)

LEDTDIVGEGSFGKVVRAYDIKNQN-----------------EDLVAKIIPLDDQQKY--ESMQMELKVLC-------KLPQ---------HVNLVNYKK
 .   . |.|.||.| .. ..|.|.                 |   .||. .  ..|.  |.. .|....        |. .         | |..... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

IKMS-SQNKQYFIMDYCNGGTLTQYLKNQ-----------KKISENEILEFLQQFCRGY---------------RVLYKEG-IIHRDIKPDNILIHNRIF
   . ..|. |..|.||.||.| .|.||.           |...|.||... .| ..|.               . | ... ||||||||.|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KIADFGLAKIVDTLQVQNIS-------------------------------TRGTPLYIAPELVKKEK---------ASSKVDMWSLGVILFRMLFKGQY
||.||||.|..|. . ...                                . ||| | ||| ....|          . |.|.|||||||..||| |..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF-GKP

PFLDPLIKYDVPTALKHIQQKKLIIP----------------SNPQRSPEIIDLVKR----MLEKDESKRIS-WEELFSHNLI
||            .. |.|.|. .|                |. . |.| .|| |.    ||.||..|||. ||... |  .
PF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 2836.AA Pkinase 58-316 28 1.2e-61 215.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 58-316
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

LEDTDIVGEGSFGKVVRAYDIKNQNEDLVA-KIIPLDDQQKYESMQ----MELKVLCKLPQHVNLVNYKKIKMSSQNKQYFIMDYCNGG----TLTQYLK
..   ..|.||||.| ........   .|| |||..... . . ..    .|.... .| .| | | .. . ..  .. |..|.||.||     |  |..
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

--NQKKI--SENEILEFLQQFCRGYRVLYKEGIIHRDIKPDNILIH-NRIF----KIADFGLAKIV-DTLQVQNISTRGTPLYIAPELVK-KEKASSKVD
  .....  ||.|.  .. | .||   ....||||||.||.||||. |       ||.|||||| .    .. . .  ||| |.|||...  .. ..|||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

MWSLGVILFRMLFKGQYPFLDPL----IKYDVPTALKHIQQKKLIIPSNPQRS-------------------PEIIDLVKRMLEKDESKRISWEELFSHN
|||.|.||. ||. |. ||          .|    .. | ...|  ..   .|                   .| .|..|..|.|| .||...|... | 
MWSCGCILYEMLC-GRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

LI
 .
WF
Kinase 2836.AA Ciliate-E2-Unclassified 59-316 24 4.5e-61 209.2 In-house 2-352 (352) Show / Hide 
Range on Protein: 59-316
Range on HMM: 2-352/352
Sequence Identity: 24% (86 aa)

EDTDIVGEGSFGKVVRAYDIKNQNEDLVAKIIPLDDQQKYESMQ------MELKVLCKL----------------PQHVNLVNYKKIKMS-SQNKQYFIM
.   . |.|.|||| .....|.. .  . |..    ..|  ...      .|.| ....                 .| ... .|.. .  .... |..|
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DYCNGGTLTQYLKNQKK-----------------ISENEIL-----EFLQQFCRGY-RVLYKEGIIHRDIKPDNILIHNR----IFKIADFGLAKIVDTL
.||.||.| ||.|..||                 ..|....      .. | . |     .| .||||||||.|||..|       ||.|||..|  .. 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------QVQNISTR-GTPLYI----APELVKKEKAS----SKVDMWSLGVILFRMLFKGQYPFLDPLIKY-------------DVPTALKHI
              . |...|. ||| |.    |||. .... .     |.|.|||||||. ||| |.||| |.  .              .     . .
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF-GYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

QQKKLIIPSNP-----QRSPEIIDLVK----RMLEKDESKRISWEELFSHNLI
|..  . ....     . ||| .|...    .||.|. .|||..|... | ..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 2836.AA Ciliate-E2c 132-316 35 2.9e-55 189.93 In-house 90-310 (310) Show / Hide 
Range on Protein: 132-316
Range on HMM: 90-310/310
Sequence Identity: 35% (79 aa)

YFIMDYCNGGTLTQYLKNQKKISENEILEFLQQFCRGYRVLYKE-GIIHRDIKPDNILIHNRIFKIADFGLAKIVDTLQVQNIS----TRGTPLYIAPEL
|.|| |||||||.||...  |..| ..|    |  ..  .|.|| .|.|||||| |||||| . ||||||..||.... .|| .      |||.| ||. 
YLIMEYCNGGTLEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQI

VKK-EKASSKVDMWSLGVILFRMLFKGQYPFLD---------------PLIKYDVPTALKHIQ---------------QKKLIIPSN--PQRSPEIIDLV
 .   .  .| | ||||| |. ||..  .|. .               | .   .    .||                ....  | |    .|.|. .| 
LEGKNYYTEKSDIWSLGVTLYYMLCY-KLPW-ESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLI

KRMLEKDESKRISWEELFSHNLI
..||..||.|||.|.|.| | .|
HKMLQVDEEKRIDWDEIFNHECI
Kinase 2836.AA STE 58-316 21 6.2e-55 188.82 In-house 1-359 (359) Show / Hide 
Range on Protein: 58-316
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

LEDTDIVGEGSFGKVVRAYDIK-----NQNED---------LVAKIIPLDDQ-----------------QKYESMQMELKVLCKLPQ-HVNLVNYKKIKM
.|. ...|.|.||.|..|...|       .|             |...|...                 .. .. ..|.|.. |. . | | |.|    .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SS------QNKQYFIMDYCNGGTLTQYLKN--------------QKKISENEILEFLQQFCRG-YRVLYKEGIIHRDIKPDNILIHNRIFKIADFGLAKI
         .. . .| |..||.|.. .|.              |....|..|  ...| ..|    | . .||||||||.|||.     |..|||....
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VD----------------TLQVQNISTRGTPLYIAPELVKK------EKASSKVDMWSLGVILFRMLFKGQYPFLDPLIKYDVPTAL--KHIQQ------
..                | | .. .  ||| . ||| ...       . . |.|.||||  .  |.  |..|. |    .    ..  .|.||      
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT-GKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----KKLIIPS-----------------NPQRSPEIIDLVKRMLEKDESKRISWEELFS--HNLI
    .   .|.                   . ||| .| ... |.|| .|| . ..| .  |  |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 2836.AA Ciliate-A1 58-317 24 4.6e-52 175.54 In-house 1-301 (301) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-301/301
Sequence Identity: 24% (74 aa)

LEDTDIVGEGSFGKVVRAYDIKNQNEDLVAKIIPLDDQQKYESMQMELKVLCKLPQHVNLVNYKKIKMSSQ--NKQYFIMDYCNGGTLTQYLKNQKKISE
      .. |||| | ||||| ||   |  |||   .   | .   |....  ...  ...|| ...   .    ...|| || .| | .| .. . ...
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQNDYMKK

NEILEFLQQFCRGYRVLYKEGIIHRDIKPDNILIH-NRIFKIADFGLAKIVDTLQ------------------VQNISTRGTPLYIAPEL---------V
 || |.. |.  ||  . .  |.|||.||.|||||    .||.|.|. |.    |                   . ..  |. .| .||.          
EEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMF

KKEKASSKVDMWSLGVILFRMLF-KGQYPFLDPLIKYDVPTALKHIQQ-------------KKLIIPSNP-QRSPEIIDLVKRMLEKDESKRISWEELFS
.. | ... ||.|||.|..         |.   ...  .. .   .|              || | |. .  |. |.  |...|. ..   |.| ... .
IENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVN--IFGN--NMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCID

HNLIA
   | 
CLYIF
Kinase 2836.AA CAMK 63-316 18 7e-50 158.52 In-house 1-425 (425) Show / Hide 
Range on Protein: 63-316
Range on HMM: 1-425/425
Sequence Identity: 18% (78 aa)

IVGEGSFGKVVRAYDIKNQN-----------EDLVAKIIPLD----------------------------DQQKYESMQMELKVLCKLP------QHVNL
. |.|||||| .........           .   .|||. .                            .... .... |.... ||       .| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNYKK-------------------IKMSSQNKQYFIM---DYCNGG----TLTQYLKNQ---------------KKISENEILEFLQQFCRGYRVLYKEG
..                      .  ..... |..|   .|| ||     | .|.. .               ....| |   . .| | . . . . .
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPDNILIHNR------------------IFKIADFGLAKIVDTLQVQNIS-----------------------TRGTPLYIA-PELVKK-----
|.|||.||.|||. ..                    ||.|||.|...|  . ..                           ||| |.| ||....     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EKASSKVDMWSLGVILFRMLFKGQYPFLDPL---------IKYDVPTALKHIQQKKLIIPSNPQRS----------------------PEI
         .  . |.||||.||||. ||  | .|| ..          |... .  .. |.. |   |. .                         .| 
MQNATDEEKPYYGPKCDMWSCGVILYIMLC-GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

IDLVKRMLEKDESKRISWEELFSHNLI
.||...||..| .||.. |.  .|  .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 2836.AA MSK 58-316 27 5.7e-40 132.81 In-house 1-277 (277) Show / Hide 
Range on Protein: 58-316
Range on HMM: 1-277/277
Sequence Identity: 27% (76 aa)

LEDTDIVGEGSFGKVVRAYDIKNQNEDLVAKIIP---LDDQQKYESM-QMELKVLCKLPQHVNLVNYKKIKMSSQNKQYFIMDYCNGGTLTQYLKNQKKI
|..    |.|.|. ..|    ....    .||..   .  ..| ..  | |  .|  . || |.||..    ..| . | .|.||||| |.  ..  .. 
LKVLGTGGYGKFF-ICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYA-FQDQCHTYLVMEYCNGGELFTHIRKREHF

SENEILEFLQQFCRGYRVLYKEGIIHRDIKPDNILIHNR----IFKIADFGLAKIVDTLQVQNIST-RGTPLYIAPELVKK---EKA--SSKVDMWSLGV
.| |  . . .     . . ..||||||.|| |||  ..      |. |||.|..  . . .   . ..|  | |||....   ..   .. .|.|||||
DESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGV

ILFRMLFKGQYPFL--DPLIK---YDVPTALKHIQQKKLIIPSN--PQRSPEIIDLVKRMLEKDESKRISWEELFSHNLI
||. ||  || ||   .. ..          | |. ..  .|.    . ||.  ||....|.|| .|| . ..|  |  .
ILYTMLT-GQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase 2836.AA STE20 58-242 27 1.9e-34 120.75 In-house 1-214 (288) Show / Hide 
Range on Protein: 58-242
Range on HMM: 1-214/288
Sequence Identity: 27% (60 aa)

LEDTDIVGEGSFGKVVRAYDIKNQNED---LVAKIIPLDDQ----QKYESMQMELKVLCKLPQHVNLVNYKKIKMSS---QNKQYFIMDYCNGGTLTQYL
 |... .|.||.||| .||........      |...|...    .. |. | |  .. ..  | | |.|    . .   ... . .|.||.||.||. .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

K---NQKK------ISENEILEFLQQFCRGYRVLYKEGIIHRDIKPDNILIHNR-IFKIADFGLAKIVDT-----LQVQNISTRGTPLYIAPELVKK---
|   . .|      ..| .|   ... ..|   | ...||||||| ||||.  .   |.||||..  ...      | .  .  ||| . |||....   
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--EKASSKVDMWSLG
   .  .|.| ||||
PDKGYDYKCDIWSLG
Kinase 2836.AA TyrKc 58-316 21 1.8e-16 43.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 58-316
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

LEDTDIVGEGSFGKVVRAYDIKNQNEDLVAKIIPLDDQQKYESMQMELKVLCKL-PQHVNLVNYKKIKMSSQ------NKQYFIMDYCNGGTLTQYLKNQ
..  .. ||| ||.|...  .    ..   | .  |     | .  |....||| ..| |.|.   . ....         . .| |. .| | .||.. 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KK-ISENEILEFLQQFCRGYRVLYKEGIIHRDIKPDNILIHNR-IFKIADFGLAKIVDTL-------QVQNI----STRG-TPL-YIAPELVKKEKASSK
.. ..  . |.|  | ..| . | . ..||||.   |.|.... . ||.||||.. ..         ..       ....  |.   |||  .. | ..|
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDMWSLGVILFRMLFKGQYPFLDP--LIKYDVPTALKHIQQK-KLIIPSN------PQRSPEIIDLVKRMLEKDESKRISWEELFSHNLI
 | || || .. ..  || |  ..    . .   ......|   . .| |      .  ..|. .. |.  . | ..| . .|.  | ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Pkinase_Tyr 2836.AA Pkinase_Tyr 56-246 25 2.6e-15 52.48 Pfam 1-205 (270) Show / Hide 
Range on Protein: 56-246
Range on HMM: 1-205/270
Sequence Identity: 25% (53 aa)

ISLEDTDIVGEGSFGKVVRAYDI--KNQNEDLVA-KII-PLDDQQK--YESMQMELKVLCKLPQHVNLVNYKKIKM-SSQN-KQYFIMDYCNGGTLTQYL
|..  .   |||.||.|....    . ...  || |.. .  ...    |..  |.|....|..| |.|..  . .  ..  . | .| |. .| |  ||
ITFGKK--LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KN----QKKISENEILEFLQQFCRGYRVLYKEGIIHRDIKPDNILIH-NRIFKIADFGLAKIV---DTL-QVQN---ISTRGTPLYIAPELVKKEKASSK
..    .....  ..|.. .| ..|   |   ..||||.   |.|.. |.. ||.|||||. .   |.  ...    .  . .    |||  .  | ..|
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTK

VDMWSLGVILF
 | || || ..
SDVWSFGVLMW
Kinase 2836.AA STE20 286-316 41 0.000131 13.11 In-house 258-288 (288) Show / Hide 
Range on Protein: 286-316
Range on HMM: 258-288/288
Sequence Identity: 41% (13 aa)

SPEIIDLVKRMLEKDESKRISWEELFSHNLI
|||  |.|...|.|| .|| . ..| .|  |
SPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 2836.AA Ciliate-E2c 58-92 31 0.002107 7.89 In-house 1-44 (310) Show / Hide 
Range on Protein: 58-92
Range on HMM: 1-44/310
Sequence Identity: 31% (14 aa)

LEDTDIVGEGSFGKVVRAYDIK-NQNEDLV--------AKIIPL
 . . |.| ||.||| .||  .  ||| ..         |...|
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCL